公开(公告)号：US20090270351A1

公开(公告)日：2009-10-29

申请号：US12309459

申请日：2007-07-16

申请人： Joshua Close ,  Jonathan Grimm ,  Richard W. Heidebrecht, JR. ,  Solomon Kattar ,  Thomas A. Miller ,  Karin M. Otte ,  Scott Peterson ,  Phieng Siliphaivanh ,  Paul J. Tempest ,  Kevin J. Wilson ,  David J. Witter

发明人： Joshua Close ,  Jonathan Grimm ,  Richard W. Heidebrecht, JR. ,  Solomon Kattar ,  Thomas A. Miller ,  Karin M. Otte ,  Scott Peterson ,  Phieng Siliphaivanh ,  Paul J. Tempest ,  Kevin J. Wilson ,  David J. Witter

IPC分类号： A61K31/675 ,  A61K31/67 ,  C07F9/28 ,  C07D333/04

CPC分类号： C07F9/655345 ,  C07F9/5304 ,  C07F9/5325 ,  C07F9/65031 ,  C07F9/65586 ,  C07F9/657154 ,  C07F9/657181 ,  C07F9/6584

摘要： The present invention relates to a novel class of phosphorus derivatives. The phosphorus compounds can be used to treat cancer. The phosphorus compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the phosphorus derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the phosphorus derivatives in vivo.

摘要翻译： 本发明涉及一类新型的磷衍生物。 磷化合物可用于治疗癌症。 磷化合物也可以抑制组蛋白脱乙酰酶，适用于选择性诱导末端分化，阻止肿瘤细胞的细胞生长和/或细胞凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统疾病（CNS），例如 神经退行性疾病 本发明进一步提供包含磷衍生物和这些药物组合物的安全给药方案的药物组合物，其易于遵循，并且其在体内导致治疗有效量的磷衍生物。

公开(公告)号：US20090082308A1

公开(公告)日：2009-03-26

申请号：US11918913

申请日：2006-04-14

申请人： Jed Lee Hubbs ,  Dawn M. Mampreian ,  Joey L. Methot ,  Thomas A. Miller ,  Karin M. Otte ,  Phieng Siliphaivanh ,  David L. Sloman ,  Matthew G. Stanton ,  Kevin J. Wilson ,  David J. Witter

发明人： Jed Lee Hubbs ,  Dawn M. Mampreian ,  Joey L. Methot ,  Thomas A. Miller ,  Karin M. Otte ,  Phieng Siliphaivanh ,  David L. Sloman ,  Matthew G. Stanton ,  Kevin J. Wilson ,  David J. Witter

IPC分类号： A61K31/695 ,  C07D333/56 ,  A61K31/381 ,  C07D409/12 ,  A61K31/4709 ,  C07D409/10 ,  A61K31/4025 ,  C07D409/06 ,  A61K31/496 ,  C07D413/12 ,  A61P25/00 ,  A61P35/00 ,  A61K31/4155 ,  A61K31/506 ,  C07F7/08 ,  A61K31/5377 ,  C07D409/14 ,  A61K31/4178 ,  A61K31/404 ,  A61K31/4436 ,  A61K31/4245 ,  A61K31/4192

CPC分类号： C07D333/70 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14

摘要： The present invention relates to a novel class of benzothiophene amide derivatives. The hydroxamic acid compounds can be used to treat cancer. The benzothiophene amide compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

摘要翻译： 本发明涉及一类新型的苯并噻吩酰胺衍生物。 异羟肟酸化合物可用于治疗癌症。 苯并噻吩酰胺化合物也可以抑制组蛋白脱乙酰酶，适用于选择性诱导末端分化，阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统疾病（CNS），例如 神经退行性疾病 本发明进一步提供包含异羟肟酸衍生物和这些药物组合物的安全投药方案的药物组合物，它们易于遵循，并且其在体内导致治疗有效量的异羟肟酸衍生物。

公开(公告)号：US07199134B2

公开(公告)日：2007-04-03

申请号：US10817688

申请日：2004-04-01

申请人： Ronald Breslow ,  Thomas A. Miller ,  Sandro Belvedere ,  Paul A. Marks ,  Victoria M. Richon ,  Richard A. Rifkind

发明人： Ronald Breslow ,  Thomas A. Miller ,  Sandro Belvedere ,  Paul A. Marks ,  Victoria M. Richon ,  Richard A. Rifkind

IPC分类号： C07D215/38 ,  C07D215/36 ,  A61K31/47 ,  A61K31/44

CPC分类号： C07D211/02 ,  C07D215/38 ,  C07D401/12

摘要： The present invention relates to a novel class of hydroxamic acid derivatives having at least two aryl containing groups, at least one of which is a quinolinyl, isoquinolinyl or benzyl moiety, linked to the hydroxamic acid group through a methylene chain. The hydroxamic acid compounds can be used to treat cancer, for example, brain cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.

公开(公告)号：US07148257B2

公开(公告)日：2006-12-12

申请号：US10650025

申请日：2003-08-26

申请人： Nicholas G. Bacopoulos ,  Judy H. Chiao ,  Thomas A. Miller ,  Carolyn M. Paradise ,  Victoria M. Richon

发明人： Nicholas G. Bacopoulos ,  Judy H. Chiao ,  Thomas A. Miller ,  Carolyn M. Paradise ,  Victoria M. Richon

IPC分类号： A61K31/165

CPC分类号： A61K9/4866 ,  A61K9/0019 ,  A61K9/1652 ,  A61K31/13 ,  A61K31/165 ,  A61K31/19 ,  A61K31/44 ,  A61K47/12 ,  A61K47/38

摘要： Methods for treating mesothelioma comprising administering the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) are disclosed.

摘要翻译： 公开了用于治疗间皮瘤的方法，包括给予组蛋白脱乙酰酶抑制剂辛二酰苯胺异羟肟酸（SAHA）。

公开(公告)号：US5865232A

公开(公告)日：1999-02-02

申请号：US813669

申请日：1997-03-07

申请人： Thomas A. Miller ,  Darrel C. Pinkston

发明人： Thomas A. Miller ,  Darrel C. Pinkston

IPC分类号： B25B5/00 ,  B25B5/08 ,  B25B5/14 ,  B27L5/00 ,  B27L5/04 ,  B27L5/06 ,  B27C1/00 ,  B27M1/02

CPC分类号： B27L5/04 ,  B25B5/003 ,  B25B5/087 ,  B25B5/147 ,  B27L5/004 ,  B27L5/06

摘要： A novel method and apparatus for cutting veneer sheets from a tapered flitch (one-half of a veneer log which has been sawn in half longitudinally) that places the veneer producing face of a tapered flitch in a stable, parallel relationship with the veneer slicing knife, thereby allowing full utilization of the natural taper of a veneer log.

摘要翻译： 一种新颖的方法和装置，用于从锥形薄片（已经锯切成两半纵向的薄板原木的一半）切割单板，其将单板生产锥形薄片的表面与单板切片刀保持稳定的平行关系 ，从而允许充分利用单板日志的天然锥度。

公开(公告)号：US5747057A

公开(公告)日：1998-05-05

申请号：US626001

申请日：1996-04-01

申请人： Thomas A. Miller

发明人： Thomas A. Miller

IPC分类号： A01K13/00 ,  A01K27/00 ,  A01N37/52 ,  A01N43/40 ,  A01N47/12 ,  A01N53/02 ,  A61K9/00 ,  A01N25/34 ,  A01N31/44

CPC分类号： A01N43/40

摘要： The invention comprises a composition of matter containing a matrix, a plasticizer and pyriproxifen for controlling fleas.

摘要翻译： 本发明包括含有基质的物质组合物，增塑剂和用于控制跳蚤的吡哆酮。

公开(公告)号：US5632999A

公开(公告)日：1997-05-27

申请号：US108909

申请日：1993-08-18

申请人： Thomas A. Miller

发明人： Thomas A. Miller

IPC分类号： A01K13/00 ,  A01K27/00 ,  A01N37/52 ,  A01N43/40 ,  A01N47/12 ,  A01N53/02 ,  A61K9/00 ,  A01N25/34

CPC分类号： A01N43/40

摘要： The invention comprises a method of controlling fleas which includes continuously administering to the haircoat of a homeothermic animal an ovicidally effective amount of 2-(1-methyl-2-(4-phenoxyphenoxy)ethoxy)pyridine (pyriproxifen) from a sustained release matrix at a rate of 0.1 mcg/kg/day to 100 mcg/kg/day. The method may also include the use of additional ingredients such as insecticides, plasticizers, lubricants and antioxidants in a sustained release matrix.

摘要翻译： 本发明包括一种控制跳蚤的方法，其包括向持续释放基质中的持续释放基质中持续施用有效量的2-（1-甲基-2-（4-苯氧基苯氧基）乙氧基）吡啶（吡氯西泮） 速率为0.1mcg / kg /天至100mcg / kg /天。 该方法还可以包括在持续释放基质中使用附加成分例如杀虫剂，增塑剂，润滑剂和抗氧化剂。

公开(公告)号：US20200263672A1

公开(公告)日：2020-08-20

申请号：US16277600

申请日：2019-02-15

申请人： Ethan Q. Miller ,  Thomas A. Miller

发明人： Ethan Q. Miller ,  Thomas A. Miller

IPC分类号： F03G7/06 ,  C09K3/18

摘要： An energy generation device is disclosed which includes a reservoir adapted to receive a supply of water, a spring proximate the reservoir, a supply of calcium chloride, a drive shaft connected to the spring, an electric generator connected to the drive shaft, and a processor, the processor adapted to release the supply of calcium chloride when the supply of water in the reservoir is frozen.

公开(公告)号：US20160326156A1

公开(公告)日：2016-11-10

申请号：US15105316

申请日：2014-12-18

申请人： Thomas A. MILLER ,  Alessia PETROCCHI ,  Eric T. ROMEO ,  Dilrukshi VITHARANA ,  Solomon D. KATTAR ,  Alan B. NORTHRUP ,  Michael D. ALTMAN ,  Neville J. ANTHONY ,  MERCK SHARP & DOHME CORP.

发明人： Thomas A. Miller ,  Alessia Petrocchi ,  Eric T. Romeo ,  Dilrukshi Vitharana ,  Solomon D. Kattar ,  Alan B. Northrup ,  Michael D. Altman ,  Neville J. Anthony

IPC分类号： C07D417/12 ,  C07D495/04 ,  A61K31/437 ,  C07D471/04 ,  A61K31/444 ,  C07D491/048 ,  A61K31/517 ,  A61K31/519

CPC分类号： C07D417/12 ,  A61K31/437 ,  A61K31/444 ,  A61K31/517 ,  A61K31/519 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) (I), or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring A, and the subscripts n1, n2, and r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

摘要翻译： 本发明提供了式（I）（I）的某些噻唑取代的氨基杂芳基化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，环A和下标n 1，n 2和r如上定义 这里。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）介导的疾病或病症的方法。

公开(公告)号：US08461189B2

公开(公告)日：2013-06-11

申请号：US12666415

申请日：2008-06-24

申请人： Richard W. Heidebrecht, Jr. ,  Thomas A. Miller ,  Matthew G. Stanton ,  David J. Witter

发明人： Richard W. Heidebrecht, Jr. ,  Thomas A. Miller ,  Matthew G. Stanton ,  David J. Witter

IPC分类号： A01N43/40 ,  A01N47/10 ,  A61K31/44 ,  C07D213/55

CPC分类号： C07D213/75 ,  C07D409/04 ,  C07D409/14

摘要： The present invention relates to a novel class of pyridyl and pyrimidinyl derivatives. The pyridyl and pyrimidinyl compounds can be used to treat cancer. The pyridyl and pyrimidinyl compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the pyridyl and pyrimidinyl derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the pyridyl and pyrimidinyl derivatives in vivo.

摘要翻译： 本发明涉及一类新的吡啶基和嘧啶基衍生物。 吡啶基和嘧啶基化合物可用于治疗癌症。 吡啶基和嘧啶基化合物也可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如 神经退行性疾病 本发明进一步提供包含吡啶基和嘧啶基衍生物的药物组合物以及易于遵循的这些药物组合物的安全给药方案，并且其在体内导致治疗有效量的吡啶基和嘧啶基衍生物。