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41.发明授权Polymerizable biodegradable polymers including carbonate or dioxanone linkages 失效可聚合的可生物降解聚合物，包括碳酸盐或二氧杂环己酮键
公开(公告)号：US6083524A
公开(公告)日：2000-07-04
申请号：US944739
申请日：1997-10-06
申请人： Amarpreet S. Sawhney , David J. Enscore , Stephen D. Goodrich , William C. Nason , Fei Yao , Douglas Weaver , Peter K. Jarrett , Arthur J. Coury , Ronald S. Rudowsky , Michelle D. Powell , Luis Z. Avila , Shikha P. Barman
发明人： Amarpreet S. Sawhney , David J. Enscore , Stephen D. Goodrich , William C. Nason , Fei Yao , Douglas Weaver , Peter K. Jarrett , Arthur J. Coury , Ronald S. Rudowsky , Michelle D. Powell , Luis Z. Avila , Shikha P. Barman
IPC分类号： A61K9/16 , A61L24/00 , A61L24/04 , A61L26/00 , A61L31/06 , A61L31/14 , C08G63/64 , A61R2/02 , A61K31/74
CPC分类号： C08G63/64 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/06 , A61L31/148 , A61K9/1635
摘要： Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.
摘要翻译： 描述了包括由碳酸酯或二恶烷酮基团形成的至少一种可水解键，至少一种水溶性聚合物嵌段和至少一种可聚合基团的水溶性大分子单体及其制备方法和用途。 大分子单体优选在长波长紫外光或可见光激发的影响下使用自由基引发剂进行聚合。 生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。 大分子单体可用于包封细胞，以受控的方式递送预防性，治疗性或诊断性药物，堵塞组织中的渗漏，防止外科手术后的粘连形成，暂时保护或分离组织表面，以及将组织粘附或密封在一起。
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42.发明授权
公开(公告)号：US5785993A
公开(公告)日：1998-07-28
申请号：US689139
申请日：1996-07-29
申请人： Keith Baker , Arthur J. Coury
发明人： Keith Baker , Arthur J. Coury
IPC分类号： A61K9/127 , A61K9/00 , A61K9/14 , A61K9/50 , A61K9/52 , A61K38/44 , A61K45/00 , A61K47/32 , A61P29/00 , A61P43/00 , A61K9/16
CPC分类号： A61K9/0024 , A61K38/44 , A61K38/446 , A61K47/32 , Y10S514/944 , Y10S514/963
摘要： SOD and other active oxygen inhibitors are directly applied in combination with a barrier material at local sites of tissue injury to prevent or decrease formation of adhesions and undesirable proliferation of cells. Preferred barrier materials are polymeric hydrogels providing controlled release of AOI which are directly applied to the afflicted tissue. Examples demonstrate the effects of SOD on pelvic adhesions in the rat when administered by intraperitoneal (I.P.) bolus and by localized sustained release from a topically applied hydrogel system.
摘要翻译： SOD和其他活性氧抑制剂直接与局部组织损伤部位的阻隔材料结合使用，以防止或减少粘连的形成和细胞的不期望的增殖。 优选的阻隔材料是提供直接施用于受影响组织的AOI的受控释放的聚合物水凝胶。 实施例证明当通过腹膜内（I.P.）推注和通过局部持续释放从局部施用的水凝胶系统施用时，SOD对大鼠骨盆粘连的影响。
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公开(公告)号：US5741323A
公开(公告)日：1998-04-21
申请号：US477370
申请日：1995-06-07
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： 公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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公开(公告)号：US5651174A
公开(公告)日：1997-07-29
申请号：US429451
申请日：1995-04-27
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A method for making a radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film applied to the cylindrical body such that it extends between the metal elements of the stent. Therapeutic substances may be incorporated within the applied film. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
摘要翻译： 一种用于制造径向扩张的支架用于植入体腔内的方法，所述支架具有开放的近端和远端的具有大致圆柱形的主体，所述圆柱形主体包括多个金属元件，所述多个金属元件连接以允许圆柱体沿着身体的纵向轴线弯曲 由此支架可以符合弯曲体腔和施加到圆柱体的聚合物膜，使得其在支架的金属元件之间延伸。 治疗物质可以并入施加的膜中。 支架提供生物相容的聚合物表面以接触和支撑体腔以及柔性结构，以允许支架紧密地符合体腔内的弯曲。 支架对于修复血管成形术过程中引起的血管损伤特别有用。
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公开(公告)号：US5443496A
公开(公告)日：1995-08-22
申请号：US138041
申请日：1993-10-15
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film extending between the metal elements of the stent. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
摘要翻译： 一种用于植入体腔内的径向可扩张的支架，其具有开放的近端和远端的大致圆柱体，所述圆柱形主体包括多个金属元件，所述多个金属元件连接以允许圆柱形主体沿着身体的纵向轴线弯曲，由此支架可 符合弯曲体腔和在支架的金属元件之间延伸的聚合物膜。 支架提供生物相容的聚合物表面以接触和支撑体腔以及柔性结构，以允许支架紧密地符合体腔内的弯曲。 支架对于修复血管成形术过程中引起的血管损伤特别有用。
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46.发明授权
公开(公告)号：US5001210A
公开(公告)日：1991-03-19
申请号：US416798
申请日：1989-10-03
CPC分类号： C08G18/5045 , C08G18/3831 , C08G18/61 , C08G71/04
摘要： By reacting polyamines with cyclic carbonates, di-poly-(hydroxyalkyl urethanes) are produced. These diols and polyols are particularly useful for the synthesis of polyurethanes by reaction with diisocyanates or polyisocyanates.
摘要翻译： 通过使多胺与环状碳酸酯反应，生成二聚（羟基烷基氨基甲酸酯）。 这些二醇和多元醇特别可用于通过与二异氰酸酯或多异氰酸酯反应来合成聚氨酯。
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47.发明授权Medical electrical lead with polymeric monolithic controlled release device and method of manufacture 失效具有聚合物单片控制释放装置的医用电线和制造方法
公开(公告)号：US4972848A
公开(公告)日：1990-11-27
申请号：US398220
申请日：1989-08-23
申请人： Edward D. Di Domenico , Christopher M. Hobot , Kenneth B. Stokes , Arthur J. Coury , Phong D. Doan , Richard D. Sandstrom
发明人： Edward D. Di Domenico , Christopher M. Hobot , Kenneth B. Stokes , Arthur J. Coury , Phong D. Doan , Richard D. Sandstrom
CPC分类号： A61K9/0024 , A61K9/2031 , A61K9/7007 , A61N1/0568 , A61N1/0573
摘要： A cardiac pacing lead or other stimulation lead carrying a steroid compounded within a polymer matrix. The steroid is dispersed in thermoplastic or thermoset polyurethane or polyurea forming monomers or prepolymers. The mixture is then chain extended by addition of the appropriate difunctional or multifunctional isocyanate, hydroxyl or amine curing agent to form a solid polymer. The resulting formulation is molded or cast into a desired shape, and incorporated in the distal end of a medical electrical lead, adjacent to or within the electrode. In a preferred embodiment, the medical lead employs an extendable helix which is screwed into body tissue, and the polymer containing the drug takes the form of a generally dimensionally stable annular member mounted to the lead, encircling the helix.
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公开(公告)号：US4393125A
公开(公告)日：1983-07-12
申请号：US142662
申请日：1980-04-21
CPC分类号： H01M4/36 , H01M4/06 , Y10T428/24058
摘要： Battery cathodes of the iodine-complex type including one or more additives for improved iodine utilization.
摘要翻译： 包括一种或多种用于改善碘利用的添加剂的碘络合物类型的电池阴极。
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公开(公告)号：US4278745A
公开(公告)日：1981-07-14
申请号：US124082
申请日：1980-02-25
CPC分类号： H01M4/60
摘要： Novel cathode materials for use in electrochemical cells are disclosed. The cathode materials consist essentially of a conductive solution comprised of iodine dissolved in a mixture of two organic pyridine-based constituents, both of which function as donors to form complexes with iodine. Preferably, the cathode materials further include, in addition to the dissolved iodine, an iodine solid phase suspended therein. Large amounts of the iodine solid phase, relative to the dissolved iodine, may be used.
摘要翻译： 公开了用于电化学电池的新型阴极材料。 阴极材料基本上由导电溶液组成，该溶液由溶解在两种有机吡啶基组分的混合物中的碘组成，两者都起到与碘形成络合物的作用。 优选地，除了溶解的碘之外，阴极材料还包括悬浮在其中的碘固相。 可以使用大量的碘固相，相对于溶解的碘。
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