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公开(公告)号：US10393747B2
公开(公告)日：2019-08-27
申请号：US15113006
申请日：2014-10-22
Inventor： Jung Hoe Kim , Sung Hyeon Lee , Seung Yeol Park , Jin Man Kim , Hyun Joo An , Jae-Han Kim , Myung Jin Oh
IPC: G01N33/574
Abstract: This invention relates to a method for gastric cancer diagnosis through the detection of glycan changes, and to a kit for gastric cancer diagnosis. More specifically, based on the fact that in gastric cancer patient-derived haptoglobin, there are changes in N-linked glycosylation of haptoglobin, which are detected through lectin and mass spectrometery, that is, an increase in fucosylation, increases or significant changes in specific glycan structures depending on the classification of antennary structures, or a remarkable decrease in a high mannose structure of the N-glycan as compared to normal persons, N-glycan structures identified using the changes in N-linked glycosylation of haptoglobin may be usefully used as a diagnosis marker in a method for gastric cancer diagnosis using lectin or mass spectrometry, and a kit for gastric cancer diagnosis.
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432.发明申请公开(公告)号：US20190233788A1
公开(公告)日：2019-08-01
申请号：US16315761
申请日：2017-07-05
Inventor： Sung Gap IM , Eun Jung LEE , Ji Eung BAEK , Young Hak CHO , Seung Jung YU , Go Ro CHOI
CPC classification number: C12M23/10 , B05D1/60 , B05D7/02 , C08F212/36 , C08F226/06 , C08J5/18 , C08L25/16 , C08L39/08 , C08L57/06 , C08L2203/02 , C08L2203/16 , C12N5/00 , C12N5/0018 , C23C16/452
Abstract: The present invention provides a culture plate comprising a copolymer formed from a first monomer for forming a thin film having high surface free energy and a second monomer for forming a thin film having low surface free energy, a method for producing the culture plate, and a method for producing and transferring a cell aggregate in the form of a cell sheet by using the culture plate. The present invention has the effect of producing a cell aggregate in the form of a cell sheet through an easy and simple process in comparison with prior art.
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公开(公告)号：US10364293B2
公开(公告)日：2019-07-30
申请号：US15310585
申请日：2015-05-21
Inventor： Hak-Sung Kim , Joong-Jae Lee
Abstract: The present invention relates to a polypeptide capable of binding specifically to the extracellular domain of epidermal growth factor receptor, a polynucleotide that encodes the polypeptide, an expression vector comprising the polynucleotide, a recombinant microorganism having the expression vector introduced therein, and a method of producing the polypeptide using the recombinant microorganism. The polypeptide according to the present invention can bind to the extracellular domain of epidermal growth factor receptor with a high binding affinity comparable to those of existing monoclonal antibodies that are widely used as targeted therapeutic agents, thereby inhibiting the activity of the epidermal growth factor receptor. The polypeptide is useful for the development of agents for the prevention or diseases associated with overexpression of epidermal growth factor receptor.
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434.发明申请公开(公告)号：US20190222655A1
公开(公告)日：2019-07-18
申请号：US16186000
申请日：2018-11-09
Inventor： In-Young KO , Kyeongdeok BAEK
CPC classification number: H04L67/16 , H04L43/045 , H04L67/12 , H04L67/18
Abstract: Spatio-cohesive service discovery and handover methods for distributed IoT environments are disclosed. The spatio-cohesive service discovery and handover methods include discovering a set of IoT (internet of thing) resources for providing a set of services which is a set of functionalities necessary for a task in distributed IoT environments, wherein the discovering a set of IoT resources may discover the set of IoT resources through a spatio-cohesive method considering spatial distance between a user and a service and between two services.
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公开(公告)号：US10337016B2
公开(公告)日：2019-07-02
申请号：US15327596
申请日：2016-10-14
Inventor： Byong-Seok Choi , Suk-Jo Kang , Janghyun Lee , Ji Youn Min , Dongmin Chun , Si-Eun Sung
IPC: C12N15/117 , A61K31/713 , C12N15/113
Abstract: The present disclosure provides a pharmaceutical composition for treating cancer comprising an RNA oligonucleotide having a particular sequence and structure. Specifically, when a cell line is treated with an RNA oligonucleotide having specific sequence and helical bend structure according to the present disclosure, the expression of ISG56 is increased and apoptosis of cancer cells is induced. Thus, a composition comprising the RNA oligonucleotide can be used as an anticancer agent.
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Patent Agency Ranking
436.发明申请公开(公告)号：US20190180931A1
公开(公告)日：2019-06-13
申请号：US16304910
申请日：2017-02-23
Applicant: Korea Advanced Institute of Science and Technology , Research & Business Foundation Sungkyunkwan University
Inventor： Hyung-joun Yoo , Sang-sun Yoo , Kang-yoon Lee
Abstract: Disclosed are an inductor layout and an integrated circuit device with improved isolation between inductors through shielding magnetic coupling between the inductors. first and second inductor coils are horizontally spaced apart from each other. A conductor loop is disposed in parallel above the first inductor coil and shields magnetic coupling between the first and second inductor coils in the manner that a part of magnetic flux of a first time-varying magnetic field generated by the second inductor coil is cancelled by magnetic flux of a second magnetic field generated by an induction current that flows in the conductor loop magnetically interlinked with the first time-varying magnetic field. The inductor layout can be applied to an RFIC device to reduce magnetic coupling between inductors of a power amplifier and an oscillator. Improved performance of the device and a very small RFIC can be achieved.
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437.发明授权公开(公告)号：US10306006B2
公开(公告)日：2019-05-28
申请号：US15003740
申请日：2016-01-21
Inventor： Jun Kyun Choi , Seung Hyun Jeon , Man Sun Park
IPC: G06F15/16 , H04L29/08 , G06F17/30 , H04L12/751 , H04L12/747
Abstract: A bio-inspired algorithm based P2P content caching method and system for mesh networks is provided. The bio-inspired algorithm based P2P content caching method for mesh networks includes the steps of checking a request of a content of a user in a mesh router, and searching the content from the mesh router, which is requested for the content, based on a bio-inspired algorithm.
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公开(公告)号：US10304248B2
公开(公告)日：2019-05-28
申请号：US15322075
申请日：2015-06-26
Inventor： Woon Tack Woo , Tae Jin Ha
IPC: G06K9/34 , G06T19/00 , G06T7/11 , G06T7/73 , G06T7/593 , G06F3/01 , G06K9/00 , G06K9/52 , G06K9/62 , G06F3/0484 , G06T7/12 , G06T7/149
Abstract: Provided is a method of providing an augmented reality interaction service, the method including: generating reference coordinates based on a 3-dimensional (3D) image including depth information obtained through a camera; segmenting a region corresponding to a pre-set object from the 3D image including the depth information obtained through the camera, based on depth information of the pre-set object and color space conversion; segmenting a sub-object having a motion component from the pre-set object in the segmented region, and detecting a feature point by modeling the sub-object and a palm region linked to the sub-object based on a pre-set algorithm; and controlling a 3D object for use of an augmented reality service by estimating a posture of the sub-object based on joint information of the pre-set object provided through a certain user interface (UI).
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公开(公告)号：US10295643B2
公开(公告)日：2019-05-21
申请号：US14804678
申请日：2015-07-21
Inventor： Hyun Wook Park , Yong Wan Lim , Ye Ji Han
IPC: G01R33/567 , G01R33/48
Abstract: A magnetic resonance imaging (MRI) apparatus and a control method thereof are provided. The MRI apparatus includes a scanner, and a controller configured to control the scanner to receive magnetic resonance (MR) signals corresponding to a magnitude of a y-axis gradient magnetic field in a respiration cycle of a patient, each of the MR signals being received at a time interval equal to a time period of the respiration cycle over a number of the received MR signals. The MRI apparatus further includes a processor configured to extract an MR signal received in a respiration condition of the patient from the received MR signals, fill a k-space with the extracted MR signal, and generate an MR image by reconstructing data of the filled k-space.
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公开(公告)号：US10287554B2
公开(公告)日：2019-05-14
申请号：US14839603
申请日：2015-08-28
Inventor： Yong-mahn Han , Sang-Wook Park
Abstract: The present invention relates to an induced pluripotent stem cell model of Fabry disease, a preparation method thereof, and a use of the same for the study of Fabry disease development and for the screening of a therapeutic agent for the disease. Particularly, Fabry disease derived induced pluripotent stem cells (iPSCs), embryoid body (EB), and vascular cells were developed and differentiated from fibroblasts originated from Fabry disease patient, wherein the Fabry disease originated iPSCs displayed significantly reduced expression and activity of GLA protein therein, compared with the normal cells, resulting in the accumulation of globotriaosylceramide (Gb3, CD77). Also, the differentiation of vascular cells was induced from the Fabry disease originated iPSCs, and as a result the iPSCs were successfully differentiated into vascular endothelial cells and vascular smooth muscle cells with significantly expressing the marker protein. When the vascular endothelial cells and vascular smooth muscle cells were treated with Fabrazyme, the accumulation of Gb3 was significantly reduced, suggesting that the said cell model can be effectively used for the analysis/study of Fabry disease outbreak mechanism and for the screening of a therapeutic agent for the disease.
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