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1337 条记录 (耗时 0.038 秒)

    Finding the origin of an arrythmia
    41.
    发明授权
    Finding the origin of an arrythmia 有权

    公开(公告)号：US11445935B2

    公开(公告)日：2022-09-20

    申请号：US16663945

    申请日：2019-10-25

    申请人： Biosense Webster (Israel) Ltd. ,  Rutgers, The State University of New Jersey

    发明人： Gal Hayam ,  Michael Timofeyev ,  Tal Haim Bar-On ,  Amardeep Saluja

    IPC分类号： A61B5/06 ,  A61B34/20 ,  A61B5/0538 ,  G06T17/20 ,  A61B5/283 ,  A61B5/364 ,  A61B5/00

    摘要： A probe generates location signals, and has an electrode at a distal end which acquires from heart chamber surface positions electrical signals due to a conduction wave traversing the surface. A processor derives LATs from the electrical signals, calculates a first time difference between LATs at a first pair of positions and a second time difference between LATs at a second pair of positions. The processor calculates first and second LAT-derived distances as products of the first and second time differences with a conduction wave velocity, identifies an arrhythmia origin at a surface location where a first difference in distances from the location to the first pair of the positions is equal to the first LAT-derived distance, and a second difference in distances from the location to the second pair of the positions is equal to the second LAT-derived distance, and marks the origin on a surface representation.

    Cystine diamide analogs for the prevention of cystine stone formation in cystinuria
    44.
    发明授权
    Cystine diamide analogs for the prevention of cystine stone formation in cystinuria 有权

    公开(公告)号：US11420949B2

    公开(公告)日：2022-08-23

    申请号：US17068354

    申请日：2020-10-12

    申请人： Rutgers, The State University of New Jersey

    发明人： Longqin Hu

    IPC分类号： C07D295/185 ,  C07D211/16 ,  C07C323/60

    摘要： Cystine analogs that improve the solubility of L-cystine in urine for treatment of cystinuria and which have the structure: and pharmaceutically acceptable salts, solvates and prodrugs thereof, wherein each R and R′ pair are independently selected from (i) or (ii); (i) R and R′ are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alcohol, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic, and substituted or unsubstituted heteroaryl, or (ii) R and R′ together form a substituted or unsubstituted heterocyclic ring structure, or a substituted or unsubstituted heteroaryl ring structure; X is hydrogen, or an alkyl; and Y is O or S.