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公开(公告)号：US5753488A
公开(公告)日：1998-05-19
申请号：US465388
申请日：1995-06-05
申请人： William John Martin
发明人： William John Martin
CPC分类号： C07K14/005 , C12N7/00 , C12Q1/701 , C12Q1/702 , C12Q1/705 , G01N33/56983 , A61K39/00 , C12N2710/16021 , C12N2710/16022 , C12N2710/16622 , C12N2740/10022
摘要： An isolated stealth virus that is positively correlated with chronic fatigue syndrome is provided from a patient having a disease. Examples of diseases the patient may have include multiple sclerosis, unexplained encephalopathy, acute encephalopathy, psychiatric disorder, Alzheimer's disease, fibromyalgia, myositis, muscle neuritis, chronic pain syndrome, salivary gland enlargement, autoimmune disease, and unexplained hepatitis. A vaccine having an isolated stealth virus or antigen is also provided.
摘要翻译： 与患有疾病的患者提供与慢性疲劳综合征正相关的孤立隐形病毒。 患者可能患有疾病的实例包括多发性硬化，不明原因脑病，急性脑病，精神病，阿尔茨海默病，纤维肌痛，肌炎，肌肉神经炎，慢性疼痛综合征，唾液腺增大，自身免疫性疾病和不明原因肝炎。 还提供了具有分离的隐形病毒或抗原的疫苗。
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公开(公告)号：US12061198B2
公开(公告)日：2024-08-13
申请号：US16601627
申请日：2019-10-15
申请人： ENZO BIOCHEM, INC
发明人： Gerard Nuovo , Virginia Nivar
IPC分类号： C12Q1/68 , C07K16/08 , C07K16/24 , C12Q1/6883 , C12Q1/6886 , C12Q1/70 , G01N33/569
CPC分类号： G01N33/56994 , C07K16/085 , C07K16/244 , C12Q1/6883 , C12Q1/6886 , C12Q1/701 , C12Q1/705 , C07K2317/33 , C07K2317/76 , C12N2710/16021 , C12Q2600/118 , C12Q2600/158 , G01N2333/03 , G01N2800/7052
摘要： Provided are methods of diagnosing a viral disease such as idiopathic pulmonary fibrosis, Castleman's disease, a lymphoma, a thymoma or a sarcoma in a patient by identifying one or more virus-specific elements such as a nucleic acid or a viral protein or a patient antibody to a virus-specific element, as well as to kits for diagnosing the viral disease in a patient. Further provided are methods of monitoring disease progression and/or the efficacy of therapy by measuring the levels of a virus-specific element in a sample from a patient, and methods of identifying therapeutic agents that show efficacy in reducing levels of virus-specific agents in vitro. Still further provided are methods of treating idiopathic pulmonary fibrosis, a lymphoproliferative disease and cancer, as well as to methods of preventing viral infection, including Herpesvirus saimiri infection.
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公开(公告)号：US09617607B2
公开(公告)日：2017-04-11
申请号：US14759687
申请日：2014-01-08
申请人： Enzo Biochem, Inc.
发明人： Gerard Nuovo , Virginia Nivar
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/569 , C07K16/08
CPC分类号： G01N33/56994 , C07K16/085 , C07K16/244 , C07K2317/33 , C07K2317/76 , C12N2710/16021 , C12Q1/6883 , C12Q1/6886 , C12Q1/705 , C12Q2600/158 , G01N2333/03 , G01N2800/7052
摘要： Provided are methods of diagnosing a viral disease such as idiopathic pulmonary fibrosis, Castleman's disease, a lymphoma, a thymoma or a sarcoma in a patient by identifying one or more virus-specific elements such as a nucleic acid or a viral protein or a patient antibody to a virus-specific element, as well as to kits for diagnosing the viral disease in a patient. Further provided are methods of monitoring disease progression and/or the efficacy of therapy by measuring the levels of a virus-specific element in a sample from a patient, and methods of identifying therapeutic agents that show efficacy in reducing levels of virus-specific agents in vitro. Still further provided are methods of treating idiopathic pulmonary fibrosis, a lymphoproliferative disease and cancer, as well as methods of preventing viral infection, including Herpesvirus saimiri infection.
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34.发明授权Recombinant equine herpesvirus-1 vaccine containing mutated glycoprotein C and uses thereof 有权含有突变糖蛋白C的重组马疱疹病毒-1疫苗及其应用公开(公告)号：US09555101B2
公开(公告)日：2017-01-31
申请号：US14543300
申请日：2014-11-17
申请人： Merial Limited
IPC分类号： A61K39/245 , C12N7/00 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2710/16021 , C12N2710/16034 , C12N2710/16722 , C12N2710/16734 , C12N2710/16762
摘要： The present invention provides compositions or vaccines that contain a recombinant EHV-1 that elicit an immune response in animals against equine herpesvirus, including compositions comprising the recombinant EHV-1, methods of vaccination against equine herpesvirus, and kits for use with such methods and compositions.
摘要翻译： 本发明提供了包含在动物中引发马疱疹病毒的免疫应答的重组EHV-1的组合物或疫苗，包括包含重组EHV-1的组合物，针对马疱疹病毒的接种方法，以及用于这些方法和组合物的试剂盒 。
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公开(公告)号：US20150344976A1
公开(公告)日：2015-12-03
申请号：US14759687
申请日：2014-01-08
申请人： Gerard NUOVO , Virginia NIVAR , ENZO BIOCHEM, INC.
发明人： Gerard Nuovo , Virginia Nivar
IPC分类号： C12Q1/70 , C07K16/08 , G01N33/569
CPC分类号： G01N33/56994 , C07K16/085 , C07K16/244 , C07K2317/33 , C07K2317/76 , C12N2710/16021 , C12Q1/6883 , C12Q1/6886 , C12Q1/705 , C12Q2600/158 , G01N2333/03 , G01N2800/7052
摘要： This disclosure relates to methods of diagnosing a viral disease such as idiopathic pulmonary fibrosis, Castleman's disease, a lymphoma, a thymoma or a sarcoma in a patient by identifying one or more virus-specific elements such as a nucleic acid or a viral protein or a patient antibody to a virus-specific element, as well as to kits for diagnosing the viral disease in a patient. The disclosure further relates to methods of monitoring disease progression and/or the efficacy of therapy by measuring the levels of a virus-specific element in a sample from a patient, in addition, the disclosure relates to methods of identifying therapeutic agents that show efficacy in reducing levels of virus-specific agents in vitro. The disclosure further relates to methods of treating idiopathic pulmonary fibrosis, a lymphoproliferative disease and cancer, as well as to methods of preventing viral infection, including Herpesvirus saimiri infection.
摘要翻译： 本公开涉及通过鉴定一种或多种病毒特异性元件如核酸或病毒蛋白或病毒蛋白质来诊断患者中病毒性疾病如特发性肺纤维化，卡斯尔曼氏病，淋巴瘤，胸腺瘤或肉瘤的方法， 患者对病毒特异性元件的抗体，以及用于诊断患者病毒性疾病的试剂盒。 本公开还涉及通过测量来自患者的样品中病毒特异性元件的水平来监测疾病进展和/或治疗功效的方法，此外，本公开涉及鉴定治疗剂的方法，其在 在体外降低病毒特异性药物的水平。 本发明进一步涉及治疗特发性肺纤维化，淋巴组织增生性疾病和癌症的方法，以及预防病毒感染的方法，包括疱疹病毒西米尔感染。
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36.发明申请公开(公告)号：US20150290318A1
公开(公告)日：2015-10-15
申请号：US14748634
申请日：2015-06-24
发明人： Craig J. Eagle , H. Craig Dees , Eric A. Wachter , Jamie Singer
IPC分类号： A61K39/395 , A61K31/352
CPC分类号： A61K39/3955 , A61K31/352 , A61K31/365 , A61K38/193 , A61K38/20 , A61K38/2006 , A61K38/2013 , A61K38/204 , A61K38/21 , A61K38/212 , A61K38/217 , A61K39/0005 , A61K39/0011 , A61K39/245 , A61K39/39558 , A61K45/06 , A61K47/02 , A61K47/60 , A61K2039/505 , C07K16/30 , C12N7/00 , C12N2710/16021 , C12N2710/16034
摘要： A method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic immunomodulatory anticancer agent. A further method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic targeted anticancer agent. The present invention is further directed to pharmaceutical compositions for treatment of cancer. The intralesional chemoablative pharmaceutical composition can comprise an IL chemoablative agent comprising primarily a halogenated xanthene.
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公开(公告)号：US20150232812A1
公开(公告)日：2015-08-20
申请号：US14700036
申请日：2015-04-29
申请人： BioVex Limited
发明人： Robert S. COFFIN
IPC分类号： C12N7/00 , A61K48/00 , A61K35/763
CPC分类号： C12N7/00 , A61K35/763 , A61K48/00 , A61K2039/55516 , A61K2039/55522 , C12N15/86 , C12N2710/16021 , C12N2710/16033 , C12N2710/16632 , C12N2710/16643
摘要： The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional ICP34.5 gene and a functional ICP47 encoding gene.
摘要翻译： 本发明提供具有改进的溶瘤性质的疱疹病毒，其包含编码免疫调节细胞因子的基因，并且缺少功能性ICP34.5基因和功能性ICP47编码基因。
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公开(公告)号：US20140314811A1
公开(公告)日：2014-10-23
申请号：US14320923
申请日：2014-07-01
发明人： Feng YAO
IPC分类号： A61K39/245 , C12N7/00
CPC分类号： A61K39/245 , A61K35/763 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N15/869 , C12N15/8695 , C12N2710/16011 , C12N2710/16021 , C12N2710/16034 , C12N2710/16062 , C12N2710/16071 , C12N2710/16611 , C12N2710/16621 , C12N2710/16622 , C12N2710/16634 , C12N2710/16661 , C12N2710/16662 , C12N2830/003 , C12N2830/006 , G01N33/56994
摘要： The present invention is directed to Herpes simplex-2 viruses that may be used in vaccines to immunize patients against genital herpes.
摘要翻译： 本发明涉及可用于免疫患者的生殖器疱疹疫苗的单纯疱疹病毒2型病毒。
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公开(公告)号：US20140154216A1
公开(公告)日：2014-06-05
申请号：US14175855
申请日：2014-02-07
申请人： AMGEN INC.
发明人： Robert S. COFFIN
IPC分类号： C12N15/86
CPC分类号： C12N7/00 , A61K35/763 , A61K48/00 , A61K2039/55516 , A61K2039/55522 , C12N15/86 , C12N2710/16021 , C12N2710/16033 , C12N2710/16632 , C12N2710/16643
摘要： The present invention relates to non-laboratory virus strains, for example of herpes viruses such as HSV, with improved oncolytic and/or gene delivery capabilities as compared to laboratory virus strains.
摘要翻译： 本发明涉及非实验室病毒株，例如疱疹病毒如HSV，与实验室病毒株相比具有改善的溶瘤和/或基因递送能力。
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公开(公告)号：US20120263752A1
公开(公告)日：2012-10-18
申请号：US13517232
申请日：2010-12-20
申请人： Feng Yao
发明人： Feng Yao
IPC分类号： A61K39/245 , A61P31/22 , C12N7/01
CPC分类号： A61K39/245 , A61K35/763 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N15/869 , C12N15/8695 , C12N2710/16011 , C12N2710/16021 , C12N2710/16034 , C12N2710/16062 , C12N2710/16071 , C12N2710/16611 , C12N2710/16621 , C12N2710/16622 , C12N2710/16634 , C12N2710/16661 , C12N2710/16662 , C12N2830/003 , C12N2830/006 , G01N33/56994
摘要： The present invention is directed to Herpes simplex-2 viruses that may be used in vaccines to immunize patients against genital herpes.
摘要翻译： 本发明涉及可用于免疫患者的生殖器疱疹疫苗的单纯疱疹病毒2型病毒。
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