Optically trapped atom transfer tweezer through hologram and method using the same

    公开(公告)号:US10409220B2

    公开(公告)日:2019-09-10

    申请号:US15482082

    申请日:2017-04-07

    Abstract: An optically trapped atom transfer tweezer includes an optical modulator which modulates incident light and generates a first hologram; a first lens which images the first hologram on an intermediate image plane and generates a first holographic image having any potential shape; a second lens which re-images the first holographic image on an entrance pupil of a third lens; the third lens which re-images a second hologram generated by the re-imaging of the second lens on a plane where an optically trapped atom array exists; a photographing device which captures optically trapped cold atoms from a second holographic image generated on the plane where an optically trapped atom array exists; and a controller which controls the optical modulator to adjust the second holographic image on the basis of the optically trapped atom image captured by the photographing device such that the optically trapped atom array is transferred to any spatial position.

    Method and apparatus for analyzing protein-protein interaction on single molecule level within the cellular environment

    公开(公告)号:US10401367B2

    公开(公告)日:2019-09-03

    申请号:US15945890

    申请日:2018-04-05

    Inventor: Tae-Young Yoon

    Abstract: A method of analyzing protein-protein interactions includes binding the first proteins to the substrate where the first proteins are tagged with the first markers which bind specifically to the biomolecules immobilized on the substrate or the first proteins bind specifically to the biomolecules immobilized on the substrate; incubating the substrate bound first proteins with cell lysate containing the second proteins which are tagged with second markers; analyzing the interactions between the first proteins and the second proteins in the cell lysate, and obtaining the first analytic value representing the kinetic picture of the interactions; incubating the substrate bound first proteins with cell lysate mixture of a cell lysate consisting of the second markers-tagged second proteins and another cell lysate comprising other proteins including unlabelled second proteins and obtaining the second analytic value; comparing and analyzing the first and the second analytic values.

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