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公开(公告)号：US20120165367A1
公开(公告)日：2012-06-28
申请号：US13193739
申请日：2011-07-29
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily , Jingrong Cao
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Keily , Jingrong Cao
IPC分类号： A61K31/437 , A61K31/4545 , A61P37/00 , A61P29/00 , A61P35/00 , A61P25/28 , C07D471/04 , A61P37/06
CPC分类号： C07D471/02 , C07D471/04 , C07D487/02
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08188134B2
公开(公告)日：2012-05-29
申请号：US12891973
申请日：2010-09-28
申请人： Guy Brenchley , Steven Durrant , Jean-Damien Charrier , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Steven Durrant , Jean-Damien Charrier , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： A61K31/4155 , A61K31/4178
CPC分类号： C07D409/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供药学上可接受的组合物，其包含化合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08173635B2
公开(公告)日：2012-05-08
申请号：US12262459
申请日：2008-10-31
申请人： Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
发明人： Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
IPC分类号： A61K31/496 , C07D471/04 , A61K31/5377 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20110178146A1
公开(公告)日：2011-07-21
申请号：US12891973
申请日：2010-09-28
申请人： Guy Brenchley , Steven Durrant , Jean-Damien Charrier , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Steven Durrant , Jean-Damien Charrier , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： A61K31/4178 , A61K31/4155 , A61P35/00 , A61P29/00 , A61P19/00 , A61P9/00 , A61P3/00 , C12N9/99
CPC分类号： C07D409/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20100280026A1
公开(公告)日：2010-11-04
申请号：US12713811
申请日：2010-02-26
申请人： Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
发明人： Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/519 , C07D413/14 , C07D495/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P29/00 , A61P9/00 , A61P35/00 , A61P11/06 , A61P19/08 , A61P37/00
CPC分类号： A61K31/496 , C07D239/70 , C07D239/84 , C07D333/22 , C07D333/38 , C07D333/54 , C07D333/70 , C07D471/04 , C07D487/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供了制备化合物的方法，包含该化合物的药学上可接受的组合物，以及使用该化合物和组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20070219205A1
公开(公告)日：2007-09-20
申请号：US11656876
申请日：2007-01-23
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： A61K31/519 , A61K31/498 , A61K31/4745 , C07D487/04 , C07D471/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20070179156A1
公开(公告)日：2007-08-02
申请号：US11511086
申请日：2006-08-28
申请人： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Guy Brenchley , Ronald Knegtel , Michael Mortimore
发明人： Jean-Damien Charrier , Sharn Ramaya , Steven Durrant , Juan-Miguel Jimenez , Guy Brenchley , Ronald Knegtel , Michael Mortimore
IPC分类号： A61K31/497 , A61K31/4709 , A61K31/444 , C07D401/14 , C07D403/14
CPC分类号： C07D213/64 , C07D401/14 , C07D417/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US07041687B2
公开(公告)日：2006-05-09
申请号：US10350806
申请日：2003-01-23
申请人： Hayley Binch , Guy Brenchley , Julian M. C. Golec , Ronald Knegtel , Michael Mortimore , Sanjay Patel , Alistair Rutherford
发明人： Hayley Binch , Guy Brenchley , Julian M. C. Golec , Ronald Knegtel , Michael Mortimore , Sanjay Patel , Alistair Rutherford
IPC分类号： A61K31/41
CPC分类号： C07D417/12 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein R1, R2, V1, V2, and V3 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT, PKA, PDK1, p70S6K, or ROCK kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.
摘要翻译： 本发明提供式I化合物或其药学上可接受的衍生物，其中R 1，R 2，V 1，V SUP > 2 和V 3 3如说明书中所述。 这些化合物是蛋白激酶的抑制剂，特别是AKT，PKA，PDK1，p70S6K或ROCK激酶的抑制剂，涉及增殖性和神经变性疾病的哺乳动物蛋白激酶。 本发明还提供包含本发明化合物的药物组合物和利用这些组合物治疗各种疾病的方法。
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公开(公告)号：US20050004150A1
公开(公告)日：2005-01-06
申请号：US10809946
申请日：2004-03-25
申请人： Guy Brenchley , Luc Farmer , Edmund Harrington , Ronald Knegtel , Michael O'Donnell , Francesco Salituro , John Studley , Jian Wang
发明人： Guy Brenchley , Luc Farmer , Edmund Harrington , Ronald Knegtel , Michael O'Donnell , Francesco Salituro , John Studley , Jian Wang
IPC分类号： A61K31/506 , A61P29/00 , A61P35/00 , A61P37/00 , C07D417/00 , C07D417/04 , C07D417/14
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US08569337B2
公开(公告)日：2013-10-29
申请号：US12670989
申请日：2010-01-27
申请人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
发明人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Christopher John Davis , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , A61K31/496 , A61K31/506 , C07D239/24 , C07D241/10 , C07D519/00
摘要： The present invention relates to compounds of tri-cyclic pyrazolopyridine useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions containing such compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的三环吡唑并吡啶化合物。 本发明还提供含有这些化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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