公开(公告)号：US11013529B2

公开(公告)日：2021-05-25

申请号：US16515591

申请日：2019-07-18

Applicant: TUSKEGEE UNIVERSITY

Inventor： Deidre Quinn-Gorham ,  Sharanabasaweshwara Asundi ,  Jimesh Bhagatji

IPC: A61B17/3213 ,  A61B17/3211

Abstract: A handle system includes a body extending between a first end and a second end. The handle system also includes a slot extending, at least partially, in the body, the slot forming a cavity. The handle system further includes a carrier arranged, at least partially, within the slot, the carrier further comprising a friction locker and at least one arm coupled to the friction locker, the at least one arm being rotatable about the friction locker. The handle system also includes a cap arranged on at least one of the first end or the second end. The handle system further includes a blade coupled to the at least one arm, the blade being rotatable about the axis between a retracted position where the blade is positioned within the slot and an extended position where the blade extends outwardly from the body.

公开(公告)号：US10907026B2

公开(公告)日：2021-02-02

申请号：US14698467

申请日：2015-04-28

Applicant: Tuskegee University

Inventor： Heshmat Aglan

IPC: C08K3/04 ,  C08J3/205 ,  B82Y30/00 ,  B05D1/00 ,  B05D3/02 ,  C08J5/18

Abstract: Structured films containing multi-walled carbon nanotubes (“MWCNTs”) have enhanced mechanical performance in terms of strength, fracture resistance, and creep recovery of polyimide (“PI”) films. Preferably, the loadings of MWCNTs can be in the range of 0.1 wt % to 0.5 wt %. The strength of the new PI films dried at 60° C. increased by 55% and 72% for 0.1 wt % MWCNT and 0.5 wt % MWCNT loadings, respectively, while the fracture resistance increased by 23% for the 0.1 wt % MWCNTs and then decreases at a loading of 0.5 wt % MWCNTs. The films can be advantageously be created by managing a corresponding shift in the annealing temperature at which the maximum strength occurs as the MWCNT loadings increase.

公开(公告)号：US20190310223A1

公开(公告)日：2019-10-10

申请号：US16364694

申请日：2019-03-26

Applicant: Tuskegee University

Inventor： Tamara Floyd SMITH ,  Julaunica TIGNER ,  Jessica KOEHNE

IPC: G01N27/327 ,  G01N27/30 ,  C23C16/26 ,  C23F17/00

Abstract: A general methodology for the development of sensitive and selective sensors that can achieve a low cost detection of glucose without using enzymes is disclosed. The method uses carbon nanofiber (CNF) array electrodes for the electrochemical detection of glucose. CNFs grown by plasma enhanced chemical vapor deposition (PECVD) with diameters ranging from 13-160 nm and a height of approximately one micrometer are preferred. The CNFs have a sensitivity of 2.7 μA/mM cm2 and detection limit of 2 mM. Also provided are methods of preparing the CNF sensors and kit components. Methods of using such CNF sensors for detecting target agents, particularly glucose, are also provided.

公开(公告)号：US20190048147A1

公开(公告)日：2019-02-14

申请号：US16028127

申请日：2018-07-05

Applicant: TUSKEGEE UNIVERSITY

Inventor： Michael L. CURRY ,  Donald WHITE

IPC: C08J3/07 ,  C08L1/02 ,  D01F2/02

Abstract: The invention relates to a method of manufacturing a nanocellulosic composition comprising cellulose nanoparticles and/or nanoparticles. The nanocellulosic compositions are useful in the manufacturing of biodegradable plastics. The invention also includes a method of manufacturing biodegradable plastics using such nanocellulosic compositions.

公开(公告)号：US20190023896A1

公开(公告)日：2019-01-24

申请号：US16040250

申请日：2018-07-19

Applicant: TUSKEGEE UNIVERSITY

Inventor： Vijaya RANGARI ,  Boniface TIIMOB

IPC: C08L67/04 ,  C08L67/02 ,  C08L77/00 ,  C08L89/00 ,  C08J5/18

Abstract: A biopolymer blend is provided that comprises a combination of three components: poly (butylene adipate-co-terephthalate) (PBAT); agriculture sourced polylactic acid (PLA); and engineered proteinaceous eggshell nanoparticles. The two polymer components can be present in any ratio but an approximate 70:30 ratio is preferred. The engineered proteinaceous eggshell nanoparticles are preferably about 10-25 nanometers. Also provided are methods of preparing biopolymer film and packaging components. Pelleted poly (butylene adipate-co-terephthalate) and agriculture sourced polylactic acid (PLA) are dissolved in chloroform and mixed together to form a polymer blend, and engineered proteinaceous eggshell nanoparticles are incorporated into the polymer blend, which is then extruded to create a biopolymer film or component.

公开(公告)号：US20150164860A1

公开(公告)日：2015-06-18

申请号：US14568730

申请日：2014-12-12

Applicant: TUSKEGEE UNIVERSITY

Inventor： Temesgen Samuel ,  Teshome Yehualaeshet ,  Tesfaye Serbessa ,  Khalda Fadlalla

IPC: A61K31/404 ,  A61K45/06 ,  C07D209/10

CPC classification number: A61K31/404 ,  A61K45/06 ,  C07D209/10 ,  A61K2300/00

Abstract: Methods for inhibiting cancer cell proliferation and killing cancer cells are disclosed. Such methods comprise treating cancer cells with an indole compound having the structure of formula (I): wherein R is defined herein.

Abstract translation: 公开了抑制癌细胞增殖和杀死癌细胞的方法。 这样的方法包括用具有式（I）结构的吲哚化合物治疗癌细胞：其中R在本文中定义。

公开(公告)号：US09034426B2

公开(公告)日：2015-05-19

申请号：US13678914

申请日：2012-11-16

Applicant: TUSKEGEE UNIVERSITY

Inventor： Heshmat Aglan

IPC: B05D3/12 ,  C08K3/04 ,  C08J3/205 ,  C08K7/24 ,  B82Y30/00 ,  B05D1/00

CPC classification number: C08K3/04 ,  B05D1/005 ,  B82Y30/00 ,  C08J3/205 ,  C08J2379/08 ,  C08K3/041 ,  C08K7/24 ,  C08K2201/011 ,  Y10S977/742 ,  Y10S977/752 ,  Y10S977/753 ,  C08L79/08

Abstract: Structured films containing multi-walled carbon nanotubes (“MWCNTs”) have enhanced mechanical performance in terms of strength, fracture resistance, and creep recovery of polyimide (“PI”) films. Preferably, the loadings of MWCNTs can be in the range of 0.1 wt % to 0.5 wt %. The strength of the new PI films dried at 60° C. increased by 55% and 72% for 0.1 wt % MWCNT and 0.5 wt % MWCNT loadings, respectively, while the fracture resistance increased by 23% for the 0.1 wt % MWCNTs and then decreases at a loading of 0.5 wt % MWCNTs. The films can be advantageously be created by managing a corresponding shift in the annealing temperature at which the maximum strength occurs as the MWCNT loadings increase.

Abstract translation: 含有多壁碳纳米管（“MWCNT”）的结构膜在聚酰亚胺（“PI”）膜的强度，耐断裂性和蠕变恢复方面具有增强的机械性能。 优选地，MWCNT的负载量可以在0.1重量％至0.5重量％的范围内。 在60℃下干燥的新PI膜的强度分别对于0.1重量％MWCNT和0.5重量％MWCNT负载分别增加了55％和72％，而0.1重量％MWCNT的耐断裂性提高了23％，然后 在负载量为0.5wt％的MWCNT时减少。 可以有利地通过管理当MWCNT负载增加时发生最大强度的退火温度的相应偏移来产生膜。

公开(公告)号：US20140286868A1

公开(公告)日：2014-09-25

申请号：US14296676

申请日：2014-06-05

Applicant: Tuskegee University

Inventor： Clayton Yates ,  Timothy Turner

IPC: A61K49/00 ,  G01N33/50

CPC classification number: A61K49/0008 ,  C12Q1/025 ,  G01N33/5011 ,  G01N2500/04 ,  G01N2500/10

Abstract: Immortalized human cell lines derived from prostate cells are disclosed. Immortalized cells derived from a human epithelial prostate tissue cancer tumor are provided, as well as immortalized cells derived from healthy human epithelial prostate tissue from the same patient. Methods for utilizing such immortalized cell lines for researching, screening, and evaluating antimalignancy therapies and drug candidates are also disclosed.

Abstract translation: 公开了源自前列腺细胞的永生化人细胞系。 提供源自人上皮前列腺组织癌肿瘤的永生化细胞，以及衍生自来自同一患者的健康人上皮前列腺组织的永生化细胞。 还公开了利用这种永生化细胞系研究，筛选和评估抗偏倚药物和候选药物的方法。