公开(公告)号：US20120108677A1

公开(公告)日：2012-05-03

申请号：US13287008

申请日：2011-11-01

Applicant: Joachim B. Kohn ,  Durgadas Bolikal

Inventor： Joachim B. Kohn ,  Durgadas Bolikal

IPC: A61K47/34 ,  C08G64/42 ,  C07D241/02 ,  A61L31/06 ,  C07D241/08 ,  C08G64/16 ,  C08G64/24

CPC classification number: C08G64/12 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/14 ,  A61L27/54 ,  A61L31/04 ,  A61L31/16 ,  C07D241/18 ,  C08G64/24 ,  C08G64/42 ,  C08G69/48

Abstract: Disclosed are biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an imine group, wherein the inclusion of said imine group is effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without an imine group.

Abstract translation: 公开了包含多个含有亚胺基团的单体重复单元的生物相容性生物可吸收聚合物，其中与不含亚胺基团的相同聚合物相比，所述亚胺基团的包含可有效降低熔体粘度，溶液粘度或两者。

公开(公告)号：US07722896B2

公开(公告)日：2010-05-25

申请号：US11856219

申请日：2007-09-17

Applicant: Joachim B. Kohn ,  Satish Pulapura ,  Arthur Schwartz ,  Raman Bahulekar

Inventor： Joachim B. Kohn ,  Satish Pulapura ,  Arthur Schwartz ,  Raman Bahulekar

IPC: A61F2/02 ,  A61F2/28 ,  A61K47/32 ,  A61K9/02 ,  B32B9/00 ,  C08G64/04 ,  C12N5/02

CPC classification number: A61K9/0024 ,  A61K9/146 ,  A61K9/1641 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/258 ,  A61L2300/80 ,  C08G63/672 ,  C08G63/6856 ,  Y10T428/31504 ,  C08L67/02

Abstract: Biocompatible polyarylates of diphenol compounds and poly(alkylene oxide) dicarboxylic acids, articles formed therefrom and therapeutic uses are disclosed.

Abstract translation: 公开了二酚化合物和聚（环氧烷）二羧酸的生物相容性多芳基化合物，由其形成的制品和治疗用途。

公开(公告)号：US20090317472A1

公开(公告)日：2009-12-24

申请号：US12525529

申请日：2008-01-31

Applicant: Joachim B. Kohn ,  Bozena Michniak ,  David Devore ,  Larisa Sheihet ,  Prafulla Chandra ,  Priya Batheja

Inventor： Joachim B. Kohn ,  Bozena Michniak ,  David Devore ,  Larisa Sheihet ,  Prafulla Chandra ,  Priya Batheja

IPC: A61K9/14 ,  A61P35/00 ,  A61P31/00

CPC classification number: A61K9/0014 ,  A61K8/90 ,  A61K9/5153 ,  A61K2800/412 ,  A61K2800/413 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/04 ,  B82Y5/00 ,  Y02A50/401

Abstract: Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is —C —R—C— or —C—; Z is between 2 and about 100, inclusive; R1 is CH═CH or (CH2), wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.

Abstract translation: 提供了局部组合物，其中通过角质层局部递送的活性化合物与具有A-B-A结构的三嵌段共聚物的纳米球络合，其中每个A端嵌段是水溶性的，亲水的和无毒的聚合物或低聚物; 并且疏水性中间B嵌段是具有相同或不同重复单元的疏水性聚合物或低聚物，其具有根据下式的结构：（I）其中X是-C-C-C或-C-; Z在2至约100之间（含）; R1为CH-CH或（CH2），其中n为0至18，包括端值; R2选自氢和含有至多18个碳原子的直链和支链烷基，烷氧基，烷基芳基和烷氧基芳基; 并且R选自含有至多18个碳原子的键或直链和支链烷基，烷氧基，烷基芳基和烷氧基芳基。

公开(公告)号：US20080194469A1

公开(公告)日：2008-08-14

申请号：US11970028

申请日：2008-01-07

Applicant: Joachim B. Kohn ,  Deborah M. Schachter

Inventor： Joachim B. Kohn ,  Deborah M. Schachter

IPC: A61K38/12 ,  A61K47/34 ,  A61K38/02

CPC classification number: C07K7/06 ,  A61K9/7007 ,  A61K38/12 ,  A61K47/593 ,  A61K47/60 ,  A61K47/645

Abstract: A formulation containing a biologically active compound having a chemical structure with hydrogen bonding sites, a first biocompatible, hydrolytically degrading polycarbonate with hydrogen bonding sites and tyrosine-derived diphenol monomer units, and a second biocompatible hydrolytically degrading polymer that is less hydrophobic than the polycarbonate, wherein the second polymer degrades hydrolytically to form acidic degradation products that promote the release of the active compound. Methods for active compound delivery are also disclosed.

Abstract translation: 包含具有氢键结合位点的化学结构的生物活性化合物，具有氢键位点的第一生物相容性，水解降解性聚碳酸酯和酪氨酸衍生的二酚单体单元的制剂，以及比聚碳酸酯疏水性低的第二生物相容性水解降解聚合物， 其中第二聚合物水解降解以形成促进活性化合物释放的酸性降解产物。 还公开了活性化合物递送的方法。

公开(公告)号：US07005454B2

公开(公告)日：2006-02-28

申请号：US09257145

申请日：1999-02-24

Applicant: Stephen Brocchini ,  Stephen R. Hanson ,  Joachim B. Kohn

Inventor： Stephen Brocchini ,  Stephen R. Hanson ,  Joachim B. Kohn

IPC: A61K47/30 ,  A61K47/32 ,  A61K47/34

CPC classification number: A61K9/146 ,  A61K9/2031 ,  A61K9/204 ,  A61K9/7007

Abstract: Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also disclosed containing a single-phase dispersion of a water-soluble drug and a water-insoluble tissue-compatible polymer matrix, and a second, phase-disrupting polymer that is non-miscible with the tissue-compatible polymer and is present in an amount sufficient to form phase-separated microdomains of the second polymer in the tissue-compatible polymer matrix, so that the release rate of the water-soluble drug from the tissue-compatible polymer matrix is related to the amount of the second polymer. Methods of preparing the polymeric drug formulations are also described, as well as methods for site-specific drug delivery utilizing the polymeric drug formulations.

Abstract translation: 含水溶性药物的非释放单相分散体在水不溶性组织相容的聚合物基质中的聚合药物制剂。 还公开了含有水溶性药物和水不溶性组织相容聚合物基质的单相分散体的聚合药物制剂，以及与组织相容的聚合物不可混溶的第二种相位破坏性聚合物，并且是 存在的量足以在组织相容性聚合物基质中形成第二聚合物的相分离微区，使得来自组织相容性聚合物基质的水溶性药物的释放速率与第二聚合物的量相关 。 还描述了制备聚合物药物制剂的方法，以及利用聚合物药物制剂的用于位点特异性药物递送的方法。

公开(公告)号：USRE37795E1

公开(公告)日：2002-07-16

申请号：US09358015

申请日：1999-07-21

Applicant: Joachim B. Kohn ,  Stephen Brocchini ,  Arthur L. Schwartz

Inventor： Joachim B. Kohn ,  Stephen Brocchini ,  Arthur L. Schwartz

IPC: C08G6800

CPC classification number: C08G69/44 ,  C07C231/02 ,  C07C235/34 ,  C08G63/6856 ,  C08G64/12

Abstract: A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with a L-tyrosine ester in a water-miscible organic reaction solvent containing a carbodiimide capable of forming a water-soluble urea by-product, thereby forming a diphenol reaction product; and combining the reaction mixture with an amount of water effective to precipitate the diphenol as a water-immiscible organic phase, so that a water-immiscible organic phase is formed containing the diphenol reaction product. New diphenol monomers and polymers polymerized therefrom are also discussed.

Abstract translation: 一种制备二酚化合物的方法，该方法包括将羟基苯基羧酸与L-酪氨酸酯偶联在含有可形成水溶性尿素副产物的碳二亚胺的水混溶性有机反应溶剂中，由此形成 二酚反应产物; 并将反应混合物与一定量的水组合，将水作为与水不混溶的有机相沉淀，使得形成含有二酚反应产物的与水不混溶的有机相。 还讨论了新的二酚单体和从其聚合的聚合物。

公开(公告)号：US5198507A

公开(公告)日：1993-03-30

申请号：US804767

申请日：1991-12-09

Applicant: Joachim B. Kohn ,  Satish K. K. Pulapura

Inventor： Joachim B. Kohn ,  Satish K. K. Pulapura

IPC: C07C235/34 ,  C08G64/12 ,  C08G69/44

CPC classification number: C07C235/34 ,  C08G64/12 ,  C08G69/44

Abstract: Novel amino acid-derived polycarbonates and amino acid-derived diphenol compound starting materials from which the polycarbonates are polymerized. Polymer blends of the amino acid-derived polycarbonates with polyiminocarbonates prepared from identical amino acid-derived diphenol starting materials.

Abstract translation: 来自聚碳酸酯的新型氨基酸衍生的聚碳酸酯和氨基酸衍生的二酚化合物原料聚合。 氨基酸衍生的聚碳酸酯与由相同的氨基酸衍生的二酚起始原料制备的聚亚碳酸酯的聚合物共混物。

公开(公告)号：US08685367B2

公开(公告)日：2014-04-01

申请号：US10952274

申请日：2004-09-27

Applicant: Donald K. Brandom ,  Eric Schmid ,  Joan Zeltinger ,  Durgadas Bolikal ,  Joachim B. Kohn

Inventor： Donald K. Brandom ,  Eric Schmid ,  Joan Zeltinger ,  Durgadas Bolikal ,  Joachim B. Kohn

IPC: A61K51/00 ,  A61M36/14

CPC classification number: A61K31/785 ,  A61K49/0442

Abstract: Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.

Abstract translation: 优选的实施方案涉及固有的不透射线的，生物相容的，生物可再吸收的聚合物颗粒的组合物和使用它们来栓塞体腔的方法。

公开(公告)号：US08415449B2

公开(公告)日：2013-04-09

申请号：US13387798

申请日：2010-07-31

Applicant: Joachim B. Kohn ,  Durgadas Bolikal ,  Ramiro Rojas

Inventor： Joachim B. Kohn ,  Durgadas Bolikal ,  Ramiro Rojas

IPC: C08G64/00 ,  C08G63/02

CPC classification number: C08G79/02 ,  A61K47/59 ,  A61K47/60 ,  C08G79/025

Abstract: This invention discloses biocompatible polymers prepared from monomers (IV), and (IVa), or derivatives thereof, for which the variables are described in the claims and specification. These polymers may be bioresorbable and thus useful for manufacture of medical devices. Therefore, methods for preparing these polymers and medical devices prepared therefrom are also encompassed by this disclosure.

Abstract translation: 本发明公开了由权利要求和说明书中描述的变体描述的由单体（IV）和（IVa）或其衍生物制备的生物相容性聚合物。 这些聚合物可以是生物可再吸收的，因此可用于制造医疗器械。 因此，制备这些聚合物的方法和由其制备的医疗装置也包括在本公开中。

公开(公告)号：US20120135523A1

公开(公告)日：2012-05-31

申请号：US13361268

申请日：2012-01-30

Applicant: Ken James ,  Brochini Stephen ,  Varawut Tangpasuthadol ,  Joachim B. Kohn

Inventor： Ken James ,  Brochini Stephen ,  Varawut Tangpasuthadol ,  Joachim B. Kohn

IPC: C12N5/071 ,  C08G63/685 ,  C07C237/20

CPC classification number: C08G63/78 ,  A61L17/10 ,  A61L27/18 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  B01J2219/00722 ,  C08G63/19 ,  C08G63/6856 ,  C08G63/6858 ,  C08G64/045 ,  C08G64/12 ,  C40B40/14 ,  C08L69/00

Abstract: The present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substrates.

Abstract translation: 本发明涉及包含具有以下结构的重复单元的聚芳酯：以及它们作为细胞生长底物的制备和用途。