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公开(公告)号：US07491815B2
公开(公告)日：2009-02-17
申请号：US11211803
申请日：2005-08-25
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含靶向编码C反应蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节C反应蛋白表达和治疗与C反应蛋白表达相关的疾病的方法。
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公开(公告)号：US07425545B2
公开(公告)日：2008-09-16
申请号：US10858500
申请日：2004-06-01
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided.
摘要翻译： 提供化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含针对编码C反应蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节C-反应蛋白表达和用于诊断和治疗与C-反应蛋白表达相关的疾病的方法。
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公开(公告)号：US07132529B2
公开(公告)日：2006-11-07
申请号：US09918187
申请日：2001-07-30
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C12N15/1137 , A61K38/00 , C12N9/0083 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.
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公开(公告)号：US08859514B2
公开(公告)日：2014-10-14
申请号：US12902051
申请日：2010-10-11
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
IPC分类号： C07H21/02 , C07H21/04 , A61K31/70 , C12N15/113 , C12Q1/68
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided.
摘要翻译： 提供化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含针对编码C反应蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节C-反应蛋白表达和用于诊断和治疗与C-反应蛋白表达相关的疾病的方法。
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公开(公告)号：US08710023B2
公开(公告)日：2014-04-29
申请号：US13309835
申请日：2011-12-02
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含靶向编码C反应蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节C反应蛋白表达和治疗与C反应蛋白表达相关的疾病的方法。
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公开(公告)号：US08492355B2
公开(公告)日：2013-07-23
申请号：US11969096
申请日：2008-01-03
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
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公开(公告)号：US20120077865A1
公开(公告)日：2012-03-29
申请号：US13302070
申请日：2011-11-22
申请人： Susan M. FREIER , Rosanne M. Crooke , Mark J. Graham , Kristina M. Lemonidis , Sanjay Bhanot , Diane Tribble , Andrew T. Watt
发明人： Susan M. FREIER , Rosanne M. Crooke , Mark J. Graham , Kristina M. Lemonidis , Sanjay Bhanot , Diane Tribble , Andrew T. Watt
IPC分类号： A61K31/713 , A61P7/00 , A61P3/06 , A61P9/10 , A61P3/10 , A61P1/16 , A61P3/00 , C07H21/04 , A61P9/00
CPC分类号： C12N15/1137 , A61K45/06 , A61K48/00 , C12N2310/11 , C12N2310/321 , C12N2310/351 , C12N2320/30
摘要： Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
摘要翻译： 本文公开了用于降低具有升高的LDL-C的个体中的LDL-C的反义化合物和方法。 另外公开了用于治疗，预防或改善高胆固醇血症和/或动脉粥样硬化的反义化合物和方法。 进一步公开的是用于降低冠心病风险的反义化合物和方法。 这样的方法包括向需要治疗的个体施用靶向PCSK9核酸的反义化合物。 施用的反义化合物包括gapmer反义寡核苷酸。
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公开(公告)号：US20110319469A1
公开(公告)日：2011-12-29
申请号：US13016917
申请日：2011-01-28
申请人： Rosanne M. Crooke , Mark J. Graham , Steven Mah
发明人： Rosanne M. Crooke , Mark J. Graham , Steven Mah
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2320/30 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for diagnosis and treatment of diseases and conditions associated with expression of apolipoprotein B are provided.
摘要翻译： 提供了用于调节载脂蛋白B表达的化合物，组合物和方法。该组合物包含靶向编码载脂蛋白B的核酸的寡核苷酸。使用这些化合物调节载脂蛋白B表达并用于诊断和治疗与 提供载脂蛋白B的表达。
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公开(公告)号：US20110230544A1
公开(公告)日：2011-09-22
申请号：US12902051
申请日：2010-10-11
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
IPC分类号： A61K31/7088 , C07H21/00 , C12N5/071 , A61P9/00 , A61P25/00 , A61P3/00 , A61P29/00 , A61P31/00 , A61P11/00 , A61P19/00 , A61P35/00 , A61P25/28 , A61P25/16 , A61P27/02 , A61P3/04 , A61P3/10 , A61P9/10 , A61P9/12 , A61P3/06 , A61P9/04 , A61P15/00 , A61P19/02 , A61P31/04 , A61P11/06
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided.
摘要翻译： 提供化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含针对编码C反应蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节C-反应蛋白表达和用于诊断和治疗与C-反应蛋白表达相关的疾病的方法。
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公开(公告)号：US07888324B2
公开(公告)日：2011-02-15
申请号：US09920033
申请日：2001-08-01
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节载脂蛋白B的表达。组合物包含靶向编码载脂蛋白B的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节载脂蛋白B表达和治疗疾病的方法 与载脂蛋白B的表达相关。
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