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公开(公告)号：US11623079B2
公开(公告)日：2023-04-11
申请号：US17461886
申请日：2021-08-30
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
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公开(公告)号：US11623078B2
公开(公告)日：2023-04-11
申请号：US17072392
申请日：2020-10-16
申请人： ELECTROCORE, INC.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices and methods for non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode spaced from the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is positioned within the housing and operably coupled to the electrode, either wirelessly or via a lead or other wired connection. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises bursts each with a frequency from about 1 Hz to about 100 Hz, wherein each of the bursts comprises 2 pulses to 20 pulses.
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公开(公告)号：US11517742B2
公开(公告)日：2022-12-06
申请号：US16540476
申请日：2019-08-14
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
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公开(公告)号：US11439818B2
公开(公告)日：2022-09-13
申请号：US16599285
申请日：2019-10-11
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The devices comprise a housing and an energy source for generating an electric current and transmitting the electric current from the electrode through an interface and the outer skin surface of the patient to a selected nerve fiber within the patient as the interface contacts the outer skin surface. The electric current is sufficient to modulate the selected nerve fiber to at least one of treat or prevent at least one of gastroparesis, functional dyspepsia, or ileus in the patient.
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公开(公告)号：US11439390B2
公开(公告)日：2022-09-13
申请号：US16969483
申请日：2019-02-26
发明人： Atal C Patel , Matthew Aaron Wixey
IPC分类号： A61B17/068 , A61B17/072
摘要： Locking assemblies for surgical clamping and cutting instruments include a locking member and a switch. A drive member may be configured to releasably engage a knife and/or a shuttle of the surgical instrument for translating the knife and/or shuttle in a distal direction through a firing stroke. The locking member is movable from a first position permitting distal translation of the drive member through the firing stroke, and a second position inhibiting distal translation of the drive member through the firing stroke. A switch, when proximally positioned, releasably engages the locking member to maintain the locking member in the first position. The switch disengages from the locking member when the switch is moved to a distal position.
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公开(公告)号：US11426574B1
公开(公告)日：2022-08-30
申请号：US17506851
申请日：2021-10-21
申请人： Theragen, Inc.
摘要： Systems, devices and methods are provided for transcutaneously delivering energy impulses to bodily tissues for therapeutic purposes, such as for enhancing the body's bone healing process in spinal fusion patients. A therapeutic stimulator system comprises a housing for an energy source and a signal generator. The system further includes one or more electrodes coupled to the signal generator. A processor is coupled to the housing and configured to determine usage levels of the signal generator and/or motion data of the housing. The system may include a mobile device that allows the patient to input user status data, such as pain levels, and compare the user status data with the usage levels and/or the motion data, thereby improving patient compliance with a prescribed therapy regimen.
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公开(公告)号：US11286097B2
公开(公告)日：2022-03-29
申请号：US15890788
申请日：2018-02-07
发明人： Steven B. Jung
IPC分类号： B65D77/04 , B65D81/107 , B65D81/133 , A61L27/50 , B65D85/07 , B65D25/10 , A61F13/00 , A61L27/10 , B65D75/22 , A61F2/00 , B65D5/50 , B65D81/113
摘要： A more robust packaging structure for maintaining the integrity of compressible biologically active materials during storage and especially during transportation is provided. These containers protect the materials from shock, vibration, deformation, or separation from agitation. The compressible materials may be in the form of synthetic fibers, and may include a composite of fibers and beads or granules. Suitable materials that may benefit from such a robust packaging structure include synthetic materials that comprise a biologically active ceramic or glass.
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公开(公告)号：US11160585B2
公开(公告)日：2021-11-02
申请号：US16126381
申请日：2018-09-10
申请人： Paradigm Spine, LLC
发明人： Frank T. Trautwein , Ralf Riesinger
摘要： A surgical instrument system comprises surgical instruments for use with an implantable interspinous device having at least one pair of wings for securing the implantable device to a spinous process. The instrument system may include a surgical instrument for expanding or spreading the pair of wings to accommodate the spinous process. Further, a surgical instrument may be provided for crimping or compressing the pair of wings against the spinous process for secure attachment of the device to a vertebra. The surgical instruments may be configured similar to pliers and apply force to the pair of wings within a predetermined range so as to avoid damage, weakening or breakage of the pair of wings. The surgical instrument system may also include interspinous devices of differing sizes.
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公开(公告)号：US11141582B2
公开(公告)日：2021-10-12
申请号：US17010634
申请日：2020-09-02
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a spinal nerve within the patient such that the patient experiences at least some pain relief. The methods include varying an electric field such that burst periods and constant periods are created. The electric field has a charge that alternates between positive and negative during the burst periods and a charge with a magnitude of zero during the constant periods.
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公开(公告)号：US11129925B2
公开(公告)日：2021-09-28
申请号：US16458858
申请日：2019-07-01
申请人： Prosidyan, Inc.
发明人： Charanpreet S. Bagga , Steve B. Jung , Hyun W. Bae
IPC分类号： A61L27/56 , A61L27/54 , A61L27/30 , A61L27/32 , A61L27/42 , A61L27/10 , C08L71/02 , A61L27/44 , A61L27/12 , A61L27/48 , A61L27/58
摘要： Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.
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