公开(公告)号：US20090062825A1

公开(公告)日：2009-03-05

申请号：US12259965

申请日：2008-10-28

Applicant: Scott Pool ,  Blair Walker ,  Jay R. McCoy ,  Peter P. Tran ,  Richard L. Quick ,  Shahram Moaddeb ,  Arvin Chang

Inventor： Scott Pool ,  Blair Walker ,  Jay R. McCoy ,  Peter P. Tran ,  Richard L. Quick ,  Shahram Moaddeb ,  Arvin Chang

IPC: A61B17/08 ,  A61F2/02 ,  A61N2/00

CPC classification number: A61F5/0053 ,  A61F5/003 ,  A61F5/0059 ,  A61F5/0066 ,  A61F2005/002

Abstract: A system includes an adjustable implant configured for implantation internally within a subject, the adjustable implant having a permanent magnet configured for rotation about an axis of rotation, the permanent magnet operatively coupled to a drive transmission configured to alter a dimension of the adjustable implant. The system further includes an external adjustment device configured for placement on or adjacent to the skin of the subject comprising at least one magnet configured for rotation, the external adjustment device further comprising a motor configured to rotate the at least one magnet, whereby rotation of the at least one magnet of the external adjustment device effectuates rotational movement of the permanent magnet of the adjustable implant and alters the dimension of the adjustable implant. The system includes drive control circuitry configured to drive the motor of the external adjustment device to achieve a target dimension of the adjustable implant.

Abstract translation: 系统包括被配置用于在对象内部进行植入的可调节植入物，所述可调节植入物具有被配置为围绕旋转轴线旋转的永磁体，所述永磁体可操作地耦合到构造成改变可调节植入物的尺寸的驱动变速器。 所述系统还包括外部调节装置，其被配置为放置在所述对象的皮肤上或与所述对象的皮肤相邻，所述外部调节装置包括被配置为旋转的至少一个磁体，所述外部调整装置还包括被配置为旋转所述至少一个磁体的马达， 外部调节装置的至少一个磁体实现可调节植入物的永磁体的旋转运动并改变可调节植入物的尺寸。 该系统包括被配置为驱动外部调节装置的电动机以实现可调节植入物的目标尺寸的驱动控制电路。

公开(公告)号：US07402813B2

公开(公告)日：2008-07-22

申请号：US11610196

申请日：2006-12-13

Applicant: Shlomo Ben-Haim ,  Benny Rousso ,  Shahram Moaddeb

Inventor： Shlomo Ben-Haim ,  Benny Rousso ,  Shahram Moaddeb

IPC: G01T1/24

CPC classification number: G01T1/1648 ,  G01T1/249

Abstract: A gamma ray camera system is provided, which includes a lens system comprising at least one crystal diffraction lens, and a camera. The camera is configured to perform gamma ray imaging of a first region of a volume of interest using the lens system, and perform gamma ray imaging of a second region of the volume of interest without using the lens system. Other embodiments are also described.

Abstract translation: 提供了一种伽马射线照相机系统，其包括包括至少一个晶体衍射透镜的透镜系统和照相机。 相机被配置为使用透镜系统对感兴趣体积的第一区域进行伽马射线成像，并且在不使用透镜系统的情况下执行感兴趣体积的第二区域的伽马射线成像。 还描述了其它实施例。

公开(公告)号：US07396364B2

公开(公告)日：2008-07-08

申请号：US11124409

申请日：2005-05-06

Applicant: Shahram Moaddeb ,  Emanuel Shaoulian ,  Samuel M. Shaolian

Inventor： Shahram Moaddeb ,  Emanuel Shaoulian ,  Samuel M. Shaolian

IPC: A61F2/06

CPC classification number: A61F2/2448 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a body member including a shape memory material, and an energy absorption enhancement material configured to absorb energy in response to an activation energy. The energy absorption enhancement material is in thermal communication with said shape memory material. The body member has a first size of a dimension in a first configuration and a second size of the dimension in a second configuration, and is configured to be implanted in the first configuration into a heart. The body member is configured to transform from the first configuration to the second configuration in response to the activation energy. The second configuration is configured to reduce a dimension of a cardiac valve annulus in the heart.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施方案中，所述装置包括包括形状记忆材料的主体构件和被配置为响应于活化能吸收能量的能量吸收增强材料。 能量吸收增强材料与所述形状记忆材料热连通。 主体构件具有第一构造的尺寸的第一尺寸和第二构造中的尺寸的第二尺寸，并且构造成以第一构造植入心脏。 身体构件被配置为响应于激活能量从第一配置变换到第二配置。 第二配置被配置为减小心脏中的心脏瓣膜环的尺寸。

公开(公告)号：US20080015688A1

公开(公告)日：2008-01-17

申请号：US11881336

申请日：2007-07-25

Applicant: James Hill ,  Shahram Moaddeb ,  Samuel Shaolian

Inventor： James Hill ,  Shahram Moaddeb ,  Samuel Shaolian

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2448 ,  A61F2250/0004

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，装置包括前部，后部和对应于前部和后部的交叉点的两个侧部。 这些装置具有第一配置的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。 该变换被配置为减小前部和后部之间的距离，而基本上不减小两个侧部之间的距离。

公开(公告)号：US20060015002A1

公开(公告)日：2006-01-19

申请号：US11142078

申请日：2005-05-31

Applicant: Shahram Moaddeb ,  Samuel Shaolian ,  Emanuel Shaoulian ,  Richard Rhee ,  Steven Anderson

Inventor： Shahram Moaddeb ,  Samuel Shaolian ,  Emanuel Shaoulian ,  Richard Rhee ,  Steven Anderson

IPC: A61F2/00

CPC classification number: A61B17/00234 ,  A61B17/06166 ,  A61B17/0644 ,  A61B17/068 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2017/06052

Abstract: Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.

公开(公告)号：US20050288778A1

公开(公告)日：2005-12-29

申请号：US11123891

申请日：2005-05-06

Applicant: Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel Shaolian

Inventor： Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel Shaolian

IPC: A61F2/00 ,  A61F2/02 ,  A61F2/24

CPC classification number: A61F2/2448 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a first body member including a first shape memory material configured to transform the annuloplasty ring from a first configuration having a first size of a dimension to a second configuration having a second size of the dimension. The second size is less than said first size in septal lateral distance. The devices also include a second body member including a second shape memory material configured to transform the annuloplasty ring from the second configuration to a third configuration having a third size of the dimension, wherein the second size is less than the third size in septal lateral distance.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，所述装置包括第一主体构件，所述第一主体构件包括第一形状记忆材料，所述第一形状记忆材料构造成将瓣膜成形术环从具有尺寸的第一尺寸的第一构型转换成具有尺寸的第二尺寸的第二构型。 第二尺寸小于所述第一尺寸在间隔侧向距离。 所述装置还包括第二主体构件，所述第二主体构件包括第二形状记忆材料，所述第二形状记忆材料构造成将瓣膜成形术环从第二构型转换成具有尺寸的第三尺寸的第三构型，其中第二尺寸小于第三尺寸的间隔横向距离 。

公开(公告)号：US06466818B1

公开(公告)日：2002-10-15

申请号：US09371905

申请日：1999-08-10

Applicant: Shahram Moaddeb ,  Michele M. Fung ,  Gregory G. Brucker ,  Steven D. Savage

Inventor： Shahram Moaddeb ,  Michele M. Fung ,  Gregory G. Brucker ,  Steven D. Savage

IPC: A61N130

CPC classification number: A61N1/06

Abstract: An irrigated tip catheter comprises a catheter body, a tip section, and a porous tip electrode. The catheter body has an outer wall, proximal and distal ends, and a lumen extending therethrough. The tip section comprises a segment of flexible tubing having proximal and distal ends and at least one lumen therethrough. The proximal end of the tip section is fixedly attached to the distal end of the catheter body. The porous tip electrode is fixedly attached to the distal end of the tubing of the tip section. The tip electrode has an outer surface and comprises a body and an insert. The body comprises a porous material through which fluid can pass and has a cavity therein. The insert, which comprises a non-porous material, is contained within the cavity of the shell. The insert has at least one passage extending therethrough in fluid communication with a lumen in the tip section. An infusion tube having proximal and distal ends extends through the central lumen in the catheter body. The distal end of the infusion tube is in fluid communication with the proximal end of the passage in the tip electrode, whereby fluid can flow through the infusion tube, into the passage in the tip electrode and through the porous material of tip electrode to the outer surface of the tip electrode.

Abstract translation: 灌注的尖端导管包括导管主体，尖端部分和多孔尖端电极。 导管主体具有外壁，近端和远端以及从其延伸穿过的内腔。 尖端部分包括具有近端和远端以及穿过其中的至少一个内腔的柔性管段。 尖端部分的近端固定地附接到导管主体的远端。 多孔尖端电极固定地附接到尖端部分的管道的远端。 尖端电极具有外表面并且包括主体和插入件。 主体包括多孔材料，流体可穿过该多孔材料并且其中具有空腔。 包括无孔材料的插入件被包含在壳的空腔内。 插入件具有至少一个通过其延伸穿过其中的通道，其与尖端部分中的内腔流体连通。 具有近端和远端的输液管延伸穿过导管主体中的中心腔。 输液管的远端与尖端电极中的通道的近端流体连通，由此流体可以流过输注管，进入尖端电极的通道并通过尖端电极的多孔材料到外部 尖端电极的表面。

公开(公告)号：US06405078B1

公开(公告)日：2002-06-11

申请号：US09371438

申请日：1999-08-10

Applicant: Shahram Moaddeb ,  Michele M. Fung

Inventor： Shahram Moaddeb ,  Michele M. Fung

IPC: A61N130

CPC classification number: A61N1/06

Abstract: A porous tip electrode for a catheter comprises a body and an insert. The body comprises a porous material through which fluid can pass and a cavity therein. The insert, which is contained therein, has proximal and distal ends and comprises a non-porous material contained within the cavity. The insert having at least one passage extending therethrough and at least blind hole extending from its proximal end.

Abstract translation: 用于导管的多孔尖端电极包括主体和插入件。 主体包括流体可以通过的多孔材料和其中的空腔。 其中包含的插入件具有近端和远端，并且包括容纳在腔内的无孔材料。 所述插入件具有至少一个通过其延伸的通道和至少从其近端延伸的盲孔。

公开(公告)号：US5833715A

公开(公告)日：1998-11-10

申请号：US495767

申请日：1995-06-27

Applicant: David J. Vachon ,  Shahram Moaddeb

Inventor： David J. Vachon ,  Shahram Moaddeb

IPC: A61N1/05

CPC classification number: A61N1/056 ,  A61N1/057 ,  A61N1/0575

Abstract: A pacing lead having a stylet introduced anti-inflammatory drug delivery element advanceable from the distal tip electrode. The element is preferably formed as a moldable biocompatible composite material. The element has a biocompatible matrix material which may be combined with drugs and therapeutic agents to deliver the drugs and agents by co-dissolution or diffusion to the point of either passive or active fixation. The drug delivery element may be rigid and serve to center an active fixation mechanism, preferably a helix, which penetrates the myocardium.

Abstract translation: 具有探针的起搏引线引入从远端末端电极可推进的抗炎药物递送元件。 该元件优选形成为可模制的生物相容性复合材料。 该元件具有生物相容的基质材料，其可与药物和治疗剂组合以通过共溶或扩散至被动或主动固定点来递送药物和试剂。 药物递送元件可以是刚性的并且用于使穿透心肌的主动固定机构，优选螺旋线居中。

公开(公告)号：US5755767A

公开(公告)日：1998-05-26

申请号：US692023

申请日：1996-08-02

Applicant: Phong D. Doan ,  Benedict Gomperz ,  Shahram Moaddeb

Inventor： Phong D. Doan ,  Benedict Gomperz ,  Shahram Moaddeb

IPC: A61N1/05

CPC classification number: A61N1/057 ,  A61N1/0565

Abstract: A transvenous endocardial lead comprises an elongated flexible body member encompassing an electrical conductor which has an electrode at its distal end. A stabilizer adjacent the distal electrode extends outwardly from the flexible body member by a distance no greater than approximately one-half of the shortest distance between a longitudinal axis and the outer peripheral surface for minimizing dislodgment of the distal end from an intended implanted position into the myocardial tissue of the heart and for preventing penetration of the distal end of the flexible body member into the myocardial tissue. The stabilizer may be employed in conjunction with conventional active or passive fixation members and may take a variety of forms.

Abstract translation: 经静脉的心内膜包括细长的柔性体部件，其包围在其远端具有电极的电导体。 邻近远侧电极的稳定器从柔性本体构件向外延伸不大于纵向轴线和外周表面之间的最短距离的大约二分之一的距离，以使远端从预期的植入位置移动到 心脏的心肌组织并且用于防止柔性体部件的远端穿透入心肌组织。 稳定剂可以与常规的主动或被动固定构件结合使用，并且可以采取多种形式。