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    RIGID DINITROXIDE BIRADICAL COMPOUNDS USED AS IMPROVED POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION TECHNIQUES
    41.
    发明申请
    RIGID DINITROXIDE BIRADICAL COMPOUNDS USED AS IMPROVED POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION TECHNIQUES 审中-公开
    用于动态核极化技术的改进的极化剂的刚性四氮化​​钛化合物

    公开(公告)号：US20160052934A1

    公开(公告)日：2016-02-25

    申请号：US14784472

    申请日：2014-04-15

    Applicant: UNIVERSITE D'AIX-MARSEILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  BRUKER BIOSPIN ,  ECOLE NORMALE SUPERIEURE DE LYON ,  ETH ZURICH ,  UNIVERSITE CLAUDE BERNARD LYON 1

    Inventor： Olivier Ouari ,  Paul Tordo ,  Gilles Casano ,  Melanie Rosay ,  Fabien Aussenac ,  Christophe Coperet ,  Anne Lesage ,  Aaron Rossini ,  Lyndon Emsley ,  Alexandre Zagdoun

    IPC: C07D491/22 ,  G01N24/08 ,  G01R33/28

    CPC classification number: C07D491/22 ,  G01N24/08 ,  G01R33/282

    Abstract: The invention concerns a dinitroxide biradical compound, in which the two nitroxide units are held by a rigid linkage, of general formula (I) in which—A is a carbon, an ammonium or a phosphonium, each of A1 to A6 is selected separately from the group comprising a single bond, O, N, N(O), S, S(O), SO2, C(O), a (C1-C4) alkyl chain, Z1 and Z2 are chosen from RI and R2 in combination, such that there is always, in the combination, at least one R2 group that needs to be substituted by an R3 group, RI is an H, a (C6-C18) aryl or a (C3-C18) heteroaryl, R2 a (C1-C17) alkyl chain, a (C1-C17) alkenyl chain, a (C1-C17) alkynyl chain, a (C4-C17) cycloalkyl, a (C4-C17) heterocycloalkyl, a (C6-C18) aryl, a (C3-C18) heteroaryl, R3 is a (C1-C17) alkyl chain, a (C1-C17) alkenyl chain, a (C1-C17) alkynyl chain, a (C4-C17) cycloalkyl, a (C4-C17) heterocycloalkyl, a (C6-C18) aryl, a (C3-C18) heteroaryl, an ether —OR, an ester —C(O)O—R (in which R is any hydrocarbon radical), an azide, and in which, when Z1 and Z2 are combined together with the same carbon atom of the nitroxide ring to which they are bonded, they form a spirocycloalkyl or a spiroheterocycloalkyl substituted by R3.

    Abstract translation: 本发明涉及二硝基双基化合物，其中两个硝基氧单元由刚性键保持，通式（I）其中-A是碳，铵或鏻，每个A1至A6分别选自 包含单键O，N，N（O），S，S（O），SO 2，C（O），（C 1 -C 4）烷基链，Z 1和Z 2的基团选自R 1和R 2组合 ，使得总共存在至少一个需要被R 3基团取代的R 2基团，R 1是H，（C 6 -C 18）芳基或（C 3 -C 18）杂芳基，R 2 a（ C1-C17）烷基链，（C1-C17）烯基链，（C1-C17）炔基链，（C4-C17）环烷基，（C4-C17）杂环烷基，（C6-C18）芳基， （C 3 -C 18）烷基链，（C 1 -C 17）烯基链，（C 1 -C 17）炔基链，（C 4 -C 17）环烷基，（C 4 -C 17） 杂环烷基，（C 6 -C 18）芳基，（C 3 -C 18）杂芳基，醚-OR，酯-C（O）O-R（其中R是任何烃基），叠氮化物，其中 当Z1和Z2与它们所键合的氮氧自由基的相同碳原子结合在一起时，它们形成由R3取代的螺环烷基或螺杂环烷基。

    PHOTOREFLECTANCE DEVICE
    42.
    发明申请
    PHOTOREFLECTANCE DEVICE 有权
    光电设备

    公开(公告)号：US20150338212A1

    公开(公告)日：2015-11-26

    申请号：US14651414

    申请日：2013-12-09

    Applicant: NEXCIS ,  UNIVERSITE D'AIX-MARSEILLE

    Inventor： Antonin MOREAU ,  Véronica BERMUDEZ ,  Ludovic ESCOUBAS ,  Jean-Jacques SIMON

    IPC: G01B11/30

    CPC classification number: G01B11/303 ,  G01N21/1717 ,  G01N2021/1725 ,  G01N2201/065

    Abstract: A photoreflectance device for characterizing a rough surface includes a pump beam emitter to emit a pump beam; a probe beam emitter to emit a probe beam; a detector to detect the probe beam reflected by the surface; an integrating sphere to collect the probe beam reflected by the surface, the integrating sphere including: a first output connected to the detector, and disposed so as to receive a majority of the probe beam reflected by the surface; a second output arranged so as to receive a majority of the pump beam reflected by the surface.

    Abstract translation: 用于表征粗糙表面的光反射装置包括：泵浦光束发射器，用于发射泵浦光束; 用于发射探测光束的探测光束发射器; 用于检测由表面反射的探测光束的检测器; 用于收集由表面反射的探测光束的积分球，所述积分球包括：连接到所述检测器的第一输出，并且被设置为接收由所述表面反射的所述探测光束的大部分; 布置成接收由表面反射的泵浦光束的大部分的第二输出。

    METHOD FOR THE DIAGNOSIS OF ROSACEA
    43.
    发明申请
    METHOD FOR THE DIAGNOSIS OF ROSACEA 审中-公开
    ROSACEA诊断方法

    公开(公告)号：US20150307922A1

    公开(公告)日：2015-10-29

    申请号：US14420400

    申请日：2013-08-08

    Applicant: GALDERMA RESEARCH & DEVELOPMENT ,  UNIVERSITE D'AIX-MARSEILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

    Inventor： Jérôme AUBERT ,  Nathalia MURILLO ,  Didier RAOULT

    IPC: C12Q1/68

    CPC classification number: C12Q1/689 ,  C12Q1/6883 ,  C12Q1/6888 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

    Abstract: A method of characterizing specific microbiota associated with Demodex mites from a rosacea patient is described. The method can include a step of realizing a biopsy on the patient and analyzing the microbiota based on a method of 16SrRNA sequencing or pyrosequencing. A method for the diagnosis of rosacea in a patient is also described. This method can include characterizing microbiota associated with Demodex mites in the patient. Also described, are methods of differentiating a subtype of rosacea in a patient with rosacea and methods of controlling and measuring an active agent's treatment effectiveness on rosacea.

    Abstract translation: 描述了与来自红斑痤疮患者的Demodex螨相关的特定微生物群的表征方法。 该方法可以包括基于16SrRNA测序或焦磷酸测序的方法实现患者活检和分析微生物群的步骤。 还描述了用于诊断患者中的红斑痤疮的方法。 该方法可以包括表征患者中与Demodex螨相关的微生物群。 还描述了用于区分患有红斑痤疮的患者中红斑痤疮亚型的方法以及控制和测量活性剂对红斑痤疮的治疗有效性的方法。

    USER INTERFACE WITH OPTICAL DETECTION DEVICE
    49.
    发明申请
    USER INTERFACE WITH OPTICAL DETECTION DEVICE 有权

    公开(公告)号：US20250138160A1

    公开(公告)日：2025-05-01

    申请号：US18730571

    申请日：2023-01-20

    Applicant: UNIVERSITE D'AIX MARSEILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

    Inventor： Stéphane Viollet

    IPC: G01S7/481 ,  G06F3/03

    Abstract: A user interface, which includes a device for optically detecting the presence and position of an object in a detection zone, includes a lighting means for illuminating the detection zone. A linear detection strip is oriented toward the detection zone. The linear detection strip includes a row of photosensors that are configured to measure the light intensity of the light emitted by the lighting means. The sensitivity to light of each photosensor is weighted depending on the position of the photosensor along the row of photosensors.

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