公开(公告)号：US20190056323A1

公开(公告)日：2019-02-21

申请号：US15770593

申请日：2016-11-04

Applicant: SHISEIDO COMPANY, LTD. ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

Inventor： Masashi MITA ,  Eiichi NEGISHI ,  Kazuhiko Mibayashi ,  Kenji HAMASE

IPC: G01N21/64 ,  G01N30/74 ,  G01N33/50 ,  G01N30/46

Abstract: [Problem]To provide a fluorescence detection apparatus that is capable of simultaneously detecting a plurality of analyte components contained at different concentrations with a wide measurement range.[Solution]A fluorescence detection apparatus 100 includes a cell 110 into which an analyte of a sample is introduced, a light source 130 that irradiates excitation light on the analyte in the cell; a first detector 52 that detects fluorescence generated from the analyte after the excitation light has been irradiated on the analyte, and a second detector 53 that detects the fluorescence generated from the analyte after the excitation light has been irradiated on the analyte. The second detector detects the fluorescence with a measurement range that is different from the measurement range of the first detector, and the first detector and second detector detect the fluorescence simultaneously.

公开(公告)号：US20190038526A1

公开(公告)日：2019-02-07

申请号：US16069979

申请日：2016-12-12

Applicant: SHISEIDO COMPANY, LTD.

Inventor： TAKAYUKI OMURA

IPC: A61K8/06 ,  A61K8/25 ,  A61K8/894 ,  A61Q13/00 ,  A61Q19/00

Abstract: A water-in-oil emulsion cosmetic, has good stability and does not cause a decrease in viscosity when a large quantity of fragrance material is blended. The water-in-oil emulsion cosmetic, includes: (a) 5 to 15% by mass of a fragrance material, (b) 1.5 to 3% by mass of dimethyldistearylammonium hectorite, and, (c) a nonionic surfactant, wherein, the (c) nonionic surfactant comprises (c1) 2 to 10% by mass relative to the total weight of the composition of a polyether modified silicone having a C12-22 branched hydrocarbon chain, and may comprise (c2) 10% by mass or less relative to the total weight of the composition of a polyether modified silicone having no alkyl chain, wherein, a ratio of the total blending quantity of the component (c 1) and the component (c2) relative to a blending quantity of the component (b) is 2 or more, a ratio of the total blending quantity of the component (c1) and the component (c2) to a blending quantity of the component (a) is 0.8 or more, the total blending quantity of the component (c1) and the component (c2) is 4% by mass or more, a ratio of a blending quantity of the component (c1) to that of the component (c2) is 0.8 or more, and the composition has a hardness of 6 or more as measured using a rheometer.

公开(公告)号：US20190025320A1

公开(公告)日：2019-01-24

申请号：US16137968

申请日：2018-09-21

Applicant: Shiseido Company, Ltd.

Inventor： Kenji Hamase ,  Yousuke Toujo ,  Masashi Mita ,  Chieko Mizumoto

IPC: G01N33/68 ,  G16H50/30 ,  G06F19/18 ,  G01N30/88

Abstract: The apparatus for analyzing a disease sample according to the present invention includes: a member for separating and quantitatively determining an amino acid stereoisomer in a biological material from a subject; a member for obtaining a disease state index value through a calculation by substituting the amount of the amino acid stereoisomer into a discriminant equation; and a member for outputting disease state information on the subject on the basis of the disease state index value. The method for analyzing a disease sample according to the present invention includes: a step of measuring the amount of amino acid stereoisomers in a biological material from a subject; a step of obtaining a disease state index value through a calculation by substituting the amount of the amino acid stereoisomers into a discriminant equation; and the like.

公开(公告)号：US20180271755A1

公开(公告)日：2018-09-27

申请号：US15521490

申请日：2015-10-30

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Satoshi YAMAKI ,  Kazutaka SASAKI ,  Takashi MATSUI ,  Kazuhiro YAMAGUCHI

IPC: A61K8/06 ,  A61K8/36 ,  A61K8/86 ,  A61K8/37 ,  A61Q17/04

CPC classification number: A61K8/062 ,  A61K8/06 ,  A61K8/36 ,  A61K8/361 ,  A61K8/37 ,  A61K8/40 ,  A61K8/44 ,  A61K8/86 ,  A61K2800/522 ,  A61Q17/04

Abstract: An oil-in-water emulsified sunblock cosmetic has excellent feeling when used and maintains a high ultraviolet-ray protective effect even upon contact with water or sweat. The oil-in-water emulsified sunblock cosmetic contains an (A) ultraviolet-ray protective agent and a (B) fatty acid forming a solid at room temperature, the cosmetic is characterized in that 51% or less of the fatty acid is neutralized, and the formulation ratio ((A)/(B) of the (A) ultraviolet-ray protective agent to the (B) fatty acid is in the range of at least 0.1 and less than 10.0. The cosmetic exhibits the unprecedented and surprising property of contact with water causing an improvement to the ultraviolet-ray protective ability. It is preferable for the cosmetic to contain an (C) oily component having IOB of 0.5 or higher.

公开(公告)号：US20180263883A1

公开(公告)日：2018-09-20

申请号：US15762813

申请日：2016-09-06

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Makoto UYAMA ,  Reiji MIYAHARA

IPC: A61K8/58 ,  A61K8/06 ,  A61K8/891 ,  A61K8/31 ,  A61K8/34 ,  A61K8/86 ,  A61Q19/00

CPC classification number: A61K8/585 ,  A61K8/06 ,  A61K8/068 ,  A61K8/31 ,  A61K8/342 ,  A61K8/345 ,  A61K8/39 ,  A61K8/86 ,  A61K8/89 ,  A61K8/891 ,  A61Q5/00 ,  A61Q19/00 ,  A61Q19/007

Abstract: A fine emulsion-type cosmetic comprises a finely-emulsified oil phase mainly based on a silicone oil or hydrocarbon oil without use of a high-pressure emulsifying apparatus, and optionally has an average emulsion particle size of 150 nm or less comprising: an aqueous phase as a continuous layer; an oil phase dispersed in the aqueous phase and comprising 82% by mass or more of a silicone oil and a hydrocarbon oil therein; a carboxy-modified silicone represented by the following formula (1); a C16 to 22 higher alcohol; a nonionic surfactant having a POE chain and an HLB of 5 to 10; and a dihydric glycol; wherein R1 and R2 are respectively a functional group represented by —O—Si(R4)3 in which R4 is an alkyl group having 1 to 6 carbon atoms; R3 is a monovalent hydrocarbon group having 1 to 10 carbon atoms; M is a hydrogen atom, metal atom, or organic cation; A is a linear or branched alkylene group represented by CqH2q; and q is an integer of 6 to 20.

公开(公告)号：US09970848B2

公开(公告)日：2018-05-15

申请号：US14761386

申请日：2014-01-21

Applicant: Shiseido Company, Ltd.

Inventor： Eiichiro Yagi ,  Ichiro Iwai

IPC: G01N1/30 ,  A61Q19/00 ,  G01N33/52 ,  A61B5/00 ,  A61K8/49 ,  G01N33/50

CPC classification number: G01N1/30 ,  A61B5/442 ,  A61B5/443 ,  A61B5/4848 ,  A61K8/498 ,  A61K2800/434 ,  A61Q19/00 ,  G01N33/5088 ,  G01N33/52 ,  G01N2001/302

Abstract: The invention relates to providing a method for more conveniently evaluating stratum corneum condition. A stratum corneum sheet is contacted with a solution of a water-soluble dye, and the staining intensity or fluorescence intensity is measured to allow convenient evaluation of the stratum corneum condition. There is further provided a method for evaluating the ameliorating effect of a cosmetic or cosmetic treatment on the stratum corneum, by implementing the method for evaluating stratum corneum condition using a water-soluble dye according to the invention.

公开(公告)号：US09913788B2

公开(公告)日：2018-03-13

申请号：US14650769

申请日：2013-07-01

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Takayuki Omura ,  Daisuke Suzuki

IPC: A61K8/73 ,  A61Q19/00 ,  A61K8/06 ,  A61Q19/08 ,  A61K8/81 ,  A61K8/34 ,  A61K8/37 ,  A61K8/86 ,  A61K8/891

CPC classification number: A61K8/37 ,  A61K8/062 ,  A61K8/34 ,  A61K8/345 ,  A61K8/735 ,  A61K8/8152 ,  A61K8/8158 ,  A61K8/86 ,  A61K8/891 ,  A61K2800/59 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

Abstract: The present invention provides an oil-in-water emulsion composition that is high in the moisturizing effect and the skin smoothing effect, excellent in the improving effect on wrinkles and elasticity, good in spreadability during application, and without an oily feeling and sticky feeling.The oil-in-water emulsion composition of the present invention is characterized by comprising the below-described components (a) hyaluronic acid or a salt thereof, (b) ammonium acryloyldimethyltaurate/beheneth-25 methacrylate crosspolymer, (c) water-holding oil, (d) glycerin, and (e) ethanol.

公开(公告)号：US20170336199A1

公开(公告)日：2017-11-23

申请号：US15525133

申请日：2015-11-10

Applicant: Shiseido Company, Ltd.

Inventor： Yuji MASUDA ,  Eiichiro YAGI ,  Tomohiro KUWAHARA

IPC: G01B11/30 ,  A61B5/00 ,  A61K8/368 ,  A61K8/44 ,  A61Q19/00 ,  G01N21/57 ,  G01N21/21

CPC classification number: G01B11/30 ,  A61B5/00 ,  A61B5/0059 ,  A61B5/107 ,  A61B5/441 ,  A61K8/368 ,  A61K8/44 ,  A61Q19/00 ,  G01N21/21 ,  G01N21/57

Abstract: Provided are an evaluation method for objectively evaluating the glow of the skin, a skin glow improver, and a method for examining skin glow improvers. This method for evaluating the glow of the skin comprises assessing the specular reflectance and diffuse reflectance of skin after polarized light is applied to the surface of the skin, and determining that glow is present in the skin when prescribed conditions are satisfied. A skin glow improver is provided by combining an alkali metal salt of alkoxysalicylic acid and trimethylglycine. This method for examining skin glow improvers makes it possible, using a significant decrease in surface roughness as an indicator, to examine samples capable of improving the specular reflectance of the skin.

公开(公告)号：US20170319454A1

公开(公告)日：2017-11-09

申请号：US15656220

申请日：2017-07-21

Applicant: SHISEIDO COMPANY, LTD.

Inventor： SHIHOKA OOHASHI ,  Yukiko HIRUMA

IPC: A61K8/49 ,  A61Q1/08 ,  A61K8/92 ,  A61Q1/04 ,  A61K8/04 ,  A61Q1/10 ,  A61K8/36 ,  A61Q1/06

CPC classification number: A61K8/498 ,  A61K8/04 ,  A61K8/361 ,  A61K8/92 ,  A61K2800/262 ,  A61K2800/31 ,  A61K2800/434 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q1/08 ,  A61Q1/10

Abstract: A makeup cosmetic has bright fluorescent coloring whilst having excellent transparency (being clear), and a cosmetic coloring material that is suitable for the cosmetic. A makeup cosmetic comprising (A) at least one kind of oil-soluble dye selected from the group consisting of red no. 218, red no. 223 and orange no. 201, (B) a higher fatty acid metal salt, and (C) oil, wherein the blending amount of pigment is not greater than 0.5 mass %, and the oil-soluble dye is dissolved or dispersed in the oil. The makeup cosmetic, achieves high luminance fluorescent coloring whilst also having excellent transparency, and can be used as a lip cosmetic, blusher or eye shadow.

公开(公告)号：US20170266082A1

公开(公告)日：2017-09-21

申请号：US15310369

申请日：2015-04-23

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Yoko MATSUFUJI ,  Hiroko WATANABE ,  Chicko NOMIZU ,  Makoto TSUNENAGA ,  Sawako OOTAKE ,  Tomomi FURUKAWARA

IPC: A61K8/02 ,  A61K8/891 ,  A61K8/92 ,  A61Q19/00 ,  A61Q19/02

CPC classification number: A61K8/0229 ,  A61K8/064 ,  A61K8/31 ,  A61K8/34 ,  A61K8/37 ,  A61K8/585 ,  A61K8/81 ,  A61K8/891 ,  A61K8/894 ,  A61K8/895 ,  A61K8/92 ,  A61Q1/00 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/02

Abstract: The purpose of the present invention is to provide a stick cosmetic that has a stick shape and a novel function that allows said stick cosmetic to be used to replenish moisture throughout the day. The present invention relates to a stick cosmetic for moisture replenishment, said stick cosmetic comprising: (A) 0.01-50 mass % of a fluid volatile oil component; (B) 10 mass % or more of water; (C) a wax that is capable of gelating the fluid volatile oil component; (D) a silicone elastomer; and (E) a silicone-based surfactant. The cosmetic of the present invention preferably further comprises (F) a moisturizing agent. The cosmetic of the present invention is suitable for use in touching up makeup and has a stick shape that exhibits excellent portability.