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    Method for reducing pain
    41.
    发明申请
    Method for reducing pain 有权
    减轻疼痛的方法

    公开(公告)号：US20050192218A1

    公开(公告)日：2005-09-01

    申请号：US10956252

    申请日：2004-10-01

    Applicant: David Ellis ,  George Miljanich ,  David Shields

    Inventor： David Ellis ,  George Miljanich ,  David Shields

    IPC: A61K31/195 ,  A61K31/4168 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/4535 ,  A61K31/485 ,  A61K38/17 ,  A61K45/06 ,  A61P25/04

    CPC classification number: A61K38/1767 ,  A61K9/0085 ,  A61K31/137 ,  A61K31/195 ,  A61K31/4168 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/4535 ,  A61K31/485 ,  A61K38/17 ,  A61K45/06 ,  A61K47/12 ,  A61K47/183 ,  C07K14/43504 ,  A61K2300/00

    Abstract: The present invention is direct to a method of producing analgesia in a mammalian subject. The method includes administering to the subject an omega conopeptide, preferably ziconotide, in combination with an analgesic selected from the group consisting of morphine, bupivicaine, clonidine, hydromorphone, baclofen, fentanyil, buprenorphine, and sufentanil, or its pharmaceutically acceptable salts thereof, wherein the ω-conopeptide retains its potency and is physically and chemically compatible with the analgesic compound. A preferred route of administration is intrathecal administration, particularly continuous intrathecal infusion. The present invention is also directed to a pharmaceutical formulation comprising an omega conopeptide, preferably ziconotide, in combination with an analgesic selected from the group consisting of morphine, bupivicaine, clonidine, hydromorphone, baclofen, fentanyl, buprenorphine, and sufentanil.

    Abstract translation: 本发明直接涉及在哺乳动物受试者中产生止痛的方法。 该方法包括向受试者施用欧米加多肽，优选西科肽，与选自吗啡，布比卡因，可乐定，氢吗啡酮，巴氯芬，芬太尼，丁丙诺啡和舒芬太尼的止痛剂或其药学上可接受的盐组合，其中 欧米加肽保留其效力并且与止痛化合物物理和化学相容。 优选的给药途径是鞘内给药，特别是连续鞘内输注。 本发明还涉及一种药物制剂，其包含ω-配肽，优选齐考诺铵，与选自吗啡，布比卡因，可乐定，氢吗啡酮，巴氯芬，芬太尼，丁丙诺啡和舒芬太尼的止痛剂组合。

    System and method for determining dose area product in an X-ray imaging system
    43.
    发明授权
    System and method for determining dose area product in an X-ray imaging system 有权
    用于确定X射线成像系统中的剂量面积乘积的系统和方法

    公开(公告)号：US06330299B1

    公开(公告)日：2001-12-11

    申请号：US09591418

    申请日：2000-06-10

    Applicant: Steven Emerson Curtis ,  Richard Larry Anderton ,  Steven James Brown ,  David Ellis Barker ,  Matthew Scott Curtis

    Inventor： Steven Emerson Curtis ,  Richard Larry Anderton ,  Steven James Brown ,  David Ellis Barker ,  Matthew Scott Curtis

    IPC: G01N2304

    CPC classification number: G01T1/14 ,  G01N23/04

    Abstract: A system an method for determining the Dose Area Product (DAP) in an X-ray imaging system is provided. The present system constructs a pre-determined parameter space describing the DAP contour over ranges of typical imaging parameters. Later, when the employed in clinical imaging, a DAP processor on board the imaging system received a set of the imaging parameters being employed. The DAP applies the set of parameters to the parameter space to interpolate the DAP being delivered by the clinical imaging system. The present system may be individually calibrated to a specific X-ray imaging system to provide more optimal DAP values. Additionally, in imaging system employing an asymmetric shutter, such as a one-leaf shutter, the present system may determine a rotational scale factor for the DAP based on the rotation of the shutter. The rotational scale factor may also be calibrated to an individual X-ray imaging system.

    Abstract translation: 提供了一种用于确定X射线成像系统中的剂量面积积（DAP）的方法。 本系统在典型成像参数的范围内构建描述DAP轮廓的预定参数空间。 之后，当临床成像中使用时，成像系统上的DAP处理器接收到一组成像参数。 DAP将参数集合应用于参数空间以内插由临床成像系统递送的DAP。 可以将本系统单独地校准到特定的X射线成像系统以提供更优化的DAP值。 另外，在使用诸如单叶快门的非对称快门的成像系统中，本系统可以基于快门的旋转来确定DAP的旋转比例因子。 旋转比例因子也可以被校准到单独的X射线成像系统。

    Antithrombotic amidinophenylalanine and amidinopyridylalanine derivatives
    45.
    发明授权
    Antithrombotic amidinophenylalanine and amidinopyridylalanine derivatives 失效
    抗疟原酸脒基苯丙氨酸和脒基吡啶基丙氨酸衍生物

    公开(公告)号：US5861393A

    公开(公告)日：1999-01-19

    申请号：US902917

    申请日：1997-07-30

    Applicant: John Christopher Danilewicz ,  David Ellis ,  Ryszard Jurek Kobylecki

    Inventor： John Christopher Danilewicz ,  David Ellis ,  Ryszard Jurek Kobylecki

    IPC: A61K31/47 ,  A61K31/55 ,  A61K38/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  C07D401/12 ,  C07D401/14 ,  C07K5/065

    CPC classification number: C07D401/12

    Abstract: This invention relates to compounds of formula (I), ##STR1## pharmaceutically acceptable salt thereof, and pharmaceutically acceptable solvates of either entity, wherein X is CH or N; Y is optionally monousaturated C.sub.3 -C.sub.5 alkylene optionally substituted with C.sub.1 -C.sub.4 allyl or methylene; R.sup.1 is H; C.sub.1 -C.sub.4 alkyl optionally substituted with C.sub.1 -C.sub.4 alkoxy, OH, NR.sup.5 R.sup.6, CONR.sup.5 R.sup.6, C.sub.3 -C.sub.6 cycloalkyl or aryl; or C.sub.3 -C.sub.6 alkenyl; R.sup.2 is H; C.sub.1 -C.sub.4 alkyl optionally substituted with C.sub.1 -C.sub.4 alkoxy, OH, NR.sup.5 R.sup.6, CONR.sup.5 R.sup.6, C.sub.3 -C.sub.6 cycloalkyl or aryl; or CONR.sup.5 R.sup.6 ; R.sup.3 and R.sup.4 are each independently selected from H; C.sub.1 -C.sub.4 alkyl optionally substituted with NR.sup.5 R.sup.6 ; C.sub.1 -C.sub.4 alkoxy; halo; CONR.sup.5 R.sup.6 and aryl; and R.sup.5 and R.sup.6 are each independently selected from H and C.sub.1 -C.sub.4 alkyl; are potent and selective thrombin inhibitors useful in the treatment of, inter alia, deep vein thrombosis; reocclusion following thrombolytic therapy; chronic arterial obstruction; peripheral vascular disease; acute myocardial infarction; unstable angina; atrial fibrillation; thrombotic stroke; transient ischaemic attacks; restenosis and occlusion following angioplasty; or neurodegenerative disorders.

    Abstract translation: 本发明涉及式（I）化合物，其药学上可接受的盐，以及任一实体的药学上可接受的溶剂化物，其中X为CH或N; Y任选被C1-C4烯丙基或亚甲基取代的单饱和C 3 -C 5亚烷基; R1是H; 任选被C 1 -C 4烷氧基，OH，NR 5 R 6，CONR 5 R 6，C 3 -C 6环烷基或芳基取代的C 1 -C 4烷基; 或C 3 -C 6烯基; R2为H; 任选被C 1 -C 4烷氧基，OH，NR 5 R 6，CONR 5 R 6，C 3 -C 6环烷基或芳基取代的C 1 -C 4烷基; 或CONR5R6; R3和R4各自独立地选自H; 任选被NR 5 R 6取代的C 1 -C 4烷基; C1-C4烷氧基; 光环; CONR5R6和芳基; 并且R 5和R 6各自独立地选自H和C 1 -C 4烷基; 是有效和选择性的凝血酶抑制剂，可用于治疗特别是深静脉血栓形成; 溶栓治疗后再闭塞; 慢性动脉阻塞; 周边血管疾病; 急性心肌梗塞; 不稳定型心绞痛; 房颤; 血栓性脑卒中 短暂性脑缺血发作; 血管成形术后再狭窄和闭塞; 或神经变性疾病。

    Method and apparatus for measuring frequency and high/low time of a digital signal
    46.
    发明授权
    Method and apparatus for measuring frequency and high/low time of a digital signal 失效
    用于测量数字信号的频率和高/低时间的方法和装置

    公开(公告)号：US5440592A

    公开(公告)日：1995-08-08

    申请号：US40623

    申请日：1993-03-31

    Applicant: David Ellis ,  Gary Brady

    Inventor： David Ellis ,  Gary Brady

    IPC: G01R23/02 ,  G01R31/30 ,  H04L7/00

    CPC classification number: G01R23/02 ,  G01R31/30

    Abstract: A delay chain having a known number of delay elements providing various delayed outputs of its input, a first and a second register set, and preferably, an array of multiplexors, are provided to measure the frequency of a digital signal, and the high and low time of its period. The digital signal to be measured is provided to the delay chain as input. A first and a second sample of the various delayed outputs are taken at the beginning and the end of a known time period, and stored in the first and second registers, one delayed output per register bit. The sample results stored in the register sets are read out through the multiplexors, and used to determine the frequency of the digital signal being measured, and the high and low time of its period.

    Abstract translation: 提供具有已知数量的延迟元件的延迟链，其提供其输入，第一和第二寄存器组，以及优选地，多路复用器阵列的各种延迟输出，以测量数字信号的频率，以及高低 时间的时间。 要测量的数字信号作为输入提供给延迟链。 各种延迟输出的第一和第二采样在已知时间周期的开始和结束时获取，并存储在第一和第二寄存器中，每个寄存器位一个延迟的输出。 存储在寄存器组中的采样结果通过多路复用器读出，用于确定正在测量的数字信号的频率以及其周期的高低时间。

    Enterprise architecture system and method
    50.
    发明授权
    Enterprise architecture system and method 有权
    企业架构系统及方法

    公开(公告)号：US08903815B2

    公开(公告)日：2014-12-02

    申请号：US13705156

    申请日：2012-12-04

    Applicant: Robert David Ellis ,  Erem Mustafa Tanyeri

    Inventor： Robert David Ellis ,  Erem Mustafa Tanyeri

    IPC: G06F17/30

    CPC classification number: G06Q30/0206 ,  G06F17/30 ,  G06F17/30424 ,  G06Q20/085

    Abstract: A method for operating a web service to search one or more data sources, the method including receiving a query directed to a first data source, wherein the first data source defines at least one characteristic of at least one first data object returned by the query, receiving at least one first data object from the first data source in response to querying the first data source, retrieving linked relationships between the at least one first data object and one or more second data objects from a second data source, receiving the one or more second data objects from the second data source in response to querying the second data source, generating a composite data object in response to the received query, the composite data object including the at least one first data object and the one or more second data objects formatted as markup language.

    Abstract translation: 一种用于操作web服务以搜索一个或多个数据源的方法，所述方法包括接收针对第一数据源的查询，其中所述第一数据源定义所述查询返回的至少一个第一数据对象的至少一个特性， 响应于查询所述第一数据源，从所述第一数据源接收至少一个第一数据对象，从所述第二数据源检索所述至少一个第一数据对象与一个或多个第二数据对象之间的链接关系，接收所述一个或多个 响应于所述第二数据源的查询响应于所述第二数据源的第二数据对象，响应于所接收的查询生成复合数据对象，所述合成数据对象包括所述至少一个第一数据对象和所述一个或多个第二数据对象被格式化 作为标记语言。

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