公开(公告)号：US20080264716A1

公开(公告)日：2008-10-30

申请号：US11569884

申请日：2005-06-03

申请人： Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks

发明人： Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks

IPC分类号： G10K11/30

CPC分类号： G10K11/30

摘要： A device comprises an acoustic lens (100) with a variable focal length and means (12) for directing incoming acoustic waves onto the lens. The acoustic lens comprises a curved boundary between two fluid media (1, 2) in which the acoustic waves have different propagation velocities. Means (5, 6, 7) are provided for applying a force directly onto one of the fluid media (1) so as to induce a displacement of the boundary (M1, M2). Such arrangement of the acoustic lens makes it possible to achieve rapid variations in the focal.

摘要翻译： 装置包括具有可变焦距的声透镜（100）和用于将入射的声波引导到透镜上的装置（12）。 声透镜包括两个流体介质（1,2）之间的弯曲边界，其中声波具有不同的传播速度。 提供装置（5,6,7）用于将力直接施加到流体介质（1）中的一个上，以引起边界（M 1，M 2）的位移。 声透镜的这种布置使得可以实现焦点的快速变化。

公开(公告)号：US20080252989A1

公开(公告)日：2008-10-16

申请号：US11569607

申请日：2005-05-18

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

IPC分类号： G02B3/14

CPC分类号： G02B3/14 ,  G02B26/005

摘要： Disclosed is a variable focus lens, having an optical axis, comprising: a fluid chamber, the fluid chamber comprising a first fluid and an axially displaced second fluid, the fluids being non-miscible, in contact over a meniscus and having different indices of refraction; a fluid contact layer arranged on the inside of the chamber wall; a first electrode separated from the first fluid and second electrode by the fluid contact layer; a second electrode acting on the second fluid; the fluid contact layer having a wettability by the second fluid which varies under the application of a voltage between the first electrode and the second electrode, such that the shape of the meniscus varies in dependence on said voltage; wherein the fluid chamber is shaped such that an angle formed between the wall of the chamber and the optical axis decreases along the length of the optical axis.

摘要翻译： 公开了一种具有光轴的可变焦距透镜，包括：流体室，所述流体室包括第一流体和轴向移动的第二流体，所述流体不可混溶，在弯液面上接触并具有不同的折射率 ; 布置在室壁内侧的流体接触层; 通过流体接触层与第一流体和第二电极分离的第一电极; 作用在第二流体上的第二电极; 所述流体接触层具有在所述第一电极和所述第二电极之间的电压施加下变化的所述第二流体的润湿性，使得所述弯液面的形状根据所述电压而变化; 其中所述流体室被成形为使得在所述室的壁和所述光轴之间形成的角度沿着所述光轴的长度减小。

公开(公告)号：US20080247019A1

公开(公告)日：2008-10-09

申请号：US10599347

申请日：2005-03-21

申请人： Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Marco Andreas Jacobus Van As ,  Gerard Eduard Van Rosmalen

发明人： Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Marco Andreas Jacobus Van As ,  Gerard Eduard Van Rosmalen

IPC分类号： G02B26/08

CPC分类号： G02B3/14 ,  G02B5/1828 ,  G02B26/005 ,  G02B26/0808

摘要： A switchable optical unit, capable of controlling a beam of radiation (b) passing through an optically active portion (8) of the unit, comprises a fluid chamber (10) including an electrically conductive liquid (18), which chamber comprises at least one first electrode (20,22) fixed to the chamber inner walls (12,14) at the position of the optically active portion and second electrode means (24) fixed to inner walls of the chamber outside the optically active portion and a third electrode (28) connected to the conductive liquid. By applying a voltage (V) to the at least one first electrode and the second electrode means, respectively the conductive liquid can be moved in and out the optically active portion so that the unit (1) is switched between a least two discrete states.

摘要翻译： 能够控制通过该单元的光学活性部分（8）的辐射束（b）的可切换光学单元包括包括导电液体（18）的流体室（10），该腔室包括至少一个 在光学活性部分的位置处固定到腔室内壁（12,14）的第一电极（20,22）和固定到光学活性部分外部的室内壁的第二电极装置（24）和第三电极 28）连接到导电液体。 通过分别将电压（V）施加到至少一个第一电极和第二电极装置，导电液体可以移入和移出光学有效部分，使得单元（1）在至少两个离散状态之间切换。

公开(公告)号：US07230771B2

公开(公告)日：2007-06-12

申请号：US10531975

申请日：2003-10-17

申请人： Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rudolph Maria Snoeren ,  Willem Gerard Ophey

发明人： Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rudolph Maria Snoeren ,  Willem Gerard Ophey

IPC分类号： G02B1/06 ,  G02B15/14

CPC分类号： G02B26/005 ,  G02B3/14 ,  G02B15/00

摘要： A zoom lens comprising, from the object side to the image side, a front lens group (72), a controllable lens group, and a rear lens group (74), the controllable lens group comprising a voltage-controlled electrowetting device, which device contains a first fluid (A) and a second fluid (B) having different refractive indices, with at least two first fluid-second fluid interfaces (40,42). The curvatures, and thus the lens power, of these interfaces can be changed independently by supplying a voltage (V1, V2) to electrodes (22,32) of the device, so that no mechanical movement of lens elements is needed.

摘要翻译： 一种变焦透镜，包括从物体侧到像侧的前透镜组（72），可控透镜组和后透镜组（74），所述可控透镜组包括电压控制的电润湿装置，所述装置 包含具有不同折射率的第一流体（A）和第二流体（B），以及至少两个第一流体 - 第二流体界面（40,42）。 通过向装置的电极（22,32）提供电压（V 1，V 2），可以独立地改变这些界面的曲率以及因此的透镜功率，使得不需要透镜元件的机械运动。

公开(公告)号：US09733466B2

公开(公告)日：2017-08-15

申请号：US12593298

申请日：2008-03-31

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

IPC分类号： G02B23/24 ,  G02B26/10 ,  A61B5/00 ,  A61B10/00 ,  A61B17/00 ,  G02B3/00 ,  A61B90/20 ,  G02B3/10 ,  G02B3/02 ,  A61B90/00

CPC分类号： G02B23/243 ,  A61B5/0068 ,  A61B5/0084 ,  A61B10/00 ,  A61B90/20 ,  A61B90/361 ,  A61B2017/00061 ,  A61B2090/3616 ,  G02B3/0081 ,  G02B3/02 ,  G02B3/10 ,  G02B26/10 ,  G02B26/103

摘要： An objective lens system for an optical biopsy device has a lens that comprises a first part configured for viewing at a first magnification, and a second part configured for viewing at a second magnification. The second magnification is substantially different from the first magnification. The first magnification enables viewing a larger area of a target and the second magnification enables viewing the target at a cellular level with high sensitivity and specificity. Combining viewing at two different magnifications in a single objective lens results in a compact optical biopsy device.

公开(公告)号：US07982963B2

公开(公告)日：2011-07-19

申请号：US12405639

申请日：2009-03-17

申请人： Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks

发明人： Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks

IPC分类号： G02B1/06

CPC分类号： G02B26/005 ,  G02B3/14

摘要： The present invention discloses an optical device comprising a container enclosing an insulating liquid (A) and a liquid responsive to an electric field (B), the insulating liquid (A) and the liquid responsive to an electric field (B) being immiscible and being in contact with each other via an interface (14), at least one of the liquids (A; B) being at least partially placed in a light path through the container. The optical device further comprises an electrode arrangement (2; 12) for controlling the shape of the interface (14) by means of a voltage; and means (100) for preventing the interface from an exposure to an external electric field. Consequently, the build-up of electrostatic charge on a surface of the optical device is avoided, which prevents the unwanted distortion of the interface (14) caused by the interaction of the liquid responsive to an electric field (B) and the electrostatic charge.

摘要翻译： 本发明公开了一种光学装置，其包括容纳绝缘液体（A）的容器和响应于电场（B）的液体，所述绝缘液体（A）和响应于电场（B）的液体不混溶， 通过接口（14）彼此接触，至少一个液体（A; B）至少部分地放置在通过容器的光路中。 光学装置还包括用于通过电压控制接口（14）的形状的电极装置（2; 12） 以及用于防止接口暴露于外部电场的装置（100）。 因此，避免了在光学器件的表面上积聚静电电荷，这防止了由于响应于电场（B）的液体与静电电荷的相互作用而引起的界面（14）的不期望的失真。

公开(公告)号：US07957219B2

公开(公告)日：2011-06-07

申请号：US12297902

申请日：2007-04-27

申请人： Christopher S. Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

发明人： Christopher S. Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

IPC分类号： G03B42/06

CPC分类号： G10K11/30

摘要： An acoustic probe includes an acoustic transducer having acoustic transducer elements arranged in a one-dimensional array; and a variably-refracting acoustic lens coupled to the acoustic transducer. The variably-refracting acoustic lens has a pair of electrodes configured to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.

摘要翻译： 声探头包括具有以一维阵列布置的声换能器元件的声换能器; 以及耦合到声换能器的可变折射声透镜。 可变折射声透镜具有一对电极，其被配置为响应于跨过电极施加的选定电压来调节可变折射声透镜的焦点。 在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质和一对电极。 第一流体介质中声波的声速不同于第二流体介质中声波的声速。 第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

公开(公告)号：US20100277809A1

公开(公告)日：2010-11-04

申请号：US12811831

申请日：2009-01-12

申请人： Jan Frederik Suijver ,  Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Szabolcs Deladi ,  Antonius Johannes Josephus Rademakers ,  Cornelius Antonius Micolaas Maria Van Der Vleuten ,  Johannes Wilhelmus Weekamp ,  Waltherus Cornelis Jozef Bierhoff

发明人： Jan Frederik Suijver ,  Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Szabolcs Deladi ,  Antonius Johannes Josephus Rademakers ,  Cornelius Antonius Micolaas Maria Van Der Vleuten ,  Johannes Wilhelmus Weekamp ,  Waltherus Cornelis Jozef Bierhoff

IPC分类号： G02B3/14 ,  A61B1/06

CPC分类号： G02B7/008 ,  A61B1/0019 ,  G02B3/14 ,  G02B23/2407

摘要： Fluid lens system, e.g. for medical imaging or medical treatment, with a container enclosing a fluid arranged to refract incoming waves. A pressure release mechanism is in contact with the fluid so as to compensate changes in its volume due to thermal variations, e.g. during high temperature medical cleaning. This pressure release mechanism is positioned within a pathway of incoming waves. In preferred embodiments a fluid container connected via a tube to the fluid as a reservoir, is arranged within or outside the container, e.g. beyond an image sensor. Alternatively, an easily compressible body, e.g. a small closed metal bellows enclosing a gas, is positioned inside the fluid to absorb volume changes by compression. In both embodiments, the pressure release elements are preferably positioned in a peripheral part of the pathway of incoming waves to not affect performance of the lens. In another aspect, a fluid lens includes a container with an inner container part that fits inside an outer container part, wherein the inner container part is in rigid connection to at least a one boundary arranged for penetration of incoming waves. The pressure release mechanism is positioned within the outer container part, and it is in contact with the fluid so as to compensate changes in volume of the fluid due to thermal variations. In one embodiment the inner and outer container parts are arranged for relative one-dimensional movement and fluid tight interconnected. In another embodiment, a fluid filled cavity is formed between the inner and outer container parts, and this cavity houses a compressible body. The lens systems are suited for applications such as medical endoscopes, catheters and needles, optically as well as acoustically based.

摘要翻译： 流体透镜系统，例如 用于医疗成像或医疗处理，容器包围布置成折射入射波的流体。 压力释放机构与流体接触，以便补偿由于热变化引起的体积变化，例如， 在高温医疗清洗过程中。 该压力释放机构位于入射波的通路内。 在优选实施例中，经由管连接到作为储存器的流体的流体容器设置在容器内或外部，例如， 超越图像传感器。 或者，容易压缩的主体，例如， 围绕气体的小封闭金属波纹管位于流体内部以通过压缩吸收体积变化。 在两个实施例中，压力释放元件优选地定位在入射波通路的周边部分中，从而不影响透镜的性能。 在另一方面，一种流体透镜包括具有内部容器部分的容器，该内部容器部分装配在外部容器部分内部，其中内部容器部分刚好连接至布置成用于穿透入射波的至少一个边界。 压力释放机构定位在外部容器部分内，并且与流体接触，以补偿由于热变化引起的流体体积的变化。 在一个实施例中，内部和外部容器部件布置用于相对一维运动并且流体密封互连。 在另一个实施例中，在内部和外部容器部分之间形成流体填充空腔，并且该空腔容纳可压缩体。 透镜系统适用于诸如医用内窥镜，导管和针的应用，光学和声学基础。

公开(公告)号：US20090197272A1

公开(公告)日：2009-08-06

申请号：US12305399

申请日：2007-05-14

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Erik Robbert Vossenaar ,  Gerhard Spekowius ,  Nijs Cornelis Van Der Vaart ,  Stein Kuiper

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Erik Robbert Vossenaar ,  Gerhard Spekowius ,  Nijs Cornelis Van Der Vaart ,  Stein Kuiper

IPC分类号： C12Q1/68

CPC分类号： G01N33/582 ,  C12Q1/68 ,  G01N15/147 ,  G01N21/33 ,  G01N33/5035 ,  G01N33/5076 ,  G01N33/5308 ,  G01N33/574 ,  G06K9/00134 ,  G06T7/0012 ,  G06T7/41 ,  G06T2207/10056 ,  G06T2207/30024 ,  C12Q2523/313

摘要： The invention relates to a method of determining in vitro the amount of nuclear DNA within a human or animal cell using UV absorption measurement with UV light. The invention also relates to a method for detecting in vitro cancerous cells in a biological sample relying on the aforementioned principles. The invention also relates to an in vitro method of diagnosing or predicting the likely occurrence of cancer in a human or animal subject.

摘要翻译： 本发明涉及使用UV光的紫外吸收测量体外测定人或动物细胞内核DNA的量的方法。 本发明还涉及一种用于根据上述原理检测生物样品中的体外癌细胞的方法。 本发明还涉及诊断或预测人或动物受试者中癌症可能发生的体外方法。

公开(公告)号：US20090122639A1

公开(公告)日：2009-05-14

申请号：US12297902

申请日：2007-04-27

申请人： Christopher Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

发明人： Christopher Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

IPC分类号： G03B42/06

CPC分类号： G10K11/30

摘要： An acoustic probe (100) includes an acoustic transducer (20) including a plurality of acoustic transducer elements arranged in a one-dimensional array; and a variably- refracting acoustic lens (10) coupled to the acoustic transducer. The variably-refracting acoustic lens has at least a pair of electrodes (150, 160) adapted to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.

摘要翻译： 声探针（100）包括声换能器（20），其包括以一维阵列排列的多个声换能器元件; 以及耦合到声换能器的可变折射声透镜（10）。 可变折射声透镜具有至少一对电极（150,160），其适于响应于施加在电极上的选定电压来调节可变折射声透镜的焦点。 在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。 第一流体介质中声波的声速不同于第二流体介质中声波的声速。 第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。