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59 条记录 (耗时 0.041 秒)

    Antibiotics Derivatives
    48.
    发明申请
    Antibiotics Derivatives 失效

    公开(公告)号：US20080280888A1

    公开(公告)日：2008-11-13

    申请号：US11915179

    申请日：2006-05-24

    申请人： Daniel Bur ,  Christian Hubschwerlen ,  Jean-Philippe Surivet ,  Cornelia Zumbrunn-Acklin

    发明人： Daniel Bur ,  Christian Hubschwerlen ,  Jean-Philippe Surivet ,  Cornelia Zumbrunn-Acklin

    IPC分类号： A61K31/5415 ,  C07D417/02 ,  A61K31/538 ,  A61K31/428 ,  A61K31/542 ,  C07D513/04

    CPC分类号： C07D277/64 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D513/04

    摘要： The invention relates to antibiotic derivatives of formula I wherein: A represents —O—, S, —C(═O)—, —C(═NOR6)—; Z-B represents NCH2CH2, NCOCH2, NCH2CO, NCH2CH(OH), CHN(R8)CH2 or CHN(R8)CO; D represents binuclear heteroaryl; Y1 represents —CR1— or —N—, Y2 represents —CR2— or —N—, Y3 represents —CR3— or —N— and Y4 represents —CR4— or —N—; U represents —NH—, —O— or —S— and V represents —N— or —CH—; W represents —CH2—, —O— or —NR7—; R1 represents H, methyl, ethyl or halogen; R2, R3 and R4 each represent independently H, C1-C4 alkyl, halogen, or C1-C4 alkoxy; R5 represents H, C1-C4 alkyl or fluorine; R6 represents H, C1-C4 alkyl or aryl-C1-C4 alkyl; R7 represents H, C1-C4 alkyl, aryl-C1-C4 alkyl or —CH2—COOH; R8 represents H, C1-C4 alkyl or —CH2—COOH; with the provisos that if Z-B represents NCH2CH2, NCOCH2, NCH2CO or NCH2CH(OH), then W represents —CH2—; if A represents O or S, then W represents —CH2—; and only one or two of Y1, Y2, Y3 and Y4 can represent N at the same time.