-
41.发明申请TREATMENT OF DEGENERATIVE BRAIN DISORDERS USING TRANSCRANIAL MAGNETIC STIMULATION 审中-公开使用转移性磁刺激治疗变应性脑疾病公开(公告)号：US20150099921A1
公开(公告)日：2015-04-09
申请号：US14510858
申请日：2014-10-09
申请人： M. Bret SCHNEIDER
发明人： M. Bret SCHNEIDER
摘要： Methods and systems for transcranial magnetic stimulation applied to the posterior cingulate including bundle fibers to treat Alzheimer's. Excitatory impulses from (or triggered by) the applied TMS may be transmitted through to the entorhinal cortex and hippocampus, which are early sites in which Alzheimer's disease begins to develop. Excitatory signals in the hippocampus and entorhinal cortex strengthen connectivity between cells, and increase. Overall metabolic activity may be increased, serving to help promote resistance to the Alzheimer's disease process and encouraging maturation and integration of neural stem cells native to this region of the brain.
摘要翻译： 用于经颅磁刺激的方法和系统应用于后扣带，包括治疗阿尔茨海默病的束纤维。 来自（或由应用的TMS引发）的兴奋性冲动可以传播到痴呆皮层和海马，这是阿尔茨海默病开始发展的早期部位。 兴奋性信号在海马和内嗅皮层增强细胞间的连通性，并增加。 总体代谢活动可能会增加，用于帮助促进对阿尔茨海默病过程的抵抗，并促进天然的神经干细胞成熟和整合到大脑的这个区域。
-
公开(公告)号：US08926959B2
公开(公告)日：2015-01-06
申请号：US11651422
申请日：2007-01-09
CPC分类号： A61N5/062 , A61K38/177 , A61K41/0057 , A61K48/005 , A61K48/0058 , A61K48/0075 , A61K48/0083 , A61N5/0601 , A61N5/0622 , A61N2005/0651 , Y10S530/825
摘要： Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. According to an example embodiment of the present invention, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo.
摘要翻译： 使用光（例如，体内）使用各种方法和装置来实现靶细胞的刺激。 根据本发明的示例性实施例，使用可植入装置刺激靶细胞。 该装置包括用于产生光和生物部分的电光产生装置。 生物部分具有通过在体内刺激靶细胞来响应所产生的光的感光生物分子结构。
-
43.发明申请TRANSCRANIAL MAGNETIC STIMULATION FOR ALTERING SUSCEPTIBILITY OF TISSUE TO PHARMACEUTICALS AND RADIATION 有权用于改变组织对药物和辐射的不适的转移磁性刺激公开(公告)号：US20130204330A1
公开(公告)日：2013-08-08
申请号：US13808806
申请日：2011-07-15
IPC分类号： A61N5/00
摘要： Described herein are methods for modulating the susceptibility of one or more target or tissue regions, and particularly one or more brain regions, to a therapeutic agent such as a drug, immune agent, compound, radiation, etc. In particular, the methods and systems described herein may include magnetic stimulation (including transcranial magnetic stimulation) of target or non-target regions to modulate the susceptibility of the one or more target or tissue regions to a therapeutic agent.
摘要翻译： 本文描述的是调节一种或多种目标或组织区域，特别是一个或多个脑区域对治疗剂如药物，免疫剂，化合物，辐射等的敏感性的方法。特别地，方法和系统 本文描述的可以包括目标或非靶区域的磁刺激（包括经颅磁刺激），以调节一个或多个靶组织区域对治疗剂的敏感性。
-
44.发明申请公开(公告)号：US20130184511A1
公开(公告)日：2013-07-18
申请号：US13708076
申请日：2012-12-07
IPC分类号： A61N5/10
CPC分类号： A61N5/1084 , A61N5/10 , A61N5/1039 , A61N5/1049 , A61N5/1077
摘要： Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.
摘要翻译： 放射外科技术和系统通过将来自患者外部的辐射引导到患者大脑内的目标组织来治疗行为障碍（例如抑郁症，强迫症（Obcessive-compulsive Disorder，“OCD”），成瘾，食欲过盛等），通常不施加外科手术 外伤。 目标通常被包括在与行为障碍相关的神经回路中。 可以施用细胞亚致死剂量的辐射，并且可以通过调节靶和相关组织内的神经活性水平来减轻行为障碍，肥胖症等。 过敏和/或过度活跃的神经元组织可能被靶向，辐射向下调节过度活跃的神经元活动。 通过下调通常对相关神经电路施加负反馈或限制作用的目标的活动，可以增加电路的活动。
-
45.发明授权Radiosurgical neuromodulation devices, systems, and methods for treatment of behavioral disorders by external application of ionizing radiation 有权放射外科神经调节装置，系统和通过外部应用电离辐射治疗行为障碍的方法公开(公告)号：US08337382B2
公开(公告)日：2012-12-25
申请号：US12261347
申请日：2008-10-30
申请人： M. Bret Schneider , John R. Adler, Jr. , Doyle John Borchers, III , Michele Borchers, legal representative
IPC分类号： A61N5/10
CPC分类号： A61N5/1084 , A61N5/10 , A61N5/1039 , A61N5/1049 , A61N5/1077
摘要： Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.
摘要翻译： 放射外科技术和系统通过将来自患者外部的辐射引导到患者大脑内的目标组织来治疗行为障碍（例如抑郁症，强迫症，强迫症，强奸症，痴呆等），通常不会引起手术创伤。 目标通常被包括在与行为障碍相关的神经回路中。 可以施用细胞亚致死剂量的辐射，并且可以通过调节靶和相关组织内的神经活性水平来减轻行为障碍，肥胖症等。 过敏和/或过度活跃的神经元组织可能被靶向，辐射向下调节过度活跃的神经元活动。 通过下调通常对相关神经电路施加负反馈或限制作用的目标的活动，可以增加电路的活动。
-
公开(公告)号：US08246649B2
公开(公告)日：2012-08-21
申请号：US12383094
申请日：2009-03-18
申请人： M. Bret Schneider , Rogelio Moncada
发明人： M. Bret Schneider , Rogelio Moncada
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/008 , A61F2230/0093 , A61F2250/0001
摘要： An intravascular filter is constructed to electrostatically capture and retain particles of a targeted type (for example fat or methacrylate emboli), even if those particles are physically small enough to slip through the filter in the absence of electrostatic attraction. Specific types of targeted particles are thereby captured and retained with improved efficiency, while permitting free flow of non-targeted particles. This improvement permits intravascular filters to be constructed with low-resistance, widely spaced filter elements. Accordingly, more targeted particles are captured, less thrombosis occurs, less pressure drop occurs across the filter, and perfusion or blood collection in downstream areas is maintained.
摘要翻译： 构造血管内过滤器以静电捕获和保留靶向类型的颗粒（例如脂肪或甲基丙烯酸酯栓塞），即使这些颗粒物理上足够小以在没有静电吸引力的情况下穿过过滤器。 从而捕获并保持特定类型的目标颗粒，同时提供非目标颗粒的自由流动。 这种改进允许血管内过滤器由低电阻，宽间隔的过滤元件构成。 因此，捕获更有针对性的颗粒，发生较少的血栓形成，在过滤器上发生较少的压降，并维持下游区域的灌注或血液收集。
-
47.发明申请TRAJECTORY-BASED DEEP-BRAIN STEREOTACTIC TRANSCRANIAL MAGNETIC STIMULATION 有权基于TRAJECTORY的深层脑血管交叉神经刺激公开(公告)号：US20120016177A1
公开(公告)日：2012-01-19
申请号：US13240060
申请日：2011-09-22
摘要： The present invention provides for Stereotactic Transcranial Magnetic Stimulation (sTMS) at predetermined locations with the brain or spinal cord and incorporates an array of electromagnets arranged in a specified configuration where selected coils in the array are pulsed simultaneously. Activation of foci demonstrated by functional MRI or other imaging techniques can be used to locate the neural region affected. Imaging techniques can also be utilized to determine the location of the designated targets.
摘要翻译： 本发明提供了在具有脑或脊髓的预定位置处的立体定向经颅磁刺激（sTMS），并且包括以特定配置布置的电磁体阵列，其中阵列中的选定线圈同时脉冲。 通过功能性MRI或其他成像技术证实的焦点活化可用于定位受影响的神经区。 成像技术也可用于确定指定目标的位置。
-
公开(公告)号：US20110273251A1
公开(公告)日：2011-11-10
申请号：US13141100
申请日：2010-01-07
IPC分类号： H01F5/00
摘要： Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.
摘要翻译： 这里描述的是由两个弯曲的磁性线圈环形成的成形线圈TMS电磁体，该弯曲的磁性线圈环在顶点处连接，该顶点在线圈的外部线圈区域之间的角度通常小于120度（例如，在约45度和约70度，60度之间， 等等。）。 顶点区域成形为优化从TMS电磁体投射的磁场。 例如，顶点区域可以是水平的或垂直的。 在一些变型中，顶点区域通过重新排列形成两个线圈的导电绕组而形成，使得它们不再被布置在与弯曲的磁性线圈环的其它部分中相同的柱状结构中。 这些TMS电磁铁可能非常适合用于深脑经颅磁刺激。
-
49.发明授权公开(公告)号：US08052591B2
公开(公告)日：2011-11-08
申请号：US11429504
申请日：2006-05-05
IPC分类号： A61N2/00
摘要： The present invention provides for Stereotactic Transcranial Magnetic Stimulation (sTMS) at predetermined locations with the brain or spinal cord and incorporates an array of electromagnets arranged in a specified configuration where selected coils in the array are pulsed simultaneously. Activation of foci demonstrated by functional MRI or other imaging techniques can be used to locate the neural region affected. Imaging techniques can also be utilized to determine the location of the designated targets.
摘要翻译： 本发明提供了在具有脑或脊髓的预定位置处的立体定向经颅磁刺激（sTMS），并且包括以特定配置布置的电磁体阵列，其中阵列中的选定线圈同时脉冲。 通过功能性MRI或其他成像技术证实的焦点活化可用于定位受影响的神经区。 成像技术也可用于确定指定目标的位置。
-
公开(公告)号：US20110004450A1
公开(公告)日：2011-01-06
申请号：US12679960
申请日：2008-10-09
摘要： Methods and systems for modeling and displaying magnetic field intensities during Transcranial Magnetic Stimulation (TMS) are described, particularly methods and system for modeling and displaying TMS using overlapping magnetic fields to stimulate deep brain regions.
摘要翻译： 描述了经颅磁刺激（TMS）期间建模和显示磁场强度的方法和系统，特别是使用重叠磁场来建模和显示TMS以刺激深部脑区域的方法和系统。
-
-
-
-
-
-
-
-
-
搜索结果
82 条记录 (耗时 0.031 秒)
