公开(公告)号：US20110092492A1

公开(公告)日：2011-04-21

申请号：US12975949

申请日：2010-12-22

Applicant: Peter HEROLD ,  Robert Mah ,  Vincenzo Tschinke ,  Aleksandar Stojanovic ,  Christiane Marti ,  Stjepan Jelakovic ,  Stefan Stutz

Inventor： Peter HEROLD ,  Robert Mah ,  Vincenzo Tschinke ,  Aleksandar Stojanovic ,  Christiane Marti ,  Stjepan Jelakovic ,  Stefan Stutz

IPC: A61K31/542 ,  C07D498/04 ,  C07D513/04 ,  A61K31/5383 ,  A61P3/00 ,  A61P9/04 ,  A61P7/00 ,  A61P5/40

CPC classification number: C07D513/04 ,  C07D498/04

Abstract: Heterocyclic compounds of the formula (I) and salts, preferably pharmaceutically acceptable salts thereof, are provided in which R, R1, R2, Q, m and n have the meanings explained in detail in the description. Also provided are a process for their preparation and the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.

Abstract translation: 提供式（I）的杂环化合物和其盐，优选其药学上可接受的盐，其中R，R 1，R 2，Q，m和n具有在说明书中详细解释的含义。 还提供了它们制备和使用这些化合物作为药物的方法，特别是作为醛固酮合成酶抑制剂。

公开(公告)号：US07879847B2

公开(公告)日：2011-02-01

申请号：US12226214

申请日：2007-04-12

Applicant: Peter Herold ,  Robert Mah ,  Vincenzo Tschinke ,  Aleksandar Stojanovic ,  Christiane Marti ,  Stjepan Jelakovic ,  Stefan Stutz

Inventor： Peter Herold ,  Robert Mah ,  Vincenzo Tschinke ,  Aleksandar Stojanovic ,  Christiane Marti ,  Stjepan Jelakovic ,  Stefan Stutz

IPC: C07D498/04 ,  A61K31/5365

CPC classification number: C07D513/04 ,  C07D498/04

Abstract: The application relates to novel heterocyclic compounds of the general formula (I) and salts, preferably pharmaceutically acceptable salts, thereof in which R, R1, R2, Q, m and n have the meanings explained in detail in the description, a process for their preparation and the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.

Abstract translation: 本申请涉及通式（I）的新型杂环化合物和其盐，优选其药学上可接受的盐，其中R，R 1，R 2，Q，m和n具有在说明书中详细解释的含义， 制备和使用这些化合物作为药物，特别是作为醛固酮合酶抑制剂。

公开(公告)号：US07767690B2

公开(公告)日：2010-08-03

申请号：US10587046

申请日：2005-01-21

Applicant: Peter Herold ,  Stefan Stutz ,  Aleksandar Stojanovic ,  Vincenzo Tschinke ,  Christiane Marti ,  Michael Quirmbach

Inventor： Peter Herold ,  Stefan Stutz ,  Aleksandar Stojanovic ,  Vincenzo Tschinke ,  Christiane Marti ,  Michael Quirmbach

IPC: A61K31/435 ,  C07D221/04

CPC classification number: C07D215/38 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D471/08 ,  C07D471/10

Abstract: The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.

Abstract translation: 本申请涉及通式（I）的新型氨基醇，其中R，R 1，R 2，R 3，R 4，R 5和R 6各自具有在说明书中详细说明的定义，其制备方法和使用 这些化合物作为药物，特别是作为肾素抑制剂。

公开(公告)号：US20090275651A1

公开(公告)日：2009-11-05

申请号：US11992127

申请日：2006-09-14

Applicant: Peter Herold ,  Robert Mah ,  Vincenzo Tschinke ,  Stefan Stutz ,  Aleksandar Stojanovic ,  Stjepan Jelakovic ,  Christiane Marti

Inventor： Peter Herold ,  Robert Mah ,  Vincenzo Tschinke ,  Stefan Stutz ,  Aleksandar Stojanovic ,  Stjepan Jelakovic ,  Christiane Marti

IPC: A61K31/351 ,  C07D315/00 ,  A61P9/10 ,  A61P9/04 ,  C07D307/14 ,  A61K31/341

CPC classification number: A61K31/335

Abstract: Compounds of the general formula (formula I) in which the meanings of the substituents R1 to R6 are as indicated in claim 1, have renin-inhibiting properties and can be used as medicines.

Abstract translation: 取代基R 1〜R 6的含义如权利要求1所示的通式（式I）的化合物具有肾素抑制性质，可用作药物。

公开(公告)号：US20090111840A1

公开(公告)日：2009-04-30

申请号：US11921312

申请日：2006-05-30

Applicant: Peter Herold ,  Robert Mah ,  Vincenzo Tschinke ,  Aleksandar Stojanovic ,  Christiane Marti ,  Nathalie Jotterand ,  Christoph Schumacher ,  Michael Quirmbach

Inventor： Peter Herold ,  Robert Mah ,  Vincenzo Tschinke ,  Aleksandar Stojanovic ,  Christiane Marti ,  Nathalie Jotterand ,  Christoph Schumacher ,  Michael Quirmbach

IPC: A61K31/438 ,  C07D401/14 ,  A61P9/12

CPC classification number: C07D471/20

Abstract: The patent application relates to new heterocyclic compounds of the general formula (I) in which R, R1, R2, W, X, Y, Z and n have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.

Abstract translation: 该专利申请涉及通式（I）的新的杂环化合物，其中R，R 1，R 2，W，X，Y，Z和n具有在说明书中更详细阐述的定义，及其制备方法 使用这些化合物作为药物，特别是作为醛固酮合酶抑制剂。

公开(公告)号：US20080176947A1

公开(公告)日：2008-07-24

申请号：US11885967

申请日：2006-03-10

Applicant: Peter Herold ,  Robert Mah ,  Vincenzo Tschinke ,  Stefan Stutz ,  Dirk Behnke ,  Aleksandar Stojanovic ,  Stjepan Jelakovic ,  Christiane Marti

Inventor： Peter Herold ,  Robert Mah ,  Vincenzo Tschinke ,  Stefan Stutz ,  Dirk Behnke ,  Aleksandar Stojanovic ,  Stjepan Jelakovic ,  Christiane Marti

IPC: A61K31/165 ,  C07C237/20 ,  A61P9/00

CPC classification number: C07D309/06 ,  C07C237/20 ,  C07D207/14 ,  C07D211/58 ,  C07D303/36 ,  C07D307/00 ,  C07D307/14 ,  C07D307/20 ,  C07D307/52 ,  C07D307/93 ,  C07D309/08 ,  C07D309/10 ,  C07D311/00 ,  C07D311/94 ,  C07D311/96 ,  C07D313/14 ,  C07D319/12 ,  C07D319/14 ,  C07D321/08 ,  C07D493/08

Abstract: Compounds of the general formula (I) in which the meanings of the substituents R1 and R2 are as stated in claim 1, have renin-inhibiting properties and can be used as medicines.

Abstract translation: 其中取代基R 1和R 2的含义如权利要求1所述的通式（I）的化合物具有肾素抑制性质并且可以使用 作为药物

公开(公告)号：US20080171748A1

公开(公告)日：2008-07-17

申请号：US12076221

申请日：2008-03-14

Applicant: Peter Herold ,  Robert Mah ,  Vincenzo Tschinke ,  Christiane Marti ,  Stefan Stutz ,  Stjepan Jelakovic ,  Zenon D. Konteatis ,  Jennifer L. Ludington ,  Michael Quirmbach ,  Aleksandar Stojanovic ,  Dirk Behnke ,  Frank Hollinger

Inventor： Peter Herold ,  Robert Mah ,  Vincenzo Tschinke ,  Christiane Marti ,  Stefan Stutz ,  Stjepan Jelakovic ,  Zenon D. Konteatis ,  Jennifer L. Ludington ,  Michael Quirmbach ,  Aleksandar Stojanovic ,  Dirk Behnke ,  Frank Hollinger

IPC: A61K31/50 ,  A61K31/4965

CPC classification number: C07D413/12 ,  C07D413/14

Abstract: Substituted piperidines of formulae (I) and (II) with the substituent definitions as explained in the specification. The compounds are suitable in particular as renin inhibitors and are highly potent.

Abstract translation: 式（I）和（II）的取代的哌啶与说明书中所述的取代基定义相同。 该化合物特别适合作为肾素抑制剂，并且是非常有效的。

公开(公告)号：US20070167433A1

公开(公告)日：2007-07-19

申请号：US11655108

申请日：2007-01-19

Applicant: Peter Herold ,  Robert Mah ,  Stefan Stutz ,  Vincenzo Tschinke ,  Christoph Schumacher ,  Aleksandar Stojanovic ,  Nathalie Jotterand ,  Dirk Behnke

Inventor： Peter Herold ,  Robert Mah ,  Stefan Stutz ,  Vincenzo Tschinke ,  Christoph Schumacher ,  Aleksandar Stojanovic ,  Nathalie Jotterand ,  Dirk Behnke

IPC: A61K31/551 ,  A61K31/55 ,  A61K31/542 ,  A61K31/5383 ,  A61K31/517 ,  A61K31/445

CPC classification number: C07D413/14 ,  A61K31/452 ,  A61K31/453 ,  A61K31/4545 ,  C07D405/12 ,  C07D413/12 ,  Y02A50/411

Abstract: Use of compounds of the general formula (I) and pharmaceutically acceptable salt thereof, in which R1, R2, R3, R4, W, X and Z, n and m have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibitors.

Abstract translation: 使用通式（I）的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 3， SEQ ID NO：4，W，X和Z，n和m具有在说明书中详细说明的定义，如β-分泌酶，组织蛋白酶D，浆细胞素II和/或HIV蛋白酶抑制剂。

公开(公告)号：US20070161622A1

公开(公告)日：2007-07-12

申请号：US10586814

申请日：2005-01-21

Applicant: Peter Herold ,  Stefan Stutz ,  Aleksandar Stojanovic ,  Vincenzo Tschinke ,  Christiane Martin ,  Michael Quirmbach

Inventor： Peter Herold ,  Stefan Stutz ,  Aleksandar Stojanovic ,  Vincenzo Tschinke ,  Christiane Martin ,  Michael Quirmbach

IPC: A61K31/55 ,  A61K31/5415 ,  A61K31/54 ,  A61K31/5375 ,  A61K31/495

CPC classification number: C07D207/27 ,  C07C233/36 ,  C07C233/78 ,  C07C311/05 ,  C07D205/04 ,  C07D207/12 ,  C07D207/273 ,  C07D209/18 ,  C07D211/34 ,  C07D211/76 ,  C07D213/56 ,  C07D223/10 ,  C07D239/10 ,  C07D277/42 ,  C07D295/13 ,  C07D295/15 ,  C07D303/48 ,  C07D309/04 ,  C07D333/34 ,  C07D413/06 ,  C07D471/10

Abstract: The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation, and to the use of these compounds as medicines, in particular as renin inhibitors.

Abstract translation: 本申请涉及通式（I）的新型氨基醇，其中R 1，R 1，R 2，R 3，R 3， R 5，R 5和R 6各自具有在说明书中详细说明的定义，其制备方法以及这些的使用 化合物作为药物，特别是作为肾素抑制剂。

公开(公告)号：US09277238B2

公开(公告)日：2016-03-01

申请号：US13051768

申请日：2011-03-18

Applicant: Yoshinori Suzuki ,  Choong Seng Boon ,  Jens-Rainer Ohm ,  Mathias Wien ,  Aleksandar Stojanovic ,  Thiow Keng Tan

Inventor： Yoshinori Suzuki ,  Choong Seng Boon ,  Jens-Rainer Ohm ,  Mathias Wien ,  Aleksandar Stojanovic ,  Thiow Keng Tan

IPC: H04N19/51 ,  H04N19/593 ,  H04N19/573

CPC classification number: H04N19/573 ,  H04N19/51 ,  H04N19/593

Abstract: A moving image encoding and decoding system reduces compressed moving picture data amounts by producing a prediction signal suitable for moving pictures including dynamic textures. The system includes a moving picture encoding device 1 that includes a block divider 102 receiving a target pixel signal, a prediction signal generator 103 producing a prediction signal, a subtractor 105 producing a differential signal, and a transformer 106 and quantizer 107 producing an encoded differential signal. The encoding device 1 also includes an inverse quantizer 108 and inverse transformer 109 producing a decoded differential signal, an adder 110 producing a reproduction signal, a frame memory 104 storing the reproduction signal as a reference image, and a reference image generator 113. The reference image generator 113 may obtain an observation matrix C by using a pre-existing reference image. The encoding system 1 produces a new reference image y″t+5 based on the observation matrix C and a state vector xt+5, and stores the new reference image in the frame memory 104. The prediction signal generator 103 produces the prediction signal by using at least the new reference image y″t+5.

Abstract translation: 运动图像编码和解码系统通过产生适合于包括动态纹理的运动图像的预测信号来减少压缩的运动图像数据量。 该系统包括运动图像编码装置1，其包括接收目标像素信号的块分割器102，产生预测信号的预测信号发生器103，产生差分信号的减法器105以及产生编码差分的变换器106和量化器107 信号。 编码装置1还包括产生解码差分信号的逆量化器108和逆变换器109，产生再现信号的加法器110，存储再现信号作为参考图像的帧存储器104和参考图像生成器113。 图像生成器113可以通过使用预先存在的参考图像来获得观察矩阵C. 编码系统1基于观察矩阵C和状态向量xt + 5产生新的参考图像y“t + 5，并将新的参考图像存储在帧存储器104中。预测信号发生器103通过 至少使用新的参考图像y“t + 5。