公开(公告)号：US07991715B2

公开(公告)日：2011-08-02

申请号：US12163976

申请日：2008-06-27

Applicant: Jeremy Schiff ,  Justin Fiedler ,  Dominic Antonelli ,  Heston Liebowitz ,  Neil Warren ,  Jonathan Burgstone ,  Sharam Shirazi

Inventor： Jeremy Schiff ,  Justin Fiedler ,  Dominic Antonelli ,  Heston Liebowitz ,  Neil Warren ,  Jonathan Burgstone ,  Sharam Shirazi

IPC: G06N5/00

CPC classification number: G06Q30/02 ,  G06Q30/0244 ,  G06Q30/0273

Abstract: Systems and methods for image classification are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, of selecting a predetermined number of training images that are representative of images associable with a particular topic category. One embodiment can include, extracting training image features from the training images, generating a set of descriptors characteristic of images associable with the particular topic category, and generating the particular set of predetermined models that correspond to the particular topic category based on the set of descriptors.

Abstract translation: 公开了用于图像分类的系统和方法。 在一个方面，本公开的实施例包括可以在系统上实现的方法，其选择代表与特定主题类别相关联的图像的预定数量的训练图像。 一个实施例可以包括：从训练图像提取训练图像特征，生成与特定主题类别相关联的图像特征的一组描述符，以及基于描述符集合生成与特定主题类别相对应的特定预定模型集合 。

公开(公告)号：US20100076077A1

公开(公告)日：2010-03-25

申请号：US12236171

申请日：2008-09-23

Applicant: Michael Fitzpatrick Wempe ,  Liu Deng ,  Stephanie Kay Clendennen ,  Neil Warren Boaz

Inventor： Michael Fitzpatrick Wempe ,  Liu Deng ,  Stephanie Kay Clendennen ,  Neil Warren Boaz

IPC: A61K31/215 ,  C07C69/608 ,  C12P7/62 ,  A61P17/00

CPC classification number: A61K31/22 ,  A61K31/23 ,  C07C67/08 ,  C07C69/95 ,  C07C2601/16

Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.

Abstract translation: 化学和/或酶促制备4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯。 取决于酯，实现了改善的黑素细胞细胞毒性。 改进的细胞毒性特征与酯类似物与其相应的酸相比更具生理学相容性并且对皮肤刺激性较低。

公开(公告)号：US07667067B1

公开(公告)日：2010-02-23

申请号：US12393631

申请日：2009-02-26

Applicant: Stephanie Kay Clendennen ,  Neil Warren Boaz

Inventor： Stephanie Kay Clendennen ,  Neil Warren Boaz

IPC: C07C229/00 ,  A61K6/00 ,  A01N25/00

CPC classification number: C07C219/06 ,  A61K8/416 ,  A61Q19/00 ,  C07C219/08

Abstract: A composition, process of preparation, and utility of salts of fatty acid esters of amino-alcohols such as dimethylaminoethanol (DMAE) as emulsifiers useful for formulating with lipids and waxes is described. DMAE fatty acid esters were prepared enzymatically in the absence of added solvent, and then salified directly with carboxylic acids to form the salts. The compounds were used to make stable emulsions with a variety of cosmetically acceptable lipids.

Abstract translation: 描述了可用于配制脂质和蜡的氨基醇的脂肪酸酯的盐，例如二甲基氨基乙醇（DMAE）作为乳化剂的组合物，制备方法和用途。 在不加入溶剂的情况下酶促制备DMAE脂肪酸酯，然后直接用羧酸成盐形成盐。 这些化合物用于制备具有各种化妆品可接受的脂质的稳定乳液。

公开(公告)号：US20090172730A1

公开(公告)日：2009-07-02

申请号：US12163974

申请日：2008-06-27

Applicant: Jeremy SCHIFF ,  Justin Fiedler ,  Dominic Antonelli ,  Heston Liebowitz ,  Neil Warren ,  Jonathan Burgstone ,  Sharam Shirazi

Inventor： Jeremy SCHIFF ,  Justin Fiedler ,  Dominic Antonelli ,  Heston Liebowitz ,  Neil Warren ,  Jonathan Burgstone ,  Sharam Shirazi

IPC: H04N7/10

CPC classification number: G06Q30/02 ,  G06Q30/0244 ,  G06Q30/0273

Abstract: Systems and methods for advertisement delivery optimization are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, of identifying multimedia content associated with a web-user. One embodiment can include, analyzing the multimedia content to retrieve a set of descriptors, comparing the set of descriptors with metadata of a plurality of advertisements, selecting a candidate pool of advertisements from the plurality of advertisements based on relevancy indicated by the comparison, and presenting at least a portion of the candidate pool of advertisements to the web-user.

Abstract translation: 公开了广告传递优化的系统和方法。 在一个方面，本公开的实施例包括可以在系统上实现识别与网络用户相关联的多媒体内容的方法。 一个实施例可以包括：分析多媒体内容以检索一组描述符，将描述符集合与多个广告的元数据进行比较，基于由比较指示的相关性从多个广告中选择广告的候选库，以及呈现 至少一部分广告的候选汇集给网络用户。

公开(公告)号：US20090172030A1

公开(公告)日：2009-07-02

申请号：US12163976

申请日：2008-06-27

Applicant: Jeremy SCHIFF ,  Justin Fiedler ,  Dominic Antonelli ,  Heston Liebowitz ,  Neil Warren ,  Jonathan Burgstone ,  Sharam Shirazi

Inventor： Jeremy SCHIFF ,  Justin Fiedler ,  Dominic Antonelli ,  Heston Liebowitz ,  Neil Warren ,  Jonathan Burgstone ,  Sharam Shirazi

IPC: G06F17/30

CPC classification number: G06Q30/02 ,  G06Q30/0244 ,  G06Q30/0273

Abstract: Systems and methods for image classification are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, of selecting a predetermined number of training images that are representative of images associable with a particular topic category. One embodiment can include, extracting training image features from the training images, generating a set of descriptors characteristic of images associable with the particular topic category, and generating the particular set of predetermined models that correspond to the particular topic category based on the set of descriptors.

Abstract translation: 公开了用于图像分类的系统和方法。 在一个方面，本公开的实施例包括可以在系统上实现的方法，其选择代表与特定主题类别相关联的图像的预定数量的训练图像。 一个实施例可以包括：从训练图像提取训练图像特征，生成与特定主题类别相关联的图像特征的一组描述符，以及基于描述符集合生成与特定主题类别相对应的特定预定模型集合 。

公开(公告)号：US20080085534A1

公开(公告)日：2008-04-10

申请号：US11544152

申请日：2006-10-06

Applicant: Neil Warren Boaz ,  Stephanie Kay Clendennen

Inventor： Neil Warren Boaz ,  Stephanie Kay Clendennen

IPC: C12P23/00 ,  C07C69/608

CPC classification number: C12P23/00

Abstract: Long-chain esters of retinol are prepared via a chemoenzymatic process from short-chain retinyl esters and an appropriate long-chain acid or ester in the presence of an enzyme. Use of various additives enhance the yield of the desired ester and facilitated its purification.

Abstract translation: 视黄醇的长链酯通过化学酶法从短链视黄酯和合适的长链酸或酯在酶的存在下制备。 使用各种添加剂可提高所需酯的产率，促进其纯化。

公开(公告)号：US06977303B2

公开(公告)日：2005-12-20

申请号：US10721714

申请日：2003-11-25

Applicant: Neil Warren Boaz ,  Sheryl Davis Debenham

Inventor： Neil Warren Boaz ,  Sheryl Davis Debenham

IPC: B01J31/24 ,  C07B61/00 ,  C07C231/18 ,  C07C233/47 ,  C07C233/83 ,  C07C233/84 ,  C07C253/30 ,  C07C255/60 ,  C07C269/06 ,  C07C271/22 ,  C07D203/04 ,  C07D205/08 ,  C07D207/26 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10 ,  C07D225/02 ,  C07F9/553 ,  C07F9/564 ,  C07F9/568 ,  C07F9/572 ,  C07F9/576 ,  C07F9/59 ,  C07D9/02 ,  C07D207/12 ,  C07D207/24

CPC classification number: C07D203/04 ,  C07B2200/07 ,  C07C231/18 ,  C07C253/30 ,  C07C269/06 ,  C07C2601/02 ,  C07D205/08 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10 ,  C07D225/02 ,  C07F9/5532 ,  C07F9/564 ,  C07F9/568 ,  C07F9/572 ,  C07F9/59 ,  Y02P20/52 ,  C07C233/47 ,  C07C233/83 ,  C07C233/84 ,  C07C255/60 ,  C07C271/22

Abstract: The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reaction sequence, asymmetric hydrogenation of a lactam-enamide was performed to produce an intermediate that can ultimately be converted to a series of pharmaceutical compounds. The invention also contemplates the in situ synthesis of an intermediate of the multi-step synthesis, which provides economic advantages to the overall synthesis of the lactam compounds.

公开(公告)号：US5777164A

公开(公告)日：1998-07-07

申请号：US837134

申请日：1997-04-14

Applicant: Neil Warren Boaz

Inventor： Neil Warren Boaz

IPC: C07C239/20 ,  C07C259/00 ,  C07C259/06 ,  C07C259/10

CPC classification number: C07C239/20

Abstract: The present invention discloses a method comprising the steps of; a) forming in an aqueous solution a hydroxamic acid from a hydroxylamine free base and anhydride having the formula (RCO).sub.2 O wherein R is H or a substituted or unsubstituted C.sub.2-6 alkyl, C.sub.2-6 alkenyl, C.sub.6-10 aryl, or C.sub.4-10 heteroaryl; and b) treating said hydroxamic acid with an alkylating agent in the presence of at least one proton scavenger under conditions sufficient to consume substantially all of said alkylating agent to form an O-substituted hydroxamate. The protection and alkylation are readily effected in water (with no alcohol co-solvent) without the need for phase-transfer catalysis and with little hydrolysis of the alkylating agent.

Abstract translation: 本发明公开了一种方法，包括以下步骤： a）在水溶液中形成来自无羟胺基的异羟肟酸和具有式（RCO）2 O的酸酐，其中R是H或取代或未取代的C 2-6烷基，C 2-6烯基，C 6-10芳基或C 4 -10个杂芳基; 和b）在至少一种质子清除剂的存在下，在足以消耗基本上全部所述烷基化剂以形成O-取代的异羟肟酸酯的条件下，用烷基化剂处理所述异羟肟酸。 保护和烷基化容易在水（不含醇共溶剂）中进行，而不需要相转移催化剂，并且烷基化剂几乎没有水解。