公开(公告)号：US11035011B2

公开(公告)日：2021-06-15

申请号：US16299107

申请日：2019-03-11

申请人： Luc Montagnier

发明人： Luc Montagnier

IPC分类号： C12Q1/70 ,  C12Q1/689 ,  C12N1/20 ,  C12N15/11 ,  A61K31/7052 ,  A61K31/65

摘要： A method for identifying a risk factor for diseases, disorders or conditions, such as those caused by human immunodeficiency virus, using the polymerase chain reaction and specific primers. Methods for treating patients having these diseases, disorders or conditions by antimicrobial treatment of the risk factor by combined antiviral and antibacterial treatment or by sustaining or stimulating the subject's immune system. Methods for screening biological products including red blood cell preparations. Primers and methods for detecting nucleic acids or microbial agents associated with red blood cells, such as those associated with red blood cells in subjects infected with HIV and undergoing antiretroviral therapy.

公开(公告)号：US11028386B2

公开(公告)日：2021-06-08

申请号：US16582392

申请日：2019-09-25

申请人： AJINOMOTO CO., INC.

发明人： Daisuke Takahashi ,  Takayoshi Torii

IPC分类号： C07F9/6558 ,  C07F9/6533 ,  C12N15/11 ,  C12N15/09 ,  C12N15/113 ,  A61K31/7052

摘要： Morpholino oligonucleotides can be produced efficiently in a high yield by a liquid-phase synthesis method, which includes subjecting a reaction mixture of a condensation reaction to an extraction operation and separating the morpholino oligonucleotide as a resultant product to the organic layer side.

公开(公告)号：US10953039B2

公开(公告)日：2021-03-23

申请号：US16144040

申请日：2018-09-27

申请人： International Business Machines Corporation ,  Agency for Science, Technology and Research

发明人： James L. Hedrick ,  Simone Bianco ,  Mark Kunitomi ,  Yi Yan Yang ,  Xin Ding ,  Chuan Yang ,  Zhen Chang Liang ,  Paola Florez de Sessions ,  Balamurugan Periaswamy

IPC分类号： A61K31/785 ,  A61P31/04 ,  A61K31/407 ,  A61K31/496 ,  A61K31/7052 ,  A61K31/43

摘要： Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.

公开(公告)号：US10941115B2

公开(公告)日：2021-03-09

申请号：US16508253

申请日：2019-07-10

申请人： Oxular Acquisitions Limited

发明人： Thomas Matthew Baker ,  Matthew Colin Thor Fyfe ,  Geraint Jones ,  Stephen Malcolm Thom

IPC分类号： C07D213/74 ,  C07F9/6512 ,  C07H19/048 ,  C07F9/59 ,  C07F9/6503 ,  A61K31/505 ,  A61K31/444 ,  A61K45/06 ,  A61K31/635 ,  A61K31/4375 ,  A61K31/7052 ,  A61K31/4412 ,  C07D405/12 ,  A61K31/541 ,  A61K31/551 ,  A61K31/553 ,  C07F9/58 ,  A61K31/44 ,  A61K31/506 ,  A61K31/675 ,  C07D213/80 ,  C07D401/12 ,  C07D239/47 ,  C07D413/12 ,  C07D453/02 ,  C07F9/6558 ,  C07H13/08 ,  C07H15/26 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/706

摘要： There are provided compounds of formula I, wherein R1A to R1E, R2 to R4, R5a, L and X1 to X3 have meanings given in the description, which compounds have anti-inflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

公开(公告)号：US20210008011A1

公开(公告)日：2021-01-14

申请号：US16923729

申请日：2020-07-08

申请人： Charles W. STRATTON ,  Nicole M. SCHULTEK

发明人： Charles W. STRATTON ,  Nicole M. SCHULTEK

IPC分类号： A61K31/145 ,  A61K31/047 ,  A61K31/438 ,  A61K31/65 ,  A61P29/00 ,  A61K31/7052 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/573 ,  A61K31/58 ,  A61K31/519 ,  A61K38/13 ,  A61K31/436 ,  A61K31/42 ,  A61K31/5377 ,  A61K39/395 ,  A61K38/20

摘要： The present invention relates to treatment of inflammatory diseases with agents that target different phases of the life cycle of Chlamydia spp. In particular, the invention features the use of a combination of one or more of taurine, dimethylglycine, and trimethylglycine with one or more of a rifamycin antibiotic, a macrolide antibiotic, and a tetracycline antibiotic for treating inflammatory diseases resulting from Chlamydial infection.

公开(公告)号：US20210000826A1

公开(公告)日：2021-01-07

申请号：US16930214

申请日：2020-07-15

申请人： Apros Therapeutics, Inc.

发明人： Tom Yao-Hsiang WU

IPC分类号： A61K31/506 ,  A61K31/505 ,  A61K31/675 ,  A61K31/69 ,  A61K31/7052 ,  C07F9/6512 ,  C07D239/49 ,  C07D403/10 ,  C07D403/12 ,  C07F5/02 ,  A61K39/395

摘要： The present disclosure relates to a class of pyrimidine derivatives having immunomodulating properties that act via TLR7 which are useful in the treatment of viral infections and cancers.

公开(公告)号：US10786502B2

公开(公告)日：2020-09-29

申请号：US16364053

申请日：2019-03-25

申请人： Apros Therapeutics, Inc.

发明人： Tom Yao-Hsiang Wu

IPC分类号： A61K31/505 ,  C07D239/48 ,  A61K31/506 ,  C07D403/10 ,  C07D239/49 ,  A61K39/395 ,  A61K31/69 ,  C07F9/6512 ,  A61K31/675 ,  C07D403/12 ,  C07F5/02 ,  A61K31/7052

摘要： The present disclosure relates to a class of pyrimidine derivatives having immunomodulating properties that act via TLR7 which are useful in the treatment of viral infections and cancers. One aspect of the present disclosure relates to a compound represented by Formula 1:

公开(公告)号：US20200297853A1

公开(公告)日：2020-09-24

申请号：US16861494

申请日：2020-04-29

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Muthiah MANOHARAN ,  Kallanthottathil G. RAJEEV ,  Jayaprakash NAIR ,  Martin MAIER

IPC分类号： A61K47/28 ,  A61K31/7004 ,  A61K31/7052 ,  A61K31/70 ,  A61K47/60 ,  A61K47/54 ,  C07H21/02 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/16 ,  A61K47/22

摘要： The present invention provides a phosphorothioate-modified oligonucleotide comprising a structure shown below: The present invention also provides a phosphorothioate-modified oligonucleotide comprising a structure having formula (CIII):

公开(公告)号：US20200297820A1

公开(公告)日：2020-09-24

申请号：US16694494

申请日：2019-11-25

申请人： The Schepens Eye Research Institute, Inc.

发明人： David A. Sullivan ,  Juan Ding ,  Yang Liu ,  Wendy Kam

IPC分类号： A61K38/30 ,  A61K31/5685 ,  A61K31/7052 ,  A61K38/28 ,  A61K38/27 ,  A61K47/36 ,  A61K31/573 ,  A61K45/06 ,  A61K31/568 ,  A61K9/00 ,  A61K31/57

摘要： Disclosed herein are systems and methods for stimulating meibomian gland epithelial cell function by administering to the ocular surface or immediate vicinity of an eye of a subject an effective amount of a pharmaceutical composition containing a PLD-inducing compound, such as the cationic amphiphilic drugs (e.g. azithromycin), androgen or an androgen analogue with androgen effectiveness, corticosteroid, progesterone, IGF-1 or an IGF-1 analogue (e.g. insulin), GH, and mixtures thereof. The pharmaceutical compositions are effective to treat a variety of aliments to the eye including meibomian gland dysfunction, evaporative dry eye disease, lipid abnormalities in meibum or the tear film, and autoimmune diseases such as Sjögren's syndrome.

公开(公告)号：US10780105B2

公开(公告)日：2020-09-22

申请号：US16105859

申请日：2018-08-20

申请人： Janssen BioPharma, Inc.

发明人： Lawrence M. Blatt ,  Leonid Beigelman ,  Natalia Dyatkina ,  Julian Alexander Symons ,  David Bernard Smith

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K31/7068 ,  A61K31/708 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064

摘要： Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.