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公开(公告)号：US10575516B2
公开(公告)日：2020-03-03
申请号：US16190766
申请日：2018-11-14
摘要： Disclosed are products having animal tissue packed within the lumen of a device such as a needle cannula and being therein impregnated with a cryopreservation medium. The needle cannula or other device can be received in a capsule and/or other container, which in some forms can contain additional amounts of the cryopreservation medium occurring external of the lumen. Methods of use of the products are also described and can include ejecting the animal tissue from the lumen of device using pressurized liquid passed through the lumen, potentially to deliver the animal tissue directly into a patient. Methods of manufacture of the products are also described.
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公开(公告)号：US10512463B2
公开(公告)日：2019-12-24
申请号：US14873335
申请日：2015-10-02
IPC分类号： A61B17/08 , A61B17/072 , A61B17/064 , A61B17/00 , A61B90/00 , A61B50/20
摘要： Described are medical devices useful for applying a bolster material to a surgical fastening device such as a stapler, and related methods of manufacture and use. The devices include an applicator element for receipt between arms of the stapler, and a bolster material, desirably a remodelable extracellular matrix material, coupled to the applicator element. In certain embodiments, the bolster material is held by the applicator element, for example having at least a portion looped around or received through or over a portion of the applicator element. Also described are unique implantable materials including coatings of dried, reversible adhesive.
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公开(公告)号：US20180296223A1
公开(公告)日：2018-10-18
申请号：US16002452
申请日：2018-06-07
发明人： Aidan Furey , Steen Aggerholm , Palle Munk Hansen , Anders Ginge Jensen , Kirsten Asser Larsen , Ryan Bernstein
摘要： There are disclosed various dispensing mechanisms for dispensing filamentary material through a catheter into a treatment site of a patient, for example into an aneurysm sack in a patient's vessel. In one embodiment the assembly includes a conical material carrier which is substantially aligned with the dispensing direction, thereby avoiding the need to have a rotating carrier. Another embodiment has a carrier which is at least partially cylindrical. The carrier provides for efficient dispensation of filamentary material at substantial dispensing speeds.
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公开(公告)号：US20180228939A1
公开(公告)日：2018-08-16
申请号：US15843159
申请日：2017-12-15
发明人： Michael C. Hiles , Jason P. Hodde , David M.J. Ernst , Lal Ninan
CPC分类号： A61L27/54 , A61K35/38 , A61K38/1825 , A61L27/227 , A61L27/24 , A61L27/3629 , A61L27/3633 , A61L27/3687 , A61L27/50 , A61L2300/414 , A61L2400/06
摘要： Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.
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公开(公告)号：US09993253B2
公开(公告)日：2018-06-12
申请号：US14732420
申请日：2015-06-05
发明人： Aidan Furey , Steen Aggerholm , Palle Munk Hansen , Anders Ginge Jensen , Kirsten Asser Larsen , Ryan Bernstein
CPC分类号： A61B17/12113 , A61B17/12031 , A61B17/12118 , A61B17/1214 , A61B2017/00004 , A61B2017/00539 , A61B2017/1205 , A61B2090/032 , A61F2/82 , A61F2/90 , A61F2002/823
摘要： There are disclosed various dispensing mechanisms for dispensing filamentary material (24) through a catheter (12) into a treatment site of a patient, for example into an aneurysm sack (20) in a patient's vessel (22). In one embodiment the assembly (100) includes a conical material carrier (150) which is substantially aligned with the dispensing direction, thereby avoiding the need to have a rotating carrier. Another embodiment has a carrier (340) which is at least partially cylindrical. The carrier (150, 340) provides for efficient dispensation of filamentary material at substantial dispensing speeds.
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公开(公告)号：US20180071526A1
公开(公告)日：2018-03-15
申请号：US15698798
申请日：2017-09-08
发明人： TYLER NOVAK , F. Joseph Obermiller
CPC分类号： A61N1/326 , A61B17/1128 , A61B2017/00884 , A61F2/04 , A61F2/2846 , A61F2002/2821 , A61F2002/2835 , A61F2002/30013 , A61F2002/30235 , A61F2002/30784 , A61F2002/30971 , A61F2230/0069 , A61L27/24 , A61L27/3604 , A61L27/3683 , A61L27/50 , A61L27/56 , A61L27/58 , A61N1/0432 , A61N1/05 , A61N1/205 , A61N1/3606
摘要： Disclosed are electrostimulative grafts that include at least one galvanic couple with an anode spaced from a cathode. The anode and cathode can be made from biodegradable metals. The graft can include a porous graft matrix material receptive to tissue ingrowth that occurs between the anode and cathode. The electrostimulation provided by the galvanic couple after implantation of the graft can impact the development of tissue within and/or around the porous graft matrix material. Also disclosed are methods for making electrostimulative grafts and for galvanically electrostimulating tissue growth in a porous graft matrix material.
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公开(公告)号：US20170128628A1
公开(公告)日：2017-05-11
申请号：US15333740
申请日：2016-10-25
发明人： Michael C. Hiles , Jason P. Hodde , David M.J. Ernst , Lal Ninan
摘要： Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.
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公开(公告)号：US20170086808A1
公开(公告)日：2017-03-30
申请号：US15372577
申请日：2016-12-08
CPC分类号： A61B17/0057 , A61B1/31 , A61B17/12159 , A61B17/3468 , A61B50/30 , A61B2017/00004 , A61B2017/00628 , A61B2017/00641 , A61B2017/00654 , A61B2017/00659 , A61B2017/00862 , A61B2017/00867 , A61B2017/22038 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3641 , A61L27/50
摘要： Described are medical graft products, systems, and methods for treating fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening, e.g., one occurring in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member, which is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and an elongate plug member extending from the capping member, which is configured to extend into at least a portion of the fistula. In certain embodiments, a graft body component has the capacity to expand or otherwise change form to provide a suitable capping arrangement. Such a component can include a resilient wire frame, e.g., one that is self-expandable or one that requires at least some manipulation in order to expand.
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公开(公告)号：US20160206785A1
公开(公告)日：2016-07-21
申请号：US15084080
申请日：2016-03-29
CPC分类号： A61L27/3633 , A61F2/0063 , A61F2/0077 , A61F2/02 , A61L27/3625 , A61L27/3629 , A61L27/50 , A61L31/005
摘要： Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.
摘要翻译： 描述了具有包含可重塑胶原片材料的说明性移植物的多层或多层可植入手术移植物的实施方案，所述移植物包括一个或多个交织构件以将移植物缝合在一起以帮助防止层在处理期间分层或分离，并且初始 重塑阶段。 交织构件可以包括以期望的图案编织穿过生物材料层的缝合线，线，单个线迹，材料条等。 在一个实施方案中，交织构件包含药理学活性物质，例如药物，生长因子等，以在宿主组织中引发所需的生物反应。 在另一个实施方案中，移植物还包括在可重塑生物材料层内的增强材料，例如合成网，并由一个或多个交织构件缝合在一起。
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公开(公告)号：US09254188B2
公开(公告)日：2016-02-09
申请号：US13835539
申请日：2013-03-15
发明人： Ryan Dempsey
CPC分类号： A61F2/12 , A61B90/39 , A61B2017/00792 , A61B2017/00796 , A61B2017/320052 , A61B2090/395 , A61F2240/005
摘要： Described are components, component combinations, kits and methods useful for creating reconstructed tissue structures such as reconstructed nipple structures. Novel combinations are described involving surgical marking templates, implants having features correlated to the templates, and/or post-surgical shields.
摘要翻译： 描述了用于创建重建的组织结构（例如重建的乳头结构）的组件，部件组合，试剂盒和方法。 描述的新型组合涉及手术标记模板，具有与模板相关的特征的植入物和/或手术后护罩。
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