公开(公告)号：US20050137521A1

公开(公告)日：2005-06-23

申请号：US10944479

申请日：2004-09-17

申请人： Alex Stenzler

发明人： Alex Stenzler

IPC分类号： A61M13/00 ,  A61B19/00 ,  A61H33/14 ,  A61M1/00 ,  A61M27/00 ,  A61M35/00 ,  A61M37/00

CPC分类号： A61M1/0088 ,  A61B90/40 ,  A61H33/14 ,  A61M1/0031 ,  A61M13/003 ,  A61M13/006 ,  A61M27/00 ,  A61M35/00 ,  A61M2202/0275 ,  A61M2205/3334

摘要： A device for the topical delivery of nitric oxide gas to an infected area of skin includes a source of nitric oxide gas, a bathing unit, a flow control valve, and a vacuum unit. The bathing unit is adapted to surround the area of the infected skin and form a substantially air-tight seal with the skin surface. The bathing unit is also in fluidic communication with the source of nitric oxide. The flow control valve is position downstream of the source of nitric oxide and upstream of the bathing unit. The flow control valve controls the amount of nitric oxide gas that is delivered to the bathing unit. The vacuum unit is positioned downstream of the bathing unit and is used to withdraw gas from the bathing unit. Application of nitric oxide gas to the infected area of skin reduces levels of bacteria in the infected area and promotes the healing process.

摘要翻译： 用于将一氧化氮气体局部递送到皮肤感染区域的装置包括一氧化氮气体源，洗澡单元，流量控制阀和真空单元。 洗澡单元适于包围被感染皮肤的区域并与皮肤表面形成基本上气密的密封。 洗澡单元也与一氧化氮来源流体连通。 流量控制阀位于一氧化氮源和洗澡单元上游的下游。 流量控制阀控制输送到洗澡单元的一氧化氮气体的量。 真空单元位于洗澡单元的下游，用于从洗澡单元中抽出气体。 一氧化氮气体在感染皮肤区域的应用可以减少感染区域的细菌数量，促进愈合过程。

公开(公告)号：US06793644B2

公开(公告)日：2004-09-21

申请号：US10172270

申请日：2002-06-14

申请人： Alex Stenzler

发明人： Alex Stenzler

IPC分类号： A61M3700

CPC分类号： A61M1/0088 ,  A61B90/40 ,  A61H33/14 ,  A61M1/0031 ,  A61M13/003 ,  A61M13/006 ,  A61M27/00 ,  A61M35/00 ,  A61M2202/0275 ,  A61M2205/3334

摘要： A method of treating infected tissue with topical nitric oxide exposure includes the steps of providing a source of nitric oxide containing gas and delivering the nitric oxide containing gas to a skin surface containing infected tissue so as to bathe the infected tissue with nitric oxide.

摘要翻译： 用局部一氧化氮暴露处理感染组织的方法包括提供含一氧化氮的气体源并将含有一氧化氮的气体输送到含有感染组织的皮肤表面以便用一氧化氮洗涤感染组织的步骤。

公开(公告)号：US06612308B2

公开(公告)日：2003-09-02

申请号：US10093797

申请日：2002-03-08

申请人： Joseph Fisher ,  Alex Vesely ,  Hiroshi Sasano ,  Steve Iscoe ,  Alex Stenzler

发明人： Joseph Fisher ,  Alex Vesely ,  Hiroshi Sasano ,  Steve Iscoe ,  Alex Stenzler

IPC分类号： A62B700

CPC分类号： A61M16/12 ,  A61M16/0045 ,  A61M16/08

摘要： A portable isocapnia circuit and an isocapnia method. A breathing port of the circuit allows a subject to inhale and exhale. Connected to the breathing port, a bifurcate conduit has a first conduit branch and a second conduit branch. The first conduit branch has an atmospheric air inlet, from which the atmospheric air is provided for inhalation, an inspiratory check valve to allow a one-way flow of the atmospheric air, and an atmospheric air aspirator. The second conduit branch has a one-way expiratory check valve and a expiratory gas reservoir. A one-way check valve is used to interconnect the first and second conduit branch, from which the expiratory gas stored in the expiratory gas reservoir flows to the first conduit branch to mix with the atmospheric air when the minute ventilation exceeds the atmospheric air.

摘要翻译： 便携式异卡路里电路和异味法。 电路的呼吸口允许受试者吸入并呼气。 连接到呼吸端口，分叉导管具有第一导管支路和第二导管支路。 第一管道分支具有大气空气入口，大气从该空气入口提供用于吸入，吸气止回阀允许大气空气的单向流动，以及大气抽气器。 第二导管分支具有单向呼气止回阀和呼气气体储存器。 单向止回阀用于互连第一和第二导管分支，当微小通气超过大气时，从呼吸气体储存器中吸入的呼吸气体流向第一导管支路与大气混合。

公开(公告)号：US5937854A

公开(公告)日：1999-08-17

申请号：US3717

申请日：1998-01-06

申请人： Alex Stenzler

发明人： Alex Stenzler

IPC分类号： A61M16/00

CPC分类号： A61M16/00 ,  A61M2230/40

摘要： A method and apparatus for ventilator pressure and optimization administers fixed stepwise pressure changes to the lungs of a patient and measures the lung volume change resulting from each pressure change. Critical opening pressure, critical closing pressure, and overdistention pressure are determined by changes in lung volume corresponding to the fixed stepwise pressure changes.

摘要翻译： 用于呼吸机压力和优化的方法和装置对患者的肺进行固定的逐步压力变化，并测量由每个压力变化导致的肺体积变化。 临界开启压力，临界闭合压力和过度停止压力由对应于固定逐步压力变化的肺容积变化确定。

公开(公告)号：US20180147371A1

公开(公告)日：2018-05-31

申请号：US15566426

申请日：2016-04-13

申请人： Alex Stenzler ,  Sansa Corporation (Barbados) Inc.

发明人： Alex Stenzler ,  Steve Han ,  Arthur Slutsky ,  Steven Ellis ,  Noe Zamel ,  Bildad Nyambura

IPC分类号： A61M15/00 ,  A61M15/06 ,  A24F47/00

CPC分类号： A61M15/0003 ,  A24F47/002 ,  A61M15/0036 ,  A61M15/0041 ,  A61M15/06 ,  A61M2202/064 ,  A61M2206/18

摘要： A device for adding a flavor and/or cough suppressant component to an inhaler is described. The device includes a housing having an interior chamber, wherein the housing includes at least one air inlet and at least one air outlet connected to the interior chamber, thereby forming an airflow pathway through the interior chamber, and at least one flavoring and/or cough suppressant component positioned within the interior chamber, wherein the housing is attachable to an exterior surface of an inhaler having at least one air inlet, such that the at least one air outlet of the device aligns with the at least one air inlet of the inhaler to form an airflow path through the device and into the inhaler.

公开(公告)号：US20180125882A1

公开(公告)日：2018-05-10

申请号：US15675773

申请日：2017-08-13

申请人： Alex Stenzler ,  Christopher C. Miller ,  Gilly Regev-Shoshani

发明人： Alex Stenzler ,  Christopher C. Miller ,  Gilly Regev-Shoshani

IPC分类号： A61K33/00 ,  A61K9/00 ,  A61K9/08 ,  A61K9/70 ,  A61K47/12 ,  C01B21/24

CPC分类号： A61K33/00 ,  A61K9/0043 ,  A61K9/08 ,  A61K9/7007 ,  A61K47/12 ,  C01B21/24

摘要： The present invention relates to a liquid nitric oxide releasing solution (NORS) comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of nitric oxide gas (gNO). The present invention also relates to a liquid NORS comprised of at least one nitrite compound having a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment of a wound in a human, the method comprising administering to the human a liquid NORS comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment, prevention, or reduction of incidence of a disease or disorder in a human in need thereof, the method comprising administering to the human a liquid NORS comprised of at least one nitrite compound at a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO.

公开(公告)号：US20160051579A1

公开(公告)日：2016-02-25

申请号：US14779541

申请日：2014-12-30

申请人： Alex STENZLER ,  Chrlstopher C. MILLER ,  Gilly REGEV-SHOSHANI

发明人： Alex Stenzler ,  Christopher C. Miller ,  Gilly Regev-Shoshani

IPC分类号： A61K33/00 ,  A61K9/00

CPC分类号： A61K33/00 ,  A61K9/0043 ,  A61K9/0078 ,  A61K47/12

摘要： Methods, devices, and systems for treating a respiratory condition using gNO delivered from a nitric oxide releasing solution (NORS) are disclosed and described. In one embodiment, the respiratory condition may be bovine respiratory disease complex (BRDc).

摘要翻译： 公开和描述了使用从一氧化氮释放溶液（NORS）递送的gNO治疗呼吸状况的方法，装置和系统。 在一个实施方案中，呼吸状况可以是牛呼吸道疾病复合物（BRDc）。

公开(公告)号：US08973603B2

公开(公告)日：2015-03-10

申请号：US12372087

申请日：2009-02-17

申请人： Steve Han ,  Alex Stenzler

发明人： Steve Han ,  Alex Stenzler

IPC分类号： F16K31/12 ,  G05D7/01 ,  A61B5/097

CPC分类号： G05D7/0106 ,  A61B5/097 ,  Y10T137/0379 ,  Y10T137/7808 ,  Y10T137/7836

摘要： A gas flow regulating device including a housing assembly, an inlet tube assembly, and a biasing device. The housing assembly has a main housing, a valve seat body, and a distal plate forming an outlet orifice. The inlet tube assembly includes a proximal inlet end, a tube forming a lumen, and a flange, and is slidably disposed within the main housing, biased to an open state by the biasing device. The flange separates middle and constant pressure chambers within the housing assembly. The inlet tube assembly is transitionable to a closed state in response to pressure in the constant pressure chamber to generate a relatively constant flow rate of air exiting the device via the outlet orifice.

摘要翻译： 一种气流调节装置，包括壳体组件，入口管组件和偏压装置。 壳体组件具有主壳体，阀座体和形成出口孔的远侧板。 入口管组件包括近端入口端，形成内腔的管和凸缘，并且可滑动地设置在主壳体内，由偏置装置偏压到打开状态。 凸缘将壳体组件内的中压室和恒压室分开。 入口管组件响应于恒压室中的压力而可转换到关闭状态，以产生经由出口孔离开设备的相对恒定的空气流速。

公开(公告)号：US08490622B2

公开(公告)日：2013-07-23

申请号：US12511382

申请日：2009-07-29

申请人： Alex Stenzler ,  Steve Han ,  David Matthew Young

发明人： Alex Stenzler ,  Steve Han ,  David Matthew Young

IPC分类号： A62B7/00

CPC分类号： A61M16/0463 ,  A61M16/0066 ,  A61M16/0465 ,  A61M16/0816 ,  A61M16/208 ,  A61M39/045 ,  A61M2039/1077

摘要： A respiratory apparatus including an adapter assembly and a catheter assembly. The adapter assembly includes ventilator, respiratory, access, and flush ports. The access port includes a conduit defining a passageway. The flush port projects from the conduit and is fluidly open to the passageway at an outlet. The catheter assembly includes a catheter assembled to a fitting. The fitting includes a hub and a tube, with the tube defining an exterior surface, an interior surface forming a lumen, a circumferential groove in the exterior surface, and a plurality of apertures fluidly open to the lumen and the circumferential groove. The tube is sized to be slidably received within the passageway such that upon final assembly, a fluid pathway is formed between the flush port and a distal end of the catheter via the flush port outlet, the circumferential groove, the plurality of apertures, and the lumen.

摘要翻译： 包括适配器组件和导管组件的呼吸装置。 适配器组件包括呼吸机，呼吸，通路和冲洗口。 进入端口包括限定通道的导管。 冲洗口从导管突出并且在出口处流体地通向通道。 导管组件包括组装到配件的导管。 配件包括轮毂和管，其中管限定外表面，形成内腔的内表面，外表面中的周向槽，以及向内腔和周向槽流体地开放的多个孔。 该管的尺寸被设计成可滑动地容纳在通道内，使得在最终组装时，在冲洗口和导管的远端之间通过冲洗口出口，周向槽，多个孔和 流明。

公开(公告)号：US08231606B2

公开(公告)日：2012-07-31

申请号：US12048575

申请日：2008-03-14

申请人： Alex Stenzler ,  David Matthew Young

发明人： Alex Stenzler ,  David Matthew Young

IPC分类号： A61M1/00

CPC分类号： A61M16/0463 ,  A61M16/0418 ,  A61M16/0479

摘要： A minimally invasive tracheal fluid removal device and corresponding method of use for removing accumulated subglottic secretions in an intubated patient's endotracheal tube. The device may be configured as a dual-track or single-tube suction guidance system. This device presents a significant improvement over the art as it eliminates the need to reintubate the patient each time the suction mechanism is removed to be cleaned.

摘要翻译： 一种微创气管切除装置和相应的用于去除插管患者气管插管中累积的声门下分泌物的方法。 该装置可以被配置为双轨或单管抽吸引导系统。 该装置对于现有技术具有显着的改进，因为它不需要在每次抽吸机构被移除以清洁时重新套管病人。