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公开(公告)号：US07981874B2
公开(公告)日：2011-07-19
申请号：US12309459
申请日：2007-07-16
申请人： Joshua Close , Jonathan Grimm , Richard W. Heidebrecht, Jr. , Solomon Kattar , Thomas A. Miller , Karin M. Otte , Scott Peterson , Phieng Siliphaivanh , Paul J. Tempest , Kevin J. Wilson , David J. Witter
发明人： Joshua Close , Jonathan Grimm , Richard W. Heidebrecht, Jr. , Solomon Kattar , Thomas A. Miller , Karin M. Otte , Scott Peterson , Phieng Siliphaivanh , Paul J. Tempest , Kevin J. Wilson , David J. Witter
IPC分类号： A61K31/662 , A61K31/683 , A61K31/67 , A61K31/675 , A61K31/4747 , A61K31/4545 , A61K31/4436 , A61K31/415 , A61K31/427 , C07F9/28 , C07F9/53 , C07F9/40 , C07F9/32 , C07F9/6571 , C07F9/6584 , C07D333/20 , C07D277/50 , C07D231/40 , C07D221/20 , C07F9/58 , C07F9/59
CPC分类号： C07F9/655345 , C07F9/5304 , C07F9/5325 , C07F9/65031 , C07F9/65586 , C07F9/657154 , C07F9/657181 , C07F9/6584
摘要： The present invention relates to a novel class of phosphorus derivatives. The phosphorus compounds can be used to treat cancer. The phosphorus compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the phosphorus derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the phosphorus derivatives in vivo.
摘要翻译： 本发明涉及一类新型的磷衍生物。 磷化合物可用于治疗癌症。 磷化合物也可以抑制组蛋白脱乙酰酶，适用于选择性诱导末端分化，阻止肿瘤细胞的细胞生长和/或细胞凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如 神经退行性疾病 本发明进一步提供包含磷衍生物和这些药物组合物的安全给药方案的药物组合物，其易于遵循，并且其在体内导致治疗有效量的磷衍生物。
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公开(公告)号：US20090270351A1
公开(公告)日：2009-10-29
申请号：US12309459
申请日：2007-07-16
申请人： Joshua Close , Jonathan Grimm , Richard W. Heidebrecht, JR. , Solomon Kattar , Thomas A. Miller , Karin M. Otte , Scott Peterson , Phieng Siliphaivanh , Paul J. Tempest , Kevin J. Wilson , David J. Witter
发明人： Joshua Close , Jonathan Grimm , Richard W. Heidebrecht, JR. , Solomon Kattar , Thomas A. Miller , Karin M. Otte , Scott Peterson , Phieng Siliphaivanh , Paul J. Tempest , Kevin J. Wilson , David J. Witter
IPC分类号： A61K31/675 , A61K31/67 , C07F9/28 , C07D333/04
CPC分类号： C07F9/655345 , C07F9/5304 , C07F9/5325 , C07F9/65031 , C07F9/65586 , C07F9/657154 , C07F9/657181 , C07F9/6584
摘要： The present invention relates to a novel class of phosphorus derivatives. The phosphorus compounds can be used to treat cancer. The phosphorus compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the phosphorus derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the phosphorus derivatives in vivo.
摘要翻译： 本发明涉及一类新型的磷衍生物。 磷化合物可用于治疗癌症。 磷化合物也可以抑制组蛋白脱乙酰酶，适用于选择性诱导末端分化，阻止肿瘤细胞的细胞生长和/或细胞凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统疾病（CNS），例如 神经退行性疾病 本发明进一步提供包含磷衍生物和这些药物组合物的安全给药方案的药物组合物，其易于遵循，并且其在体内导致治疗有效量的磷衍生物。
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公开(公告)号：US20110130361A1
公开(公告)日：2011-06-02
申请号：US12672441
申请日：2008-08-05
申请人： Jonathan Grimm , Richard W. Heidebrecht, JR. , Dawn M. Mampreian , Joey L. Methot , Thomas A. Miller , Karin M. Otte , Scott Peterson , Phieng Siliphaivanh , Kevin J. Wilson , David J. Witter
发明人： Jonathan Grimm , Richard W. Heidebrecht, JR. , Dawn M. Mampreian , Joey L. Methot , Thomas A. Miller , Karin M. Otte , Scott Peterson , Phieng Siliphaivanh , Kevin J. Wilson , David J. Witter
IPC分类号： A61K31/695 , C07C271/28 , C07D333/22 , C07D209/32 , C07F7/02 , A61K31/24 , A61K31/381 , A61K31/4015 , A61P35/00
CPC分类号： C07F7/0812
摘要： The present invention relates to a novel class of Silicon derivatives. The Silicon compounds can be used to treat cancer. The Silicon compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the Silicon derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the Silicon derivatives in vivo.
摘要翻译： 本发明涉及一类新型的硅衍生物。 硅化合物可用于治疗癌症。 硅化合物还可以抑制组蛋白脱乙酰酶，并且适用于选择性诱导末端分化，并阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统疾病（CNS），例如 神经退行性疾病 本发明还提供包含硅衍生物和这些药物组合物的安全给药方案的药物组合物，其易于遵循，并且其在体内导致治疗有效量的硅衍生物。
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公开(公告)号：US09328099B2
公开(公告)日：2016-05-03
申请号：US14345978
申请日：2012-09-21
申请人： Jason Brubaker , Matthew Lloyd Childers , Matthew Christopher , Joshua T. Close , Jason David Katz , Joon Jung , Scott Peterson , Phieng Siliphaivanh , Tony Siu , Graham Frank Smith , Luis E. Torres , Hyun Chong Woo , Jonathan R. Young , Hongjun Zhang
发明人： Jason Brubaker , Matthew Lloyd Childers , Matthew Christopher , Joshua T. Close , Jason David Katz , Joon Jung , Scott Peterson , Phieng Siliphaivanh , Tony Siu , Graham Frank Smith , Luis E. Torres , Hyun Chong Woo , Jonathan R. Young , Hongjun Zhang
IPC分类号： C07D231/38 , C07D405/04 , C07D401/14 , C07D401/04 , C07D403/04 , C07D405/08 , C07D403/12 , C07D401/12 , C07D403/08 , C07D405/12 , C07D409/12 , C07D413/12 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14
CPC分类号： C07D405/08 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译： 本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。
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公开(公告)号：US20150261615A1
公开(公告)日：2015-09-17
申请号：US14215637
申请日：2014-03-17
申请人： Scott Peterson , Phillip Krueger
发明人： Scott Peterson , Phillip Krueger
CPC分类号： G06F11/1446 , G06F3/0619 , G06F3/0688 , G06F11/2058 , G06F11/2069 , G06F12/0246 , G06F12/0813 , G06F12/084 , G06F12/0871 , G06F2201/80 , G06F2212/1016 , G06F2212/154 , G06F2212/214 , G06F2212/261 , G06F2212/284 , G06F2212/7201 , G06F2212/7207
摘要： A method for information handling systems includes receiving a storage operation to be applied to a cache block in a location in a distributed storage system. The location is defined by a logical block address (LBA). The method further includes swapping a first portion of the LBA with a second portion of the LBA, resulting in a modified LBA, and performing the storage operation with the modified LBA. The first portion and the second portion are both x bits wide.
摘要翻译： 一种用于信息处理系统的方法包括接收在分布式存储系统中的位置处应用于高速缓存块的存储操作。 位置由逻辑块地址（LBA）定义。 该方法还包括将LBA的第一部分与LBA的第二部分交换，导致修改的LBA，并且使用修改的LBA执行存储操作。 第一部分和第二部分都是x位宽。
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公开(公告)号：US08962608B2
公开(公告)日：2015-02-24
申请号：US14345976
申请日：2012-09-21
申请人： Jason Brubaker , Christopher Dinsmore , Dawn Marie Hoffman , Joon Jung , Duan Liu , Scott Peterson , Tony Siu , Luis E. Torres , Hongjun Zhang , Zhongyong Wei , Feng Shi
发明人： Jason Brubaker , Christopher Dinsmore , Dawn Marie Hoffman , Joon Jung , Duan Liu , Scott Peterson , Tony Siu , Luis E. Torres , Hongjun Zhang , Zhongyong Wei , Feng Shi
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/415 , C07D231/38 , C07D403/08 , C07D403/12 , C07D405/08 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14
CPC分类号： C07D405/08 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译： 本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。
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公开(公告)号：US08349865B2
公开(公告)日：2013-01-08
申请号：US12677375
申请日：2008-09-08
申请人： Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Matthew Katcher , Ellalahewage Sathyajith Kumarasinghe , Ekaterina Kozina , Scott Peterson , Matthew Childers
发明人： Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Matthew Katcher , Ellalahewage Sathyajith Kumarasinghe , Ekaterina Kozina , Scott Peterson , Matthew Childers
IPC分类号： C07D471/06 , A61K31/4375
CPC分类号： C07D471/04 , C07D471/14
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
摘要翻译： 本发明提供抑制四种已知的哺乳动物JAK激酶（JAK1，JAK2，JAK3和TYK2）和PDK1的化合物。 本发明还提供了包含这种抑制化合物的组合物和通过向需要治疗骨髓增生性疾病或癌症的患者施用化合物来抑制JAK1，JAK2，JAK3 TYK2和PDK1的活性的方法。
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公开(公告)号：US08329639B2
公开(公告)日：2012-12-11
申请号：US13553061
申请日：2012-07-19
申请人： Scott Peterson , Linda Pestano , Jeffrey Millard , Diana F. Hausman , Sandy Koppenol , Robert Kirkman
发明人： Scott Peterson , Linda Pestano , Jeffrey Millard , Diana F. Hausman , Sandy Koppenol , Robert Kirkman
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1271 , A61K39/00 , A61K39/0011 , A61K45/06 , A61K47/6911 , A61K2039/505 , A61K2039/55555 , A61K2039/55572 , A61K2039/585 , C07K16/3092
摘要： Provided herein are liposomal glycolipopeptidic vaccine formulations comprising an adjuvant and an immunogen for immunotherapy and/or treatment of cancer.
摘要翻译： 本文提供了包含用于免疫治疗和/或治疗癌症的佐剂和免疫原的脂质体糖苷疫苗制剂。
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9.发明申请FREEZE-DRIED, DAIRY OR DAIRY-SUBSTITUTE COMPOSITIONS AND METHODS OF MAKING AND USING 审中-公开冷冻干燥，奶制或代替替代组合物及其制备和使用方法公开(公告)号：US20120121762A1
公开(公告)日：2012-05-17
申请号：US13357364
申请日：2012-01-24
CPC分类号： A23C9/1232 , A23C9/1307 , A23C9/137 , A23C9/1524 , A23C9/1546 , A23C2240/20
摘要： The present invention comprises a freeze-dried, aerated dairy or dairy-substitute composition comprising a dairy or dairy-substitute ingredient and an emulsifier and methods of using and making thereof.
摘要翻译： 本发明包括冷冻干燥，充气的乳制品或乳制品替代组合物，其包含乳制品或乳制品替代成分和乳化剂及其使用和制备方法。
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10.发明申请FREEZE-DRIED, AERATED FRUIT OR VEGETABLE COMPOSITIONS AND METHODS OF MAKING THEREOF 有权冷冻干燥，食用水果或蔬菜组合物及其制备方法公开(公告)号：US20110008515A1
公开(公告)日：2011-01-13
申请号：US12599328
申请日：2008-05-09
申请人： Scott Peterson , Frank Welch , Thomas Burkholder
发明人： Scott Peterson , Frank Welch , Thomas Burkholder
IPC分类号： A23B7/024 , A23L1/0562 , A23L1/0522 , A23L1/0532 , A23L1/0524 , A23L1/0526 , A23L1/212
CPC分类号： A23P30/40 , A23B7/024 , A23L19/09 , A23L29/10 , A23L29/20 , A23V2002/00 , G06Q99/00 , A23V2250/101 , A23V2250/5432 , A23V2250/192 , A23V2250/182
摘要： The present invention comprises a freeze-dried, aerated fruit or vegetable composition comprising a fruit or vegetable ingredient and an emulsifier and methods of making thereof.
摘要翻译： 本发明包括冷冻干燥，充气的水果或蔬菜组合物，其包含水果或蔬菜成分和乳化剂及其制备方法。
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