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公开(公告)号：US11267723B2
公开(公告)日：2022-03-08
申请号：US16333691
申请日：2017-09-08
Applicant: Royal Melbourne Institute of Technology
Inventor： Amanda Anderson , Vipul Bansal , Jos Laurie Campbell , Rajesh Ramanathan , Jyoti Arora , Ravi Shukla
IPC: C01G1/02 , C01G49/02 , C01G49/08 , B01D21/01 , H01F1/11 , A61K49/06 , A61K49/18 , B03C1/01 , B03D3/06 , C01B13/16
Abstract: A method of purifying a plurality of metal oxide particles produced from a synthesis process comprising the step of washing a plurality of metal oxide particles in a first solvent composition comprising of at least one aliphatic ether, and at least one flocculant. In one embodiment, the plurality of metal oxide particles are iron oxide particles produced from a thermal decomposition synthesis process between an iron-oleate complex and oleic acid in 1-octadecene, wherein the first solvent composition comprises a 1:1 (vol/vol) ratio of an aliphatic ether in the form of diethyl ether and a flocculant in the form of methanol. The washed iron oxide particles are further washed in a second solvent composition comprising a 1:1 (vol/vol) ratio of hexane and ethanol, and then finally dispersed in hexane. The resulting iron oxide particles find use as a contrast agent for magnetic resonance imaging (MRI) or as magnetic particles in magnetic separation, magnetism-directed targeting or magnetism-induced heating.
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公开(公告)号：US20210207033A1
公开(公告)日：2021-07-08
申请号：US17058760
申请日：2018-05-30
Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY
Inventor： Kalpit SHAH
Abstract: The invention provides a pyrolysis reaction system, the system comprising: a pyrolysis chamber comprising a feed inlet, a gas inlet and a product outlet, wherein the pyrolysis chamber is configured i) to receive a pyrolysable organic feed and an inert gas via the feed inlet and gas inlet respectively, ii) to pyrolyse the organic feed at a pyrolysis temperature to produce a carbonaceous pyrolysis product and a pyrolysis gas, wherein the pyrolysis gas will combine with the inert gas to form a gas mixture having a pyrolysis chamber pressure in the pyrolysis chamber, and iii) to discharge the carbonaceous pyrolysis product via the product outlet; a gas reactor configured to react the pyrolysis gas by combustion and/or carbon deposition at a gas reaction temperature and a gas reactor pressure; and a first partition defining a boundary between the pyrolysis chamber and the gas reactor, the first partition comprising a plurality of first apertures to provide fluid communication between the pyrolysis chamber and the gas reactor, wherein the pyrolysis reaction system is operable with the gas reactor pressure less than the pyrolysis chamber pressure such that the gas mixture flows from the pyrolysis chamber to the gas reactor through the first apertures, thereby providing at least a portion of the pyrolysis gas for reaction in the gas reactor.
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公开(公告)号：US20210177737A1
公开(公告)日：2021-06-17
申请号：US16758988
申请日：2018-10-26
Applicant: Royal Melbourne Institute of Technology
Inventor： Shwathy Ramesan , Amgad Rezk , Leslie Yeo
Abstract: An intracellular delivery device (1) including, a piezoelectric substrate (3) having a working surface (8), at least one interdigitated transducer (5) located on and in contact with the working surface (8), and a receptacle (11) located on the working surface for accommodating cells to be targeted for intracellular delivery therein, wherein an alternating signal applied to the interdigitated transducer generates acoustic wave energy through the piezoelectric substrate that can be transferred to the accommodated cells.
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公开(公告)号：US20210163311A1
公开(公告)日：2021-06-03
申请号：US17057626
申请日：2019-05-22
Applicant: Royal Melbourne Institute of Technology
Inventor： Vipul Bansal , Mandeep Singh , Rajesh Ramanathan , Amanda Anderson
Abstract: A method for preparing an aqueous dispersion of metal oxide particles is disclosed. The method comprises the step of performing phase transfer of a plurality of metal oxide particles capped with hydrophobic ligands on a surface there of by contacting the metal oxide particles with a combination of tertiary amine and water to form a biphasic mixture, and agitating said biphasic mixture to produce an aqueous dispersion of metal oxide particles capped with hydrophobic ligands and tertiary amine ligands on the surface thereof.
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公开(公告)号：US20210131998A1
公开(公告)日：2021-05-06
申请号：US17083465
申请日：2020-10-29
Inventor： Kourosh KALANTAR-ZADEH , Kyle BEREAN , Nam HA , Jian Zhen OU
IPC: G01N27/407 , G01N27/40 , B82Y30/00 , A61B5/145 , A61B5/07 , B01D67/00 , B01D69/02 , B01D69/14 , A61B5/00 , B01D53/22
Abstract: A gas permeable, liquid impermeable membrane for use with gas sensors consists of a film forming polymer which incorporates nanoparticles selected to improve one or more of the following: permeability to gases, to selectively regulate permeability of selected gases through the membrane, to inhibit microbial growth on the membrane. A capsule shaped container consists of wall material biocompatible with a mammal GI tract and adapted to protect the electronic and sensor devices in the capsule, which contains gas composition sensors, pressure and temperature sensors, a microcontroller, a power source and a wireless transmission device. The microprocessor receives data signals from the sensors and converts the signals into gas composition and concentration data and temperature and pressure data for transmission to an external computing device. The capsule wall incorporates gas permeable nano-composite membranes with embedded catalytic and nano void producing nanoparticles, enhancing the operation, selectivity and sensitivity of the gas sensors.
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Patent Agency Ranking
公开(公告)号：US20200292480A1
公开(公告)日：2020-09-17
申请号：US16610678
申请日：2018-05-04
Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY
Inventor： Adam CHRIMES , Kyle BEREAN , Nam HA , Kourosh KALANTAR-ZADEH
IPC: G01N27/12
Abstract: Disclosed herein is a method for determining a type and corresponding concentration of at least one gas in a multi-gas mixture, the method including: exposing a gas sensitive element of a gas sensor to the multi-gas mixture; modulating a drive signal supplied to a temperature control element of the gas sensor to cause a temperature of the gas sensitive element to change from an initial temperature; recording a transient impedance response of the gas sensitive element while the temperature of the gas sensitive element changes to obtain a transient impedance response that is characteristic of the multi-gas mixture; using the transient impedance response to determine a type and corresponding concentration of at least one gas in the multi-gas sample from a database including calibration data corresponding to the at least one gas. Also disclosed herein is a method of calibrating a multi-gas sensing system, a multi-gas sensing system, and related methods for determining a type and corresponding concentration of at least one gas in a multi-gas mixture.
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公开(公告)号：US20190225491A1
公开(公告)日：2019-07-25
申请号：US16333691
申请日：2017-09-08
Applicant: Royal Melbourne Institute of Technology
Inventor： Amanda Anderson , Vipul Bansal , Jos Laurie Campbell , Rajesh Ramanathan , Jyoti Arora , Ravi Shukla
Abstract: A method of purifying a plurality of metal oxide particles produced from a synthesis process is disclosed. The method comprises the step of washing a plurality of metal oxide particles in a first solvent composition comprising of at least one aliphatic ether, and at least one flocculant. In one embodiment, the plurality of metal oxide particles are iron oxide particles produced from a thermal decomposition synthesis process between an iron-oleate complex and oleic acid in 1-octadecene, wherein the first solvent composition comprises a 1:1 (vol/vol) ratio of an aliphatic ether in the form of diethyl ether and a flocculant in the form of methanol. The washed iron oxide particles are further washed in a second solvent composition comprising a 1:1 (vol/vol) ratio of hexane and ethanol, and then finally dispersed in hexane. The resulting iron oxide particles find use as a contrast agent for magnetic resonance imaging (MRI) or as magnetic particles in magnetic separation, magnetism-directed targeting or magnetism-induced heating.
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公开(公告)号：US20180207234A1
公开(公告)日：2018-07-26
申请号：US15863386
申请日：2018-01-05
Applicant: Royal Melbourne Institute of Technology , Abregen Pty Ltd
Inventor： Allison June Cowin , Zlatko Kopecki , Ian Andrew Darby , Dodie Stephanie Pouniotis
IPC: A61K38/17 , A61K31/713 , A61K38/22 , A61K38/43 , G01N33/574 , C07K16/18 , G01N33/68 , A61K31/7105 , A61K39/00
CPC classification number: A61K38/1709 , A61K31/7105 , A61K31/713 , A61K38/22 , A61K38/43 , A61K39/00 , A61K2039/505 , C07K16/18 , C07K2317/34 , C07K2317/76 , G01N33/5743 , G01N33/57496 , G01N33/6875 , G01N2333/4703 , G01N2500/00 , G01N2500/04 , G01N2500/10
Abstract: The present invention relates to methods for treating or preventing cancer and metastasis. More particularly, the present invention relates to methods for treating or preventing cancer by decreasing the expression and/or activity of Flightless I. Also provided are methods for inhibiting the growth of a cancerous cell and methods for inhibiting formation and/or growth of a tumour which also rely on decreasing the expression and/or activity of Flightless I. The present invention also extends to methods for diagnosing cancer, methods for determining if a subject is susceptible to developing cancer, and methods for assessing progression of cancer based on the finding that increased expression and/or activity of Flightless I is associated with cancer development, growth and metastasis. The present invention also provides methods for screening for a candidate therapeutic agent useful for treating or preventing cancer, and related pharmaceutical compositions and kits.
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公开(公告)号：US20150320832A1
公开(公告)日：2015-11-12
申请号：US14655119
申请日：2013-12-20
Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY , ABREGEN PTY LTD
Inventor： Allison June Cowin , Zlatko Kopecki , Ian Andrew Darby , Dodie Stephanie Pounitis
IPC: A61K38/17 , G01N33/574 , C07K16/18
CPC classification number: A61K38/1709 , A61K31/7105 , A61K31/713 , A61K38/22 , A61K38/43 , A61K39/00 , A61K2039/505 , C07K16/18 , C07K2317/34 , C07K2317/76 , G01N33/5743 , G01N33/57496 , G01N33/6875 , G01N2333/4703 , G01N2500/00 , G01N2500/04 , G01N2500/10
Abstract: The present invention relates to methods for treating or preventing cancer and metastasis. More particularly, the present invention relates to methods for treating or preventing cancer by decreasing the expression and/or activity of Flightless I. Also provided are methods for inhibiting the growth of a cancerous cell and methods for inhibiting formation and/or growth of a tumour which also rely on decreasing the expression and/or activity of Flightless I. The present invention also extends to methods for diagnosing cancer, methods for determining if a subject is susceptible to developing cancer, and methods for assessing progression of cancer based on the finding that increased expression and/or activity of Flightless I is associated with cancer development, growth and metastasis. The present invention also provides methods for screening for a candidate therapeutic agent useful for treating or preventing cancer, and related pharmaceutical compositions and kits.
Abstract translation: 本发明涉及治疗或预防癌症和转移的方法。 更具体地，本发明涉及通过降低无翅片I的表达和/或活性来治疗或预防癌症的方法。还提供了抑制癌细胞生长的方法和抑制肿瘤形成和/或生长的方法 其还依赖于降低无翅I的表达和/或活性。本发明还延伸到用于诊断癌症的方法，用于确定受试者是否易于发生癌症的方法，以及用于评估癌症进展的方法，基于以下发现： Flightless I的增加的表达和/或活性与癌症发展，生长和转移相关。 本发明还提供筛选可用于治疗或预防癌症的候选治疗剂的方法，以及相关的药物组合物和试剂盒。
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公开(公告)号：US20250059444A1
公开(公告)日：2025-02-20
申请号：US18936431
申请日：2024-11-04
Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY
Inventor： Kalpit SHAH
Abstract: The invention provides a pyrolysis reaction system, the system comprising: a pyrolysis chamber comprising a feed inlet, a gas inlet and a product outlet, wherein the pyrolysis chamber is configured i) to receive a pyrolysable organic feed and an inert gas via the feed inlet and gas inlet respectively, ii) to pyrolyse the organic feed at a pyrolysis temperature to produce a carbonaceous pyrolysis product and a pyrolysis gas, wherein the pyrolysis gas will combine with the inert gas to form a gas mixture having a pyrolysis chamber pressure in the pyrolysis chamber, and iii) to discharge the carbonaceous pyrolysis product via the product outlet; a gas reactor configured to react the pyrolysis gas by combustion and/or carbon deposition at a gas reaction temperature and a gas reactor pressure; and a first partition defining a boundary between the pyrolysis chamber and the gas reactor, the first partition comprising a plurality of first apertures to provide fluid communication between the pyrolysis chamber and the gas reactor, wherein the pyrolysis reaction system is operable with the gas reactor pressure less than the pyrolysis chamber pressure such that the gas mixture flows from the pyrolysis chamber to the gas reactor through the first apertures, thereby providing at least a portion of the pyrolysis gas for reaction in the gas reactor.
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