摘要:
Compounds of Formula (I): Wherein: R1 and R2 are independently selected from the group consisting of optionally substituted C1-C20 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted aromatic, and optionally substituted heteroaromatic groups or R1 and R2 together with the nitrogen atom to which they are attached comprise an optionally substituted saturated or unsaturated ring which may optionally contain further heteroatoms selected from the group consisting of O, N and S, and may optionally be further fused to one or more other rings; Ar is selected from the group consisting of optionally substituted aromatic and optionally substituted heteroaromatic groups; L is a linker which is a direct bond or is selected from the group consisting of optionally substituted C2 alkenylene and optionally substituted C2 alkynylene; T is independently selected from the group consisting of: R3, R4 and R9 are independently selected from the group consisting of hydrogen, optionally substituted C1-C10 alkyl, optionally substituted C3-C8 cycloalkyl and optionally substituted C1-C10 alkoxy groups, or a pair of groups selected from R3, R4 and R9 may together with the carbon atoms to which they are attached comprise an optionally substituted saturated or unsaturated ring which may optionally contain one or more heteroatoms selected from the group consisting of O, N and S, and may optionally be further fused to one or more other rings; R5 is selected from the group consisting of hydrogen, optionally substituted C1-C8 alkyl, optionally substituted C3-C8 cycloalkyl, and optionally substituted aromatic groups; R6 is selected from the group consisting of optionally substituted C1-C8 alkyl, optionally substituted C1-C8 perfluorinated alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted aromatic, and optionally substituted heteroaromatic groups; R7 is selected from the group consisting of optionally substituted C1-C30 alkyl wherein one or more carbon atoms of the alkyl are optionally replaced with one or more of O, S, NR8, carbonyl or thiocarbonyl; optionally substituted C3-C8 cycloalkyl; optionally substituted C2-C12 alkenyl wherein one or more carbon atoms of the alkenyl are optionally replaced with one or more of O, S, NR8, carbonyl or thiocarbonyl; optionally substituted C2-C8 alkynyl wherein one or more carbon atoms of the alkynyl are optionally replaced with one or more of O, S, NR8, carbonyl or thiocarbonyl; optionally substituted C3-C12alkoxy; optionally substituted aromatic; and optionally substituted heteroaromatic groups; wherein R8 is hydrogen or R6, and n is an integer of 1 to 10. The compounds are capable of charge transportation and have application in organic photovoltaic devices such as dye sensitised solar cells.
摘要:
The present invention relates to pyrazinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要:
Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, IL6, MMP1, RANTES, MMP9, IL1B, Apolipoprotein A1, Apolipoprotein E, DCN, CILP and COMP. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.
摘要:
A multi-layer laminate media is provided on which information may be applied in machine or human readable form on a visible front surface by the output of one or more lasers, or other high intensity light source. In a preferred embodiment, the media has three layers including preferably transparent substrate, a thermochromic layer and a light absorbent layer located intermediate the media substrate and the thermochromic layer. The light absorbent layer is adapted to absorb light from the light source and convert the absorbed light into heat. The heat is immediately conducted into selected portions of the thermochromic layer which is in thermal contact with the light absorbent layer, causing portions of the thermochromic layer to change visual appearance such as color to create the desired mark. The media optimally includes obscuration materials to reduce the visibility of the light absorbent layer to the naked eye. The light absorbent layer absorbs light in the NIR and visible light wavelength ranges of light and is preferably a low cost absorber such as carbon black. The invention also includes a manually operated produce labeling system utilizing the multi-layer laminate media. A rewinder is also provided which utilizes the multi-layer laminate media.
摘要:
The present invention relates to a controllable polymeric surface coating including a macromolecule, which is covalently bound to the surface of a substrate, the macromolecule including a plurality of polymerisation initiators and a plurality of surface binding groups; and pendant polymers grafted from at least some of the polymerisation initiators.
摘要:
The invention relates to a photochromic polymeric composition comprising a polymer matrix and a photochromic compound which is an adduct comprising a photochromic moiety and at least one pendant oligomer group to provide a rate of fade of the photochromic polymeric composition which is significantly changed when compared with the corresponding composition comprising the photochromic compound without said pendent oligomer. The invention also relates to a photochromic compound which is an adduct comprising a photochromic moiety and at least one pendent oligomer.
摘要:
The invention provides compounds of formula (I) wherein: T is C(O) or S(O)2; W is C(O) or S(O)2; X is CH2, O or NH; Y is CR11 or N; n is 0, 1 or 2; m is 1 or, when Y is CR11 m is 0; R1 is optionally substituted aryl or optionally substituted heterocyclyl; R2, R3, R,4, R5, R6, R7 and R8 are, independently, hydrogen or C?1-6#191 alkyl; R9 is hydrogen or C1-C6 alkyl; R10 is alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; and R11 is hydrogen or C1-C6 allkyl; that are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.
摘要翻译:本发明提供式(I)化合物,其中:T为C(O)或S(O)2; W是C(O)或S(O)2。 X是CH 2,O或NH; Y是CR 11或N; n为0,1或2; m为1或Y为CR 11时m为0; R 1是任选取代的芳基或任选取代的杂环基; R 2,R 3,R 3,R 5,R 5,R 6, R 7和R 8分别独立地为氢或C 1-6烷基; R 9是氢或C 1 -C 6烷基; R 9是氢或C 1 -C 6烷基; R 10是烷基,任选取代的芳基,任选取代的芳烷基或任选取代的杂环基; 并且R 11是氢或C 1 -C 6烷基; 它们是趋化因子(特别是CCR3)活性的调节剂,特别适用于治疗哮喘和/或鼻炎。
摘要:
A multi-layer laminate media is provided on which information may be applied in machine or human readable form on a visible front surface by the output of one or more lasers, or other high intensity light source. In a preferred embodiment, the media has three layers including a substrate, a thermochromic layer and a light absorbent layer located intermediate the media substrate and the thermochromic layer. The light absorbent layer is adapted to absorb light from the light source and convert the absorbed light into heat. The heat is immediately conducted into selected portions of the thermochromic layer which is in thermal contact with the light absorbent layer, causing portions of the thermochromic layer to change visual appearance such as color to create the desired mark. The media optimally includes obscuration materials to reduce the visibility of the light absorbent layer to the naked eye. The light absorbent layer is preferably a low cost absorber such as carbon black. An alternate form of the invention is a two layer laminate media including a substrate and a thermochromic layer. The invention is usable in conjunction with labeling produce items. The invention includes a method and apparatus for using media in conjunction with labeling produce items.
摘要:
A layered material includes a ply material and a backing film to support the ply material. The backing film includes a polyester film. The layered material is generated by disposing the backing film upon the ply material. A composite layup is generated by tacking the layered material to a tool, disposing the layered material upon the tool along a path, and removing the backing film.
摘要:
The Video Motion Anomaly Detector addresses the problem of automatically detecting events of interest to operators of CCTV systems used in security, transport and other applications, processing CCTV images. The detector may be used in a number of ways, for example to raise an alarm, summoning a human operator to view video data, or to trigger selective recording of video data or to insert an index mark in recordings of video data.