公开(公告)号：US20200093855A1

公开(公告)日：2020-03-26

申请号：US16430354

申请日：2019-06-03

申请人： Christopher C. Miller ,  Gilly Regev

发明人： Christopher C. Miller ,  Gilly Regev

IPC分类号： A61K33/00 ,  A61K31/365

摘要： The present invention relates to compositions and methods useful for immune activation that is effective for eliciting a non-antigen-specific immune response in a subject. An immunomodulator composition can include a therapeutically effective amount of a liquid nitric oxide releasing solution (NORS) for eliciting an immune response in a subject to treat an adverse health condition in the subject.

公开(公告)号：US09220505B2

公开(公告)日：2015-12-29

申请号：US13328402

申请日：2011-12-16

申请人： Venkataramanan Mandakolathur Vasudevan ,  Edward G. Chekan ,  Kevin D. Felder ,  Jerome R. Morgan ,  Carl J. Shurtleff ,  Johnny H. Alexander, III ,  John F. Cummings ,  Christopher C. Miller

发明人： Venkataramanan Mandakolathur Vasudevan ,  Edward G. Chekan ,  Kevin D. Felder ,  Jerome R. Morgan ,  Carl J. Shurtleff ,  Johnny H. Alexander, III ,  John F. Cummings ,  Christopher C. Miller

IPC分类号： A61B17/115 ,  A61B17/068 ,  A61B17/072

CPC分类号： A61B17/068 ,  A61B17/115 ,  A61B17/1155

摘要： A surgical stapling instrument for performing a circular anastomosis comprises a stapling head assembly, an actuator handle assembly, a shaft assembly, a safety latch, and a locking member. The stapling head assembly includes an anvil that moves relative to a staple holder and a staple driver to drive staples from the staple holder into tissue and against the anvil. The actuator handle assembly has a first actuator that controls motion of the anvil and a second actuator that controls motion of the staple driver. The shaft assembly couples the stapling head assembly to the actuator handle assembly. The safety latch prevents operation of the second actuator when the gap between the anvil and staple holder is outside a predetermined range. The locking member is configured to prevent adjustment of the anvil gap after the desired staple height has been set inside the predetermined range.

摘要翻译： 用于执行圆形吻合的外科缝合器械包括装订头组件，致动器手柄组件，轴组件，安全闩锁和锁定构件。 缝合头组件包括相对于缝合钉保持器和缝钉驱动器移动的砧座，以将钉从钉钉保持器驱动到组织中并抵靠砧座。 致动器手柄组件具有控制砧座运动的第一致动器和用于控制订书针驱动器运动的第二致动器。 轴组件将装订头组件耦合到致动器手柄组件。 当砧座和钉仓之间的间隙在预定范围之外时，安全闩锁防止第二致动器的操作。 锁定构件被构造成在期望的钉高度已经设定在预定范围内之前防止砧座间隙的调节。

公开(公告)号：US08518457B2

公开(公告)日：2013-08-27

申请号：US11595108

申请日：2006-11-10

申请人： Christopher C. Miller ,  Douglas R. Hole ,  Bruce R Murray ,  Bryan Perry

发明人： Christopher C. Miller ,  Douglas R. Hole ,  Bruce R Murray ,  Bryan Perry

IPC分类号： A61K33/00 ,  A61M16/00 ,  A61M16/10

CPC分类号： A61K33/00 ,  A61K9/007

摘要： Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide or nitric oxide releasing compounds as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.

摘要翻译： 提供了通过施用气体吸入一氧化氮或一氧化氮释放化合物作为粘液溶解剂或祛痰剂来治疗哺乳动物中过量粘液积累的方法和装置。 气态一氧化氮的输送可以鼻或口服制成，优选地基本上与哺乳动物的吸入或基于哺乳动物呼吸循环的同步参数一致。 根据过量粘液积聚的严重程度，不同的治疗方案可用于输送气态一氧化氮。 用于治疗特征的参数可以包括含有一氧化氮的气体的流速，含有一氧化氮的气体的施用持续时间，要施用一氧化氮的气体的呼吸次数和输送到气道的治疗性NO的浓度。

公开(公告)号：US20130175320A1

公开(公告)日：2013-07-11

申请号：US13344093

申请日：2012-01-05

申请人： Venkataramanan Mandakolathur Vasudevan ,  Adam R. Dunki-Jacobs ,  Chester O. Baxter, III ,  Jerome R. Morgan ,  Cortney E. Henderson ,  Christopher C. Miller ,  Kent P. Baker ,  John V. Hunt ,  Barry T. Jamison ,  Patrick A. Weizman ,  Joseph E. Young ,  Cory G. Kimball ,  Carl J. Shurtleff ,  Edward G. Chekan ,  Kevin D. Felder ,  Johnny H. Alexander, III ,  Patrick J. Swindon ,  Joseph P. Schowalter ,  John F. Cummings ,  Julia F. Serber

发明人： Venkataramanan Mandakolathur Vasudevan ,  Adam R. Dunki-Jacobs ,  Chester O. Baxter, III ,  Jerome R. Morgan ,  Cortney E. Henderson ,  Christopher C. Miller ,  Kent P. Baker ,  John V. Hunt ,  Barry T. Jamison ,  Patrick A. Weizman ,  Joseph E. Young ,  Cory G. Kimball ,  Carl J. Shurtleff ,  Edward G. Chekan ,  Kevin D. Felder ,  Johnny H. Alexander, III ,  Patrick J. Swindon ,  Joseph P. Schowalter ,  John F. Cummings ,  Julia F. Serber

IPC分类号： A61B17/068

CPC分类号： A61B17/1155 ,  A61B17/072 ,  A61B2017/00407 ,  A61B2017/2923

摘要： A surgical instrument includes a body, a pivotable trigger, and a ratcheting assembly. The ratcheting assembly may include a rotary ratchet coupled to the trigger and a pawl coupled to the body. The rotary ratchet may further include a ramp that disengages the ratchet from the pawl. A release feature may be included to selectively disengage a second member of the ratcheting assembly from a first member. In some versions, the release feature may include a rotation knob or a slidable handle. In another configuration, the ratcheting assembly may have a first member coupled to an actuator and a second member coupled to the body. The assembly may include a lock member coupled to the body that selectively engages a plurality of teeth disposed on the actuator. Alternatively, the assembly may include a pivotable pawl coupled to the actuator that engages one or more notches formed in the body.

摘要翻译： 手术器械包括主体，可枢转扳机和棘轮组件。 棘轮组件可以包括联接到扳机的旋转棘轮和联接到主体的棘爪。 旋转棘轮还可以包括使棘轮与棘爪脱离的斜坡。 可以包括释放特征以选择性地将棘轮组件的第二构件与第一构件分离。 在一些版本中，释放特征可以包括旋转旋钮或可滑动的手柄。 在另一种构造中，棘轮组件可以具有联接到致动器的第一构件和联接到主体的第二构件。 组件可以包括联接到主体的锁定构件，其选择性地接合设置在致动器上的多个齿。 或者，组件可以包括联接到致动器的可枢转的棘爪，其接合形成在主体中的一个或多个凹口。

公开(公告)号：US20130153630A1

公开(公告)日：2013-06-20

申请号：US13328344

申请日：2011-12-16

申请人： Christopher C. Miller ,  Edward G. Chekan ,  Johnny H. Alexander, III ,  John F. Cummings ,  Carl J. Shurtleff ,  Adam R. Dunki-Jacobs ,  Barry T. Jamison ,  Joseph E. Young ,  Cortney E. Henderson

发明人： Christopher C. Miller ,  Edward G. Chekan ,  Johnny H. Alexander, III ,  John F. Cummings ,  Carl J. Shurtleff ,  Adam R. Dunki-Jacobs ,  Barry T. Jamison ,  Joseph E. Young ,  Cortney E. Henderson

IPC分类号： A61B17/068

CPC分类号： A61B17/1155 ,  A61B17/115 ,  A61B2017/00367 ,  A61B2017/00407 ,  A61B2017/00862 ,  A61B2090/034 ,  A61B2090/0811

摘要： A surgical instrument includes an anvil selectively coupleable to a stapling head assembly and a trigger operable to fire staples into tissue compressed between the anvil and the stapling head assembly. In some versions, a lockout member may engage a securing feature to prevent actuation of the anvil relative to the stapling head assembly. For instance, a tab may engage a slot on an actuator, a screen door lock may provide frictional resistance or engage teeth on the actuator, a door may actuate into engagement with one or more recesses, geared teeth may mesh with teeth on the actuator, the lockout member may include a ratcheting assembly to engage actuator, and/or a push button may actuate into a recess while disengaging the lockout member. Alternatively, in some versions, the trigger actuation assembly may be disengaged prior to firing. An anvil position indicator may restrict engagement of the trigger actuation assembly.

摘要翻译： 手术器械包括可选择性地联接到缝合头组件的砧座和可操作地将钉钉钉入压缩在砧座和缝合头组件之间的组织的触发器。 在一些形式中，锁定构件可以接合固定特征以防止砧座相对于缝合头组件的致动。 例如，突片可以接合致动器上的槽，屏幕门锁可以提供摩擦阻力或接合致动器上的齿，门可以致动与一个或多个凹部接合，齿轮齿可以与致动器上的齿啮合， 锁定构件可以包括棘轮组件以接合致动器，和/或按钮可以在释放锁定构件的同时致动到凹部中。 或者，在一些版本中，触发器致动组件可以在点火之前脱开。 砧位置指示器可以限制触发器致动组件的接合。

公开(公告)号：US20120241505A1

公开(公告)日：2012-09-27

申请号：US13433179

申请日：2012-03-28

申请人： Johnny H. Alexander, III ,  Cortney E. Henderson ,  Christopher C. Miller ,  John P. Measamer ,  Katherine J. Schmid ,  Frederick E. Shelton, IV ,  Stephanie A. Mutchler ,  Bret W. Smith ,  Michael S. Cropper

发明人： Johnny H. Alexander, III ,  Cortney E. Henderson ,  Christopher C. Miller ,  John P. Measamer ,  Katherine J. Schmid ,  Frederick E. Shelton, IV ,  Stephanie A. Mutchler ,  Bret W. Smith ,  Michael S. Cropper

IPC分类号： A61B17/068

CPC分类号： A61B17/0643 ,  A61B17/00491 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/072 ,  A61B17/07207 ,  A61B17/07292 ,  A61B17/1155 ,  A61B17/2909 ,  A61B46/10 ,  A61B46/17 ,  A61B2017/00004 ,  A61B2017/00526 ,  A61B2017/0053 ,  A61B2017/00818 ,  A61B2017/00862 ,  A61B2017/00884 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61B2017/00991 ,  A61B2017/0641 ,  A61B2017/07214 ,  A61B2017/07228 ,  A61B2017/07235 ,  A61B2017/07242 ,  A61B2017/07257 ,  A61B2017/07264 ,  A61B2017/07271 ,  A61B2017/07278 ,  A61B2017/07285 ,  A61B2017/2908 ,  A61B2017/2919 ,  A61B2017/2923 ,  A61B2017/2927 ,  A61B2017/2932 ,  A61B2017/2933 ,  A61B2017/2936 ,  A61B2017/2946 ,  A61B2017/320052 ,  A61B2090/037 ,  A61B2090/08021 ,  A61B2090/0807 ,  A61B2090/0811

摘要： Tissue thickness compensators for use with circular surgical staplers. Various tissue thickness compensators are disclosed for deployment between a stapler head of a surgical circular stapler and an anvil attached thereto to accommodate variances in tissue thickness during stapling. Some tissue thickness compensator arrangements include means and configurations for deploying healing agents for enhancing the healing process.

摘要翻译： 用于圆形手术吻合器的组织厚度补偿器。 公开了各种组织厚度补偿器，用于在手术圆形缝合器的吻合器头部和附接到其的砧座之间展开，以适应缝合期间组织厚度的变化。 一些组织厚度补偿器装置包括用于部署用于增强愈合过程的愈合剂的装置和构造。

公开(公告)号：US07531133B2

公开(公告)日：2009-05-12

申请号：US11445965

申请日：2006-06-01

申请人： Douglas Hole ,  Christopher C. Miller

发明人： Douglas Hole ,  Christopher C. Miller

IPC分类号： A61M1/00 ,  A61M37/00 ,  C02F1/44

CPC分类号： A61K33/00 ,  A61M1/1698 ,  A61M1/3472 ,  A61M1/3496 ,  A61M1/3687 ,  A61M2202/0275 ,  A61K2300/00

摘要： A method of reducing pathogens in blood by exposure to a nitric oxide containing gas in an extracorporeal circuitry is provided. The method includes: obtaining blood from a mammal or a blood source, separating the blood into plasma and blood cells, exposing the plasma to nitric oxide containing gas, combining the exposed plasma with the blood cells, reducing nitric oxide content in the recombined blood, and returning the blood to the mammal or blood source.

摘要翻译： 提供了通过在体外电路中暴露于含有一氧化氮的气体来减少血液中的病原体的方法。 该方法包括：从哺乳动物或血液源获得血液，将血液分离成血浆和血细胞，将血浆暴露于含有一氧化氮的气体中，将暴露的血浆与血细胞结合，减少重组血液中的一氧化氮含量， 并将血液返回哺乳动物或血源。

公开(公告)号：US06986351B2

公开(公告)日：2006-01-17

申请号：US10691649

申请日：2003-10-24

申请人： Curtis B. Figley ,  Darin W. Hunt ,  Christopher C. Miller

发明人： Curtis B. Figley ,  Darin W. Hunt ,  Christopher C. Miller

IPC分类号： A62B7/00 ,  A62B7/10 ,  A62B9/02 ,  F16K31/00 ,  F16K31/12

CPC分类号： A61M16/0816 ,  A61M16/0051 ,  A61M16/024 ,  A61M16/0677 ,  A61M16/203 ,  A61M16/208 ,  A61M16/209 ,  A61M2016/0027 ,  A61M2016/0039 ,  A61M2016/0042 ,  A61M2202/0275 ,  A61M2205/6018 ,  A61M2205/6027 ,  A61M2205/8206 ,  A61M2205/8237 ,  Y10T137/7808

摘要： A system controls and manages administration of a therapeutic gas, such as NO, O2, or the like, to a spontaneously breathing, non-ventilated patient such that concentrated NO is as low as reasonably possible while delivering the desired amount of NO to the distal portions of the lungs. The system includes an entrainment cell that provides remote, turbulent mixing with low temporal latency and can be used with a nasal cannula or a mask. The entrainment cell uses room air to dilute the therapeutic gas; however, supplementary gases can also be used. A baffle can be included to promote mixing and a flow sensor can also be used if desired. Multiple ports can be included in the entrainment cell. An equalizing valve is also disclosed.

摘要翻译： 系统控制和管理诸如NO，O 2等的治疗气体的给药到自发呼吸的非通气患者，使得浓缩NO在合理可能的情况下尽可能低，同时递送 对肺的远端部分的NO的期望量。 该系统包括夹带细胞，其提供具有低时间潜伏期的远程湍流混合，并且可以与鼻插管或面罩一起使用。 夹带细胞使用室内空气稀释治疗气体; 然而，也可以使用补充气体。 可以包括挡板以促进混合，并且如果需要也可以使用流量传感器。 夹带单元中可以包含多个端口。 还公开了一种均衡阀。

公开(公告)号：US5994084A

公开(公告)日：1999-11-30

申请号：US596100

申请日：1996-08-23

申请人： Brian H. Anderton ,  Christopher C. Miller

发明人： Brian H. Anderton ,  Christopher C. Miller

IPC分类号： C07K14/47 ,  C12N9/12 ,  C12N15/54 ,  C12N15/85 ,  C12P21/08 ,  G01N33/53 ,  C12N5/00 ,  C12N5/08 ,  C12Q1/00

CPC分类号： C12N15/8509 ,  C07K14/4711 ,  C12N9/12 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0312 ,  C12N2830/008

摘要： Transgenic cell and animal models for Alzheimer's disease are described. Cells of the animals and the cell models themselves comprise a recombinant DNA construct comprising a control sequence and, under the control of the control sequence, a DNA sequence encoding a kinase that is capable, directly or indirectly, of modulating the phosphorylation of the microtubule-forming protein tau. The transgenic cells and animals may be used for testing potential therapeutic agents for Alzheimer's disease.

摘要翻译： PCT No.PCT / GB94 / 01669 Sec。 371日期：1996年8月23日 102（e）日期1996年8月23日PCT 1994年8月1日PCT公布。 公开号WO95 / 05466 日期1995年2月23日描述了阿尔茨海默病的转基因细胞和动物模型。 动物细胞和细胞模型本身包含重组DNA构建体，其包含对照序列，并且在对照序列的控制下，编码能够直接或间接调节微管 - 磷酸化磷酸化的激酶的DNA序列， 形成蛋白质tau蛋白。 转基因细胞和动物可用于测试阿尔茨海默病的潜在治疗剂。

公开(公告)号：US09603599B2

公开(公告)日：2017-03-28

申请号：US13328344

申请日：2011-12-16

申请人： Christopher C. Miller ,  Edward G. Chekan ,  Johnny H. Alexander, III ,  John F. Cummings ,  Carl J. Shurtleff ,  Adam R. Dunki-Jacobs ,  Barry T. Jamison ,  Joseph E. Young ,  Cortney E. Henderson

发明人： Christopher C. Miller ,  Edward G. Chekan ,  Johnny H. Alexander, III ,  John F. Cummings ,  Carl J. Shurtleff ,  Adam R. Dunki-Jacobs ,  Barry T. Jamison ,  Joseph E. Young ,  Cortney E. Henderson

IPC分类号： A61B17/068 ,  A61B17/115

CPC分类号： A61B17/1155 ,  A61B17/115 ,  A61B2017/00367 ,  A61B2017/00407 ,  A61B2017/00862 ,  A61B2090/034 ,  A61B2090/0811

摘要： A surgical instrument includes an anvil selectively coupleable to a stapling head assembly and a trigger operable to fire staples into tissue compressed between the anvil and the stapling head assembly. In some versions, a lockout member may engage a securing feature to prevent actuation of the anvil relative to the stapling head assembly. For instance, a tab may engage a slot on an actuator, a screen door lock may provide frictional resistance or engage teeth on the actuator, a door may actuate into engagement with one or more recesses, geared teeth may mesh with teeth on the actuator, the lockout member may include a ratcheting assembly to engage actuator, and/or a push button may actuate into a recess while disengaging the lockout member. Alternatively, in some versions, the trigger actuation assembly may be disengaged prior to firing. An anvil position indicator may restrict engagement of the trigger actuation assembly.