公开(公告)号：US20080215112A1

公开(公告)日：2008-09-04

申请号：US11834638

申请日：2007-08-06

申请人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

发明人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

IPC分类号： A61N1/05

CPC分类号： A61N1/375 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

公开(公告)号：US20080161880A1

公开(公告)日：2008-07-03

申请号：US11834642

申请日：2007-08-06

申请人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

发明人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

IPC分类号： A61N1/362

CPC分类号： A61N1/375 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

公开(公告)号：US20080161879A1

公开(公告)日：2008-07-03

申请号：US11834621

申请日：2007-08-06

申请人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

发明人： Andrew D. Firlik ,  Jeffrey Balzer ,  Bradford Evan Gliner ,  Alan J. Levy ,  Carlton B. Morgan ,  Katrina S. Firlik

IPC分类号： A61B1/05

CPC分类号： A61N1/375 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

公开(公告)号：US06662056B2

公开(公告)日：2003-12-09

申请号：US09852431

申请日：2001-05-09

申请人： Anthony G. Picardo ,  Christine Janae ,  Thomas Solosko ,  Steven T. Mydynski ,  Ian G. MacDuff ,  Jon M. Bishay ,  Kent W. Leyde ,  Carlton B. Morgan

发明人： Anthony G. Picardo ,  Christine Janae ,  Thomas Solosko ,  Steven T. Mydynski ,  Ian G. MacDuff ,  Jon M. Bishay ,  Kent W. Leyde ,  Carlton B. Morgan

IPC分类号： A61N104

CPC分类号： A61N1/0472 ,  A61N1/046 ,  A61N1/048 ,  A61N1/0492 ,  A61N1/39 ,  A61N2001/37294

摘要： A cartridge is provided for storing one or more electrode pads such as a defibrillator electrode pad. The cartridge includes a housing having a rigid portion, a storage space disposed within the housing, and a storage-space opening that allows one to remove/insert the electrode pad or pads from/into the storage space. Because it has a housing with a rigid portion, such a cartridge can better protect one or more electrode pads from handling damage. Furthermore, one can construct the cartridge such that it is attachable to a medical device such as an AED. This allows an operator to carry or store the medical device, cartridge, and one or more electrode pads as a single unit. In addition, one can construct the cartridge such that the one or more electrode pads can be pre-connected to the medical device. This can eliminate connecting the one or more electrode pads to the medical device during an emergency.

摘要翻译： 提供了用于存储一个或多个电极焊盘（例如除颤器电极焊盘）的盒。 盒包括具有刚性部分的壳体，设置在壳体内的存储空间，以及允许将电极垫或垫从存储空间中移出/插入的存储空间开口。 因为它具有刚性部分的壳体，所以这种盒可以更好地保护一个或多个电极垫不受处理损坏。 此外，可以构造盒，使得其可附接到诸如AED的医疗装置。 这允许操作者将医疗装置，药筒和一个或多个电极垫作为单个装置携带或储存。 此外，可以构造盒，使得一个或多个电极垫可以预先连接到医疗装置。 这可以在紧急情况期间消除将一个或多个电极焊盘连接到医疗装置。

公开(公告)号：US6075369A

公开(公告)日：2000-06-13

申请号：US678012

申请日：1996-07-10

申请人： Carlton B. Morgan

发明人： Carlton B. Morgan

IPC分类号： A61N1/39 ,  H01H31/02

CPC分类号： A61N1/3931

摘要： A defibrillator and electrode system that gives the user a visible and/or audible indication of the condition of the electrodes and other parts of the defibrillator system prior to deployment of the electrodes and use of the defibrillator. In a preferred embodiment of the method of this invention, a patient simulation and analyze circuit within the defibrillator periodically tests the condition of the system and provides the user with a visual indication of the system's condition.

摘要翻译： 除颤器和电极系统，其在部署电极和使用除颤器之前向用户提供电极和除颤器系统的其他部分的状况的可见和/或可听见的指示。 在本发明方法的优选实施例中，除颤器内的患者模拟和分析电路周期性地测试系统的状况并向用户提供系统状况的视觉指示。

公开(公告)号：US06047212A

公开(公告)日：2000-04-04

申请号：US946843

申请日：1997-10-08

申请人： Bradford E. Gliner ,  Thomas D. Lyster ,  Clinton S. Cole ,  Daniel J. Powers ,  Carlton B. Morgan

发明人： Bradford E. Gliner ,  Thomas D. Lyster ,  Clinton S. Cole ,  Daniel J. Powers ,  Carlton B. Morgan

IPC分类号： A61N1/39

CPC分类号： A61N1/3937 ,  A61N1/3906 ,  A61N1/3912

摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.

摘要翻译： 本发明提供一种外部除颤器和除颤方法，其自动补偿用于除颤和心脏复律的电疗脉冲递送中的患者对患者的阻抗差异。 在优选实施例中，除颤器具有能够通过患者身上的电极排出的能量源，以提供双相电压或电流脉冲。 在本发明的一个方面，第一和第二相位持续时间和初始第一相位振幅是预定值。 在本发明的第二方面中，如果脉冲的第一相位的幅度在预定的第一相位持续时间结束时不能下降到阈值，则脉冲的第一相位的持续时间可能会延长 与高阻抗患者。 在本发明的第三方面中，当第一相位幅度下降到低于阈值时或当第一相位持续时间达到阈值时间值（以先到者为准）时，第一相位结束，如同低平均阻抗患者可能发生的那样。 改变输送的双相脉冲的这种方法和装置由此通过改变递送的电疗脉冲的性质来补偿患者的阻抗差异，导致更小，更有效和更便宜的除颤器。

公开(公告)号：US5836978A

公开(公告)日：1998-11-17

申请号：US909656

申请日：1997-08-12

申请人： Bradford E. Gliner ,  Thomas D. Lyster ,  Clinton S. Cole ,  Daniel J. Powers ,  Carlton B. Morgan

发明人： Bradford E. Gliner ,  Thomas D. Lyster ,  Clinton S. Cole ,  Daniel J. Powers ,  Carlton B. Morgan

IPC分类号： A61N1/39

CPC分类号： A61N1/3937 ,  A61N1/3906 ,  A61N1/3912

摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.

摘要翻译： 本发明提供一种外部除颤器和除颤方法，其自动补偿用于除颤和心脏复律的电疗脉冲递送中的患者对患者的阻抗差异。 在优选实施例中，除颤器具有能够通过患者身上的电极排出的能量源，以提供双相电压或电流脉冲。 在本发明的一个方面，第一和第二相位持续时间和初始第一相位振幅是预定值。 在本发明的第二方面中，如果脉冲的第一相位的幅度在预定的第一相位持续时间结束时不能下降到阈值，则脉冲的第一相位的持续时间可能会延长 与高阻抗患者。 在本发明的第三方面中，当第一相位幅度下降到低于阈值时或当第一相位持续时间达到阈值时间值（以先到者为准）时，第一相位结束，如同低平均阻抗患者可能发生的那样。 改变输送的双相脉冲的这种方法和装置由此通过改变递送的电疗脉冲的性质来补偿患者的阻抗差异，导致更小，更有效和更便宜的除颤器。

公开(公告)号：US5782878A

公开(公告)日：1998-07-21

申请号：US783376

申请日：1997-01-13

申请人： Carlton B. Morgan ,  Daniel Powers ,  Clinton Cole ,  Steven T. Mydynski ,  Michael J. Leventhal

发明人： Carlton B. Morgan ,  Daniel Powers ,  Clinton Cole ,  Steven T. Mydynski ,  Michael J. Leventhal

IPC分类号： A61N1/39

CPC分类号： A61N1/39 ,  Y10S128/903 ,  Y10S128/904

摘要： A defibrillator system comprising an external defibrillator, a defibrillator communicator and a communication network. In a preferred embodiment, the defibrillator comprises electrodes, an energy source and a controller, with the controller comprising an ECG signal analyzer and means for local actuation of the defibrillator to deliver an electrical pulse from the energy source to the electrodes. The communication network comprises a communication station, preferably a computer with a modem, and signal carriers, such as telephone lines, so that information can be transmitted from the communicator to the communication station. Likewise, the defibrillator communicator comprises means for automatically transmitting information to the communication station in response to deployment of the defibrillator. In alternative embodiments, additional information (such as patient ECG data and defibrillator operation data) is sent from the communicator to the communication station, and information (such as use instructions) is sent from the communication station to the communicator. The invention also includes a method of operating such a defibrillator system.

摘要翻译： 一种除颤器系统，包括外部除颤器，除颤器通信器和通信网络。 在优选实施例中，除颤器包括电极，能量源和控制器，其中控制器包括ECG信号分析器和用于局部致动除颤器的装置，以将电脉冲从能量源传递到电极。 通信网络包括通信站，优选地具有调制解调器的计算机和诸如电话线的信号载体，使得信息可以从通信器发送到通信站。 类似地，除颤器通信器包括用于响应于去纤颤器的部署而自动向通信站发送信息的装置。 在替代实施例中，附加信息（例如患者ECG数据和除颤器操作数据）从通信器发送到通信站，并且信息（例如使用指令）从通信站发送到通信器。 本发明还包括操作这种除颤器系统的方法。

公开(公告)号：US5735879A

公开(公告)日：1998-04-07

申请号：US803094

申请日：1997-02-20

申请人： Bradford E. Gliner ,  Thomas D. Lyster ,  Clinton S. Cole ,  Daniel J. Powers ,  Carlton B. Morgan

发明人： Bradford E. Gliner ,  Thomas D. Lyster ,  Clinton S. Cole ,  Daniel J. Powers ,  Carlton B. Morgan

IPC分类号： A61N1/39

CPC分类号： A61N1/3937 ,  A61N1/3906 ,  A61N1/3912

摘要： This invention provides an external defibrillator and defibrillation method that automatically compensates for patient-to-patient impedance differences in the delivery of electrotherapeutic pulses for defibrillation and cardioversion. In a preferred embodiment, the defibrillator has an energy source that may be discharged through electrodes on the patient to provide a biphasic voltage or current pulse. In one aspect of the invention, the first and second phase duration and initial first phase amplitude are predetermined values. In a second aspect of the invention, the duration of the first phase of the pulse may be extended if the amplitude of the first phase of the pulse fails to fall to a threshold value by the end of the predetermined first phase duration, as might occur with a high impedance patient. In a third aspect of the invention, the first phase ends when the first phase amplitude drops below a threshold value or when the first phase duration reaches a threshold time value, whichever comes first, as might occur with a low to average impedance patient. This method and apparatus of altering the delivered biphasic pulse thereby compensates for patient impedance differences by changing the nature of the delivered electrotherapeutic pulse, resulting in a smaller, more efficient and less expensive defibrillator.

摘要翻译： 本发明提供一种外部除颤器和除颤方法，其自动补偿用于除颤和心脏复律的电疗脉冲递送中的患者对患者的阻抗差异。 在优选实施例中，除颤器具有能够通过患者身上的电极排出的能量源，以提供双相电压或电流脉冲。 在本发明的一个方面，第一和第二相位持续时间和初始第一相位振幅是预定值。 在本发明的第二方面中，如果脉冲的第一相位的幅度在预定的第一相位持续时间结束时不能下降到阈值，则脉冲的第一相位的持续时间可能会延长 与高阻抗患者。 在本发明的第三方面中，当第一相位幅度下降到低于阈值时或当第一相位持续时间达到阈值时间值（以先到者为准）时，第一相位结束，如同低平均阻抗患者可能发生的那样。 改变输送的双相脉冲的这种方法和装置由此通过改变递送的电疗脉冲的性质来补偿患者的阻抗差异，导致更小，更有效和更便宜的除颤器。

公开(公告)号：US5607454A

公开(公告)日：1997-03-04

申请号：US227553

申请日：1994-04-14

申请人： David Cameron ,  Thomas D. Lyster ,  Daniel J. Powers ,  Bradford E. Gliner ,  Clinton S. Cole ,  Carlton B. Morgan

发明人： David Cameron ,  Thomas D. Lyster ,  Daniel J. Powers ,  Bradford E. Gliner ,  Clinton S. Cole ,  Carlton B. Morgan

IPC分类号： A61N1/39

CPC分类号： A61N1/3937 ,  A61N1/3906 ,  A61N1/3912

摘要： An electrotherapy method and apparatus for delivering a multiphasic waveform from an energy source to a patient. The preferred embodiment of the method comprises the steps of charging the energy source to an initial level; discharging the energy source across the electrodes to deliver electrical energy to the patient in a multiphasic waveform; monitoring a patient-dependent electrical parameter during the discharging step; shaping the waveform of the delivered electrical energy based on a value of the monitored electrical parameter, wherein the relative duration of the phases of the multiphasic waveform is dependent on the value of the monitored electrical parameter. The preferred apparatus comprises an energy source; two electrodes adapted to make electrical contact with a patient; a connecting mechanism forming an electrical circuit with the energy source and the electrodes when the electrodes are attached to a patient; and a controller operating the connecting mechanism to deliver electrical energy from the energy source to the electrodes in a multiphasic waveform the relative phase durations of which are based on an electrical parameter monitored during delivery of the electrical energy. The preferred defibrillator apparatus weighs less than 4 pounds and has a volume less than 150 cubic inches, and most preferably, weighs approximately three pounds or less and has a volume of approximately 141 cu. in.

摘要翻译： 一种用于将多相波形从能量源递送到患者的电疗方法和装置。 该方法的优选实施例包括以下步骤：将能源充电至初始水平; 通过电极排出能量源，以多相波形向患者输送电能; 在放电步骤期间监测与患者相关的电参数; 基于所监测的电参数的值对输送的电能的波形进行整形，其中多相波形的相位的相对持续时间取决于被监测的电参数的值。 优选的装置包括能源; 两个电极，适于与患者进行电接触; 当电极附接到患者时，形成与能量源和电极的电路的连接机构; 以及控制器，其操作所述连接机构，以多相波形将能量从所述能量源传递到所述电极，所述多相波形的相对相位持续时间基于在所述电能传递期间监测的电参数。 优选的除颤器装置重量小于4磅，体积小于150立方英寸，最优选重约3磅或更小，体积约为141立方厘米。 在。