公开(公告)号：US20160338995A1

公开(公告)日：2016-11-24

申请号：US15111741

申请日：2015-01-14

Applicant: LIGAND PHARMACEUTICALS INCORPORATED

Inventor： Lin Zhi

IPC: A61K31/40 ,  A61K45/06 ,  A61K31/277 ,  A61K31/402 ,  A61K31/567 ,  A61K9/00 ,  A61K31/473

CPC classification number: A61K31/40 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/138 ,  A61K31/277 ,  A61K31/402 ,  A61K31/4535 ,  A61K31/47 ,  A61K31/473 ,  A61K31/567 ,  A61K31/58 ,  A61K45/06 ,  A61K2300/00

Abstract: Provided herein are compositions and methods for the treatment of androgen and estrogen receptors mediated conditions. Specifically, a composition that includes an effective amount of a selective estrogen receptor modulator (SERM) and an effective amount of a 5a-reductase inhibitor, or a pharmaceutically acceptable salt, ester or prodrug of the foregoing is provided. Also provided are methods for the treatment of aging related conditions and diseases.

Abstract translation: 本文提供了用于治疗雄激素和雌激素受体介导的病症的组合物和方法。 具体而言，提供了包含有效量的选择性雌激素受体调节剂（SERM）和有效量的5α-还原酶抑制剂或其前体药学上可接受的盐，酯或前药的组合物。 还提供了治疗老化相关病症和疾病的方法。

公开(公告)号：US20140155379A1

公开(公告)日：2014-06-05

申请号：US14137318

申请日：2013-12-20

Applicant: Ligand Pharmaceuticals Incorporated

Inventor： Koc-Kan Ho ,  David Diller ,  Jeffrey J. Letourneau ,  Brian F. McGuinness ,  Andrew G. Cole ,  David Rosen ,  Cornelis A. van Oeveren ,  Jason C. Pickens ,  Lin Zhi ,  Yixing Shen ,  Bijan Pedram

IPC: C07D417/12 ,  C07D513/04 ,  C07D471/04 ,  C07D417/14

CPC classification number: C07D513/04 ,  A61K31/407 ,  A61K31/4168 ,  A61K31/4353 ,  A61P29/00 ,  A61P37/00 ,  C07D235/02 ,  C07D269/02 ,  C07D277/42 ,  C07D277/60 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.

Abstract translation: 公开了化学和医学领域中的化合物和方法。 一些所公开的实施方案包括使用杂环胺的化合物，组合物和方法。 一些所公开的实施方案包括可用于治疗炎症性疾病的杂环胺。

公开(公告)号：US20030073703A1

公开(公告)日：2003-04-17

申请号：US10201524

申请日：2002-07-23

Applicant: Abbott Laboratories and Ligand Pharmaceuticals Incorporated

Inventor： Michael J. Coghlan ,  James P. Edwards ,  Steven W. Elmore ,  Todd K. Jones ,  Michael E. Kort ,  Philip R. Kym ,  Jimmie L. Moore ,  John K. Pratt ,  Alan X. Wang

IPC: A61K031/519 ,  A61K031/4741 ,  C07D491/02 ,  C07D471/02

CPC classification number: C07D491/04

Abstract: Compounds having Formula I 1 are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of inhibiting immune or autoimmune diseases in a mammal.

Abstract translation: 具有式I的化合物可用于部分或完全拮抗，镇压，激动或调节糖皮质激素受体并治疗哺乳动物的免疫，自身免疫和炎性疾病。 还公开了包含式I化合物的药物组合物和在哺乳动物中抑制免疫或自身免疫性疾病的方法。

公开(公告)号：US20020183346A1

公开(公告)日：2002-12-05

申请号：US10080926

申请日：2002-02-22

Applicant: Ligand Pharmaceuticals Incorporated

Inventor： Lin Zhi ,  Cornelis Arjan Van Oeveren ,  Jyun-Hung Chen ,  Robert I. Higuchi

IPC: C07D491/02 ,  A61K031/4745 ,  A61K031/366

CPC classification number: C07D471/04 ,  C07D491/04 ,  C07D493/04

Abstract: This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds.

Abstract translation: 本发明涉及作为雄激素受体调节剂的非甾体三环化合物以及制备和使用这些化合物的方法。

公开(公告)号：US20240294565A1

公开(公告)日：2024-09-05

申请号：US18561681

申请日：2022-05-10

Applicant: Ligand Pharmaceuticals Incorporated

Inventor： Lin Zhi

IPC: C07H19/10 ,  A61K31/44 ,  A61K31/7072 ,  C07H19/11

CPC classification number: C07H19/10 ,  A61K31/44 ,  A61K31/7072 ,  C07H19/11

Abstract: Provided herein am phosphoramidate and cyclophosphate prodrug compounds of unnatural configuration nucleotide, their preparation, and their uses, such as treating liver diseases or nonliver diseases via intervening in the molecular pathways in the liver.

公开(公告)号：US11970482B2

公开(公告)日：2024-04-30

申请号：US16960681

申请日：2019-01-08

Applicant: Ligand Pharmaceuticals Incorporated

Inventor： Lin Zhi

IPC: C07D405/14 ,  C07D239/42 ,  C07D405/06 ,  A61K31/397 ,  A61K45/06

CPC classification number: C07D405/14 ,  C07D239/42 ,  C07D405/06 ,  A61K31/397 ,  A61K45/06

Abstract: Disclosed herein are acetal and cyclic acetal compounds, compositions, their preparation, and their uses. Some embodiments relate to their use as liver-targeting compounds.

公开(公告)号：US20230391807A1

公开(公告)日：2023-12-07

申请号：US18032783

申请日：2021-10-19

Applicant: Ligand Pharmaceuticals Incorporated

Inventor： Lin Zhi

IPC: C07F9/6574

CPC classification number: C07F9/65744

Abstract: Provided herein are nucleotide prodrug compounds, their preparation and their uses, such as treating diseases or conditions of a viral infection.

公开(公告)号：US20220298198A1

公开(公告)日：2022-09-22

申请号：US17835828

申请日：2022-06-08

Applicant: Ligand Pharmaceuticals Incorporated

Inventor： Lin Zhi

IPC: C07H17/00 ,  A61P31/12 ,  A61K31/706

Abstract: Provided herein are nucleotide prodrug compounds, their preparation and their uses, such as treating diseases or conditions of a viral infection.

公开(公告)号：US20190040006A1

公开(公告)日：2019-02-07

申请号：US16148798

申请日：2018-10-01

Applicant: Ligand Pharmaceuticals Incorporated

Inventor： Lin Zhi

IPC: C07D207/09 ,  A61K45/06 ,  A61K31/5383 ,  A61K31/402 ,  C07D207/08 ,  C07D207/16 ,  C07D498/04 ,  A61K31/401

Abstract: Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.

公开(公告)号：US10030034B2

公开(公告)日：2018-07-24

申请号：US15006940

申请日：2016-01-26

Applicant: Ligand Pharmaceuticals Incorporated

Inventor： Koc-Kan Ho ,  David Diller ,  Jeffrey J. Letourneau ,  Brian F. McGuinness ,  Andrew G. Cole ,  David Rosen ,  Cornelis A. van Oeveren ,  Jason C. Pickens ,  Lin Zhi ,  Yixing Shen ,  Bijan Pedram

IPC: C07D235/02 ,  C07D269/02 ,  C07D277/42 ,  C07D277/60 ,  C07D513/04 ,  A61K31/407 ,  A61K31/4168 ,  A61K31/4353 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.