公开(公告)号：US20230035013A1

公开(公告)日：2023-02-02

申请号：US17757356

申请日：2020-12-23

Applicant: Universiteit Antwerpen ,  Universitair Ziekenhuis Antwerpen

Inventor： Marie-José TASSIGNON ,  Michel HAAGDORENS

IPC: A61K35/36 ,  C12N5/0797 ,  A61K9/06 ,  A61K47/42 ,  A61K9/00

Abstract: The invention pertains to an ophthalmological device (100, 200) for the treatment of Limbal Stem Cell Deficiency, the device (100, 200) comprising: a stem cell carrier substrate; and a culture of limbal epithelial stem cells cultivated on said stem cell carrier substrate; wherein said stem cell carrier substrate comprises a hydrogel containing collagen or collagen-mimicking peptides; and wherein a ring-shaped area on a surface of said stem cell carrier substrate is provided with a pattern of niches (110, 210). The invention also pertains to a method for producing the ophthalmological device.

公开(公告)号：US11542463B2

公开(公告)日：2023-01-03

申请号：US16500675

申请日：2018-04-13

Applicant: Universiteit Antwerpen

Inventor： Serge Martin Fernand Tavernier ,  Boris Marie Gabriel Artemieff

IPC: C12M1/26 ,  C12M1/12 ,  C12M3/04 ,  B01D29/86 ,  B01D63/06 ,  B01D65/02 ,  C12M1/00

Abstract: The present invention relates to a particulate material separation assembly. It comprises a filtration membrane and an antifouling device. The antifouling device comprises one or more magnets and a plurality of magnetisable particles. The one or more magnets cause the plurality of magnetisable particles to self-assemble into dynamic bristles, thereby forming a brush. The particulate material separation assembly is particularly useful in the context of micro algae harvesting.

公开(公告)号：US11470189B2

公开(公告)日：2022-10-11

申请号：US16613321

申请日：2018-05-14

Applicant: IMEC VZW ,  UNIVERSITEIT ANTWERPEN

Inventor： Patrick Daniel Bosch ,  Tom Johan R De Schepper ,  Ensar Zeljkovic ,  Jeroen Maurice M Famaey ,  Steven Bert Latre

IPC: H04L69/321 ,  H04L47/125 ,  H04L47/34 ,  H04L69/326 ,  H04W36/00 ,  H04W84/18 ,  H04L67/56

Abstract: A method is disclosed for providing network access by a network stack in a communication device comprising a plurality of physical communication interfaces, each comprising a data link layer for the exchange of data frames with remote communication devices and a data link layer interface for exchanging data of data frames between the data link layer and higher layers in the network stack; and wherein the method comprises i) providing an abstraction data link layer comprising a single abstracted data link layer interface such that the plurality of physical communication interfaces appear as a single data link layer interface to the higher layers; and ii) obtaining network packets from the higher layers and distributing the network packets over the plurality of physical communication interfaces according to a neutral packet distribution scheme.

公开(公告)号：US20220291239A1

公开(公告)日：2022-09-15

申请号：US17761383

申请日：2020-09-21

Applicant: UNIVERSITEIT ANTWERPEN ,  UNIVERSITAIR ZIEKENHUIS ANTWERPEN

Inventor： Peter DELPUTTE ,  Annemieke SMET ,  Stijn VERHULST ,  Benedicte DE WINTER ,  Winke VAN DER GUCHT ,  Kim STOBBELAAR

IPC: G01N33/68

Abstract: An in vitro method is provided for determining the severity and/or prognosis of a respiratory syncytial virus (RSV) infection in a subject, based on the expression of one or more mucin genes in respiratory epithelial cells. The respiratory epithelial cells can be isolated from a biological sample of a subject, or they can be cultured in vitro and exposed to a biological sample of the subject.

公开(公告)号：US20220240053A1

公开(公告)日：2022-07-28

申请号：US17612726

申请日：2020-05-20

Applicant: IMEC VZW ,  UNIVERSITEIT ANTWERPEN

Inventor： Ben BELLEKENS ,  Rafael BERKVENS ,  Stijn DENIS ,  Maarten WEYN

IPC: H04W4/029 ,  H04W4/021

Abstract: A method for estimating movements of a crowd between a first and second subregion in an area are monitored by a wireless sensor network. The wireless sensor network includes nodes configured to exchange a radio frequency signal through a first respective second link. The first respective second link crosses the first respective second subregion. The method includes the steps of exchanging radio frequency signals over the first and second link; and measuring respective first and second attenuations of the exchanged radio frequency signals over the first respective second link; and estimating based on a change in the attenuations a flow of the crowd between the first and second subregion. The estimating further includes estimating based on the first and second attenuations a density of the crowd in the first respective second subregion; and estimating based thereon a flux of the crowd between the first and second subregion.

公开(公告)号：US20220238188A1

公开(公告)日：2022-07-28

申请号：US17421420

申请日：2020-02-28

Applicant: UNIVERSITEIT ANTWERPEN ,  UNIVERSITAIR ZIEKENHUIS ANTWERPEN

Inventor： Pieter Meysman ,  Kris Laukens ,  Benson Ogunjimi

IPC: G16B40/20 ,  G16B20/30 ,  G16B5/00

Abstract: Method (100) for determining an immune responsiveness to a query epitope (126) comprising: receiving sequence data (122) comprising TCR sequences of at least a part of a TCR repertoire of a subject; selecting a predictive model (160) generated or trained using a dataset comprising TCR sequences known to bind specifically to a model epitope, said predictive model selected according to a sequence match between the model epitope and query epitope; querying (130) the selected predictive model (160) with the sequence data (122); determining (140) from outputs of the selected predictive model (160) a Responsiveness Score indicative of the immune responsiveness. The immune responsiveness can be used to predict and optimal vaccine composition and/or evaluate efficacy of a vaccine in a subject or population.

公开(公告)号：US11339124B2

公开(公告)日：2022-05-24

申请号：US16967871

申请日：2019-02-05

Applicant: VIB VZW ,  Universiteit Antwerpen ,  Universiteit Gent

Inventor： Peter Vandenabeele ,  Tom Vanden Berghe ,  Koen Augustyns ,  Sam Hofmans ,  Pieter Van Der Veken ,  Lars Devisscher

IPC: C07C311/39 ,  C07D227/02 ,  C07D295/027 ,  C07D221/00 ,  C07D241/04 ,  C07D227/04

Abstract: The present invention relates to 3-(benzylamino)-4-(cyclohexylamino)-N-(2-(piperazin-1-yl)ethyl)benzenesulfonamide derivatives and related ferrostatin-1 (Fer-1) analogues as cell death inhibitors by inhibition of ferroptosis and/or oxytosis for the treatment of stroke, myocardial infarction, diabetes, sepsis, the prevention of transplant rejection, neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, dementia with Lewy bodies and Friedreich's ataxia. The present invention further relates to pharmaceutical compositions of these compounds and discloses methods for making the compounds and the corresponding intermediate.

公开(公告)号：US11324035B2

公开(公告)日：2022-05-03

申请号：US16619927

申请日：2018-06-18

Applicant: IMEC vzw ,  Universiteit Antwerpen

Inventor： Le Tian ,  Steven Latre ,  Jeroen Famaey

IPC: H04W88/10 ,  H04W74/00 ,  H04L5/00 ,  H04W72/04 ,  H04W74/08

Abstract: The invention pertains to a method for determining transmission parameters in a wireless local area network operating under a restricted access window scheme, said wireless local area network comprising an access point and a plurality of stations, the method comprising at said access point: estimating (230) respective transmission intervals and next transmission times of said plurality of stations; and assigning (260) a subset of said plurality of stations to a restricted access window group on the basis of said estimated next transmission times. The invention also pertains to a computer program product comprising code means configured to cause a processor to carry out the method and an access point configured to carry out the method.

公开(公告)号：US20220071510A1

公开(公告)日：2022-03-10

申请号：US17424379

申请日：2020-01-21

Applicant: UNIVERSITEIT ANTWERPEN

Inventor： Joris DIRCKX ,  Sam VAN DER JEUGHT

IPC: A61B5/107 ,  A61B1/227 ,  A61B1/04 ,  A61B1/06 ,  A61B1/00 ,  A61B5/00 ,  G06T7/521

Abstract: A method for obtaining a three-dimensional map of an eardrum includes the steps of i) obtaining a two-dimensional representation of a reflection comprising a deformed illumination pattern of a structured illumination pattern projected onto the eardrum; and ii) constructing by a trained deep learning model the three-dimensional map based on the reflection. The deep learning model is further trained by a training dataset comprising a plurality of height maps and corresponding two-dimensional representations of a reflection comprising a deformed illumination pattern.

公开(公告)号：US20220023320A1

公开(公告)日：2022-01-27

申请号：US17495447

申请日：2021-10-06

Applicant: Universiteit Antwerpen

Inventor： Koen Augustyns ,  Jurgen Joossens ,  Pieter Van Der Veken ,  Paul Cos ,  Cedric Joossen ,  Benedicte Yvonne De Winter ,  Hannah Ceuleers ,  Hanne Van Spaendonk

IPC: A61K31/688 ,  A61P27/04 ,  A61P25/04

Abstract: The present invention relates to compounds for use in the prevention and/or treatment of PAR-related diseases, such as for example: pain and ocular disorders. More in particular, the present invention provides bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of pancreatitis-related pain, IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), dry eye disease and conjunctivitis sicca. These inhibitors were found to have a different inhibitory profile compared to diphenyl guanidinophenylethylphosphonates leading to a more pronounced effect on these conditions.