公开(公告)号：US20120321579A1

公开(公告)日：2012-12-20

申请号：US13356629

申请日：2012-01-23

Applicant: Jonathan EDELSON ,  Timothy KOTYLA ,  Klaus THEOBALD

Inventor： Jonathan EDELSON ,  Timothy KOTYLA ,  Klaus THEOBALD

IPC: A61K31/341 ,  A61K8/49 ,  A61Q15/00 ,  A61P17/00 ,  A61K31/7056 ,  A61P17/06 ,  A61P17/14 ,  A61P31/10 ,  A61K31/7048 ,  A61K31/65 ,  C07D307/20 ,  A61P17/10

CPC classification number: A61Q7/00 ,  A61K8/41 ,  A61K8/42 ,  A61K8/8152 ,  A61K8/86 ,  A61K8/90 ,  A61K9/0014 ,  A61K45/06 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/008 ,  A61Q19/02 ,  A61Q19/08

Abstract: The present invention provides surfactant compositions and associated methods and reagents, particularly useful for the treatment of dermatologic conditions. In some embodiments, provided compositions are formulated for and achieve transdermal delivery, for example by topical administration.

Abstract translation: 本发明提供了表面活性剂组合物和相关方法和试剂，特别可用于治疗皮肤病学病症。 在一些实施方案中，所提供的组合物被配制用于并实现透皮递送，例如通过局部施用。

公开(公告)号：US08318181B2

公开(公告)日：2012-11-27

申请号：US11607436

申请日：2006-12-01

Applicant: Jonathan Edelson ,  Robert J. Nicolosi

Inventor： Jonathan Edelson ,  Robert J. Nicolosi

IPC: A61K39/40 ,  A61K39/08 ,  A61K9/66

CPC classification number: A61K8/06 ,  A61K8/64 ,  A61K38/4893 ,  A61K2800/21 ,  A61K2800/413 ,  A61K2800/91 ,  A61Q19/08 ,  B82Y5/00 ,  Y02A50/469

Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.

公开(公告)号：US20070259391A1

公开(公告)日：2007-11-08

申请号：US11741125

申请日：2007-04-27

Applicant: Jonathan Edelson

Inventor： Jonathan Edelson

IPC: C12Q1/34 ,  C12Q1/37

CPC classification number: G01N33/5088 ,  G01N33/944 ,  G01N2333/33

Abstract: The present invention provides methods for assessing the activity of topically administered chemodenervating agents. In some embodiments, methods for assessing the activity of topically administered chemodenervating agents involve determining the extent of inhibition of acetylcholine release near the site of administration. In some embodiments, methods for assessing activity of topically administered chemodenervating agents involve observing a reflex motion of a limb of a subject.

Abstract translation: 本发明提供了评估局部给药的化学修复剂的活性的方法。 在一些实施方案中，用于评估局部施用的化学修饰剂的活性的方法涉及确定施用部位附近乙酰胆碱释放的抑制程度。 在一些实施方案中，用于评估局部施用的化学修复剂的活性的方法涉及观察受试者肢体的反射运动。

公开(公告)号：US20070216244A1

公开(公告)日：2007-09-20

申请号：US11587348

申请日：2005-04-22

Applicant: Jonathan Edelson

Inventor： Jonathan Edelson

IPC: H02K11/00 ,  H02K7/09 ,  H02K3/00

CPC classification number: F16C32/0461 ,  F16C32/0463 ,  F16C32/0497 ,  H02K3/28 ,  H02K7/09 ,  H02K17/16

Abstract: The present invention relates to the use of stator windings of an induction machine to provide both rotation of the rotor and active rotor positioning within the stator frame by modification of the magnetizing current component in the D-Q plane of the rotor applied transformed to the AC waveform current of the stator windings according to an X-Y direction describing a rotor repositioning requirement.

Abstract translation: 感应电机的定子绕组的使用本发明涉及感应电机的定子绕组的使用，通过修改转子施加的转子的DQ平面中的磁化电流分量来改变定子框架内的转子和主动转子的位置，使其转换成AC波形电流 的定子绕组根据描述转子重新定位要求的XY方向。

公开(公告)号：US20070035262A1

公开(公告)日：2007-02-15

申请号：US11585647

申请日：2006-10-23

Applicant: Jonathan Edelson

Inventor： Jonathan Edelson

IPC: H02P3/14

CPC classification number: H02P3/14 ,  H02K3/28 ,  H02K17/12 ,  H02P3/22 ,  H02P27/00

Abstract: In the present invention, several polyphase devices are connected together: an inverter, and electrical rotating machine, and a resistive load or braking resistor. The purpose of the resistive load is to dissipate excess electrical power which may be produced when the inverter acts to slow down the rotating machine, causing the rotating machine to act as a generator. In common art, this resistive load is a single DC resistor coupled to the DC link of the inverter via a separate resistor control transistor. In the present invention, the resistive load is a mesh connected array of resistors, and is electrically connected to the same inverter output terminals that the rotating machine is connected to. When it is desired that the resistors absorb energy, for example from a braking operation, then the harmonic content of the inverter output is adjusted, thus placing voltage differences across the resistor array and causing current to flow in the resistors.

Abstract translation: 在本发明中，若干多相装置连接在一起：逆变器和旋转电机以及电阻负载或制动电阻。 电阻负载的目的是消散当变频器作用于减速旋转机器时可能产生的过量电力，导致旋转机器充当发电机。 在常见技术中，该电阻性负载是通过单独的电阻器控制晶体管耦合到逆变器的DC链路的单个DC电阻器。 在本发明中，电阻负载是电阻器的网状连接阵列，并且电连接到与旋转机器连接的相同的逆变器输出端子。 当希望电阻器例如从制动操作中吸收能量时，调整逆变器输出的谐波含量，从而在电阻器阵列上施加电压差并且使电流在电阻器中流动。