公开(公告)号：US09228947B2

公开(公告)日：2016-01-05

申请号：US13502628

申请日：2010-10-18

Applicant: David Andrew Fish

Inventor： David Andrew Fish

IPC: C12M1/34 ,  G01N21/00 ,  G01N21/64 ,  C12Q1/68

CPC classification number: G01N21/6428 ,  C12Q1/6874 ,  G01N21/6452 ,  G01N2021/6421 ,  C12Q2563/107 ,  C12Q2535/122

Abstract: The present invention relates to a device and detector for monitoring a plurality of discrete fluorescence signals, in particular for DNA sequencing by use of fluorescently labeled nucleotides. The particular detector (118) is proposed comprising a plurality of pixels (130) for individually detecting said fluorescence signals from the plurality of fluorescent signal sources (104), wherein each pixel (130) comprises a predetermined number of at least two detection elements (D1, Dn) for detecting a received fluorescent signal and for generating detection signals. Further, a signal conversion circuit (140) is provide for receiving said detection signals from said at least two detection elements (D1, Dn) and for generating a pixel output signal indicating which of said at least two detection elements (D1, Dn) generated the strongest detection signal.

Abstract translation: 本发明涉及用于监测多个离散荧光信号的装置和检测器，特别是通过使用荧光标记的核苷酸进行DNA测序。 提出了特定检测器（118），其包括用于分别检测来自多个荧光信号源（104）的所述荧光信号的多个像素（130），其中每个像素（130）包括预定数量的至少两个检测元件 D1，Dn），用于检测接收到的荧光信号并产生检测信号。 此外，信号转换电路（140）用于从所述至少两个检测元件（D1，Dn）接收所述检测信号，并产生一个像素输出信号，该像素输出信号指示所生成的所述至少两个检测元件（D1，Dn）中的哪一个 最强的检测信号。

公开(公告)号：US08801763B2

公开(公告)日：2014-08-12

申请号：US13514114

申请日：2010-12-02

Applicant: David Andrew Fish ,  Nigel David Young ,  Jay Patel ,  Estelle Julie Dorothee Bernhard-Fichet ,  Peter Douglas Fairley

Inventor： David Andrew Fish ,  Nigel David Young ,  Jay Patel ,  Estelle Julie Dorothee Bernhard-Fichet ,  Peter Douglas Fairley

IPC: A61N1/26

CPC classification number: A61B5/053 ,  A46B15/0002 ,  A46B15/0004 ,  A46B2200/1066 ,  A61C19/063 ,  A61C19/066

Abstract: The appliance includes a brushhead having conductive fiber bristles by which a potential is applied to electrochemically activate a teeth whitening substance, such as peroxide, in the vicinity of the teeth. An impedance appliance system (62) or an optical appliance system (27) provides information concerning whether the conductive fiber bristles are adjacent a tooth surface or gum region. The impedance system uses an electrical signal through the fiber to determine the impedance of a circuit which includes the tooth or gum surface, the impedance being different, depending on whether a tooth or gum surface is in the circuit. The optical system generates a light beam which is directed to the mouth surface through a conductive fiber, the color of the returning light indicating whether the surface is a tooth or gum region. If a tooth is determined, the teeth whitening substance is activated at that bristle, while if gum tissue is determined, the teeth whitening substance is not activated at that bristle.

Abstract translation: 该器具包括具有导电纤维刷毛的刷头，通过该刷头施加电位以电化学地激活牙齿附近的牙齿美白物质，例如过氧化物。 阻抗器具系统（62）或光学器具系统（27）提供关于导电纤维刷毛是否邻近牙齿表面或牙龈区域的信息。 阻抗系统使用通过光纤的电信号来确定包括牙齿或牙龈表面的电路的阻抗，阻抗是不同的，这取决于牙齿或牙龈表面是否在电路中。 光学系统产生通过导电纤维指向口表面的光束，返回光的颜色表示表面是牙齿或牙龈区域。 如果确定牙齿，牙齿美白物质在该刷毛处被活化，而如果确定牙龈组织，那么该牙齿美白物质在那根毛上不被激活。

公开(公告)号：US20120251971A1

公开(公告)日：2012-10-04

申请号：US13514114

申请日：2010-12-02

Applicant: David Andrew Fish ,  Nigel David Young ,  Jay Patel ,  Estelle Julie Dorothee Bernhard-Fichet ,  Peter Douglas Fairley

Inventor： David Andrew Fish ,  Nigel David Young ,  Jay Patel ,  Estelle Julie Dorothee Bernhard-Fichet ,  Peter Douglas Fairley

IPC: A61C19/06 ,  A61B1/24 ,  A46B15/00

CPC classification number: A61B5/053 ,  A46B15/0002 ,  A46B15/0004 ,  A46B2200/1066 ,  A61C19/063 ,  A61C19/066

Abstract: The appliance includes a brushhead having conductive fiber bristles by which a potential is applied to electrochemically activate a teeth whitening substance, such as peroxide, in the vicinity of the teeth. An impedance appliance system (62) or an optical appliance system (27) provides information concerning whether the conductive fiber bristles are adjacent a tooth surface or gum region. The impedance system uses an electrical signal through the fiber to determine the impedance of a circuit which includes the tooth or gum surface, the impedance being different, depending on whether a tooth or gum surface is in the circuit. The optical system generates a light beam which is directed to the mouth surface through a conductive fiber, the color of the returning light indicating whether the surface is a tooth or gum region. If a tooth is determined, the teeth whitening substance is activated at that bristle, while if gum tissue is determined, the teeth whitening substance is not activated at that bristle.

Abstract translation: 该器具包括具有导电纤维刷毛的刷头，通过该刷头施加电位以电化学地激活牙齿附近的牙齿美白物质，例如过氧化物。 阻抗器具系统（62）或光学器具系统（27）提供关于导电纤维刷毛是否邻近牙齿表面或牙龈区域的信息。 阻抗系统使用通过光纤的电信号来确定包括牙齿或牙龈表面的电路的阻抗，阻抗是不同的，这取决于牙齿或牙龈表面是否在电路中。 光学系统产生通过导电纤维指向口表面的光束，返回光的颜色表示表面是牙齿或牙龈区域。 如果确定牙齿，牙齿美白物质在该刷毛处被活化，而如果确定牙龈组织，那么该牙齿美白物质在那根毛上不被激活。

公开(公告)号：US20120208263A1

公开(公告)日：2012-08-16

申请号：US13502628

申请日：2010-10-18

Applicant: David Andrew Fish

Inventor： David Andrew Fish

IPC: C12M1/34

CPC classification number: G01N21/6428 ,  C12Q1/6874 ,  G01N21/6452 ,  G01N2021/6421 ,  C12Q2563/107 ,  C12Q2535/122

Abstract: The present invention relates to a device and detector for monitoring a plurality of discrete fluorescence signals, in particular for DNA sequencing by use of fluorescently labeled nucleotides. The particular detector (118) is proposed comprising a plurality of pixels (130) for individually detecting said fluorescence signals from the plurality of fluorescent signal sources (104), wherein each pixel (130) comprises a predetermined number of at least two detection elements (D1, Dn) for detecting a received fluorescent signal and for generating detection signals. Further, a signal conversion circuit (140) is provide for receiving said detection signals from said at least two detection elements (D1, Dn) and for generating a pixel output signal indicating which of said at least two detection elements (D1, Dn) generated the strongest detection signal.

Abstract translation: 本发明涉及用于监测多个离散荧光信号的装置和检测器，特别是通过使用荧光标记的核苷酸进行DNA测序。 提出了特定检测器（118），其包括用于分别检测来自多个荧光信号源（104）的所述荧光信号的多个像素（130），其中每个像素（130）包括预定数量的至少两个检测元件 D1，Dn），用于检测接收到的荧光信号并产生检测信号。 此外，信号转换电路（140）用于从所述至少两个检测元件（D1，Dn）接收所述检测信号，并产生一个像素输出信号，该像素输出信号指示所生成的所述至少两个检测元件（D1，Dn）中的哪一个 最强的检测信号。

公开(公告)号：US20100181194A1

公开(公告)日：2010-07-22

申请号：US12376612

申请日：2007-07-10

Applicant: David Andrew Fish ,  Mark Thomas Johnson

Inventor： David Andrew Fish ,  Mark Thomas Johnson

IPC: G01N27/26 ,  H02G5/02 ,  B23P17/04

CPC classification number: B03C5/005 ,  B03C5/026 ,  Y10T29/49002

Abstract: The invention relates to a microelectronic device for manipulating a sample, the device comprising an array of actuator units (AU) and an array of sensitive units (SU). The actuator units (AU) may particularly exert dielectrophoretic forces on a sample (1) in an adjacent sample chamber, and the sensitive units (SU) optionally measure properties of said sample. Furthermore, the actuator units (AU) are linked to a set of power lines (PL) and the sensitive units (SU) are linked to a set of signal lines (SL), wherein the routing of these lines is such that the effects of parasitic couplings are minimized for a given set of alternating electrical power signals on the power lines. The power lines (PL) may particularly be supplied with alternating electrical signals that are identical besides a phase shift. Optionally, the couplings between the power lines and the signal lines are adapted to provide a maximal compensation of cross-talk effects.

Abstract translation: 本发明涉及一种用于操纵样品的微电子装置，该装置包括一组致动器单元（AU）和一组敏感单元（SU）。 致动器单元（AU）可以特别地在相邻的样品室中的样品（1）上施加介电电泳力，并且敏感单元（SU）可选地测量所述样品的性质。 此外，致动器单元（AU）链接到一组电力线（PL），并且敏感单元（SU）链接到一组信号线（SL），其中这些线路的路由使得 对于电力线上的给定的一组交流电功率信号，寄生耦合被最小化。 电源线（PL）可以特别地提供除了相移之外相同的交替电信号。 可选地，电力线和信号线之间的耦合适于提供串扰效应的最大补偿。

公开(公告)号：US20100032299A1

公开(公告)日：2010-02-11

申请号：US12376634

申请日：2007-07-10

Applicant: David Andrew Fish

Inventor： David Andrew Fish

IPC: B03C5/02

CPC classification number: B03C5/024

Abstract: The invention relates to a microelectronic device with an array (10) of field electrodes (11) that are individually addressable and can for example generate dielectrophoretic forces on particles (2) above the array (10). In a preferred embodiment, the field electrodes (1) can selectively be put to one of two phase-inverted potentials (+,−) or a floating potential (Z). Various space saving circuits are described that allow the operation of the field electrodes (11) with a minimal number of components.

Abstract translation: 本发明涉及一种具有场电极（11）的阵列（10）的微电子器件，该阵列（10）可单独寻址，并且可以例如在阵列（10）上方的颗粒（2）上产生介电电泳力。 在优选实施例中，场电极（1）可以选择性地被置于两个相位反转电位（+， - ）或浮动电位（Z）中的一个。 描述了允许具有最少数量的部件的场电极（11）的操作的各种节省空间的电路。

公开(公告)号：US20090046090A1

公开(公告)日：2009-02-19

申请号：US12091596

申请日：2006-10-16

Applicant: David Andrew Fish

Inventor： David Andrew Fish

IPC: G09G5/00

CPC classification number: G09G3/3233 ,  G09G3/2014 ,  G09G2300/0417 ,  G09G2300/0819 ,  G09G2300/0842 ,  G09G2300/0852 ,  G09G2300/0861 ,  G09G2320/0238 ,  G09G2320/043 ,  G09G2320/045 ,  G09G2360/148

Abstract: An active matrix display device comprises an array of display pixels, each pixel comprising a current-driven light emitting display element (2), a drive transistor (22) for driving a current through the display element (2) and a storage capacitor (30) for storing a voltage to be used for addressing the drive transistor (22). A discharge transistor (36) is used for discharging the storage capacitor (30) thereby to switch off the drive transistor in dependence on the light output of the display element (2). The storage capacitor (30) is adapted to store a voltage which is a function of the threshold voltage of the drive transistor (22). In this way, two-level compensation is provided for threshold voltage variations of the drive transistor, one using a current sampling approach and one using optical feedback. This can extend the lifetime of the display.

Abstract translation: 有源矩阵显示装置包括显示像素阵列，每个像素包括电流驱动发光显示元件（2），用于驱动通过显示元件（2）的电流的驱动晶体管（22）和存储电容器（30） ），用于存储用于寻址驱动晶体管（22）的电压。 放电晶体管（36）用于放电存储电容器（30），从而根据显示元件（2）的光输出关断驱动晶体管。 存储电容器（30）适于存储作为驱动晶体管（22）的阈值电压的函数的电压。 以这种方式，为驱动晶体管的阈值电压变化提供两级补偿，一种采用电流采样方式，另一种采用光反馈。 这可以延长显示器的使用寿命。

公开(公告)号：US20080308548A1

公开(公告)日：2008-12-18

申请号：US12097793

申请日：2006-12-15

Applicant: David Andrew Fish ,  Marc Wilhemus Gijsbert Ponjee ,  Mark Thomas Johnson

Inventor： David Andrew Fish ,  Marc Wilhemus Gijsbert Ponjee ,  Mark Thomas Johnson

IPC: G05D23/20 ,  C12M1/34

CPC classification number: G05D23/20 ,  G05D23/1934

Abstract: In an array for temperature controlled cells the cells are driven in an active matrix array. A temperature processing array may be employed in biochip, such as underneath a biosensor or underneath reaction chambers. Due to the active matrix complex driver circuitry may be positioned outside the actual array of cells. Each cell is provided with a switch for coupling the cell circuitry to the driver circuitry. When coupled to the driver circuitry, a memory element in the cell circuitry may be provided with a heating setting. Then, the cell circuitry is uncoupled from the driver circuitry and a heating element is controlled to heat the cell in accordance with the setting stored in the memory element.

Abstract translation: 在温度控制单元阵列中，以有源矩阵阵列驱动单元。 温度处理阵列可以用在生物芯片中，例如生物传感器下方或反应室下方。 由于有源矩阵复合驱动器电路可以位于实际的单元阵列之外。 每个单元设置有用于将单元电路耦合到驱动器电路的开关。 当耦合到驱动器电路时，单元电路中的存储元件可以设置有加热设置。 然后，单元电路与驱动器电路分离，并且加热元件被控制以根据存储在存储元件中的设置来加热单元。

公开(公告)号：US20080252573A1

公开(公告)日：2008-10-16

申请号：US12089725

申请日：2006-09-29

Applicant: David Andrew Fish ,  John M. Shannon

Inventor： David Andrew Fish ,  John M. Shannon

IPC: G09G3/30 ,  H03H11/00 ,  H03F3/16 ,  G09G3/36

CPC classification number: G09G3/3233 ,  G09G3/3275 ,  G09G2300/0408 ,  G09G2300/0417 ,  G09G2300/0819 ,  G09G2300/0852 ,  G09G2300/0861 ,  G09G2310/0251 ,  G09G2310/0256 ,  G09G2310/027 ,  G09G2320/043 ,  G09G2330/021

Abstract: A transistor control circuit (74) comprises a source-gated thin film transistor (70), an input for receiving a drive voltage representing a desired control of the source-gated transistor and a current source (82) for causing a known current to pass through the source-gated transistor (70). A first capacitor (78) stores a resulting gate-source voltage of the source-gated transistor when the known current is passed through the source-gated transistor The drive voltage is modified using the resulting gate-source voltage, and the modified voltage is used in the control of the source-gated transistor This control can provide a translational shift in the operating characteristics of the transistor, and it has been found that this can compensate for ageing of the transistor, for non-uniformity between different devices, and for temperature variations.

Abstract translation: 晶体管控制电路（74）包括源选通薄膜晶体管（70），用于接收表示源极栅极晶体管的期望控制的驱动电压的输入端和用于使已知电流通过的电流源（82） 通过源极栅极晶体管（70）。 当已知电流通过源极栅极晶体管时，第一电容器（78）存储源极栅极晶体管的所得栅极 - 源极电压。使用所得到的栅极 - 源极电压来修改驱动电压，并且使用修正的电压 在源极栅极晶体管的控制中，该控制可以提供晶体管的工作特性的平移位移，并且已经发现，这可以补偿晶体管的老化，对于不同器件之间的不均匀性以及温度 变化。

公开(公告)号：US07147035B2

公开(公告)日：2006-12-12

申请号：US10950773

申请日：2004-09-27

Applicant: John Andrew Fish ,  Heiji Kato

Inventor： John Andrew Fish ,  Heiji Kato

IPC: B22D11/06

CPC classification number: B22D11/0642 ,  B22D11/066

Abstract: A method for casting metal strip by controlling the distance between the confining side plates confining the casting pool and the outer nozzle ends of discrete nozzle pieces of the delivery nozzle delivering the molten melt. The nozzle pieces defining the outer nozzle ends may be moved and control separately from the position of the confining plates, or with the position of the confining plates, by a nozzle delivery drive. The distance between the outer nozzle ends and the confining plates may be set before casting and maintained during casting with wear and thermal expansion of the confining plates, nozzle pieces, or both, or varied during the casting operation, to inhibit the formation of skulls in the casting pool and the formation of “snake eggs” in the cast strip.

Abstract translation: 通过控制限制浇注池的限制侧板与输送熔融物的输送喷嘴的离散喷嘴件的外喷嘴端之间的距离来铸造金属带的方法。 限定外部喷嘴端部的喷嘴片可以通过喷嘴传送驱动器与限制板的位置或限制板的位置分开地移动和控制。 外喷嘴端和限制板之间的距离可以在铸造之前设置，并且在铸造期间保持在限制板，喷嘴件或两者的磨损和热膨胀，或在铸造操作期间变化，以抑制头骨的形成 铸造池和铸造条中形成“蛇卵”。