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    Glue composition for lung volume reduction
    41.
    发明授权
    Glue composition for lung volume reduction 有权
    用于肺容积减少的胶组合物

    公开(公告)号：US07468350B2

    公开(公告)日：2008-12-23

    申请号：US11008580

    申请日：2004-12-08

    申请人： Glen Gong ,  Ronald Dieck

    发明人： Glen Gong ,  Ronald Dieck

    IPC分类号： A61K38/00 ,  C07K14/00

    CPC分类号： A61K38/55 ,  A61K38/57 ,  A61K47/6425 ,  A61K47/66 ,  A61K51/088 ,  B82Y5/00

    摘要： The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.

    摘要翻译： 本发明涉及用于密封损伤的肺组织的局部区域以减少整体肺容积的方法和组合物。 粘合剂组合物提供了胶粘剂，其特征在于连接至一个或多个其它部分的粘合部分，包括例如可交联部分和/或一个其它粘合部分。 本发明的方法和组合物可用于例如治疗肺部疾病如肺气肿。

    Tuned strength chronic obstructive pulmonary disease treatment
    42.
    发明授权
    Tuned strength chronic obstructive pulmonary disease treatment 有权

    公开(公告)号：US10390838B1

    公开(公告)日：2019-08-27

    申请号：US14831007

    申请日：2015-08-20

    申请人： PneumRx, Inc.

    发明人： Mark Mathis ,  Verna Rodriguez

    IPC分类号： A61B1/04 ,  A61B17/12 ,  A61B5/08 ,  A61B17/00

    摘要： The present invention generally provides improved medical devices, systems, and methods, particularly for treating one or both lungs of a patient with an implant, such as a coil, having a strength tuned to a patient's tissue treatment region. More particularly, embodiments of the present invention include a method for treating a lung of a patient with chronic obstructive pulmonary disease. The method comprises determining a regional tissue density of at least a portion of lung tissue of the patient and selecting between first and second coils based on the determined regional tissue density of the portion of lung tissue. In particular, the first coil has a first austenite final tuning and second coil has a second austenite final tuning different than the first tuning. Determining may comprise imaging at least the portion of lung tissue of the patient so as to identify a localized lung tissue density. Selecting may comprise matching the determined tissue density of the treatment region to a tuned strength of the first or second coil.

    Lung Volume Reduction Devices, Methods, and Systems
    43.
    发明申请
    Lung Volume Reduction Devices, Methods, and Systems 审中-公开

    公开(公告)号：US20190150936A1

    公开(公告)日：2019-05-23

    申请号：US16256652

    申请日：2019-01-24

    申请人： PneumRx, Inc.

    发明人： Mark L. Mathis ,  David Thompson ,  Nathan Aronson ,  Patrick Wu

    IPC分类号： A61B17/12 ,  A61B17/122 ,  A61M16/20 ,  A61M16/04 ,  A61B1/267

    摘要： The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.

    Cross-sectional modification during deployment of an elongate lung volume reduction device
    44.
    发明授权
    Cross-sectional modification during deployment of an elongate lung volume reduction device 有权

    公开(公告)号：US10188398B2

    公开(公告)日：2019-01-29

    申请号：US15263195

    申请日：2016-09-12

    申请人： PneumRx, Inc.

    发明人： Mark L. Mathis ,  Patrick Wu ,  David Lehrberg ,  Jaime Vasquez ,  Erin McGurk ,  Ronald Dieck ,  Andrew Stein

    IPC分类号： A61B17/12 ,  A61B1/267 ,  A61B17/10 ,  A61F2/04 ,  A61B17/00

    摘要： Elongate implant structures can be introduced into an airway system to a target airway axial region, often to apply lateral bending and/or compression forces against the lung tissue from within the airways for an extended period of time. Structures or features of the implants may inhibit tissue reactions that might otherwise allow portions of the device to eventually traverse through the wall of the airway. The devices may enhance the area bearing laterally on the tissue of a surrounding airway lumen wall. Embodiments may have features which increase the device friction with the airway to allow the device to grip the surrounding airway as the device is deployed. An appropriate adhesive may be introduced around the device in the lung. Hydrophilic material may inhibit biofilm formation, or features which induce some tissue ingrowth (stimulation of tissue growth) may enhance implanted device supported.

    Torque alleviating intra-airway lung volume reduction compressive implant structures
    46.
    发明授权
    Torque alleviating intra-airway lung volume reduction compressive implant structures 有权
    扭转减轻气道内肺容积减少压缩植入物结构

    公开(公告)号：US09402633B2

    公开(公告)日：2016-08-02

    申请号：US14209194

    申请日：2014-03-13

    申请人： PneumRx, Inc.

    发明人： Jaime Vasquez ,  Mark L. Mathis ,  Timothy Machold ,  Andrew Stein

    IPC分类号： A61B17/08 ,  A61B17/12

    CPC分类号： A61B17/12104 ,  A61B17/12036 ,  A61B17/12145 ,  A61B17/1215 ,  A61B2017/1205

    摘要： A device for enhancing the breathing efficiency of a patient is provided. The implantable device may include a deployed configuration with one or more helical sections with proximal end in a stand-off proximal end configuration. The stand-off proximal end configuration may reduce migration of the deployed device and may preserve implant tissue compression. Alternative configurations may include two or more helical sections with a transition section disposed between the two or more helical sections. A device may include a right-handed helical section and a left-handed helical section and the transition section comprises a switchback transition section. The switchback section may provide greater control of the device during deployment by limiting recoiling forces of a device comprising a spring material. The deployed device may compress the lung to increase a gas filling resistance of the compressed portion of the lung, and/or increase tension and elastic recoil in other portions of the lung.

    摘要翻译： 提供了一种用于增强患者呼吸效率的装置。 可植入装置可以包括具有一个或多个螺旋部分的展开构造，其中近端处于支撑近端构型。 邻近的近端构型可以减少所展开的装置的移动并且可以保持植入物组织的压缩。 替代配置可以包括两个或多个螺旋部分，其中过渡部分设置在两个或多个螺旋部分之间。 设备可以包括右旋螺旋部分和左旋螺旋部分，并且过渡部分包括回转过渡部分。 回转部分可以通过限制包括弹簧材料的装置的反冲力来在展开期间提供对装置的更大的控制。 所展开的装置可以压缩肺以增加肺的压缩部分的气体填充阻力，和/或增加肺其他部分的张力和弹性反冲。