公开(公告)号：US1413914A

公开(公告)日：1922-04-25

申请号：US34846719

申请日：1919-12-30

Applicant: HOLLIDAY CO LTD L B

Inventor： HOLLIDAY LIONEL B ,  BADIER LOUIS G

IPC: C07C205/24

CPC classification number: C07C201/14 ,  C07C205/24

公开(公告)号：US1380186A

公开(公告)日：1921-05-31

申请号：US25652418

申请日：1918-10-02

Applicant: BREWSTER THEODORE J

Inventor： BREWSTER THEODORE J

IPC: C07C205/24

CPC classification number: C07C201/14 ,  C07C201/08 ,  C07C205/24

公开(公告)号：US11891375B2

公开(公告)日：2024-02-06

申请号：US17814815

申请日：2022-07-25

Applicant: MOEHS IBERICA, S.L.

Inventor： Abdeslam Akhatou ,  Alicia Dobarro Rodríguez

IPC: C07D401/12 ,  C07C201/14 ,  C07D239/34 ,  C07D239/36

CPC classification number: C07D401/12 ,  C07C201/14 ,  C07D239/34 ,  C07D239/36 ,  C07B2200/13

Abstract: A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.

公开(公告)号：US09573881B2

公开(公告)日：2017-02-21

申请号：US14652913

申请日：2013-12-20

Applicant: Nippon Soda Co., Ltd.

Inventor： Hiroki Inoue ,  Yuzuru Sakata ,  Shinichi Kobayashi ,  Yoshikazu Ito ,  Takashi Kitayama

IPC: C07C209/74 ,  C07C17/00 ,  C07C201/14 ,  C07C209/32 ,  C07C205/12 ,  C07C211/52 ,  C07C17/12

CPC classification number: C07C209/74 ,  C07C17/00 ,  C07C17/06 ,  C07C17/12 ,  C07C201/08 ,  C07C201/14 ,  C07C205/12 ,  C07C209/32 ,  C07C211/52 ,  C07C25/13

Abstract: The present invention provides a halogenated aniline represented by formula (I) (wherein each of X1 and X2 independently represents a chlorine atom, a bromine atom or an iodine atom), a method for producing the halogenated aniline, and other aspects.

Abstract translation: 本发明提供由式（I）表示的卤代苯胺（其中，X 1和X 2各自独立地表示氯原子，溴原子或碘原子），卤代苯胺的制造方法等。

公开(公告)号：US08692036B2

公开(公告)日：2014-04-08

申请号：US13823831

申请日：2011-09-05

Applicant: Shengjian Zhang ,  Yingxian Zhao ,  Hong Zhang

Inventor： Shengjian Zhang ,  Yingxian Zhao ,  Hong Zhang

IPC: C07C205/00

CPC classification number: C07C201/14 ,  C07C201/06 ,  C07C205/02

Abstract: The present invention relates to a method for preparing 2,3-dimethyl-2,3-dinitrobutane (DMNB), which includes the following steps: (1) making titanium-silicate molecular sieve catalyst, acetone, hydrogen peroxide and ammonia contact and react at 65-80° C. to obtain a modified titanium-silicate molecular sieve catalyst; and (2-1) making acetone oxime and hydrogen peroxide contact and react in the presence of the modified titanium-silicate molecular sieve catalyst and water under the conditions of temperature of 60-90° C. and pH of 8-10, and separating DMNB from the reaction products thereof; or (2-2) making acetone, ammonia and hydrogen peroxide contact and react in the presence of the modified titanium-silicate molecular sieve catalyst and water under the conditions of temperature of 60-90° C. and pH of 8-10, and separating DMNB from the reaction products thereof. By the method provided by the present invention, DMNB can be prepared without having to use dangerous chemicals, such as 2-nitropropane, NaH and the like.

Abstract translation: 本发明涉及一种制备2,3-二甲基-2,3-二硝基丁烷（DMNB）的方法，其包括以下步骤：（1）使钛硅酸盐分子筛催化剂，丙酮，过氧化氢和氨接触并反应 在65-80℃下，得到改性钛酸酯分子筛催化剂; 和（2-1）使丙酮肟和过氧化氢接触并在改性的钛酸硅酸盐分子筛催化剂和水的存在下在60-90℃的温度和pH为8-10的条件下反应，并分离 DMNB反应产物; 或（2-2）使丙酮，氨和过氧化氢接触并在改性钛硅酸盐分子筛催化剂和水的存在下在60-90℃的温度和pH为8-10的条件下反应，和 从其反应产物中分离DMNB。 通过本发明提供的方法，可以制备DMNB，而不必使用危险化学品，例如2-硝基丙烷，NaH等。

公开(公告)号：US07851661B2

公开(公告)日：2010-12-14

申请号：US10586683

申请日：2005-02-02

Applicant: Johannes Buettner ,  Wolfgang Mackenroth ,  Heinrich Hermann ,  Peter Konieczny ,  Juergen Gebauer

Inventor： Johannes Buettner ,  Wolfgang Mackenroth ,  Heinrich Hermann ,  Peter Konieczny ,  Juergen Gebauer

IPC: C07C205/00

CPC classification number: C07C201/08 ,  C07C201/14 ,  C07C205/06

Abstract: The present invention provides a process for preparing dinitrotoluene, comprising the steps of a) reacting toluene with nitric acid in the presence of sulphuric acid to give mononitrotoluene, b) separating the reaction product from step a) into an organic phase comprising mononitrotoluene and an aqueous phase comprising sulfuric acid, c) reacting the organic phase comprising mononitrotoluene with nitric acid in the presence of sulphuric acid to give dinitrotoluene, d) separating the reaction product from step c) into an organic phase comprising dinitrotoluene and an aqueous phase comprising sulfuric acid, wherein the reaction product from step a) has a content of toluene of from 3.0 to 8% by weight, based on the organic phase, and a content of nitric acid of from 0.1 to 1.2% by weight, based on the aqueous phase, and the phase separation in step b) is effected in such a way that further reaction of the toluene with the nitric acid is prevented.

Abstract translation: 本发明提供了制备二硝基甲苯的方法，包括以下步骤：a）在硫酸存在下使甲苯与硝酸反应得到一硝基甲苯，b）将步骤a）中的反应产物分离成包含单硝基甲苯和水 相，包括硫酸，c）在硫酸存在下使包含一硝基甲苯的有机相与硝酸反应，得到二硝基甲苯，d）将步骤c）中的反应产物分离成包含二硝基甲苯和含有硫酸的水相的有机相， 其中步骤a）的反应产物的甲苯含量为3.0-8重量％，基于有机相，硝酸含量为0.1-1.2重量％，基于水相，和 步骤b）中的相分离是以防止甲苯与硝酸进一步反应的方式进行的。

公开(公告)号：US20070128680A1

公开(公告)日：2007-06-07

申请号：US10595943

申请日：2004-11-25

Applicant: Claudio Lopes ,  Rosangela Sabattini Lopes ,  Jari Cardoso ,  Jacqueline Silva ,  Leticia Ferreira

Inventor： Claudio Lopes ,  Rosangela Sabattini Lopes ,  Jari Cardoso ,  Jacqueline Silva ,  Leticia Ferreira

IPC: C12Q1/66 ,  C07D237/28

CPC classification number: C07C201/14 ,  C07D237/28 ,  C07C205/57

Abstract: The present invention describes a process to form hydrazides from the reaction of a hydrazine and a dicarboxylic, using a Lewis acid as a main reagent of the reaction. The reaction occurs in a safe reactional environment, utilizing smooth conditions, neither involving high temperatures nor high pressures, producing the desired products with high yields, between 90-95%. The invention also describes a kit for utilization of chemiluminescent substances, comprised of two solutions.

Abstract translation: 本发明描述了使用路易斯酸作为反应的主要试剂从肼和二羧酸的反应形成酰肼的方法。 该反应发生在安全的反应环境中，使用平稳的条件，既不涉及高温也不高压，以高产率生产所需产物，在90-95％之间。 本发明还描述了一种用于利用由两种溶液组成的化学发光物质的试剂盒。

公开(公告)号：US4912238A

公开(公告)日：1990-03-27

申请号：US292049

申请日：1988-12-30

Applicant: William B. Alston ,  Roy F. Gratz

Inventor： William B. Alston ,  Roy F. Gratz

IPC: C07C17/26 ,  C07C49/813 ,  C07C205/57 ,  C07F9/50

CPC classification number: C07F9/5022 ,  C07C17/2637 ,  C07C201/14 ,  C07C209/78 ,  C07D307/89

Abstract: Synthetic procedures to tetraalkyls, tetraacids and dianhydrides substituted 1,1,1-triaryl-2,2,2-trifluoroethanes which comprises: (1) 1,1-bis(dialkylaryl)-1-aryl-2,2,2-trifluoroethane, (2) 1,1-bis(dicarboxyaryl)-1-aryl-2,2,2-trifluoroethane or (3) cyclic dianhydride or diamine of 1,1-bis(dialkylaryl)-1-aryl-2,2,2-trifluoroethanes. The synthesis of (1) is accomplished by the condensation reaction of an aryltrifluoromethyl ketone with a dialkylaryl compound. The synthesis of (2) is accomplished by oxidation of (1). The synthesis dianhydride of (3) is accomplished by the conversion of (2) to its corresponding cyclic dianhydride. The synthesis of the diamine is accomplished by the similar reaction of an aryltrifluoromethyl ketone with aniline or alkyl substituted or disubstituted anilines. Also, other derivatives of the above are formed by nucleophilic displacement reactions.

Abstract translation: 四烷基，四酸和二酐的合成方法取代1,1,1-三芳基-2,2,2-三氟乙烷，其包括：（1）1,1-双（二烷基芳基）-1-芳基-2,2,2-三氟乙烷 ，（2）1,1-双（二羧基芳基）-1-芳基-2,2,2-三氟乙烷或（3）1,1-双（二烷基芳基）-1-芳基-2,2,2-三氟乙烷的环状二酐或二胺， 2-三氟乙烷。 （1）的合成通过芳基三氟甲基酮与二烷基芳基化合物的缩合反应来实现。 （2）的合成通过（1）的氧化实现。 （3）的合成二酐通过（2）转化成其相应的环状二酐来实现。 二胺的合成通过芳基三氟甲基酮与苯胺或烷基取代或二取代的苯胺的类似反应来实现。 此外，上述的其它衍生物通过亲核取代反应形成。

公开(公告)号：US4885116A

公开(公告)日：1989-12-05

申请号：US159071

申请日：1988-02-23

Applicant: William B. Alston ,  Roy F. Gratz

Inventor： William B. Alston ,  Roy F. Gratz

IPC: C07C17/26 ,  C07C49/813 ,  C07C205/57 ,  C07F9/50

CPC classification number: C07F9/5022 ,  C07C17/2637 ,  C07C201/14 ,  C07C209/78 ,  C07C49/813

Abstract: Synthetic procedures to tetraalkyls, tetraacids and dianhydrides substituted 1,1,1-triaryl-2,2,2-trifluoroethanes which comprises: (1) 1,1-bis(dialkylaryl)-1-aryl-2,2,2-trifluoroethane, (2) 1,1-bis(dicarboxyaryl)-1-aryl-2,2,2-trifluoroethane or (3) cyclic dianhydride or diamine of 1,1-bis(dialkylaryl)-1-aryl-2,2,2-trifluoroethanes. The synthesis of (1) is accomplished by the condensation reaction of an aryltrifluoromethyl ketone with a dialkylaryl compound. The synthesis of (2) is accomplished by oxidation of (1). The synthesis dianhydride of (3) is accomplished by the conversion of (2) to its corresponding cyclic dianhydride. The synthesis of the diamine is accomplished by the similar reaction of an aryltrifluoromethyl ketone with aniline or alkyl substituted or disubstituted anilines. Also, other derivatives of the above are formed by nucleophilic displacement reactions.

Abstract translation: 四烷基，四酸和二酐的合成方法取代1,1,1-三芳基-2,2,2-三氟乙烷，其包括：（1）1,1-双（二烷基芳基）-1-芳基-2,2,2-三氟乙烷 ，（2）1,1-双（二羧基芳基）-1-芳基-2,2,2-三氟乙烷或（3）1,1-双（二烷基芳基）-1-芳基-2,2,2-三氟乙烷的环状二酐或二胺， 2-三氟乙烷。 （1）的合成通过芳基三氟甲基酮与二烷基芳基化合物的缩合反应来实现。 （2）的合成通过（1）的氧化实现。 （3）的合成二酐通过（2）转化成其相应的环状二酐来实现。 二胺的合成通过芳基三氟甲基酮与苯胺或烷基取代或二取代的苯胺的类似反应来实现。 此外，上述的其它衍生物通过亲核取代反应形成。

公开(公告)号：US4758380A

公开(公告)日：1988-07-19

申请号：US924474

申请日：1986-10-29

Applicant: William B. Alston ,  Roy F. Gratz

Inventor： William B. Alston ,  Roy F. Gratz

IPC: C07C17/26 ,  C07C49/813 ,  C07C205/57 ,  C07F9/50 ,  C07C15/16 ,  C07D237/02

CPC classification number: C07F9/5022 ,  C07C17/2637 ,  C07C201/14 ,  C07C205/57 ,  C07C209/78 ,  C07C41/16 ,  C07C51/27

Abstract: Synthetic procedures to tetraalkyls, tetraacids and dianhydrides substituted 1,1,1-triaryl-2,2,2-trifluoroethanes which comprises: (1) 1,1-bis(dialkylaryl)-1-aryl-2,2,2-trifluoroethane, (2) 1,1-bis(dicarboxyaryl)-1-aryl-2,2,2-trifluoroethane or (3) cyclic dianhydride or diamine of 1,1-bis(dialkylaryl)-1-aryl-2,2,2-trifluoroethanes. The synthesis of (1) is accomplished by the condensation reaction of an aryltrifluoromethyl ketone with a dialkylaryl compound. The synthesis of (2) is accomplished by oxidation of (1). The synthesis dianhydride of (3) is accomplished by the conversion of (2) to its corresponding cyclic dianhydride. The synthesis of the diamine is accomplished by the similar reaction of an aryltrifluoromethyl ketone with aniline or alkyl substituted or disubstituted anilines. Also, other derivatives of the above are formed by nucleophilic displacement reactions.