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公开(公告)号:US20240013479A1
公开(公告)日:2024-01-11
申请号:US18369904
申请日:2023-09-19
Applicant: SHANGHAITECH UNIVERSITY
Inventor: Minye WU , Chaolin RAO , Xin LOU , Pingqiang ZHOU , Jingyi YU
CPC classification number: G06T15/55 , G06T15/20 , G06T17/20 , G06T2210/56
Abstract: A computer-implemented method includes encoding a radiance field of an object onto a machine learning model; conducting, based on a set of training images of the object, a training process on the machine learning model to obtain a trained machine learning model, wherein the training process includes a first training process using a plurality of first test sample points followed by a second training process using a plurality of second test sample points located within a threshold distance from a surface region of the object; obtaining target view parameters indicating a view direction of the object; obtaining a plurality of rays associated with a target image of the object; obtaining render sample points on the plurality of rays associated with the target image; and rendering, by inputting the render sample points to the trained machine learning model, colors associated with the pixels of the target image.
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公开(公告)号:US11840685B2
公开(公告)日:2023-12-12
申请号:US17862354
申请日:2022-07-11
Applicant: ShanghaiTech University
Inventor: Jia Chen , Bei Yang , Li Yang , Xingxu Huang , Lijie Wang
CPC classification number: C12N15/102 , C12N9/22 , C12N9/506 , C12N9/78 , C12N15/111 , C07K2319/50 , C07K2319/85 , C12N2310/20 , C12Y304/22044 , C12Y305/04004 , C12Y305/04005
Abstract: Provided are fusion proteins and related molecules useful for conducting base editing with reduced or no off-target mutations. The fusion protein may include a first fragment comprising a nucleobase deaminase or a catalytic domain thereof, a second fragment comprising a nucleobase deaminase inhibitor, and a protease cleavage site between the first fragment and the second fragment. Also provided are improved prime editing systems, including prime editing guide RNA with improved stability.
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公开(公告)号:US20230312358A1
公开(公告)日:2023-10-05
申请号:US18034382
申请日:2021-11-19
Applicant: ShanghaiTech University
Inventor: Xiaofei GUAN , Zujian TANG
CPC classification number: C01C1/0411 , B01J23/14 , B01J23/04 , B01J35/1028 , C01C1/0482
Abstract: A method for catalytic synthesis of ammonia under normal pressures, including: performing a reaction of hydrogen and nitrogen to synthesize ammonia under normal pressures by taking a liquid alloy as a catalyst in a reactor, where the reactor contains a molten salt, the density of the molten salt is smaller than that of the liquid alloy, and the molten salt is used for providing a reaction interface and isolating the liquid alloy from being introduced impurities. The first metal can react with the nitrogen to produce the metal nitride, and the molten salt can provide a new reaction interface for the metal nitride to react with the hydrogen to synthesize the ammonia, so that the metal nitride can continuously generate the ammonia, and the synthesis of the ammonia can be effectively catalyzed. In addition, the molten salt can prevent the liquid alloy from contacting with the oxygen and the water vapor of the outside atmosphere, thereby preventing the liquid alloy from being oxidized and prolonging the service life of the liquid alloy.
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公开(公告)号:US20230303539A1
公开(公告)日:2023-09-28
申请号:US18021334
申请日:2021-08-12
Applicant: SHANGHAITECH UNIVERSITY
Inventor: Xiaobao YANG , Biao JIANG , Linyi LIU , Chaowei REN , Xing QIU
IPC: C07D405/14 , A61K45/06 , A61P35/00 , C07D401/14 , C07D401/04 , C07D417/14
CPC classification number: C07D405/14 , A61K45/06 , A61P35/00 , C07D401/14 , C07D401/04 , C07D417/14
Abstract: The present disclosure provides compounds of formula (I) or salts, enantiomers, stereoisomers, solvates, or polymorphs thereof, and applications thereof, and pharmaceutical compositions comprising, as an active ingredient, the compound of Formula (I) or a salt, enantiomer, stereoisomer, solvate, or polymorph thereof, and applications of the pharmaceutical compositions. The compounds can effectively prevent and/or treat diseases or disorders associated with TNF-α.
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公开(公告)号:US20230295618A1
公开(公告)日:2023-09-21
申请号:US18181583
申请日:2023-03-10
Applicant: ShanghaiTech University
Inventor: Xiajun LI
IPC: C12N15/11 , C12N15/85 , C12N5/0735
CPC classification number: C12N15/111 , C12N15/85 , C12N5/0606 , C12N2510/00
Abstract: A preparation method for mutant cells with deletion of target genes, at least comprising the following steps: (1) transfecting a sgRNA group into same host cells, where the sgRNA group includes two sgRNAs that target different sites of a same target gene, and the number of the sgRNA group may be one or more than one. When the number of the sgRNA group is more than one, each different sgRNA group targets one different target gene. (2) Enriching the host cells expressing one or more sgRNA groups. (3) Culturing the host cells obtained from step (2) to produce mutant cells with deletion of target genes.
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公开(公告)号:US20230193408A1
公开(公告)日:2023-06-22
申请号:US17925675
申请日:2021-07-16
Applicant: SHANGHAITECH UNIVERSITY
Inventor: Peixiang MA , Xinjie WANG
IPC: C12Q1/70
CPC classification number: C12Q1/701
Abstract: Disclosed is a nucleic acid test kit, comprising a Cpf1 test system, said Cpf1 test system comprising: a guide RNA, a Cpf1 protein, a nucleic acid probe, and a manganese ion-containing solution. Also provided is a mutated Cpf1 protein and a nucleic acid test kit containing the mutated Cpf1 protein. Also provided is a crRNA for testing coronavirus nucleic acid, and a nucleic acid test kit containing said crRNA. Further provided is a use of the nucleic acid test kit, and a test method for the nucleic acid. When the nucleic acid test kit, mutated Cpf1 protein, or crRNA of the present invention are used for nucleic acid testing (for example, testing the nucleic acid of a SARS-related coronavirus or MERS coronavirus), the signal strength during the test is substantially enhanced, and the test time is thus reduced and the test efficiency improved. In addition, the sensitivity, specificity, and accuracy are high, the test is visual, the cost is low, the operation is simple and convenient, and no large-scale complex t equipment is required.
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47.
公开(公告)号:US20230184774A1
公开(公告)日:2023-06-15
申请号:US17921856
申请日:2021-04-28
Applicant: SHANGHAITECH UNIVERSITY
Inventor: Haifan LIN , Shuo SHI , Zhenzhen YANG
IPC: G01N33/574 , A61K45/06
CPC classification number: G01N33/57484 , G01N33/57446 , A61K45/06
Abstract: The present invention provides an application of a drug or a pharmaceutical composition in the treatment of cancers showing high expression of PIWI and/or an NMD complex protein, such as gastric cancer. When applied in the treatment of cancers showing high expression of PIWI and/or an NMD complex protein, such as gastric cancer, the drug or the pharmaceutical composition of the present invention not only can effectively treat cancers, particularly gastric cancer, but also has higher specificity and will not cause harm to normal cells and body functions.
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48.
公开(公告)号:US20230179315A1
公开(公告)日:2023-06-08
申请号:US18049932
申请日:2022-10-26
Applicant: IMEC VZW , ShanghaiTech University
Inventor: Xinzhe Liu , Raees Kizhakkumkara Muhamad , Dessislava Nikolova , Yajun Ha , Francky Catthoor , Fupeng Chen , Peter Schelkens , David Blinder
IPC: H04J11/00
CPC classification number: H04J11/00
Abstract: Example embodiments relate to methods for disseminating scaling information and applications thereof in very large scale integration (VLSI) implementations of fixed-point fast Fourier transforms (FFTs). One embodiment includes a method for disseminating scaling information in a system. The system includes a linear decomposable transformation process and an inverse process of the linear decomposable transformation process. The inverse process of the linear decomposable transformation process is defined, in time or space, as an inverse linear decomposable transformation process. The linear decomposable transformation process is separated from the inverse linear decomposable transformation process. The linear decomposable transformation process or the inverse linear decomposable transformation process is able to be performed first and is defined as a linear decomposable transformation I. The other remaining process is performed subsequently and is defined as a linear decomposable transformation II. The method for disseminating scaling information is used for a bit width-optimized and energy-saving hardware implementation.
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公开(公告)号:US20230096517A1
公开(公告)日:2023-03-30
申请号:US17801953
申请日:2021-02-25
Applicant: SHANGHAITECH UNIVERSITY
Inventor: Xiaobao YANG , Biao JIANG , Xing QIU , Ning SUN , Renhong SUN , Chaowei REN
IPC: C07D401/04 , A61P35/00
Abstract: The present disclosure relates to glutarimide skeleton-based compounds of Formula (I) or a salt, an enantiomer, a stereoisomer, a solvate, or a polymorph thereof, and uses thereof. The present disclosure further relates to a pharmaceutical composition comprising, as an active ingredient, the glutarimide skeleton-based compounds of Formula (I), or a salt, an enantiomer, a stereoisomer, a solvate, or a polymorph thereof, and uses thereof. The series of compounds designed and synthesized in the present disclosure can effectively prevent and/or treat a tumor.
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50.
公开(公告)号:US20220401465A1
公开(公告)日:2022-12-22
申请号:US17616200
申请日:2019-06-04
Applicant: ShanghaiTech University
Inventor: Gaofeng FAN , Haopeng WANG , Yuetong WANG , Fei WANG
IPC: A61K31/7084 , A61K38/17 , A61K35/17 , A61K45/06
Abstract: Disclosed are uses of NAD+ and/or NAD+ agonists and/or NAD+ inhibitors for preparing a preparation or a kit, and a combination preparation including T cells and NAD+ and/or NAD+ agonists and/or NAD+ inhibitors. The preparation or kit is used for regulating T cell activity, regulating the expression level of CD69 on the surface of T cells, and/or regulating the phosphorylation level in T cells, and/or treating diseases related to T cell activity.
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