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1.发明授权5-hydroxy-2-methyl-4H-pyran-4-one esters as novel tyrosinase inhibitors 有权5-羟基-2-甲基-4H-吡喃-4-酮酯作为新的酪氨酸酶抑制剂公开(公告)号：US08183398B2
公开(公告)日：2012-05-22
申请号：US12755812
申请日：2010-04-07
Applicant: Michael Fitzpatrick Wempe , Jeffrey Michael Clauson , Liu Deng
Inventor： Michael Fitzpatrick Wempe , Jeffrey Michael Clauson , Liu Deng
IPC: C07D309/40 , A61K8/49 , A61K31/351
CPC classification number: C07D309/40
Abstract: Skin brightening compositions based on esters of 5-hydroxy-2-methyl-4H-pyran-4-one. Also disclosed are methods of making the compositions as well as methods of using the compositions.
Abstract translation: 基于5-羟基-2-甲基-4H-吡喃-4-酮的酯的皮肤增亮组合物。 还公开了制备组合物的方法以及使用该组合物的方法。
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2.发明申请ESTERS OF 4,5-DISUBSTITUTED-OXY-2-METHYL-3,6-DIOXO-CYCLOHEXA-1,4-DIENYL ALKYL ACIDS AND PREPARATION THEREOF 失效4,5-二氧杂-2-甲基-3,6-二氧代环己基-1,4-二烯基酸的酯及其制备公开(公告)号：US20100076077A1
公开(公告)日：2010-03-25
申请号：US12236171
申请日：2008-09-23
Applicant: Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
Inventor： Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
IPC: A61K31/215 , C07C69/608 , C12P7/62 , A61P17/00
CPC classification number: A61K31/22 , A61K31/23 , C07C67/08 , C07C69/95 , C07C2601/16
Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
Abstract translation: 化学和/或酶促制备4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯。 取决于酯，实现了改善的黑素细胞细胞毒性。 改进的细胞毒性特征与酯类似物与其相应的酸相比更具生理学相容性并且对皮肤刺激性较低。
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3.发明申请SULFO-POLYMER POWDER AND SULFO-POLYMER POWDER BLENDS WITH CARRIERS AND/OR ADDITIVES 审中-公开SULFO聚合物粉末和SULFO聚合物粉末与载体和/或添加剂混合公开(公告)号：US20090163449A1
公开(公告)日：2009-06-25
申请号：US12262986
申请日：2008-10-31
Applicant: Michael Fitzpatrick Wempe
Inventor： Michael Fitzpatrick Wempe
Abstract: Sulfo-polyester powders and sulfo-polyester blend powders, the incorporation of carriers and/or actives, and methods of making the powders as well as dispersions employing these powders.
Abstract translation: 磺基聚酯粉末和磺基 - 聚酯共混物粉末，载体和/或活性物质的引入，以及制备粉末以及使用这些粉末的分散体的方法。
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公开(公告)号：US20080286219A1
公开(公告)日：2008-11-20
申请号：US11804120
申请日：2007-05-17
Applicant: Michael Fitzpatrick Wempe , Jeffrey M. Clauson
Inventor： Michael Fitzpatrick Wempe , Jeffrey M. Clauson
IPC: A61K8/34 , A61K8/49 , A61Q19/02 , C07C43/178 , C07C59/52 , C07C69/66 , C07D207/16 , C07D277/36
CPC classification number: C07C323/59 , C07C323/20 , C07C323/52 , C07C323/57 , C07C323/60 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D277/36 , C07D333/18
Abstract: Skin brightening compositions based on hydroquinone derivatives and methods of making and using the composition. The hydroquinone derivatives are 2-thio-hydroquinone derivatives.
Abstract translation: 基于氢醌衍生物的皮肤增亮组合物和制备和使用该组合物的方法。 氢醌衍生物是2-硫代氢醌衍生物。
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5.发明申请ESTERS OF 4,5-DISUBSTITUTED-OXY-2-METHYL-3,6-DIOXO-CYCLOHEXA-1,4-DIENYL ALKYL ACIDS AND PREPARATION THEREOF 审中-公开4,5-二氧杂-2-甲基-3,6-二氧代环己基-1,4-二烯基酸的酯及其制备公开(公告)号：US20120302638A1
公开(公告)日：2012-11-29
申请号：US13569287
申请日：2012-08-08
Applicant: Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
Inventor： Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
IPC: A61K31/235 , A61P29/00 , A61P17/00 , C07C67/08 , C12P7/62
CPC classification number: A61K31/22 , A61K31/23 , C07C67/08 , C07C69/95 , C07C2601/16
Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
Abstract translation: 化学和/或酶促制备4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯。 取决于酯，实现了改善的黑素细胞细胞毒性。 改进的细胞毒性特征与酯类似物与其相应的酸相比更具生理学相容性并且对皮肤刺激性较低。
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Patent Agency Ranking
6.发明申请5-HYDROXY-2-METHYL-4H-PYRAN-4-ONE ESTERS AS NOVEL TYROSINASE INHIBITORS 审中-公开5-羟基-2-甲基-4H-吡喃-4-酮作为新型酪氨酸酶抑制剂公开(公告)号：US20090215887A1
公开(公告)日：2009-08-27
申请号：US12036358
申请日：2008-02-25
Applicant: Michael Fitzpatrick Wempe , Jeffrey Michael Clauson
Inventor： Michael Fitzpatrick Wempe , Jeffrey Michael Clauson
IPC: A61K31/351 , C07D309/40 , A61P17/00
CPC classification number: C07D309/40
Abstract: Skin brightening compositions based on esters of 5-hydroxy-2-methyl-4H-pyran-4-one. Also disclosed are methods of making the compositions as well as methods of using the compositions.
Abstract translation: 基于5-羟基-2-甲基-4H-吡喃-4-酮的酯的皮肤增亮组合物。 还公开了制备组合物的方法以及使用该组合物的方法。
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7.发明授权Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof 失效4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯及其制备公开(公告)号：US08263094B2
公开(公告)日：2012-09-11
申请号：US12236171
申请日：2008-09-23
Applicant: Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
Inventor： Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
IPC: A61K8/02 , C12P33/20 , C07D487/00
CPC classification number: A61K31/22 , A61K31/23 , C07C67/08 , C07C69/95 , C07C2601/16
Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
Abstract translation: 化学和/或酶促制备4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯。 取决于酯，实现了改善的黑素细胞细胞毒性。 改进的细胞毒性特征与酯类似物与其相应的酸相比更具生理学相容性并且对皮肤刺激性较低。
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8.发明申请ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME 审中-公开抗癌化合物靶向RAL GTPASES及其使用方法公开(公告)号：US20160280715A1
公开(公告)日：2016-09-29
申请号：US15142011
申请日：2016-04-29
Applicant: Dan THEODORESCU , Michael Fitzpatrick WEMPE , David ROSS , Samy MEROUEH , Martin A. SCHWARTZ , Phillip REIGAN
Inventor： Dan THEODORESCU , Michael Fitzpatrick WEMPE , David ROSS , Samy MEROUEH , Martin A. SCHWARTZ , Phillip REIGAN
IPC: C07D491/052
Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.
Abstract translation: 本发明提供通过抑制哺乳动物中的Ral GTP酶来抑制哺乳动物癌症生长或转移的方法。 本发明还提供可用于本发明方法的Ral GTP酶的小分子抑制剂和含有本发明治疗有效化合物的药物组合物及其使用方法。
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9.发明申请5-Hydroxy-2-Methyl-4H-Pyran-4-One Esters as Novel Tyrosinase Inhibitors 有权5-羟基-2-甲基-4H-吡喃-4-酮作为新型酪氨酸酶抑制剂公开(公告)号：US20100216873A1
公开(公告)日：2010-08-26
申请号：US12755812
申请日：2010-04-07
Applicant: Michael Fitzpatrick Wempe , Jeffrey Michael Clauson , Liu Deng
Inventor： Michael Fitzpatrick Wempe , Jeffrey Michael Clauson , Liu Deng
IPC: A61K8/49 , C07D309/32 , A61Q19/00
CPC classification number: C07D309/40
Abstract: Skin brightening compositions based on esters of 5-hydroxy-2-methyl-4H-pyran-4-one. Also disclosed are methods of making the compositions as well as methods of using the compositions.
Abstract translation: 基于5-羟基-2-甲基-4H-吡喃-4-酮的酯的皮肤增亮组合物。 还公开了制备组合物的方法以及使用该组合物的方法。
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公开(公告)号：US20090163603A1
公开(公告)日：2009-06-25
申请号：US12263010
申请日：2008-10-31
Applicant: Michael Fitzpatrick Wempe
Inventor： Michael Fitzpatrick Wempe
CPC classification number: C08G63/6884 , A61K8/85 , A61Q19/00 , C08J3/16 , C08J2367/00
Abstract: Sulfo-polymer powder and sulfo-polymer powder blends and subsequent preparation of dispersions of the sulfopolyester powder or sulfopolyester powder blends. The powders have reduced levels of volatiles and are generally whiter in color.
Abstract translation: 磺基聚合物粉末和磺基聚合物粉末混合物，随后制备磺基聚酯粉末或磺基聚酯粉末共混物的分散体。 这些粉末具有降低的挥发物含量，通常是较白的。
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