公开(公告)号：US07833164B2

公开(公告)日：2010-11-16

申请号：US12538553

申请日：2009-08-10

申请人： Avram Scheiner ,  Donald L. Hopper ,  Gerrard M. Carlson

发明人： Avram Scheiner ,  Donald L. Hopper ,  Gerrard M. Carlson

IPC分类号： A61B5/00

CPC分类号： A61B5/4035 ,  A61B5/029 ,  A61B5/0472 ,  A61N1/36585 ,  G06F19/00

摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.

摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。

公开(公告)号：US20100114217A1

公开(公告)日：2010-05-06

申请号：US12610160

申请日：2009-10-30

申请人： Paul G. Krause ,  Avram Scheiner

发明人： Paul G. Krause ,  Avram Scheiner

IPC分类号： A61N1/08 ,  A61N1/39 ,  A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/36514 ,  A61N1/36521

摘要： An implantable medical system that includes a cardiac therapy module and a neurostimulation therapy module may identify when neurostimulation electrodes have migrated toward a patient's heart. In some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on a physiological response to an electrical signal delivered to the patient via the neurostimulation electrodes. In addition, in some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on an electrical cardiac signal sensed via the neurostimulation electrodes.

摘要翻译： 包括心脏治疗模块和神经刺激治疗模块的可植入医疗系统可以识别神经刺激电极何时向患者的心脏移动。 在一些示例中，系统可以基于对通过神经刺激电极递送给患者的电信号的生理反应来确定神经刺激电极是否已经向患者的心脏迁移。 此外，在一些示例中，系统可以基于经由神经刺激电极感测的电心脏信号来确定神经刺激电极是否已经向患者的心脏迁移。

公开(公告)号：US07643875B2

公开(公告)日：2010-01-05

申请号：US10746134

申请日：2003-12-24

申请人： Ronald W. Heil, Jr. ,  Avram Scheiner ,  Imad Libbus

发明人： Ronald W. Heil, Jr. ,  Avram Scheiner ,  Imad Libbus

IPC分类号： A61N1/36

CPC分类号： A61N1/36117 ,  A61N1/3627 ,  A61N1/36564

摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.

摘要翻译： 本主题的各个方面提供可植入医疗装置。 在各种实施例中，装置包括脉冲发生器，引线，传感器和控制器。 脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。 引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。 引线包括位于心脏中或靠近心脏的电极，以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。 传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。 控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。 本文提供了其他方面。

公开(公告)号：US07617003B2

公开(公告)日：2009-11-10

申请号：US11130022

申请日：2005-05-16

申请人： Anthony Caparso ,  Julia Moffitt ,  Avram Scheiner

发明人： Anthony Caparso ,  Julia Moffitt ,  Avram Scheiner

IPC分类号： A61N1/05

CPC分类号： A61N1/0551 ,  A61N1/057 ,  A61N1/372

摘要： A system for selective activation of a nerve trunk using a transvascular reshaping lead is provided. One aspect of this disclosure relates to a system for spreading nerve bundles in a nerve trunk. The system includes a lead adapted to be chronically implanted in a blood vessel proximate a nerve trunk, and having an expandable portion adapted to be expanded to reshape the blood vessel to an elongated shape and to reshape the nerve trunk into an elongated shape to spread nerve bundles of the nerve trunk. The system also includes a plurality of electrodes and an implantable device coupled to the lead, where an electrical signal is delivered from the implanted medical device to one of the plurality of electrodes to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk. Other aspects and embodiments are provided herein.

摘要翻译： 提供了使用经血管重塑引线选择性激活神经干的系统。 本公开的一个方面涉及一种用于在神经干中扩展神经束的系统。 该系统包括适于长期植入靠近神经干的血管中的引线，并且具有适于扩张的扩张部分以将血管重塑为细长形状并将神经干重新形成细长形状以展开神经 束神经干。 该系统还包括耦合到引线的多个电极和可植入装置，其中电信号从植入的医疗装置输送到多个电极中的一个电极，以将神经刺激从电极转运到至少一个神经 束神经干。 本文提供了其它方面和实施例。

公开(公告)号：US07584004B2

公开(公告)日：2009-09-01

申请号：US11151103

申请日：2005-06-13

申请人： Anthony Caparso ,  Avram Scheiner

发明人： Anthony Caparso ,  Avram Scheiner

IPC分类号： A61N1/05 ,  A61N1/18

CPC分类号： A61N1/0551 ,  A61N1/0556 ,  A61N1/0558

摘要： A vascularly stabilized peripheral nerve cuff assembly is provided. One aspect of this disclosure relates to an electrode assembly used in the delivery of neural stimulation therapy. The electrode assembly includes a body adapted to at least partially encompass a blood vessel and a nerve proximate to the blood vessel. The electrode assembly also includes at least one electrode along at least a portion of the body. The at least one electrode is adapted to be electrically connected to a neural stimulator. According to an embodiment, the electrode assembly includes a spacer within the body, the spacer having a first and second end, the first end secured to an inside surface of the body and the second end adapted to pass between the vessel and the nerve and to be secured to the inside surface of the body. Other aspects and embodiments are provided herein.

摘要翻译： 提供血管稳定的外周神经袖带组件。 本公开的一个方面涉及用于递送神经刺激疗法的电极组件。 电极组件包括适于至少部分地包围血管和靠近血管的神经的主体。 电极组件还包括沿着身体的至少一部分的至少一个电极。 至少一个电极适于电连接到神经刺激器。 根据一个实施例，电极组件包括在主体内的间隔件，间隔件具有第一和第二端，第一端固定到主体的内表面，第二端适于在容器和神经之间通过， 固定在身体的内表面。 本文提供了其它方面和实施例。

公开(公告)号：US07572226B2

公开(公告)日：2009-08-11

申请号：US10695430

申请日：2003-10-28

申请人： Avram Scheiner ,  Donald Hopper ,  Gerrard M. Carlson

发明人： Avram Scheiner ,  Donald Hopper ,  Gerrard M. Carlson

IPC分类号： A61B5/00

CPC分类号： A61B5/4035 ,  A61B5/029 ,  A61B5/0472 ,  A61N1/36585 ,  G06F19/00

摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.

摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。

公开(公告)号：US07425210B2

公开(公告)日：2008-09-16

申请号：US10743507

申请日：2003-12-22

申请人： Robert J. Sweeney ,  Avram Scheiner ,  Ronald W. Heil, Jr.

发明人： Robert J. Sweeney ,  Avram Scheiner ,  Ronald W. Heil, Jr.

IPC分类号： A61K9/22

CPC分类号： A61N1/30 ,  A61M5/1723 ,  A61M2205/3507 ,  A61M2205/3561

摘要： A drug delivery system and method in which an implantable medical device communicates with and controls an external drug delivery device with low energy potential signals. The implantable device generates potential signals modulated with digitally encoded command information by operating a current source to cause corresponding electrical potentials that can be sensed at the skin surface by the external drug delivery device. The drug delivery device then demodulates the sensed potentials and decodes the digital data to extract command information therefrom to deliver a drug accordingly.

摘要翻译： 一种药物递送系统和方法，其中可植入医疗装置与具有低能量电位信号的外部药物递送装置通信并控制其。 可植入装置通过操作电流源产生用数字编码命令信息调制的潜在信号，以引起可由外部药物递送装置在皮肤表面感测到的相应电位。 药物递送装置然后解调所感测的电位并对数字数据进行解码以从中提取命令信息以递送药物。

公开(公告)号：US07142920B2

公开(公告)日：2006-11-28

申请号：US10853574

申请日：2004-05-25

申请人： Avram Scheiner ,  Donald Hopper

发明人： Avram Scheiner ,  Donald Hopper

IPC分类号： A61N1/30

CPC分类号： A61N1/36514

摘要： An implantable cardiac device with an exertion level sensor is programmed to determine a heart rate appropriate for a given measured exertion level in accordance with a physiological model and/or previously collected physiologic data. The device then compares the model's heart rate with a measured intrinsic heart rate. Based upon this data, the device is able to recognize changes in the patient's heart rate response and predict or recognize a chronotropically incompetent condition.

摘要翻译： 具有消耗水平传感器的可植入心脏装置被编程以根据生理模型和/或先前收集的生理数据确定适合于给定测量的运动水平的心率。 然后，该装置将模型的心率与测量的内在心率进行比较。 基于该数据，该装置能够识别患者的心率响应的变化并且预测或识别慢性无能力的状况。

公开(公告)号：US07052466B2

公开(公告)日：2006-05-30

申请号：US09833229

申请日：2001-04-11

申请人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

发明人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

IPC分类号： A61B7/04

CPC分类号： A61B7/04 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/04014 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/1118 ,  A61B5/742 ,  A61B7/023 ,  G06F19/00

摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.

公开(公告)号：US07050852B2

公开(公告)日：2006-05-23

申请号：US09961684

申请日：2001-09-24

申请人： Qingsheng Zhu ,  Avram Scheiner ,  Julio C. Spinelli ,  Victor T. Chen

发明人： Qingsheng Zhu ,  Avram Scheiner ,  Julio C. Spinelli ,  Victor T. Chen

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3682

摘要： A cardiac pacemaker is configured to estimate the intrinsic atrial conduction time from sensed signals detected by an atrial sensing channel. Atrial conduction delays have been found to be associated with the onset of atrial tachyarrhythmias. Upon detection of an atrial conduction time above a specified limit value, the pacemaker is programmed to switch from a normal pacing mode to an atrial pacing preference mode.