公开(公告)号：US11524069B2

公开(公告)日：2022-12-13

申请号：US16646894

申请日：2018-09-11

申请人： Sanofi Pasteur

发明人： Pascal Chaux ,  Rafaela Dumas ,  Jean Haensler ,  Sylvie Pichon ,  Fabienne Piras-Douce

IPC分类号： A61K39/245 ,  A61P31/22 ,  A61K39/39 ,  C12N7/00 ,  A61K9/107 ,  A61K39/00

摘要： The invention relates to an immunogenic composition comprising an HCMV gB antigen, an HCMV gH/gL/UL128/UL130/UL131 pentameric complex antigen and a Th1-inducing adjuvant. If further relates to the immunogenic composition for use as an HCMV vaccine.

公开(公告)号：US20220363724A1

公开(公告)日：2022-11-17

申请号：US17813445

申请日：2022-07-19

申请人： SANOFI PASTEUR INC.

发明人： Tod Dwayne Strugnell ,  Guadalupe Cortes-Garcia ,  Tim Alefantis

IPC分类号： C07K14/11 ,  C07K14/005 ,  C07K16/10 ,  G01N33/569

摘要： The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. Also provided are methods of preparing an influenza vaccine composition using the optimized nucleotide sequences, as well as methods of inducing an immune response using the influenza vaccine composition.

公开(公告)号：US11499777B2

公开(公告)日：2022-11-15

申请号：US16736832

申请日：2020-01-08

申请人： Sanofi Pasteur SA

发明人： Thomas Gebhard ,  Roland Kaiser ,  Bernhard Luy ,  Matthias Plitzko ,  Manfred Struschka ,  Christian Zerillo

IPC分类号： F26B5/06 ,  B01J2/04 ,  B01J2/18 ,  B01D1/18 ,  A61K9/19 ,  A61K39/00

摘要： The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamber.

公开(公告)号：US20220204593A1

公开(公告)日：2022-06-30

申请号：US17606614

申请日：2020-04-30

申请人： MEDIMMUNE LIMITED ,  SANOFI PASTEUR INC.

发明人： Anis Ahmed KHAN ,  Vadryn PIERRE

IPC分类号： C07K16/10 ,  A61K47/18 ,  A61K47/26 ,  A61P31/14

摘要： In one aspect, this disclosure describes methods of treating or preventing RSV infection in a patient in need thereof. The methods including dosing regimens for administering a composition including a fixed dose of an anti-RSV monoclonal antibody or an antigen binding fragment thereof. In another aspect, this disclosure describes pharmaceutical compositions for the treatment or prevention of RSV infection. In yet another aspect, this disclosure describes a pharmaceutical unit dose including nirsevimab.

公开(公告)号：US11325947B2

公开(公告)日：2022-05-10

申请号：US16751963

申请日：2020-01-24

申请人： SANOFI PASTEUR INC.

发明人： Tod Strugnell ,  Eliud Oloo ,  Raymond Oomen

IPC分类号： A61K39/145 ,  C07K14/005 ,  C07K14/11 ,  A61K39/00 ,  A61K39/12 ,  A61K9/00 ,  A61K39/39 ,  C12N9/24

摘要： The present invention provides, among other things, a novel and improved method for generating “mosaic” influenza antigenic polypeptides including hemagglutinin (HA) and neuraminidase (NA) polypeptides based on unique combination of epitope patterns that maximize exposure to epitopes present across multiple HA or NA sequences and therefore improved influenza strain coverage. In particular, the present invention provides engineered H1N1 influenza hemagglutinin (HA) polypeptides that are comprised of novel combinations of protective epitopes and antigenic regions from multiple H1N1 viral strains. Such engineered HA polypeptides have improved properties over HA polypeptides developed through conventional approaches that rely on consensus alignments of viral sequences.

公开(公告)号：US11305005B2

公开(公告)日：2022-04-19

申请号：US15738417

申请日：2016-06-23

申请人： Sanofi Pasteur, Inc.

发明人： Carlos DiazGranados ,  Andrew Dunning

IPC分类号： A61K39/145 ,  A61K39/12 ,  A61P29/00 ,  C12N7/00 ,  A61K39/00

摘要： This application relates to the field of prevention of pneumonia by administration of a high-dose influenza vaccine.

公开(公告)号：US20220054623A1

公开(公告)日：2022-02-24

申请号：US17400390

申请日：2021-08-12

申请人： SANOFI PASTEUR INC.

发明人： Tod Strugnell ,  Eliud Oloo ,  Raymond Oomen

IPC分类号： A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  C12N7/00

摘要： The present invention provides, among other things, modified recombinant HA polypeptides with broadened immunogenic profile that extends coverage to antigenically distinct influenza strains and methods of making and using the same.

公开(公告)号：US11224652B2

公开(公告)日：2022-01-18

申请号：US16322698

申请日：2017-08-04

申请人： SANOFI PASTEUR INC. ,  SK BIOSCIENCE CO., LTD.

发明人： Kyungjun An ,  Wooyoung Choi ,  Dongsoo Ham ,  Hun Kim ,  Jinhwan Shin ,  Robert Hopfer ,  Richard D. Kensinger ,  Moe Kyaw ,  Eric Desauziers ,  Clotilde El Guerche Seblain ,  Philippe Talaga

IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/09 ,  A61K39/385 ,  A61K47/64 ,  A61P31/04 ,  A61K39/39

摘要： Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 16 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid or CRM197, wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 9V, 12F, 14, 18C, 19A, 19F, 22F, 23F, and 33F, wherein two of the capsular polysaccharides are conjugated to tetanus toxoid and the remaining capsular polysaccharides are conjugated to CRM197, and wherein the two capsular polysaccharides that are conjugated to tetanus toxoid are selected from the group consisting of serotypes 1, 3, and 5. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject.

公开(公告)号：US11224650B2

公开(公告)日：2022-01-18

申请号：US16505168

申请日：2019-07-08

申请人： SANOFI PASTEUR BIOLOGICS, LLC

发明人： Sophia Mundle ,  Stephen Anderson ,  Simon Delagrave

IPC分类号： A61K39/245 ,  B01D15/36 ,  A61K39/12 ,  C12N7/00 ,  A61K39/00

摘要： The present disclosure provides a method to prepare purified enveloped viral particle preparations employing ion exchange chromatography and tangential flow filtration.

公开(公告)号：US11207403B2

公开(公告)日：2021-12-28

申请号：US17071817

申请日：2020-10-15

申请人： Sanofi Pasteur

发明人： Pascal Chaux ,  Rafaela Dumas ,  Jean Haensler ,  Sylvie Pichon ,  Fabienne Piras-Douce

IPC分类号： A61K39/00 ,  A61K39/245 ,  A61K39/12 ,  A61K39/39 ,  C07K14/005 ,  A61P31/22 ,  C12N7/00 ,  A61K9/107

摘要： The invention relates to an immunogenic composition comprising an HCMV gH/gL/UL128/UL130/UL131 pentameric complex antigen and a TH1-inducing adjuvant. It further relates to the immunogenic composition for use as an HCMV vaccine.