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公开(公告)号:US07807679B2
公开(公告)日:2010-10-05
申请号:US11569006
申请日:2005-05-12
申请人: Jérôme Cassayre , Peter Maienfisch , Fredrik Cederbaum , Louis-Pierre Molleyres , Camilla Corsi , Thomas Pitterna
发明人: Jérôme Cassayre , Peter Maienfisch , Fredrik Cederbaum , Louis-Pierre Molleyres , Camilla Corsi , Thomas Pitterna
IPC分类号: A01N43/60 , C07D401/00
摘要: The use of a compound of formula (I) wherein Y is a single bond, C═O, C═S or S(O)m where m is 0, 1 or 2; the ring is a 6-membered aromatic or is a 5 or 6 membered heteroaromatic ring; Ra, R1, R2, R4 and R8 are specified organic groups; n and p are independently 0-4; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs. Novel compounds are also provided.
摘要翻译: 使用其中Y为单键的式(I)化合物,其中m为0,1或2的C = O,C = S或S(O)m) 环是6元芳族或是5或6元杂芳环; Ra,R1,R2,R4和R8是指定的有机基团; n和p独立地为0-4; 或其盐或N-氧化物或含有它们的组合物来控制昆虫,螨类,线虫或软体动物。 还提供了新的化合物。
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公开(公告)号:US07737301B2
公开(公告)日:2010-06-15
申请号:US12065304
申请日:2006-08-28
申请人: Harald Walter , Camilla Corsi , Josef Ehrenfreund , Hans Tobler
发明人: Harald Walter , Camilla Corsi , Josef Ehrenfreund , Hans Tobler
IPC分类号: C07C209/62 , C07C209/10 , C07C211/45 , C07C211/48
CPC分类号: C07C209/10 , C07C209/62 , C07C2601/02 , C07C211/45 , C07C211/48
摘要: The present invention relates to a process for the preparation of compounds of formula wherein R1, R2 and R3 are each independently of the others hydrogen or C1-C4alkyl, by a) reacting compounds of formula (II) wherein R1, R2 and R3 are as defined for formula (I) and X is bromine or chlorine, with a compound of formula (III) wherein R4 is hydrogen or C1-C4alkyl, in the presence of a base and catalytic amounts of at least one palladium complex compound, to form compounds of formula (IV) wherein R1, R2, R3 and R4 are as defined for formula (I), and b) converting those compounds, using a reducing agent, into compounds of formula (I).
摘要翻译: 本发明涉及制备下式化合物的方法,其中R 1,R 2和R 3各自独立地为氢或C 1 -C 4烷基,通过a)使式(Ⅱ)化合物(其中R 1,R 2和R 3为 与式(Ⅲ)化合物(其中R 4是氢或C 1 -C 4烷基)在碱和催化量的至少一种钯络合物的存在下形成化合物(I),X是溴或氯, 其中R 1,R 2,R 3和R 4如式(I)所定义,并且b)使用还原剂将这些化合物转化为式(I)化合物。
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公开(公告)号:US07732469B2
公开(公告)日:2010-06-08
申请号:US12091189
申请日:2006-10-23
申请人: Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi
发明人: Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi
IPC分类号: A01N43/78 , C07D277/56 , C07C205/11 , A01P1/00
CPC分类号: C07C205/06 , A01N43/32 , A01N43/36 , A01N43/40 , A01N43/56 , A01N43/647 , A01N43/76 , A01N43/78 , C07C205/11 , C07C205/12 , C07C205/37 , C07C205/45 , C07C211/61 , C07C2603/66 , C07D207/34 , C07D207/46 , C07D213/89 , C07D231/14 , C07D249/04 , C07D263/34 , C07D277/56 , C07D327/06
摘要: The invention relates to a fungicidally active compound of formula (I): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by the groups R6, R7 and R8; R1 is hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, CH2 C≡CR9, CH2 CR10═CHR11, CH═C═CH2 or COR12; R2 and R3 are each, independently, hydrogen, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl or C1-4 haloalkoxy; R4 and R5 are each independently selected from halo, cyano and nitro; or one of R4 and R5 is hydrogen and the other is selected from halo, cyano and nitro; R6, R7 and R8 are each, independently, hydrogen, halo, cyano, nitro, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy(C1-4)alkyl, C1-4 haloalkoxy(C1-4)alkyl or C1-4 haloalkoxy, provided that at least one of R6, R7 and R8 is not hydrogen; R9, R10 and R11 are each, independently, hydrogen, halo, C1-4 alkyl, C1-4 haloalkyl or C1-4 alkoxy(C1-4)alkyl; and R12 is hydrogen, C1-6 alkyl, C1-6 haloalkyl, C1-4 alkoxy(C1-4)alkyl, C1-4 alkylthio(C1-4)-alkyl, C1-4 alkoxy or aryl; to the preparation of these compounds, to novel intermediates used in the preparation of these compounds, to agrochemical compositions which comprise at least one of the novel compounds as active ingredient, to the preparation of the compositions mentioned and to the use of the active ingredients or compositions in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.
摘要翻译: 本发明涉及式(I)的杀真菌活性化合物:其中Het是含有一至三个杂原子的5-或6-元杂环,各自独立地选自氧,氮和硫,该环被R6基团取代 ,R7和R8; R 1是氢,C 1-4烷基,C 1-4卤代烷基,C 1-4烷氧基,C 1-4卤代烷氧基,CH 2C≡CR9,CH 2 CR 10 = CHR 11,CH = C = CH 2或COR 12; R 2和R 3各自独立地为氢,卤素,C 1-4烷基,C 1-4烷氧基,C 1-4卤代烷基或C 1-4卤代烷氧基; R4和R5各自独立地选自卤素,氰基和硝基; 或者R4和R5之一是氢,另一个选自卤素,氰基和硝基; R 6,R 7和R 8各自独立地为氢,卤素,氰基,硝基,C 1-4烷基,C 1-4卤代烷基,C 1-4烷氧基(C 1-4)烷基,C 1-4卤代烷氧基(C 1-4)烷基或 C 1-4卤代烷氧基,条件是R 6,R 7和R 8中的至少一个不是氢; R 9,R 10和R 11各自独立地为氢,卤素,C 1-4烷基,C 1-4卤代烷基或C 1-4烷氧基(C 1-4)烷基; 和R 12是氢,C 1-6烷基,C 1-6卤代烷基,C 1-4烷氧基(C 1-4)烷基,C 1-4烷硫基(C 1-4) - 烷基,C 1-4烷氧基或芳基; 涉及这些化合物的制备,用于制备这些化合物的新型中间体,包括至少一种新化合物作为活性成分的农用化学组合物,所述组合物的制备以及使用活性成分或 用于通过植物病原微生物,优选真菌控制或预防植物感染的农业或园艺成分。
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公开(公告)号:US20080262242A1
公开(公告)日:2008-10-23
申请号:US12093619
申请日:2006-11-13
申请人: Harald Walter , Camilla Corsi , Josef Ehrenfreund , Hans Tobler
发明人: Harald Walter , Camilla Corsi , Josef Ehrenfreund , Hans Tobler
IPC分类号: C07D231/14
CPC分类号: C07D231/14
摘要: The present invention relates to a novel process for the preparation of a compound of general formula (I): wherein R1 is H or C1-4 alkyl and R2 is difluoromethyl or trifluoromethyl, which comprises reacting a compound of general formula (II): wherein R1 has the meaning given above and X is chloro or bromo, with a compound of general formula (III): wherein R2 has the meaning given above, in the presence of a base, a palladium catalyst and a ferrocenyl biphoshine ligand of the Josiphos type, the reaction being carried out in an ether solvent at a reflux temperature of at least 100° C.
摘要翻译: 本发明涉及一种制备通式(I)化合物的新方法:其中R 1是H或C 1-4烷基,R SUP 其中R 2是二氟甲基或三氟甲基,其包括使通式(II)的化合物:其中R 1具有上面给出的含义和X是氯或溴的化合物与通式 式(III):其中R 2具有上面给出的含义,在Josiphos型的碱,钯催化剂和二茂铁基二膦配体的存在下,该反应在醚溶剂中进行 在至少100℃的回流温度下
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公开(公告)号:US20080076777A1
公开(公告)日:2008-03-27
申请号:US11569006
申请日:2005-05-12
申请人: Jerome Cassayre , Peter Maienfisch , Fredrik Cederbaum , Louis-Pierre Molleyres , Camilla Corsi , Thomas Pitterna
发明人: Jerome Cassayre , Peter Maienfisch , Fredrik Cederbaum , Louis-Pierre Molleyres , Camilla Corsi , Thomas Pitterna
IPC分类号: A01N43/60 , C07D401/00
摘要: The use of a compound of formula (I) wherein Y is a single bond, C═O, C═S or S(O)m where m is 0, 1 or 2; the ring is a 6-membered aromatic or is a 5 or 6 membered heteroaromatic ring; Ra, R1, R2, R4 and R8 are specified organic groups; n and p are independently 0-4; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs. Novel compounds are also provided.
摘要翻译: 使用其中Y为单键的式(I)化合物,其中m为0,1或2的C-O,C-S或S(O)m) 环是6元芳族或是5或6元杂芳环; R 1,R 1,R 2,R 4和R 8是指定的有机基团; n和p独立地为0-4; 或其盐或N-氧化物或含有它们的组合物来控制昆虫,螨类,线虫或软体动物。 还提供了新的化合物。
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公开(公告)号:US08796274B2
公开(公告)日:2014-08-05
申请号:US12882540
申请日:2010-09-15
申请人: Jerome Cassayre , Louis-Pierre Molleyres , Peter Maienfisch , Fredrik Cederbaum , Camilla Corsi , Thomas Pitterna
发明人: Jerome Cassayre , Louis-Pierre Molleyres , Peter Maienfisch , Fredrik Cederbaum , Camilla Corsi , Thomas Pitterna
IPC分类号: A01N43/60 , C07D401/00
摘要: The use of a compound of formula I wherein Y is a single bond, C═O, C═S or S(O)m where m is 0, 1 or 2; the ring is a 6-membered aromatic or is a 5 or 6 membered heteroaromatic ring; Ra, R1, R2, R4 and R8 are specified organic groups; n and p are independently 0-4; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs. Novel compounds are also provided.
摘要翻译: 使用其中Y为单键的式I化合物,其中m为0,1或2的C = O,C = S或S(O)m) 环是6元芳族或是5或6元杂芳环; Ra,R1,R2,R4和R8是指定的有机基团; n和p独立地为0-4; 或其盐或N-氧化物或含有它们的组合物来控制昆虫,螨类,线虫或软体动物。 还提供了新的化合物。
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公开(公告)号:US08586593B2
公开(公告)日:2013-11-19
申请号:US13382688
申请日:2010-06-07
IPC分类号: C07D401/14 , A01N43/54
CPC分类号: C07D401/14 , A01N43/54
摘要: A compound of formula (I) wherein A, p, R1, R3, R4, R5, and R8 are as defined in claim 1. Furthermore, the present invention relates to intermediates used to prepare compounds of formula (I), to methods of using them to combat and control insect, acarine, nematode and mollusc pests and to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising them.
摘要翻译: 其中A,p,R 1,R 3,R 4,R 5和R 8如权利要求1中所定义的式(I)化合物。此外,本发明涉及用于制备式(I)化合物的中间体, 使用它们来对抗和控制昆虫,螨虫,线虫和软体动物害虫以及包含它们的杀虫,杀螨,杀线虫和杀软体动物的组合物。
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公开(公告)号:US08518971B2
公开(公告)日:2013-08-27
申请号:US13055204
申请日:2009-07-06
IPC分类号: A01N43/40 , C07D401/12
CPC分类号: A01N43/40 , C07D401/12 , C07D401/14
摘要: A compound of formula (I): wherein A, p, R1, R3, R4, R5, R6, m, R7, n and R8 are as defined in claim 1. Furthermore, the present invention relates to intermediates used to prepare compounds of formula (I), to methods of using them to combat and control insect, acarine, nematode and mollusc pests and to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising them.
摘要翻译: 式(I)化合物:其中A,p,R1,R3,R4,R5,R6,m,R7,n和R8如权利要求1中所定义。此外,本发明涉及用于制备 式(I)表示使用它们来对抗和控制昆虫,螨虫,线虫和软体动物害虫以及包含它们的杀虫,杀螨,杀线虫和杀软体动物的组合物的方法。
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公开(公告)号:US08436037B2
公开(公告)日:2013-05-07
申请号:US13198739
申请日:2011-08-05
申请人: Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi , Fanny Giordano , Martin Zeller , Gottfried Seifert , Shailesh Shah , Neil George , Ian Jones , Paul Bonnett
发明人: Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi , Fanny Giordano , Martin Zeller , Gottfried Seifert , Shailesh Shah , Neil George , Ian Jones , Paul Bonnett
IPC分类号: A01N43/56 , C07D231/14
CPC分类号: C07C211/61 , A01N43/56 , C07C205/06 , C07C209/325 , C07C209/70 , C07C2603/66 , C07D231/14
摘要: The present invention relates to a process for the preparation of compounds of formula I wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula II wherein R1 and R2 are as defined for formula I, with at least one reducing agent to form a compound of formula III wherein R1 and R2 are as defined for formula I, and b) reaction of that compound with at least one reducing agent to form a compound of formula IV wherein R1 and R2 are as defined for formula I, and (c) reaction of that compound with a compound of formula V wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula I, to form the compound of formula I; and to novel intermediates for use in that process.
摘要翻译: 本发明涉及一种制备式Ⅰ化合物的方法,其中R1和R2分别独立地为氢或C1-C5烷基,R3为CF3或CF2H,通过a)式II化合物与式 R 2如式I所定义,与至少一种还原剂形成式III化合物,其中R 1和R 2如式I所定义,和b)该化合物与至少一种还原剂的反应形成式 式IV其中R1和R2如式I所定义,和(c)该化合物与式V化合物的反应,其中Q是氯,氟,溴,碘,羟基或C 1 -C 6烷氧基,R 3如式 I,形成式I化合物; 以及用于该过程的新型中间体。
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公开(公告)号:US20110301031A1
公开(公告)日:2011-12-08
申请号:US13133754
申请日:2009-12-09
申请人: Michel Muehlebach , Thomas Pitterna , Jérôme Yves Cassayre , Andrew Edmunds , Camilla Corsi , Myriem El Qacemi , Roger Graham Hall , André Jeanguenat , André Stoller , Christopher Richard Ayles Godfrey , Jürgen Harry Schaetzer , Olivier Loiseleur , Peter Maienfisch , Neil Brian Carter
发明人: Michel Muehlebach , Thomas Pitterna , Jérôme Yves Cassayre , Andrew Edmunds , Camilla Corsi , Myriem El Qacemi , Roger Graham Hall , André Jeanguenat , André Stoller , Christopher Richard Ayles Godfrey , Jürgen Harry Schaetzer , Olivier Loiseleur , Peter Maienfisch , Neil Brian Carter
IPC分类号: A01N25/32 , C07D211/32 , A61K31/438 , A61K31/445 , A01N43/40 , A01P3/00 , A01P13/00 , A01P1/00 , A01P9/00 , A01P7/04 , A01P5/00 , C07D471/10 , A01N57/00
CPC分类号: C07D471/10 , A01N43/90 , A01N47/06 , C07D211/94 , C07D405/12
摘要: A compound of the formula (I), wherein the substituents are as defined in claim 1, are useful as a pesticides.
摘要翻译: 式(I)的化合物,其中取代基如权利要求1中所定义,可用作农药。
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