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1.发明申请公开(公告)号：US20130273183A1
公开(公告)日：2013-10-17
申请号：US13446240
申请日：2012-04-13
Applicant: Stephanie Kay Clendennen , Liu Deng , Neil Warren Boaz
Inventor： Stephanie Kay Clendennen , Liu Deng , Neil Warren Boaz
CPC classification number: A61Q19/02 , A61K8/4926 , A61K2800/782
Abstract: 2-Pyrimidine thioesters and thiocarbonates are disclosed as effective skin brightening agents. These compounds may be formulated with dermatologically acceptable carriers to form skin brightening compositions. Methods for brightening skin and for inhibiting melanogenesis using these agents are also disclosed.
Abstract translation: 公开了2-嘧啶硫酯和硫代碳酸酯作为有效的皮肤增亮剂。 这些化合物可以与皮肤病学上可接受的载体配制以形成皮肤增亮组合物。 还公开了使用这些试剂增亮皮肤和抑制黑素生成的方法。
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2.发明授权Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof 失效4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯及其制备公开(公告)号：US08263094B2
公开(公告)日：2012-09-11
申请号：US12236171
申请日：2008-09-23
Applicant: Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
Inventor： Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
IPC: A61K8/02 , C12P33/20 , C07D487/00
CPC classification number: A61K31/22 , A61K31/23 , C07C67/08 , C07C69/95 , C07C2601/16
Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
Abstract translation: 化学和/或酶促制备4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯。 取决于酯，实现了改善的黑素细胞细胞毒性。 改进的细胞毒性特征与酯类似物与其相应的酸相比更具生理学相容性并且对皮肤刺激性较低。
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3.发明申请公开(公告)号：US20120029198A1
公开(公告)日：2012-02-02
申请号：US12975572
申请日：2010-12-22
Applicant: Liu Deng , Neil Warren Boaz
Inventor： Liu Deng , Neil Warren Boaz
IPC: C07C69/84 , C07C69/736 , C07D309/38 , C12P17/12 , C12P13/00 , C12P7/62 , C12P17/06 , C07C229/22 , C07D213/80
CPC classification number: A61K8/671 , A61Q19/00 , A61Q19/002 , A61Q19/02 , A61Q19/08 , C07C67/03 , C07C67/10 , C07C67/11 , C07C69/734 , C07C403/12 , C07C403/20 , C07C2601/16 , C07D213/80 , C07D213/803 , C07D309/38 , C07D309/40 , C12P7/62 , C07C69/63
Abstract: Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: wherein R and R1 are independently selected from the group consisting of substituted and unsubstituted, branched- and straight-chain, saturated, unsaturated, and polyunsaturated C1-C22 alkyl, substituted and unsubstituted C3-C8 cycloalkyl, substituted and unsubstituted C6-C20 carbocyclic aryl, and substituted and unsubstituted C4-C20 heterocyclic; wherein the heteroatoms are selected from sulfur, nitrogen, and oxygen; and wherein n is 1-6. Process of producing esters of O-substituted hydroxy carboxylic acids are also provided.
Abstract translation: 提供O-取代的羟基羧酸的酯，其具有式1或2或两者或式2或其两者：其中R和R 1独立地选自取代和未取代的，支链和直链的饱和不饱和的 和多不饱和C 1 -C 22烷基，取代和未取代的C 3 -C 8环烷基，取代和未取代的C 6 -C 20碳环芳基和取代和未取代的C 4 -C 20杂环; 其中所述杂原子选自硫，氮和氧; 并且其中n为1-6。 还提供了生产O-取代羟基羧酸酯的方法。
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4.发明授权5-hydroxy-2-methyl-4H-pyran-4-one esters as novel tyrosinase inhibitors 有权5-羟基-2-甲基-4H-吡喃-4-酮酯作为新的酪氨酸酶抑制剂公开(公告)号：US08183398B2
公开(公告)日：2012-05-22
申请号：US12755812
申请日：2010-04-07
Applicant: Michael Fitzpatrick Wempe , Jeffrey Michael Clauson , Liu Deng
Inventor： Michael Fitzpatrick Wempe , Jeffrey Michael Clauson , Liu Deng
IPC: C07D309/40 , A61K8/49 , A61K31/351
CPC classification number: C07D309/40
Abstract: Skin brightening compositions based on esters of 5-hydroxy-2-methyl-4H-pyran-4-one. Also disclosed are methods of making the compositions as well as methods of using the compositions.
Abstract translation: 基于5-羟基-2-甲基-4H-吡喃-4-酮的酯的皮肤增亮组合物。 还公开了制备组合物的方法以及使用该组合物的方法。
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5.发明申请ESTERS OF 4,5-DISUBSTITUTED-OXY-2-METHYL-3,6-DIOXO-CYCLOHEXA-1,4-DIENYL ALKYL ACIDS AND PREPARATION THEREOF 失效4,5-二氧杂-2-甲基-3,6-二氧代环己基-1,4-二烯基酸的酯及其制备公开(公告)号：US20100076077A1
公开(公告)日：2010-03-25
申请号：US12236171
申请日：2008-09-23
Applicant: Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
Inventor： Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
IPC: A61K31/215 , C07C69/608 , C12P7/62 , A61P17/00
CPC classification number: A61K31/22 , A61K31/23 , C07C67/08 , C07C69/95 , C07C2601/16
Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
Abstract translation: 化学和/或酶促制备4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯。 取决于酯，实现了改善的黑素细胞细胞毒性。 改进的细胞毒性特征与酯类似物与其相应的酸相比更具生理学相容性并且对皮肤刺激性较低。
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Patent Agency Ranking
6.发明授权公开(公告)号：US08846723B2
公开(公告)日：2014-09-30
申请号：US12975572
申请日：2010-12-22
Applicant: Liu Deng , Neil Warren Boaz , Sabine Delaire
Inventor： Liu Deng , Neil Warren Boaz , Sabine Delaire
IPC: A61K31/4406 , A61K31/221 , A61K31/235 , C07C69/76 , C07C69/734 , C07C403/20 , C07C403/12 , C07C67/11 , A61Q19/08 , A61K8/67 , A61Q19/00 , C12P7/62 , C07C67/03 , C07D309/40 , A61Q19/02
CPC classification number: A61K8/671 , A61Q19/00 , A61Q19/002 , A61Q19/02 , A61Q19/08 , C07C67/03 , C07C67/10 , C07C67/11 , C07C69/734 , C07C403/12 , C07C403/20 , C07C2601/16 , C07D213/80 , C07D213/803 , C07D309/38 , C07D309/40 , C12P7/62 , C07C69/63
Abstract: Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: wherein R and R1 are independently selected from the group consisting of substituted and unsubstituted, branched- and straight-chain, saturated, unsaturated, and polyunsaturated C1-C22 alkyl, substituted and unsubstituted C3-C8 cycloalkyl, substituted and unsubstituted C6-C20 carbocyclic aryl, and substituted and unsubstituted C4-C20 heterocyclic; wherein the heteroatoms are selected from sulfur, nitrogen, and oxygen; and wherein n is 1-6. Process of producing esters of O-substituted hydroxy carboxylic acids are also provided.
Abstract translation: 提供O-取代的羟基羧酸的酯，其具有式1或2或两者或式2或其两者：其中R和R 1独立地选自取代和未取代的，支链和直链的饱和不饱和的 和多不饱和C 1 -C 22烷基，取代和未取代的C 3 -C 8环烷基，取代和未取代的C 6 -C 20碳环芳基和取代和未取代的C 4 -C 20杂环; 其中所述杂原子选自硫，氮和氧; 并且其中n为1-6。 还提供了生产O-取代羟基羧酸酯的方法。
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7.发明授权Process for preparing V-Ti-P catalysts for synthesis of 2,3-unsaturated carboxylic acids 有权制备用于合成2,3-不饱和羧酸的V-Ti-P催化剂的方法公开(公告)号：US08765629B2
公开(公告)日：2014-07-01
申请号：US13234313
申请日：2011-09-16
Applicant: David William Norman , Gerald Charles Tustin , Michael James Nash , Liu Deng , Theresa Sims Barnette
Inventor： David William Norman , Gerald Charles Tustin , Michael James Nash , Liu Deng , Theresa Sims Barnette
IPC: B01J27/198 , C07B35/00 , C07C51/00
CPC classification number: B01J27/198 , B01J21/063 , B01J35/002 , B01J37/031 , B01J2523/00 , C07C51/353 , B01J2523/47 , B01J2523/51 , B01J2523/55 , C07C57/04
Abstract: The invention relates to a catalyst composition comprising a mixed oxide of vanadium, titanium, and phosphorus. The titanium component is derived from a water-soluble, redox-active organo-titanium compound. The catalyst composition is highly effective at facilitating the vapor-phase condensation of formaldehyde with acetic acid to generate acrylic acid, particularly using an industrially relevant aqueous liquid feed.
Abstract translation: 本发明涉及包含钒，钛和磷的混合氧化物的催化剂组合物。 钛组分衍生自水溶性，氧化还原活性有机钛化合物。 催化剂组合物在促进甲醛与乙酸的气相缩合以产生丙烯酸方面是非常有效的，特别是使用工业上相关的水性液体进料。
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8.发明申请5-Hydroxy-2-Methyl-4H-Pyran-4-One Esters as Novel Tyrosinase Inhibitors 有权5-羟基-2-甲基-4H-吡喃-4-酮作为新型酪氨酸酶抑制剂公开(公告)号：US20100216873A1
公开(公告)日：2010-08-26
申请号：US12755812
申请日：2010-04-07
Applicant: Michael Fitzpatrick Wempe , Jeffrey Michael Clauson , Liu Deng
Inventor： Michael Fitzpatrick Wempe , Jeffrey Michael Clauson , Liu Deng
IPC: A61K8/49 , C07D309/32 , A61Q19/00
CPC classification number: C07D309/40
Abstract: Skin brightening compositions based on esters of 5-hydroxy-2-methyl-4H-pyran-4-one. Also disclosed are methods of making the compositions as well as methods of using the compositions.
Abstract translation: 基于5-羟基-2-甲基-4H-吡喃-4-酮的酯的皮肤增亮组合物。 还公开了制备组合物的方法以及使用该组合物的方法。
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公开(公告)号：US11104780B2
公开(公告)日：2021-08-31
申请号：US16603823
申请日：2018-04-09
Applicant: Continental Reifen Deutschland GmbH , Fabian Peters , Emily Baird Anderson , John Dayton Baker, Jr. , Terri Roxanne Carvagno , Judicael Jacques Chapelet , Wei Min Cheng , Liu Deng , Jacobus Gillis de Hullu , Sebastian Finger , Hubert Hirschlag , Christopher Lee Lester , Wentao Li , Mutombo Joseph Muvundamina , Mark Stanley Pavlin , Carla Recker , Christopher Thomas Scilla
Inventor： Fabian Peters , Emily Baird Anderson , John Dayton Baker, Jr. , Terri Roxanne Carvagno , Judicael Jacques Chapelet , Wei Min Cheng , Liu Deng , Jacobus Gillis de Hullu , Sebastian Finger , Hubert Hirschlag , Christopher Lee Lester , Wentao Li , Mutombo Joseph Muvundamina , Mark Stanley Pavlin , Carla Recker , Christopher Thomas Scilla
IPC: C08L7/00 , B60C1/00 , B60C11/00 , B60C13/00 , C08F8/42 , C08F12/22 , C08F30/08 , C08F257/02 , C09J123/08 , C09J123/20
Abstract: Polar silane linkers are provided that attach to resins to form silane-functionalized resins. The functionalized resins can be bound to hydroxyl groups on the surface of silica particles to improve the dispersibility of the silica particles in rubber mixtures. Further disclosed are synthetic routes to provide the silane-functionalized resins, as well as various uses and end products that benefit from the unexpected properties of the silane-functionalized resins. Silane-functionalized resins impart remarkable properties on various rubber compositions, such as tires, belts, hoses, brakes, and the like. Automobile tires incorporating the silane-functionalized resins are shown to possess excellent results in balancing the properties of rolling resistance, tire wear, and wet braking performance.
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10.发明申请ESTERS OF 4,5-DISUBSTITUTED-OXY-2-METHYL-3,6-DIOXO-CYCLOHEXA-1,4-DIENYL ALKYL ACIDS AND PREPARATION THEREOF 审中-公开4,5-二氧杂-2-甲基-3,6-二氧代环己基-1,4-二烯基酸的酯及其制备公开(公告)号：US20120302638A1
公开(公告)日：2012-11-29
申请号：US13569287
申请日：2012-08-08
Applicant: Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
Inventor： Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
IPC: A61K31/235 , A61P29/00 , A61P17/00 , C07C67/08 , C12P7/62
CPC classification number: A61K31/22 , A61K31/23 , C07C67/08 , C07C69/95 , C07C2601/16
Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
Abstract translation: 化学和/或酶促制备4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯。 取决于酯，实现了改善的黑素细胞细胞毒性。 改进的细胞毒性特征与酯类似物与其相应的酸相比更具生理学相容性并且对皮肤刺激性较低。
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