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公开(公告)号：US08889688B2
公开(公告)日：2014-11-18
申请号：US13519938
申请日：2011-01-04
IPC分类号： A61K31/497 , C07D403/12 , A61K31/496
CPC分类号： A61K31/496 , C07D213/56 , C07D295/192 , C07D403/12 , Y02A50/411
摘要： The invention relates to novel piperazine derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria.
摘要翻译： 本发明涉及新型哌嗪衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括含有一种或多种这些化合物的药物组合物及其作为用于治疗或预防原生动物感染的药物的用途的相关方面，例如特别是疟疾。
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公开(公告)号：US08580831B2
公开(公告)日：2013-11-12
申请号：US13376966
申请日：2010-06-07
申请人： Daniel Bur , Olivier Corminboeuf , Sylvaine Cren , Corinna Grisostomi , Xavier Leroy , Sylvia Richard-Bildstein
发明人： Daniel Bur , Olivier Corminboeuf , Sylvaine Cren , Corinna Grisostomi , Xavier Leroy , Sylvia Richard-Bildstein
IPC分类号： A61K31/422 , A61K31/427 , C07D413/14 , C07D417/14
CPC分类号： C07D413/14 , C07D417/14
摘要： The invention relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
摘要翻译： 本发明涉及式（I）的氟化氨基三唑衍生物，其中A，R 1和R 2如说明书中所定义，其制备及其作为药物活性化合物的用途。
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公开(公告)号：US20100324052A1
公开(公告)日：2010-12-23
申请号：US12855016
申请日：2010-08-12
申请人： Olivier Bezencon , Christoph Boss , Daniel Bur , Austin Chih-Yu Chen , Olivier Corminboeuf , Daniel Dube , Walter Fischli , Corinna Grisostomi , Lubos Remen , Sylvia Richard-Bildstein , Thierry Sifferlen , Michel Therien , Thomas Weller
发明人： Olivier Bezencon , Christoph Boss , Daniel Bur , Austin Chih-Yu Chen , Olivier Corminboeuf , Daniel Dube , Walter Fischli , Corinna Grisostomi , Lubos Remen , Sylvia Richard-Bildstein , Thierry Sifferlen , Michel Therien , Thomas Weller
IPC分类号： A61K31/504 , C07D471/08 , A61P9/00 , A61P13/12 , C07D211/60 , A61K31/451 , C07D213/81 , A61K31/444
CPC分类号： C07D471/08 , C07D211/78 , C07D401/10 , C07D401/12
摘要： The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin.
摘要翻译： 本发明涉及新型的哌啶羧酸酰胺衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备这些新化合物的方法，包含这些化合物的药物组合物，特别是使用这些化合物作为肾素抑制剂的相关方面。
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公开(公告)号：US08846733B2
公开(公告)日：2014-09-30
申请号：US13992143
申请日：2011-12-06
申请人： Daniel Bur , Olivier Corminboeuf , Sylvaine Cren , Corinna Grisostomi , Xavier Leroy , Sylvia Richard-Bildstein
发明人： Daniel Bur , Olivier Corminboeuf , Sylvaine Cren , Corinna Grisostomi , Xavier Leroy , Sylvia Richard-Bildstein
IPC分类号： C07D413/14
CPC分类号： C07D413/14
摘要： The invention relates to oxazolyl-methylether derivatives of formula (I), wherein R1, R2, R3, R4 and R5 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
摘要翻译： 本发明涉及式（I）的恶唑基 - 甲基醚衍生物，其中R1，R2，R3，R4和R5如说明书中所定义，它们的制备及其作为药物活性化合物的用途。
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![Bridged spiro [2.4] heptane derivatives as ALX receptor and/or FPRL2 agonists](/abs-image/US/2013/10/22/US08563714B2/abs.jpg.150x150.jpg)
5.发明授权Bridged spiro [2.4] heptane derivatives as ALX receptor and/or FPRL2 agonists 有权桥接螺[2.4]庚烷衍生物作为ALX受体和/或FPRL2激动剂公开(公告)号：US08563714B2
公开(公告)日：2013-10-22
申请号：US13321372
申请日：2010-05-17
申请人： Daniel Bur , Olivier Corminboeuf , Sylvaine Cren , Corinna Grisostomi , Xavier Leroy , Sylvia Richard-Bildstein
发明人： Daniel Bur , Olivier Corminboeuf , Sylvaine Cren , Corinna Grisostomi , Xavier Leroy , Sylvia Richard-Bildstein
IPC分类号： C07C233/58 , C07C233/60 , C07C233/63 , C07D207/09 , C07D211/26 , C07D213/40 , C07D231/12 , C07D233/64 , C07D235/14 , C07D239/30 , C07D249/08 , C07D277/28
CPC分类号： C07D295/13 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/63 , C07C255/29 , C07C2603/94 , C07D205/04 , C07D207/14 , C07D211/26 , C07D211/56 , C07D211/58 , C07D213/40 , C07D213/75 , C07D231/12 , C07D233/36 , C07D233/64 , C07D235/14 , C07D239/30 , C07D249/08 , C07D261/08 , C07D271/08 , C07D275/04 , C07D277/46 , C07D277/58 , C07D277/62 , C07D285/08 , C07D295/125 , C07D295/185 , C07D307/14 , C07D307/52 , C07D333/28 , C07D417/12
摘要： The present invention relates to bridged spiro[2.4]heptane derivatives of formula (I), wherein W, Y, Z, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds as ALX receptor and/or FPRL2 agonists for the treatment of inflammatory and obstructive airways diseases.
摘要翻译： 本发明涉及式（I）的桥连螺[2.4]庚烷衍生物，其中W，Y，Z，R 1和R 2如说明书中所定义，它们的制备及其作为药物活性化合物作为ALX受体和/或 FPRL2激动剂用于治疗炎性和阻塞性气道疾病。
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公开(公告)号：US20120101138A1
公开(公告)日：2012-04-26
申请号：US13376966
申请日：2010-06-07
申请人： Daniel Bur , Olivier Corminboeuf , Sylvaine Cren , Corinna Grisostomi , Xavier Leroy , Sylvia Richard-Bildstein
发明人： Daniel Bur , Olivier Corminboeuf , Sylvaine Cren , Corinna Grisostomi , Xavier Leroy , Sylvia Richard-Bildstein
IPC分类号： A61K31/422 , A61K31/427 , A61P29/00 , A61P37/00 , A61P37/08 , A61P31/18 , A61P9/00 , A61P25/00 , C07D413/14 , A61P11/00
CPC分类号： C07D413/14 , C07D417/14
摘要： The invention relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
摘要翻译： 本发明涉及式（I）的氟化氨基三唑衍生物，其中A，R 1和R 2如说明书中所定义，其制备及其作为药物活性化合物的用途。
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公开(公告)号：US08067419B2
公开(公告)日：2011-11-29
申请号：US12090816
申请日：2006-10-20
IPC分类号： A61K31/4965 , C07D487/00
CPC分类号： C07D295/185 , C07D209/04 , C07D209/16 , C07D213/26 , C07D213/38 , C07D213/40 , C07D213/60 , C07D213/74 , C07D217/04 , C07D217/14 , C07D233/64 , C07D239/42 , C07D277/28 , C07D307/14 , C07D317/58 , C07D333/20 , C07D333/28 , C07D333/58
摘要： The invention relates to novel piperazine derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, especially malaria.
摘要翻译： 本发明涉及新型哌嗪衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括含有一种或多种这些化合物的药物组合物及其用作治疗或预防原生动物感染，特别是疟疾的药物的相关方面。
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公开(公告)号：US20120316178A1
公开(公告)日：2012-12-13
申请号：US13519938
申请日：2011-01-04
IPC分类号： A61K31/496 , A61P33/02 , A61P33/06 , C07D403/12
CPC分类号： A61K31/496 , C07D213/56 , C07D295/192 , C07D403/12 , Y02A50/411
摘要： The invention relates to novel piperazine derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria.
摘要翻译： 本发明涉及新型哌嗪衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括含有一种或多种这些化合物的药物组合物及其作为用于治疗或预防原生动物感染的药物的用途的相关方面，例如特别是疟疾。
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![BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS](/abs-image/US/2012/05/10/US20120115841A1/abs.jpg.150x150.jpg)
9.发明申请BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS 有权BRIDGED SPIRO [2.4]作为ALX受体和/或FPRL2激动剂的HEPTANE衍生物公开(公告)号：US20120115841A1
公开(公告)日：2012-05-10
申请号：US13321372
申请日：2010-05-17
申请人： Daniel Bur , Olivier Corminboeuf , Sylvaine Cren , Corinna Grisostomi , Xavier Leroy , Sylvia Richard-Bildstein
发明人： Daniel Bur , Olivier Corminboeuf , Sylvaine Cren , Corinna Grisostomi , Xavier Leroy , Sylvia Richard-Bildstein
IPC分类号： A61K31/397 , C07D207/09 , C07D211/58 , C07C233/58 , C07D233/36 , C07D241/04 , C07D273/01 , C07D205/04 , C07D401/12 , C07D417/12 , C07D405/12 , C07D403/12 , C07D413/12 , C07D409/12 , A61K31/428 , A61K31/167 , A61K31/40 , A61K31/4468 , A61K31/341 , A61K31/4166 , A61K31/4184 , A61K31/415 , A61K31/5375 , A61K31/4439 , A61K31/506 , A61K31/422 , A61K31/4245 , A61K31/4965 , A61P11/00 , A61P29/00 , A61P37/08 , A61P31/18 , A61P9/00 , A61P25/00 , A61P37/00 , C07D235/14 , C07C233/62
CPC分类号： C07D295/13 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/63 , C07C255/29 , C07C2603/94 , C07D205/04 , C07D207/14 , C07D211/26 , C07D211/56 , C07D211/58 , C07D213/40 , C07D213/75 , C07D231/12 , C07D233/36 , C07D233/64 , C07D235/14 , C07D239/30 , C07D249/08 , C07D261/08 , C07D271/08 , C07D275/04 , C07D277/46 , C07D277/58 , C07D277/62 , C07D285/08 , C07D295/125 , C07D295/185 , C07D307/14 , C07D307/52 , C07D333/28 , C07D417/12
摘要： The present invention relates to bridged spiro[2.4]heptane derivatives of formula (I), wherein W, Y, Z, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds as ALX receptor and/or FPRL2 agonists for the treatment of inflammatory and obstructive airways diseases.
摘要翻译： 本发明涉及式（I）的桥连螺[2.4]庚烷衍生物，其中W，Y，Z，R 1和R 2如说明书中所定义，它们的制备及其作为药物活性化合物作为ALX受体和/或 FPRL2激动剂用于治疗炎性和阻塞性气道疾病。
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公开(公告)号：US20110281869A1
公开(公告)日：2011-11-17
申请号：US12993030
申请日：2009-05-18
IPC分类号： A61K31/4725 , C07D401/14 , C07D413/14 , A61P33/06 , A61K31/5377 , A61K31/497 , A61K31/501 , A61P33/02 , C07D401/12 , A61K31/506
CPC分类号： C07D401/12 , C07D217/00 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The invention relates to novel tetrahydroisoquinoline derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria.
摘要翻译： 本发明涉及新型四氢异喹啉衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括含有一种或多种这些化合物的药物组合物及其作为用于治疗或预防原生动物感染的药物的用途的相关方面，例如特别是疟疾。
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