公开(公告)号：US08424521B2

公开(公告)日：2013-04-23

申请号：US12395332

申请日：2009-02-27

申请人： Mehdi M. Jafari ,  Rhomere S. Jimenez ,  Gail F. Upham ,  Jeffrey K. Aviano

发明人： Mehdi M. Jafari ,  Rhomere S. Jimenez ,  Gail F. Upham ,  Jeffrey K. Aviano

IPC分类号： F16K31/02

CPC分类号： A61M16/026 ,  A61M16/0063 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/0033 ,  A61M2205/15 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/46

摘要： This disclosure describes systems and methods for compensating for leakage when determining the respiratory mechanics of a patient during delivery of gas from a medical ventilator to a patient. The systems and methods include monitoring an instantaneous flow in the ventilation system based on one or more measurements of pressure and flow in ventilation system. The leakage is modeled using a predetermined leakage model. A leak-compensated instantaneous lung flow of gas inhaled or exhaled by the patient is estimated. Using the leak-compensated lung flow and a predetermined respiratory mechanics model, the respiratory mechanics of a patient may be estimated including at least one of a leak-compensated lung compliance and a leak-compensated lung resistance. The method may include using a dynamic respiratory mechanics model or a static respiratory mechanics model that requires use of a pause maneuver to collect the necessary data.

摘要翻译： 本公开描述了在从医用呼吸机向患者输送气体时确定患者的呼吸力学时补偿泄漏的系统和方法。 系统和方法包括基于通风系统中的一个或多个压力和流量测量来监测通风系统中的瞬时流量。 使用预定的泄漏模型建立泄漏。 估计由患者吸入或呼出的气体的泄漏补偿的瞬时肺流。 使用泄漏补偿肺流和预定的呼吸力学模型，可以估计患者的呼吸力学，包括泄漏补偿的肺顺应性和泄漏补偿的肺阻力中的至少一种。 该方法可以包括使用动态呼吸力学模型或需要使用暂停操作来收集必要数据的静态呼吸力学模型。

公开(公告)号：US20130006134A1

公开(公告)日：2013-01-03

申请号：US13174240

申请日：2011-06-30

申请人： Peter R. Doyle ,  Gardner Kimm ,  Mehdi M. Jafari

发明人： Peter R. Doyle ,  Gardner Kimm ,  Mehdi M. Jafari

IPC分类号： A61B5/08

CPC分类号： A61B5/0836 ,  A61M16/0063 ,  A61M16/026 ,  A61M16/0833 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2205/502 ,  A61M2230/432

摘要： This disclosure describes novel systems and methods for monitoring volumetric CO2 during ventilation of a patient being ventilated by a medical ventilator. The disclosure describes more accurate, more cost effective, and/or less burdensome non-invasive methods and systems for calculating volumetric CO2 than previously utilized methods and systems. The disclosure describes estimating a flow rate in a breathing circuit to calculate a volumetric CO2. Further, the disclosure describes synchronizing the estimated flow rate with a measured CO2 to calculate a volumetric CO2. Additionally, the disclosure describes synchronizing a measured flow rate from within the breathing circuit with a measured CO2 to calculate a volumetric CO2.

摘要翻译： 本公开描述了在通过医疗呼吸机通气的患者的通气期间监测体积二氧化碳的新型系统和方法。 本公开描述了比以前使用的方法和系统更准确，更具成本效益和/或更少的非侵入性方法和用于计算体积CO 2的系统。 本公开内容描述了估计呼吸回路中的流量以计算体积二氧化碳。 此外，本公开描述了将估计的流量与测量的CO 2同步以计算体积CO 2。 此外，本公开内容描述了将来自呼吸回路内的测量流量与测量的CO 2同步以计算体积CO 2。

公开(公告)号：US08272380B2

公开(公告)日：2012-09-25

申请号：US12242756

申请日：2008-09-30

申请人： Mehdi M. Jafari ,  Jeffrey K. Aviano ,  Rhomere S. Jimenez ,  Gail F. Upham

发明人： Mehdi M. Jafari ,  Jeffrey K. Aviano ,  Rhomere S. Jimenez ,  Gail F. Upham

IPC分类号： A61M11/00

CPC分类号： A61M16/0057 ,  A61M16/0051 ,  A61M16/0063 ,  A61M16/026 ,  A61M16/04 ,  A61M16/06 ,  A61M16/0666 ,  A61M16/0875 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/0033 ,  A61M2205/15 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/46

摘要： This disclosure describes systems and methods for compensating for inelastic and elastic leaks in a ventilation system. The disclosure describes a model-based enhancement to conventional pressure triggering methodology that optimizes the timing and patient work of pressure triggering performance. The methods and systems described herein compensate for the additional effort a patient has to exert to generate the same amount of airway pressure drops compared to no leak condition. One method described includes calculating an elastic leakage and an inelastic leakage based on current measurements of pressure and flow in the ventilation system and then compensating a pressure threshold for the effects of the inelastic and elastic leaks in the system.

摘要翻译： 本公开描述了用于补偿通气系统中的非弹性和弹性泄漏的系统和方法。 本公开描述了对常规压力触发方法的基于模型的增强，其优化了压力触发性能的时间和病人工作。 本文描述的方法和系统补偿了与无泄漏状况相比，患者必须施加额外的努力以产生相同量的气道压降。 所描述的一种方法包括基于通气系统中的压力和流量的当前测量值计算弹性泄漏和非弹性泄漏，然后补偿系统中非弹性和弹性泄漏的影响的压力阈值。

公开(公告)号：US20100218765A1

公开(公告)日：2010-09-02

申请号：US12394899

申请日：2009-02-27

申请人： Mehdi M. Jafari ,  Rhomere S. Jimenez ,  Edward R. McCoy ,  Jeffrey K. Aviano

发明人： Mehdi M. Jafari ,  Rhomere S. Jimenez ,  Edward R. McCoy ,  Jeffrey K. Aviano

IPC分类号： A61M16/00 ,  G01F1/69 ,  A62B9/00

CPC分类号： A61M16/12 ,  A61M16/0057 ,  A61M16/06 ,  A61M16/0816 ,  A61M16/0875 ,  A61M2016/0042 ,  G01F1/68 ,  G01F1/6965

摘要： Systems and methods are described for application of a transitory corrective modification to a hot-wire anemometer flow voltage and/or calculated flow rate to compensate for transient thermal response of the anemometer during a change in mixture of a mixed gas being measured. According to one embodiment a method of applying the transitory corrective modification is provided. An output signal of an exhalation flow sensor of a medical ventilator is received. The flow sensor includes a hot-wire anemometer. The output signal is indicative of a rate of flow of expired gas by a patient. Transient thermal response of the hot-wire anemometer is compensated for by applying a corrective modification to the output signal or a value based thereon. The corrective modification is based at least in part on a fraction of inspired oxygen (FiO2) being supplied by the medical ventilator to the patient.

摘要翻译： 描述了系统和方法，用于对热线风速计流量电压和/或计算流量进行暂时校正修改，以补偿在测量的混合气体的混合物的变化期间风速计的瞬时热响应。 根据一个实施例，提供了应用短暂校正修改的方法。 接收医用呼吸机的呼气流量传感器的输出信号。 流量传感器包括热线风速计。 输出信号表示患者呼气气体的流速。 通过对输出信号进行校正修改或基于其的值来补偿热线风速计的瞬态热响应。 校正修改至少部分地基于医疗呼吸机向患者提供的一部分吸气氧（FiO2）。

公开(公告)号：US20100147303A1

公开(公告)日：2010-06-17

申请号：US12334354

申请日：2008-12-12

申请人： Mehdi M. Jafari ,  Rhomere S. Jimenez ,  Gail F. Upham

发明人： Mehdi M. Jafari ,  Rhomere S. Jimenez ,  Gail F. Upham

IPC分类号： A61M16/00 ,  A61B5/08 ,  A61B19/00

CPC分类号： A61M16/0051 ,  A61M16/0063 ,  A61M16/026 ,  A61M2016/0015 ,  A61M2016/0027 ,  A61M2016/003

摘要： This disclosure describes systems and methods for detecting disconnect conditions in a ventilator. The disclosure describes a model-based enhancement to conventional disconnect detection. The methods and systems described herein compensate for the additional leakage that occurs due to inelastic and elastic leaks in the ventilation system. One method described includes calculating the actual leakage from the ventilation system including leaks from elastic leakage and inelastic leakage based on measurements of pressure and flow in the ventilation system for a breath and then comparing this leakage to a calculated hypothetical maximum allowable leakage determined based on an operator-selected maximum allowable leakage and the measurements of pressure for the same breath. Disconnection is assumed if the actual leakage is greater than the maximum allowable leakage.

摘要翻译： 本公开描述了用于检测呼吸机中断开状况的系统和方法。 本公开描述了对常规断开检测的基于模型的增强。 本文描述的方法和系统补偿由于通气系统中的非弹性和弹性泄漏而发生的附加泄漏。 所描述的一种方法包括计算来自通风系统的实际泄漏，包括基于呼吸通气系统中的压力和流量测量的弹性泄漏和非弹性泄漏的泄漏，然后将该泄漏与根据以下公式确定的计算的假设最大允许泄漏进行比较 操作员选择的最大允许泄漏和相同呼吸的压力测量。 如果实际泄漏大于最大允许泄漏量，则假定断开连接。

公开(公告)号：US07000612B2

公开(公告)日：2006-02-21

申请号：US10997533

申请日：2004-11-24

申请人： Mehdi M. Jafari ,  Gardner J. Kimm ,  Karrie McGuigan

发明人： Mehdi M. Jafari ,  Gardner J. Kimm ,  Karrie McGuigan

IPC分类号： A61M16/00

CPC分类号： A61M16/205 ,  A61M16/0051 ,  A61M16/0069 ,  A61M16/026 ,  A61M16/0858 ,  A61M16/125 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/0039 ,  A61M2016/0042 ,  A61M2205/15

摘要： A medical ventilator system and method that triggers, cycles, or both based on patient effort, which is determined from cross-correlating patient flow and patient pressure. The medical ventilator is also controlled such that sensitivity to a patient initiated trigger increases as the expiratory phase of the breathing cycle progresses. The present invention also provides adaptive adjustment of cycling criteria to optimize the cycling operation.