公开(公告)号：US20240091359A1

公开(公告)日：2024-03-21

申请号：US18274875

申请日：2022-01-28

申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

发明人： Brian Czerniecki ,  Loretta Loftus ,  Gabriella K. Albert

IPC分类号： A61K39/00 ,  A61P35/00 ,  C07K14/72 ,  C07K14/725 ,  C12N5/0783 ,  G01N33/569

CPC分类号： A61K39/464401 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/4632 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/721 ,  C12N5/0636 ,  G01N33/56972 ,  C12N2501/2302 ,  C12N2502/1121 ,  C12N2503/00

摘要： Disclosed are compositions neoantigens and T cell receptors (TCRs) specific for one or more neoantigens as well as methods of their use for treating cancer.

公开(公告)号：US11865140B2

公开(公告)日：2024-01-09

申请号：US17819910

申请日：2022-08-15

申请人： Iovance Biotherapeutics, Inc.

发明人： Ian Frank ,  Michael T. Lotze

IPC分类号： A61K35/17 ,  A01N1/02 ,  A61P35/00 ,  C07K14/725 ,  C07K16/00 ,  C12N15/85 ,  C12N5/0783 ,  G01N33/50

CPC分类号： A61K35/17 ,  A01N1/0284 ,  A61P35/00 ,  C07K14/7051 ,  C07K16/00 ,  C12N5/0636 ,  C12N15/85 ,  G01N33/5005 ,  C07K2317/24 ,  C07K2319/03 ,  C07K2319/33 ,  C12N2501/04 ,  C12N2501/2302 ,  C12N2502/11 ,  C12N2502/1121 ,  C12N2502/99

摘要： The present disclosure provides methods for re-stimulating TIL populations that lead to improved phenotype and increased metabolic health of the TILs and provides methods of assaying for TIL populations to determine suitability for more efficacious infusion after restimulation.

公开(公告)号：US20230405014A1

公开(公告)日：2023-12-21

申请号：US18299640

申请日：2023-04-12

申请人： Genzyme Corporation

发明人： Sourav Roy CHOUDHURY ,  Mona MOTWANI ,  Christian MUELLER ,  John REED

IPC分类号： A61K31/4162 ,  C12N15/86 ,  C07K14/015 ,  A61K48/00 ,  C12N5/0786

CPC分类号： A61K31/4162 ,  C12N15/86 ,  C07K14/015 ,  A61K48/005 ,  A61K48/0075 ,  C12N5/0645 ,  C12N2750/14143 ,  C12N2502/1121

摘要： Provided herein are methods for enhancing gene therapy in an individual by administering an IRAK degrader with the gene therapy to suppress innate immunity to the gene therapy. In some embodiments, the gene therapy uses an adeno-associated virus (AAV) vector, an adenovirus vector, a lentivirus vector, a Herpes simplex virus (HSV) vector or a lipid nanoparticle. Also provided herein are methods for selecting an individual for treatment with an IRAK degrader in combination with a gene therapy agent.

公开(公告)号：US20230346939A1

公开(公告)日：2023-11-02

申请号：US18026336

申请日：2021-09-15

申请人： City of Hope

发明人： Fouad Kandeel

IPC分类号： A61K39/00 ,  C12N5/0783 ,  C07K14/725 ,  C07K16/28 ,  C07K14/73

CPC分类号： A61K39/46433 ,  C12N5/0637 ,  C07K14/7051 ,  C07K16/2896 ,  C07K14/70514 ,  A61K39/4611 ,  A61K39/4621 ,  A61K39/4631 ,  A61K39/46434 ,  C12N2502/1121 ,  C12N2501/231 ,  C12N2501/2302 ,  C07K2317/622 ,  C07K2317/24 ,  C07K2319/03 ,  C07K2319/61 ,  A61K2239/15 ,  A61K2239/21 ,  A61K2239/26

摘要： Provided herein, inter alia, are compositions and methods for reprogramming immune cells for treating or preventing immune disorders. The methods include contacting immune cells with antigens, and administering the resultant immune cells to a subject who has an immune disorder.

公开(公告)号：US20230346936A1

公开(公告)日：2023-11-02

申请号：US18026335

申请日：2021-09-15

申请人： City of Hope

发明人： Fouad Kandeel

IPC分类号： A61K39/00 ,  C12N5/0783 ,  A61P37/06

CPC分类号： A61K39/4621 ,  C12N5/0637 ,  A61K39/4611 ,  A61K39/4615 ,  A61K39/4612 ,  A61P37/06 ,  C12N2501/2302 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2502/1107 ,  C12N2502/1121

摘要： Provided herein, inter alia, are methods and compositions for treating or preventing graft-versus-host disease. The methods include administering to a tissue transplant recipient a composition comprising a donor-derived regulatory T cell.

公开(公告)号：US20230310608A1

公开(公告)日：2023-10-05

申请号：US18003279

申请日：2021-07-01

申请人： TCER ONCOLOGY AB

发明人： Hans GRÖNLUND ,  Rolf KIESSLING ,  Stina WICKSTRÖM

IPC分类号： A61K39/00 ,  A61P35/00 ,  C12N5/0784 ,  C12N5/0783

CPC分类号： A61K39/46449 ,  A61K39/4611 ,  A61K39/00119 ,  A61P35/00 ,  C12N5/0639 ,  C12N5/0638 ,  A61K2039/5154 ,  A61K2039/5158 ,  C12N2502/1121 ,  C12N2502/1114

摘要： The present invention provides an in vitro method for the manufacture of a dendritic cell (DC) cancer vaccine, said method comprising the steps of: (i) providing a plurality of phagocytosable particles, wherein each phagocytosable particle comprises a core and an antigenic construct tightly associated to the core, wherein the antigenic construct comprises at least one epitope peptide having an amino acid sequence corresponding to an amino acid sequence of a part of a protein or peptide known or suspected to be expressed by a cancer cell in a subject; (ii) providing a sample of DCs; and (iii) contacting the sample of DCs with the plurality of phagocytosable particles in vitro and under conditions allowing for the phagocytosis of at least one phagocytosable particle by a DC. The present invention also provides a DC cancer vaccine produced by the method of the invention, and the use a DC cancer vaccine of the invention as a medicament and for the ex vivo expansion of anticancer T-cells.

公开(公告)号：US20230303973A1

公开(公告)日：2023-09-28

申请号：US18191791

申请日：2023-03-28

申请人： James VELTMEYER

发明人： James VELTMEYER

IPC分类号： C12N5/079 ,  A61P35/00

CPC分类号： C12N5/0622 ,  A61P35/00 ,  C12N2502/1121 ,  C12N2502/30

摘要： Disclosed are means, methods, and compositions of matter useful for treatment of oncological indications through stimulation of protective anti-cancer immunity. In one embodiment the invention discloses the unexpected effect of astrocytes to augment immune stimulating activities of dendritic cells. In one embodiment dendritic cells are pulsed with tumor lysates and subsequently co-cultured with astrocytes in the presence of toll-like receptor agonists.

公开(公告)号：US09944899B2

公开(公告)日：2018-04-17

申请号：US14926761

申请日：2015-10-29

申请人： OSPEDALE SAN RAFFAELE S.R.L. ,  Fondazione Telethon

发明人： Silvia Adriana Gregori ,  Maria Grazia Roncarolo ,  Rosa Bacchetta

IPC分类号： C12N5/0783 ,  C12N5/0784 ,  A61K35/17 ,  A01N63/02 ,  C12N5/071 ,  A61K35/12

CPC分类号： C12N5/0637 ,  A61K35/17 ,  A61K2035/122 ,  A61K2035/124 ,  C12N5/0636 ,  C12N5/064 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/231 ,  C12N2502/1121 ,  C12N2506/115

摘要： The present invention relates to a tolerogenic dendritic cell population (Tr-DC) capable of generating a population of T cells having regulatory activity, method of production and uses thereof. Furthermore, soluble HLA-G promotes the differentiation of a population of T cells with regulatory activity.

公开(公告)号：US20180078626A1

公开(公告)日：2018-03-22

申请号：US15563127

申请日：2016-03-30

申请人： Dana-Farber Cancer Institute, Inc. ,  Beth Israel Deaconess Medical Center

发明人： David AVIGAN ,  Jacalyn ROSENBLATT ,  Donald KUFE

IPC分类号： A61K39/00 ,  A61K38/19 ,  A61K45/06 ,  A61K39/395 ,  C07K16/28 ,  C12N15/02

CPC分类号： A61K39/0011 ,  A61K35/15 ,  A61K38/193 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/575 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/2827 ,  C12N15/02 ,  C12N2501/22 ,  C12N2502/1121 ,  C12N2502/30

摘要： The present invention provides compositions and methods for treating renal cell carcinoma

公开(公告)号：US20170198010A1

公开(公告)日：2017-07-13

申请号：US15412760

申请日：2017-01-23

申请人： ONCOTHERAPY SCIENCE, INC.

发明人： Yusuke NAKAMURA ,  Takuya TSUNODA ,  Ryuji OSAWA ,  Sachiko YOSHIMURA ,  Tomohisa WATANABE ,  Gaku NAKAYAMA

IPC分类号： C07K7/06 ,  C12N5/0783 ,  A61K39/00

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  C07K14/705 ,  C12N5/0638 ,  C12N2501/998 ,  C12N2502/1114 ,  C12N2502/1121 ,  G01N33/57407

摘要： The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 42, which bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL). The peptides may include one of the above mentioned amino acid sequences with substitution, deletion, or addition of one, two, or several amino acids sequences. The present invention also provides pharmaceutical compositions including these peptides. The peptides of this invention can be used for treating cancer.