公开(公告)号：US20100199881A1

公开(公告)日：2010-08-12

申请号：US12704263

申请日：2010-02-11

Applicant: Peter Clark ,  Chad Hewitt

Inventor： Peter Clark ,  Chad Hewitt

IPC: B61D15/06 ,  B23P17/04

CPC classification number: B61D15/06 ,  B61D17/06 ,  Y10T29/49826

Abstract: A rail car collision system is disclosed that includes a front face and an underframe having a first anticlimber. The first anticlimber protrudes from and extends across at least a portion of the front face at a first position. At least one second anticlimber extends along at least a portion of the front face at a second position that is vertically different than the first position.

Abstract translation: 公开了一种轨道车辆碰撞系统，其包括前表面和具有第一防结构的底架。 第一防弹件在第一位置处突出并延伸穿过前表面的至少一部分。 在与第一位置垂直不同的第二位置处，至少一个第二防弹件沿前表面的至少一部分延伸。

公开(公告)号：US07690314B2

公开(公告)日：2010-04-06

申请号：US11786813

申请日：2007-04-12

Applicant: Peter Clark ,  Chad Hewitt

Inventor： Peter Clark ,  Chad Hewitt

IPC: B61D15/06

CPC classification number: B61D15/06 ,  B61D17/06 ,  Y10T29/49826

Abstract: A rail car collision system is disclosed that includes a front face and an underframe having a first anticlimber. The first anticlimber protrudes from and extends across at least a portion of the front face at a first position. At least one second anticlimber extends along at least a portion of the front face at a second position that is vertically different than the first position.

Abstract translation: 公开了一种轨道车辆碰撞系统，其包括前表面和具有第一防结构的底架。 第一防弹件在第一位置处突出并延伸穿过前表面的至少一部分。 在与第一位置垂直不同的第二位置处，至少一个第二防弹件沿前表面的至少一部分延伸。

公开(公告)号：US07432280B2

公开(公告)日：2008-10-07

申请号：US10558588

申请日：2004-05-25

Applicant: Christopher David Beadle ,  Manuel Javier Cases-Thomas ,  Barry Peter Clark ,  Peter Thaddeus Gallagher ,  John Joseph Masters ,  Graham Henry Timms ,  Magnus Wilhelm Walter ,  Maria Ann Whatton ,  Virginia Ann Wood ,  Jeremy Gilmore

Inventor： Christopher David Beadle ,  Manuel Javier Cases-Thomas ,  Barry Peter Clark ,  Peter Thaddeus Gallagher ,  John Joseph Masters ,  Graham Henry Timms ,  Magnus Wilhelm Walter ,  Maria Ann Whatton ,  Virginia Ann Wood ,  Jeremy Gilmore

IPC: A01N43/90 ,  A01N43/40 ,  A61K31/44 ,  A61K31/445 ,  C07D453/02 ,  C07D211/56 ,  C07D211/98

CPC classification number: C07D405/12 ,  C07D211/56 ,  C07D453/02

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinephrine, and dopamine).

Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐，其可用于抑制一种或多种生理活性单胺（5-羟色胺，去甲肾上腺素和多巴胺）摄取。

公开(公告)号：US20070025900A1

公开(公告)日：2007-02-01

申请号：US11157196

申请日：2005-06-20

Applicant: Peter Clark ,  David Stevens

Inventor： Peter Clark ,  David Stevens

IPC: B01D53/14 ,  C01B17/48 ,  C01B17/00 ,  C01B17/02

CPC classification number: C01B17/0413 ,  C01B17/0404 ,  C01B17/0421 ,  C01B17/508

Abstract: A process relating to the production of energy from a stream comprising hydrogen sulfide to produce greatly increased quantities of energy.

Abstract translation: 涉及从包含硫化氢的物流产生能量以产生大量增加的能量的方法。

公开(公告)号：US20060072997A1

公开(公告)日：2006-04-06

申请号：US11199299

申请日：2005-08-08

Applicant: Timothy Bell ,  Peter Clark ,  John Connolly ,  Catherine Wilson ,  Andrew Mitchell ,  James Mothersbaugh

Inventor： Timothy Bell ,  Peter Clark ,  John Connolly ,  Catherine Wilson ,  Andrew Mitchell ,  James Mothersbaugh

IPC: B60P1/00

CPC classification number: B65D88/66 ,  B65D88/548 ,  B65D88/56 ,  B65D90/046 ,  B65D2590/046

Abstract: The present invention is directed to a system and a method to unload bulk powders from large bulk containers. The system and method are particularly useful for unloading bulk cohesive powders.

公开(公告)号：US6054448A

公开(公告)日：2000-04-25

申请号：US954675

申请日：1997-10-17

Applicant: Barry Peter Clark ,  John Richard Harris

Inventor： Barry Peter Clark ,  John Richard Harris

IPC: C07D335/14 ,  A61K31/135 ,  A61K31/35 ,  A61K31/352 ,  A61K31/38 ,  A61K31/382 ,  A61P25/00 ,  C07C229/28 ,  C07C229/36 ,  C07C305/12 ,  C07C305/16 ,  C07C305/20 ,  C07C309/19 ,  C07C309/23 ,  C07C309/27 ,  C07C313/12 ,  C07C313/14 ,  C07D311/86 ,  C07D311/90 ,  C07D335/16 ,  C07D335/20 ,  C07F9/144 ,  C07F9/40 ,  C07F9/48 ,  A61K31/195 ,  A61K31/66 ,  C07C61/04

CPC classification number: C07D335/20 ,  C07C229/36 ,  C07D311/90 ,  C07C2101/04

Abstract: Compounds of the formula ##STR1## in which R.sup.1 is Y or Y--C.sub.1-6 alkyl, where Y is carboxy, tetrazolyl, --SO.sub.2 H, --SO.sub.3 H, --OSO.sub.3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR' where R' is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or optionally substituted phenyl-C.sub.1-6 alkyl,and R.sup.2, R.sup.3, R.sup.4, X and Z are as defined in the specification, possess affinity for metabotropic glutamate receptors and are useful in the treatment of disorders of the central nervous system.

Abstract translation: 其中R 1是Y或Y-C 1-6烷基，其中Y是羧基，四唑基，-SO 2 H，-SO 3 H，-OSO 3 H，-CONHOH或-P（OH）OR'，-PO（OH） OR'，-OP（OH）OR'或-OPO（OH）OR'，其中R'是氢，C 1-6烷基，C 2-6烯基或任选取代的苯基-C 1-6烷基，R 2，R 3，R 4， X和Z如说明书中所定义，对代谢型谷氨酸受体具有亲和力，可用于治疗中枢神经系统疾病。

公开(公告)号：US5891899A

公开(公告)日：1999-04-06

申请号：US990253

申请日：1997-12-15

Applicant: Barry Peter Clark ,  John Richard Harris

Inventor： Barry Peter Clark ,  John Richard Harris

IPC: C07D335/12 ,  A61K31/35 ,  A61K31/352 ,  A61K31/38 ,  A61K31/382 ,  A61K31/41 ,  A61K31/54 ,  A61K31/5415 ,  A61P1/08 ,  A61P25/00 ,  A61P25/04 ,  A61P25/18 ,  C07C229/36 ,  C07C305/18 ,  C07C309/24 ,  C07C313/04 ,  C07C323/58 ,  C07D279/22 ,  C07D311/82 ,  C07D311/90 ,  C07D335/20 ,  C07D405/10 ,  C07D521/00 ,  C07F9/48 ,  C07F9/655 ,  C07F9/6553

CPC classification number: C07D405/10 ,  C07D311/90 ,  C07D335/20 ,  C07F9/65522

Abstract: A pharmaceutical compound of the formula: ##STR1## in which A is carboxy, tetrazolyl, --SO.sub.2 H, --SO.sub.3 H, --OSO.sub.3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OPO(OH)OR'B is a bond, C.sub.1-6 alkylene or C.sub.2-6 alkenylene,R.sup.1 is hydrogen, hydroxyl, halo or group of the formula A--B--,X is C.sub.1-6 alkylene, C.sub.2-6 alkenylene, C.sub.2-6 alkynylene or C.sub.1-6 alkylene linked through --O--, --S-- or --NR"-- to Y, where R" is hydrogen or C.sub.1-6 alkyl,andY is (1) ##STR2## where p is and Z is ##STR3## or (2) ##STR4## and salts and esters thereof.

Abstract translation: 其中A为羧基，四唑基，-SO 2 H，-SO 3 H，-OSO 3 H，-CONHOH或-P（OH）OR'，-PO（OH）OR'，-OPO（ OH）OR'B是键，C 1-6亚烷基或C 2-6亚烯基，R 1是氢，羟基，卤素或式AB-的基团，X是C 1-6亚烷基，C 2-6亚烯基，C 2-6亚炔基 或通过-O - ， - S-或-NR“ - 与Y连接的C 1-6亚烷基，其中R”是氢或C 1-6烷基，Y是（1）其中p是且Z是 或其（2）＆lt; IMAGE＆gt;及其盐和酯。

公开(公告)号：US4833153A

公开(公告)日：1989-05-23

申请号：US928037

申请日：1986-11-07

Applicant: Michael D. Dowle ,  Brian Evans ,  Peter Clark

Inventor： Michael D. Dowle ,  Brian Evans ,  Peter Clark

IPC: C07D209/16 ,  C07D403/06

CPC classification number: C07D403/06 ,  C07D209/16

Abstract: Compounds are disclosed of formula (I): ##STR1## wherein one of R.sup.1, R.sup.2 and R.sup.3 represents hydrogen, C.sub.1-6 alkyl C.sub.3-6 alkenyl, hydroxy, C.sub.1-4 alkoxy or a C.sub.2-5 alkoxycarbonyl group, a phenyl or substituted phenyl group or a phen(C.sub.1-4)alkyl or substituted phen(C.sub.1-4)alkyl group; and the other two each independently represents hydrogen, C.sub.1-6 alkyl, or R.sup.2 and R.sup.3 together form an alkylene chain --(CH.sub.2).sub.n --where n is 2 or 3, bridging the nitrogen atoms to which they are attached; R.sup.4 and R.sup.5, each independently represents hydrogen, C.sub.1-3 alkyl or propenyl; R.sup.6 represents hydrogen, C.sub.1-3 alkyl, and the physiologically acceptable salts and solvates thereof.The compounds (I) have potent and selective vasoconstrictor activity and are potentially useful for the treatment of migraine. The compounds (I) may be formulated in conventional manner as pharmaceutical compositions for administration by any convenient route.

Abstract translation: 公开了式（I）的化合物：其中R 1，R 2和R 3中的一个表示氢，C 1-6烷基C 3-6烯基，羟基，C 1-4烷氧基或C 2-5烷氧基羰基， 苯基或取代的苯基或苯基（C 1-4）烷基或取代的苯基（C 1-4）烷基; 而另外两个独立地表示氢，C 1-6烷基或R 2和R 3一起形成亚烷基链 - （CH 2）n - ，其中n为2或3，桥接与它们相连的氮原子; R 4和R 5各自独立地表示氢，C 1-3烷基或丙烯基; R6代表氢，C1-3烷基及其生理上可接受的盐和溶剂合物。 化合物（I）具有有效和选择性的血管收缩剂活性，并且可用于治疗偏头痛。 化合物（I）可以以常规方式配制为用于通过任何方便途径给药的药物组合物。