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    SMALL PEPTIDE COMPOSITIONS AND USES THEREOF
    1.
    发明申请
    SMALL PEPTIDE COMPOSITIONS AND USES THEREOF 有权

    公开(公告)号：US20220257718A1

    公开(公告)日：2022-08-18

    申请号：US17724900

    申请日：2022-04-20

    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Tuskegee University

    Inventor： Cecelia C. Yates-Binder ,  Jesse Jaynes

    IPC: A61K38/19 ,  A61P9/10 ,  A61P35/00 ,  C07K7/02 ,  C12N15/62 ,  C12N15/113 ,  C12N15/86

    Abstract: Interferon-γ-inducible protein 10 (IP-10) peptides, IP-10 peptide variants and in silico designed C—X—C chemokine receptor 3 (CXCR3) peptide agonists are described. The small peptides can be used for inhibiting pathological tissue remodeling and treating fibrosis in a subject, such as a subject with fibrosis of the heart, lung, liver, kidney or skin. The peptide agonists can also be used to treat cardiovascular disease, including myocardial infarction and ischemia-reperfusion injury. Also described are in silico designed peptide antagonists that bind CXCR3 or ligands of CXCR3. These antagonist peptides block CXCR3 signaling by disrupting interaction of CXCR3 with its ligand. Antagonist peptides can be used, for example, to treat myocarditis and atherosclerosis. In additional embodiments agonists and antagonists of CXCR4 are disclosed.

    FILTRATION SYSTEM AND METHODS OF USING SUCH SYSTEM FOR IMPROVED WATER FILTRATION
    4.
    发明申请
    FILTRATION SYSTEM AND METHODS OF USING SUCH SYSTEM FOR IMPROVED WATER FILTRATION 审中-公开

    公开(公告)号：US20200376461A1

    公开(公告)日：2020-12-03

    申请号：US16668974

    申请日：2019-10-30

    Applicant: TUSKEGEE UNIVERSITY

    Inventor： Vijaya Rangari ,  Boniface Tiimob ,  Vitus Apalangya ,  Shaik Jeelani ,  Temesgen Samuel

    IPC: B01J20/02 ,  C02F1/50 ,  B01J20/20 ,  B01J20/04 ,  B01J20/28 ,  B01J20/30 ,  B01J20/32 ,  C02F1/28 ,  B01D39/06 ,  C02F1/00

    Abstract: A water filtration system is provided that comprises a combination of two components: silver nanoparticles immobilized on a porous carbon solid matrix and calcium carbonate silver nanoparticles. The silver nanoparticles immobilized on the porous carbon solid matrix are prepared in a one-step wet ball milling process that does not use an environmentally hazardous reducing agent or an organic stabilizer. The calcium carbonate in the calcium carbonate silver nanoparticles is preferably isolated from egg shells. The two filter components can be present in any ratio but an approximate 50:50 ratio is preferred. Also provided is an in situ method of preparing silver nanoparticles on active charcoal. Powdered activated charcoal and silver nitrate are mixed together in a mixture of ethanol and water to form a charcoal-silver nitrate solution which is then subjected to ball milling in the presence of polypropylene glycol to produce silver nanoparticles on active charcoal.

    Filtration system and methods of using such system for improved water filtration
    7.
    发明授权
    Filtration system and methods of using such system for improved water filtration 有权

    公开(公告)号：US11325099B2

    公开(公告)日：2022-05-10

    申请号：US16668974

    申请日：2019-10-30

    Applicant: TUSKEGEE UNIVERSITY

    Inventor： Vijaya Rangari ,  Boniface Tiimob ,  Vitus Apalangya ,  Shaik Jeelani ,  Temesgen Samuel

    IPC: B01J20/20 ,  B01J20/02 ,  B01J20/04 ,  B01J20/28 ,  B01J20/30 ,  B01J20/32 ,  B01D39/06 ,  C02F1/50 ,  C02F1/28 ,  C02F1/00

    Abstract: A water filtration system is provided that comprises a combination of two components: silver nanoparticles immobilized on a porous carbon solid matrix and calcium carbonate silver nanoparticles. The silver nanoparticles immobilized on the porous carbon solid matrix are prepared in a one-step wet ball milling process that does not use an environmentally hazardous reducing agent or an organic stabilizer. The calcium carbonate in the calcium carbonate silver nanoparticles is preferably isolated from egg shells. The two filter components can be present in any ratio but an approximate 50:50 ratio is preferred. Also provided is an in situ method of preparing silver nanoparticles on active charcoal. Powdered activated charcoal and silver nitrate are mixed together in a mixture of ethanol and water to form a charcoal-silver nitrate solution which is then subjected to ball milling in the presence of polypropylene glycol to produce silver nanoparticles on active charcoal.

    HIGH-THROUGHPUT SYNTHESIS OF METALLIC NANOPARTICLES
    8.
    发明申请
    HIGH-THROUGHPUT SYNTHESIS OF METALLIC NANOPARTICLES 有权

    公开(公告)号：US20210261431A1

    公开(公告)日：2021-08-26

    申请号：US17175137

    申请日：2021-02-12

    Applicant: Tuskegee University

    Inventor： Michael L. CURRY ,  Aiesha L. ETHRIDGE ,  Demetrius FINLEY

    IPC: C01G3/02 ,  B01J19/24 ,  B01J19/12 ,  B22F9/24

    Abstract: This invention relates to cost-effective methods for synthesizing metallic nanoparticles in high yield using non-dendrimeric branched polymeric templates, such as branched polyethyleneimine. This invention also provides a high-throughput apparatus for synthesizing metallic nanoparticles under conditions that produce less waste than conventional nanoparticle synthesis methods. Also provided are metallic nanoparticles and multi-metallic nanoparticle compositions made by methods and high-throughput apparatus of the invention.

    MULTIPLE BLADE HANDLE SYSTEM
    9.
    发明申请
    MULTIPLE BLADE HANDLE SYSTEM 审中-公开

    公开(公告)号：US20200022721A1

    公开(公告)日：2020-01-23

    申请号：US16515591

    申请日：2019-07-18

    Applicant: TUSKEGEE UNIVERSITY

    Inventor： Deidre Quinn-Gorham ,  Sharanabasaweshwara Asundi ,  Jimesh Bhagatji

    IPC: A61B17/3213

    Abstract: A handle system includes a body extending between a first end and a second end. The handle system also includes a slot extending, at least partially, in the body, the slot forming a cavity. The handle system further includes a carrier arranged, at least partially, within the slot, the carrier further comprising a friction locker and at least one arm coupled to the friction locker, the at least one arm being rotatable about the friction locker. The handle system also includes a cap arranged on at least one of the first end or the second end. The handle system further includes a blade coupled to the at least one arm, the blade being rotatable about the axis between a retracted position where the blade is positioned within the slot and an extended position where the blade extends outwardly from the body.

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