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    Azolyloxy-carboxylic acid n-oxy-amide compounds
    3.
    发明授权
    Azolyloxy-carboxylic acid n-oxy-amide compounds 失效
    芳氧基 - 羧酸正氧化酰胺化合物

    公开(公告)号：US4408055A

    公开(公告)日：1983-10-04

    申请号：US204147

    申请日：1980-11-05

    申请人： Heinz Forster ,  Fritz Maurer ,  Volker Mues ,  Ludwig Eue ,  Robert R. Schmidt

    发明人： Heinz Forster ,  Fritz Maurer ,  Volker Mues ,  Ludwig Eue ,  Robert R. Schmidt

    IPC分类号： A01N43/72 ,  A01N43/74 ,  A01N43/76 ,  A01N43/78 ,  A01N43/82 ,  A01N43/824 ,  A01N43/836 ,  C07C233/05 ,  C07C233/06 ,  C07C233/07 ,  C07C235/06 ,  C07C239/14 ,  C07C239/20 ,  C07C275/64 ,  C07C291/04 ,  C07D261/12 ,  C07D263/58 ,  C07D271/06 ,  C07D271/07 ,  C07D277/20 ,  C07D277/34 ,  C07D277/56 ,  C07D277/68 ,  C07D285/08 ,  C07D285/12 ,  C07D285/125 ,  C07D285/13 ,  C07D283/02 ,  C07D269/02 ,  C07D271/00 ,  C07D285/02

    CPC分类号： C07D271/07 ,  A01N43/74 ,  A01N43/82 ,  C07C275/64 ,  C07C291/04 ,  C07D261/12 ,  C07D277/34 ,  C07D277/56 ,  C07D277/68 ,  C07D285/08 ,  C07D285/125 ,  C07D285/13

    摘要： Azolyloxy-carboxylic acid N-oxy-amide compound of the formula ##STR1## wherein R is a five-membered hetero-aromatic monocyclic radical which contains an oxygen atom or a sulphur atom and in addition 1 to 3 nitrogen atoms and which is optionally substituted by halogen, cyano, nitro, amino, alkylamino, arylamino, dialkylamino, alkylcarbonylamino, alkylcarbonyl, carboxyl, alkoxycarbonyl, carbamoyl, alkylaminocarbonyl, dialkylaminocarbonyl, arylaminocarbonyl (which is optionally substituted by halogen, nitro or alkyl), aryl (which is optionally substituted by halogen, cyano, nitro, alkyl or alkoxy), by a radical which is optionally substituted by halogen and is selected from aralkyl, alkoxy, alkenoxy, alkynoxy, alkoxycarbonylalkoxy, aralkoxy, aryloxy, alkylthio, alkenylthio, alkoxycarbonylalkylthio, aralkylthio, arylthio, alkylsulphinyl, alkylsulphonyl, alkyl, alkenyl, alkynyl, alkoxyalkyl, aralkoxyalkyl, aryloxyalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, arylthioalkyl, arylsulphinylalkyl, arylsulphonylalkyl, carboxyalkyl, and alkoxycarbonylalkyl, or by optionally substituted aminocarbonylalkyl, cyanoalkyl or cycloalkyl, or which is optionally benzo-fused, the benzo radical optionally being substituted by halogen, alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, alkylthio, halogenoalkylthio, amino, alkylamino, dialkylamino, nitro, cyano, alkoxycarbonyl or optionally halogen-substituted alkylenedioxy,R.sup.1 is hydrogen or alkyl, andR.sup.2 and R.sup.3 are individually selected from optionally substituted radicals selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl orR.sup.2 and R.sup.3 taken together represent alkyleneare effective herbicides.

    摘要翻译： 具有下式的酰氧基 - 羧酸N-氧化 - 酰胺化合物（I）其中R是含有氧原子或硫原子的5元杂芳族单环基团，另外还含有1至3个氮原子， 烷基氨基，烷基羰基，羧基，烷氧基羰基，氨基甲酰基，烷基氨基羰基，二烷基氨基羰基，芳基氨基羰基（其任选被卤素，硝基或烷基取代），芳基（其是 任选地被卤素，氰基，硝基，烷基或烷氧基取代），其任选被卤素取代的基团，并且选自芳烷基，烷氧基，烯氧基，炔氧基，烷氧基羰基烷氧基，芳烷氧基，芳氧基，烷硫基，烯硫基，烷氧基羰基烷硫基，芳烷硫基， ，烷基亚磺酰基，烷基磺酰基，烷基，烯基，炔基，烷氧基烷基，芳烷氧基烷基，芳氧基烷基，烷硫基烷基，烷基亚磺酰基烷基，烷基磺酰基烷基，芳硫基 芳基亚磺酰基烷基，芳基磺酰基烷基，羧基烷基和烷氧基羰基烷基，或任选取代的氨基羰基烷基，氰基烷基或环烷基，或任选苯并稠合，任选被卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基， 氨基，烷基氨基，二烷基氨基，硝基，氰基，烷氧基羰基或任选卤素取代的亚烷基二氧基，R 1是氢或烷基，R 2和R 3分别选自任选取代的基团，其选自烷基，烯基，炔基，环烷基， ，芳基或R2和R3一起代表亚烷基是有效的除草剂。

    Thyromimetic organic compounds
    8.
    发明申请
    Thyromimetic organic compounds 失效
    甲状腺素有机化合物

    公开(公告)号：US20020107390A1

    公开(公告)日：2002-08-08

    申请号：US09931683

    申请日：2001-08-16

    发明人： Paivi J. Kukkola

    IPC分类号： C07D281/02 ,  C07D277/02 ,  C07D279/12 ,  C07D269/02 ,  C07D265/30 ,  C07D263/04 ,  C07D243/08 ,  C07D239/04 ,  C07D233/02

    CPC分类号： C07C235/62 ,  C07C311/29 ,  C07C317/22 ,  C07C323/67 ,  C07C2601/14 ,  C07D213/64 ,  C07D213/75 ,  C07D295/192 ,  C07D295/26

    摘要： Compounds of the formula 1 in which W is O, S, S(O) or S(O)2; X is nullSR4, nullS(O)R4, or nullS(O)2R4, nullS(O)2NR5R6; or X is nullC(O)NR5R6 provided that nullC(O)NR5R6 is located at the 3null, 4null or 5null position; Y is O or H2; Z is hydrogen, halogen, hydroxy, optionally substituted alkoxy, aralkoxy, acyloxy or alkoxycarbonyloxy; R is hydrogen, halogen, trifluoromethyl, lower alkyl or cycloalkyl; R1 is hydroxy, optionally substituted alkoxy, aryloxy, heteroaryloxy, aralkyloxy, cycloalkoxy, heteroaralkoxy or -NR5R6; R2 is hydrogen, halogen or alkyl; R3 is halogen or alkyl; R4 is optionally substituted alkyl, aryl, aralkyl, heteroaralkyl or heteroaryl; R5, R6 and R7 are independently hydrogen, optionally substituted alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; or R5 and R6 combined are alkylene optionally interrupted by O, S, S(O), S(O)2 or NR7 which together with the nitrogen atom to which they are attached form a 5- to 7-membered ring; n represents zero or an integer from 1 to 4; pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; a method to prevent and treat diseases associated with an imbalance of thyroid hormones, such as hypo- and hyperthyroidism, obesity, osteoporosis and depression; and, a method of lowering LDL cholesterol and Lp(a) levels in mammals using such compounds.

    摘要翻译： W为O，S，S（O）或S（O）2的式的化合物; X是-SR 4，-S（O）R 4或-S（O）2 R 4，-S（O）2 NR 5 R 6; 或者X是-C（O）NR 5 R 6，条件是-C（O）NR 5 R 6位于3'，4'或5'位; Y为O或H2; Z是氢，卤素，羟基，任选取代的烷氧基，芳烷氧基，酰氧基或烷氧基羰基氧基; R是氢，卤素，三氟甲基，低级烷基或环烷基; R1是羟基，任选取代的烷氧基，芳氧基，杂芳氧基，芳烷氧基，环烷氧基，杂芳烷氧基或-NR5R6; R2是氢，卤素或烷基; R3是卤素或烷基; R 4是任选取代的烷基，芳基，芳烷基，杂芳烷基或杂芳基; R5，R6和R7独立地是氢，任选取代的烷基，环烷基，芳基，芳烷基，杂芳基或杂芳烷基; 或R 5和R 6组合的是任选被O，S，S（O），S（O）2或NR 7中断的亚烷基，它们与它们所连接的氮原子一起形成5-至7-元环; n表示0或1至4的整数; 其药学上可接受的盐; 包含所述化合物的药物组合物; 一种预防和治疗与甲状腺激素失衡相关的疾病的方法，如甲状腺功能低下和甲状腺功能亢进，肥胖，骨质疏松症和抑郁症; 以及使用这种化合物降低哺乳动物的LDL胆固醇和Lp（a）水平的方法。