公开(公告)号：US20060013896A1

公开(公告)日：2006-01-19

申请号：US11180996

申请日：2005-07-13

Applicant: Giorgio Reiner ,  Alberto Reiner

Inventor： Giorgio Reiner ,  Alberto Reiner

IPC: A61K31/195

CPC classification number: A61K8/44 ,  A61K9/2009 ,  A61K31/196 ,  A61K47/02 ,  A61Q11/00

Abstract: New pharmaceutical compositions for oral use containing diclofenac preferably together with alkali metal bicarbonates in amounts of from about 20 to about 80 by weight with respect to diclofenac are described. These compositions are entirely palatable and free from any unpleasant taste or other, side effects; in particular, these formulations permit to obtain in human patients higher Cmax of the active principle and shorter Tmax together with a lower coefficient of variation.

Abstract translation: 描述了相对于双氯芬酸，含有双氯芬酸的新型口服用药物组合物，优选与碱金属碳酸氢盐相当于约20至约80重量％。 这些组合物完全可口，没有任何不愉快的味道或其他副作用; 特别地，这些制剂允许在人类患者中获得较高的活性成分的最大值和更短的最大最小值以及更低的变异系数。

公开(公告)号：US20050147671A1

公开(公告)日：2005-07-07

申请号：US11030537

申请日：2005-01-05

Applicant: Alberto Reiner ,  Giorgio Reiner

Inventor： Alberto Reiner ,  Giorgio Reiner

IPC: A61K8/44 ,  A61K9/20 ,  A61K31/196 ,  A61K47/02 ,  A61Q11/00 ,  A61K31/195

CPC classification number: A61K31/197 ,  A61K8/44 ,  A61K9/2009 ,  A61K31/196 ,  A61K47/02 ,  A61Q11/00

Abstract: New pharmaceutical compositions for oral use containing Diclofenac together with alkali metal bicarbonates in amounts of from 20 to 80 by weight with respect to Diclofenac are described. These compositions are entirely palatable and free from any unpleasant taste or other side effects; in particular, these formulations permit to obtain in human patients higher Cmax of the active principle and shorter Tmax together with a lower coefficient of variation.

Abstract translation: 描述了相对于双氯芬酸，含有重量比为20至80的新型双氯芬酸口服用药物组合物和碱金属碳酸氢盐。 这些组合物完全可口，没有任何不愉快的味道或其他副作用; 特别地，这些制剂允许在人类患者中获得较高的活性成分的最大值和更短的最大最小值以及更低的变异系数。

公开(公告)号：US5030738A

公开(公告)日：1991-07-09

申请号：US527680

申请日：1990-05-22

Applicant: Alberto Reiner

Inventor： Alberto Reiner

IPC: C07C335/06 ,  C07C67/00 ,  C07C313/00 ,  C07C323/25 ,  C07C323/44 ,  C07C325/00 ,  C07D233/64 ,  C07D307/52 ,  C07D317/58 ,  C07D407/00 ,  C07D407/12

CPC classification number: C07D407/12 ,  C07D317/58

Abstract: To synthesize molecules with antiulcer action, specifically ranitidine, niperotidine and cimetidine, having the formula: ##STR1## wherein R.sub.1 is hydrogen or together with R.sub.2 represents the rest of a cycloaliphatic or heterocyclic optionally substituted ring with 5 or 6 carbon atoms, R.sub.2 represents H, alkyl, alkyl substituted with a simple or substituted aromatic ring or with a single or substituted heterocyclic ring, Ar represents a simple or substituted phenyl group, a simple or substituted heterocyclic aromatic group, N=1, 2, 3, 4, 5 or 6 and X represents CH--NO.sub.2, S, N--C.tbd.N, the compound (II) is prepared through the following process sequence: ##STR2## wherein Z=H, NO.sub.2, halogen and R.sub.3 =--(CH.sub.2).sub.n Ar, --(CH.sub.2).sub.n --SH, --(CH.sub.2).sub.n --S--S--(CH.sub.2).sub.n, --(CH.sub.2).sub.n --S--CH.sub.2 Ar Y being halogen.The urea of formula ##STR3## is converted in a first stage into the corresponding carbodiimide ##STR4## by reaction with triphenylphosphine and bromine in the presence of a strong base and in a second stage is obtained the desired compound by reaction with nitromethane or with a saline derivative of cynamide.

Abstract translation: 为了合成具有抗溃疡作用的分子，特别是具有以下分子式的雷尼替丁，尼泊替定和西咪替丁：其中R1是氢或与R2一起代表其余的具有5或6个碳原子的脂环族或杂环任意取代的环， R 2表示H，烷基，被简单或取代的芳环或单取代的杂环取代的烷基，Ar表示简单或取代的苯基，简单或取代的杂环芳基，N = 1,2,3,4 ，5或6，X表示CH-NO 2，S，NC 3 N N，化合物（II）通过以下方法制备：其中Z = H，NO2 卤素和R 3 = - （CH 2）n Ar， - （CH 2）n -SH， - （CH 2）nSS-（CH 2）n - ，（CH 2）n S-CH 2 Ar Y是卤素。 通过在强碱的存在下，通过与三苯基膦和溴反应，将式（II）的脲在第一阶段转化成相应的碳二亚胺（VI），并且在第二阶段中通过 与硝基甲烷或与cynamide的盐水衍生物反应。

公开(公告)号：US4939291A

公开(公告)日：1990-07-03

申请号：US346320

申请日：1989-05-01

Applicant: Alberto Reiner

Inventor： Alberto Reiner

IPC: B01J27/232 ,  B01J27/00 ,  C07B61/00 ,  C07C20060101 ,  C07C67/00 ,  C07C277/00 ,  C07C279/00 ,  C07C313/00 ,  C07C319/20 ,  C07C323/00 ,  C07C323/66

CPC classification number: C07C303/32 ,  C07C319/02 ,  C07C327/26

Abstract: For the preparation of saline derivatives of mercaptoethansulfonic acid belonging to the class of the salts of alkali metals and of the salts with basic aminoacids, the sodium salt of the acid is obtained with a process comprising the reaction between sodium bromoethansulfonate with thiobenzoic acid and sodium bicarbonate and subsequent reaction of the resulting sodium benzoylethansulfonate with ammonia in water solution.

Abstract translation: 为了制备属于碱金属盐类和碱式氨基酸类的巯基乙磺酸的盐水衍生物，该酸的钠盐是通过包括溴代二磺酸钠与硫代苯甲酸和碳酸氢钠之间的反应的方法得到的 随后将所得的苯基乙烷磺酸钠与氨在水溶液中反应。

公开(公告)号：US4865765A

公开(公告)日：1989-09-12

申请号：US121257

申请日：1987-11-16

Applicant: Alberto Reiner

Inventor： Alberto Reiner

IPC: C07J41/00

CPC classification number: C07J41/0061

Abstract: Ursodeoxycholic acid amides of the formula: ##STR1## wherein R is --CH.sub.2 --SO.sub.3 H or --COOH and R' is --H and --(CH.sub.2).sub.2 --CONH, --CH.sub.2 --CONH.sub.2, --(CH.sub.2).sub.2 --SCH.sub.3 or --CH.sub.2 --S--CH.sub.2 --CH.sub.2 --COOH, and their salts with inorganic and organic pharmaceutically active bases, are useful in the treatment of altered biligenetic functions and lithiasis or dyskinesia of the biliary ducts.

公开(公告)号：US4471115A

公开(公告)日：1984-09-11

申请号：US452159

申请日：1982-12-22

Applicant: Alberto Reiner

Inventor： Alberto Reiner

IPC: A61K20060101 ,  A61K9/08 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/22

CPC classification number: C07D501/22

Abstract: The water soluble derivatives of cephalexin, having general formula: ##STR1## wherein X represents an alkali metal or the organic nitrogen containing cation of a basic aminoacid, combine the typical antibiotic action of cephalexin with the water solubility and form essentially neutral, aqueous solutions. The process for the preparation of the above derivatives comprises a first step in which the methylol derivative of cephalexin is prepared and a second step in which the treatment with a suitable base is carried out.

Abstract translation: 具有以下通式的头孢氨苄的水溶性衍生物：其中X表示碱金属或碱性氨基酸的有机含氮阳离子，其结合了头孢氨苄的典型抗生素作用与水溶性，形成基本中性的水溶液。 制备上述衍生物的方法包括制备头孢氨苄羟甲基衍生物的第一步骤和进行用合适碱处理的第二步骤。

公开(公告)号：US4393067A

公开(公告)日：1983-07-12

申请号：US325029

申请日：1981-11-25

Applicant: Alberto Reiner

Inventor： Alberto Reiner

IPC: A61K31/4406 ,  A61K31/4418 ,  A61K31/455 ,  A61P3/06 ,  A61P3/08 ,  C07D213/80 ,  C07D491/04 ,  C07D491/056 ,  A61K31/435 ,  C07D213/62

CPC classification number: C07D213/80 ,  C07D491/04

Abstract: The nicotinic ester of (3-4)-O-isopropylidene pyridixole having the formula: ##STR1## shows analgesic and anti-inflammatory activity.

Abstract translation: 具有下式的（3-4）-O-异亚丙基吡哆醇的烟酸酯显示镇痛和抗炎活性。

公开(公告)号：US4157440A

公开(公告)日：1979-06-05

申请号：US560236

申请日：1975-03-20

Applicant: Alberto Reiner ,  Giacinto Rossi

Inventor： Alberto Reiner ,  Giacinto Rossi

IPC: C07H5/06 ,  C07H19/20 ,  C07H19/213

CPC classification number: C07H19/20

Abstract: For the treatment of cardiac hypertrophy, d-glucosamine salts of the 3',5'-adenosine monophosphoric cyclic acid (AMP-c) and of the dibutyl ester thereof are disclosed, these salts having a reduced acute toxicity and an improved activity on the mitochondria of hypertrophic heart with respect to the cyclic AMP acid alone or its dibutyl ester. The compounds in question are useful for the treatment of cardiac hypertrophy and alteration of the energetic muscular metabolism.

Abstract translation: 为了治疗心脏肥大，公开了3'，5'-腺苷单磷酸环状酸（AMP-c）及其二丁基酯的d-葡糖胺盐，这些盐具有降低的急性毒性和对 相对于单独的环状AMP酸或其二丁酯，肥大心脏的线粒体。 所讨论的化合物可用于治疗心脏肥大和改变能量肌肉代谢。