公开(公告)号：US09724018B2

公开(公告)日：2017-08-08

申请号：US13282713

申请日：2011-10-27

申请人： Yong K. Cho ,  Scott A. Ransom ,  Xusheng Zhang

发明人： Yong K. Cho ,  Scott A. Ransom ,  Xusheng Zhang

IPC分类号： A61B5/08 ,  A61B5/11 ,  A61N1/08 ,  A61B5/00

CPC分类号： A61B5/1104 ,  A61B5/7217 ,  A61N1/08

摘要： Systems and methods for monitoring phrenic nerve function of a patient are disclosed, including, including establishing a diaphragmatic movement value threshold; positioning a diaphragmatic movement sensor on an external surface of an abdomen of the patient; applying a treatment regimen to a tissue region in proximity to the phrenic nerve; measuring a diaphragmatic movement value with the diaphragmatic movement sensor; comparing the measured diaphragmatic movement value to the established diaphragmatic movement value threshold; and generating an alert in response to the comparison.

公开(公告)号：US08876727B2

公开(公告)日：2014-11-04

申请号：US13474041

申请日：2012-05-17

申请人： Xusheng Zhang ,  Jeffrey M. Gillberg ,  Thomas J. Mullen ,  Paul J. DeGroot

发明人： Xusheng Zhang ,  Jeffrey M. Gillberg ,  Thomas J. Mullen ,  Paul J. DeGroot

IPC分类号： A61B5/04 ,  A61B5/08 ,  A61N1/36 ,  A61B7/04 ,  A61B5/00 ,  A61B7/00 ,  A61B5/0205 ,  A61N1/365 ,  A61B5/024

CPC分类号： A61N1/3611 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/0826 ,  A61B5/4029 ,  A61B5/7217 ,  A61B7/005 ,  A61B7/006 ,  A61B7/04 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/36535 ,  A61N1/36578

摘要： A method and system of detecting phrenic nerve stimulation in a patient that includes detecting an activation event, obtaining a heart sound signal of a patient from an implanted heart sound sensor, determining that an electrical stimulation has been applied to the patient, in response to detecting the activation event, monitoring a portion of the heart sound signal, the portion defined by a predetermined window after the application of the electrical stimulation, and determining whether phrenic nerve stimulation occurred based on the portion of the heart sound signal.

摘要翻译： 一种检测患者膈神经刺激的方法和系统，包括检测激活事件，响应于检测，从植入的心音传感器获得患者的心音信号，确定电刺激已经施加到患者 激活事件，监测心音信号的一部分，在施加电刺激之后由预定窗口定义的部分，以及基于心音信号的部分来确定是否发生膈神经刺激。

公开(公告)号：US08406872B2

公开(公告)日：2013-03-26

申请号：US12768905

申请日：2010-04-28

申请人： Robert W. Stadler ,  Xusheng Zhang

发明人： Robert W. Stadler ,  Xusheng Zhang

IPC分类号： A61N1/00

CPC分类号： A61N1/3956 ,  A61B5/0464 ,  A61B5/7203 ,  A61N1/3621

摘要： A medical device and associated method for discriminating cardiac events includes determining whether a cardiac evidence counter is greater than a predetermined detection threshold, advancing from a concerned state to a convinced state in response to the evidence counter being greater than the predetermined detection threshold, determining whether a reduction in the cardiac evidence counter occurs while in the convinced state, determining whether one of a first rate corresponding to the first sensing vector and a second rate corresponding to the second sensing vector is less than a predetermined rate limit, and determining whether to advance from the convinced state to one of a therapy delivery state, the concerned state and the unconcerned state in response to determining whether one of the first rate and the second rate is less than a predetermined rate limit.

摘要翻译： 用于鉴别心脏事件的医疗装置和相关联的方法包括：确定心脏证据计数器是否大于预定检测阈值，响应于证据计数器大于预定检测阈值，从有关状态进入确信状态，确定是否 在令人信服的状态下，发生心脏证据计数器的减少，确定对应于第一感测向量的第一速率和对应于第二感测向量的第二速率中的一个是否小于预定速率限制，并且确定是否前进 响应于确定第一速率和第二速率之一是否小于预定速率限制，从相信状态到治疗传递状态之一，相关状态和不关心状态。

公开(公告)号：US08401629B2

公开(公告)日：2013-03-19

申请号：US12768892

申请日：2010-04-28

申请人： Robert W. Stadler ,  Xusheng Zhang

发明人： Robert W. Stadler ,  Xusheng Zhang

IPC分类号： A61B5/04

CPC分类号： A61B5/0464 ,  A61B5/0245 ,  A61B5/7203 ,  A61N1/3622

摘要： A medical device and associated method for discriminating cardiac events includes determining whether a cardiac evidence counter is greater than a predetermined detection threshold, determining whether to advance from a current state to a next state in response to the evidence counter being greater than the predetermined detection threshold, determining whether advancing from a previous state to the current state occurred while in one of a low variability mode and a high variability mode during the previous state, and determining whether to advance from the current state to a previous state in response to determining whether advancing from a previous state to the current state occurred while operating in one of a low variability mode and a high variability mode during the previous state.

摘要翻译： 用于鉴别心脏事件的医疗装置和相关联的方法包括确定心脏证据计数器是否大于预定检测阈值;响应于证据计数器大于预定检测阈值来确定是否从当前状态提前到下一状态 在先前状态下，确定是否从先前状态进入到当前状态，同时以低可变性模式和高可变性模式之一发生，并且响应于是否前进而确定是否从当前状态前进到先前状态 在先前状态期间以低变异性模式和高可变性模式之一操作时发生从先前状态到当前状态。

公开(公告)号：US08301235B2

公开(公告)日：2012-10-30

申请号：US12768782

申请日：2010-04-28

申请人： Xusheng Zhang ,  Robert W. Stadler ,  Jeffrey M. Gillberg

发明人： Xusheng Zhang ,  Robert W. Stadler ,  Jeffrey M. Gillberg

IPC分类号： A61B5/0472

CPC分类号： A61B5/0464 ,  A61B5/0245 ,  A61B5/7203 ,  A61N1/3621 ,  A61N1/3956

摘要： A medical device and associated method for discriminating cardiac events sense cardiac signals that includes determining whether a first match score is within one of a first match zone corresponding to a first cardiac event, and a second match zone corresponding to the first cardiac event, and determining whether a second match score is within one of the first match zone, the second match zone, and a third match zone corresponding to a second cardiac event different from the first cardiac event. One of increasing and decreasing an event counter is performed in response to both the determination of whether the first match score is within one of the first match zone and the second match zone and the determination of whether the second match score is within one of the first match zone, the second match zone, and the third match zone.

摘要翻译： 用于识别心脏事件的医疗装置和相关联的方法检测心脏信号，所述心脏信号包括确定第一匹配分数是否在对应于第一心脏事件的第一匹配区域之内，以及对应于第一心脏事件的第二匹配区域，以及确定 第二匹配得分是否在第一匹配区域，第二匹配区域和对应于不同于第一心脏事件的第二心脏事件的第三匹配区域之一内。 响应于第一匹配分数是否在第一匹配区域和第二匹配区域之一的确定以及确定第二匹配分数是否在第一匹配区域之一内的确定来执行增加和减少事件计数器之一 匹配区，第二匹配区和第三匹配区。

公开(公告)号：US08301233B2

公开(公告)日：2012-10-30

申请号：US12415445

申请日：2009-03-31

申请人： Xusheng Zhang ,  Robert W. Stadler ,  Jeffrey M. Gillberg

发明人： Xusheng Zhang ,  Robert W. Stadler ,  Jeffrey M. Gillberg

IPC分类号： A61B5/02 ,  A61B5/08

CPC分类号： A61B5/0452 ,  A61B5/7203 ,  A61N1/3621 ,  A61N1/3702 ,  A61N1/3962

摘要： Techniques are described for detecting a condition of a patient using a probability-correlation based model that integrates a plurality of parameters associated with the condition. A medical device that operates in accordance with the techniques obtains a plurality of parameters associated with the condition of the patient. The medical device obtains probabilities that the condition of the patient exists based on each single parameter separately and correlations between each of the parameters and the other ones of the parameters. After obtaining the probabilities and correlations associated with each of the parameters, the medical device determines whether the condition of the patient exists based on the determined probabilities and correlations. Such techniques may be particularly effective for use in distinguishing whether a rhythm of a patient is treatable, e.g., VT or VF, or non-treatable, e.g., SVT.

摘要翻译： 描述了用于使用集成了与条件相关联的多个参数的基于概率相关的模型来检测患者的状况的技术。 根据技术操作的医疗装置获得与患者状况相关联的多个参数。 医疗设备根据每个单独的参数获得病人的状况存在的概率，以及每个参数与其他参数之间的相关性。 在获得与每个参数相关联的概率和相关性之后，医疗设备基于所确定的概率和相关性来确定患者的状况是否存在。 这种技术可能特别有效地用于区分患者的节律是否可治疗，例如VT或VF，或不可治疗的，例如SVT。

公开(公告)号：US20120004566A1

公开(公告)日：2012-01-05

申请号：US12826916

申请日：2010-06-30

申请人： Xusheng Zhang ,  Robert W. Stadler ,  Douglas A. Hettrick

发明人： Xusheng Zhang ,  Robert W. Stadler ,  Douglas A. Hettrick

IPC分类号： A61N1/365 ,  A61N1/39 ,  A61B5/0452

CPC分类号： A61B5/0464 ,  A61N1/3621 ,  A61N1/3962

摘要： A medical device and associated method sense a cardiac signal and initiate an arrhythmia episode detection process in response to the cardiac signal by enabling an arrhythmia detection counter to be adjusted during the detection process. Data is accumulated relating to cardiac events during the detection process. An arrhythmia episode profile is established using the accumulated data. The accumulated data includes a pattern of the adjustment of the detection counter during the detection process

摘要翻译： 医疗装置和相关联的方法感测心脏信号，并且通过使得能够在检测过程期间调节心律失常检测计数器来响应于心脏信号而引发心律失常发作检测过程。 在检测过程中与心脏事件相关的数据被累积。 使用累积数据建立心律失常发作概况。 累积数据包括在检测处理期间检测计数器的调整的模式

公开(公告)号：US20110270335A1

公开(公告)日：2011-11-03

申请号：US12768905

申请日：2010-04-28

申请人： Robert W. Stadler ,  Xusheng Zhang

发明人： Robert W. Stadler ,  Xusheng Zhang

IPC分类号： A61N1/39

CPC分类号： A61N1/3956 ,  A61B5/0464 ,  A61B5/7203 ,  A61N1/3621

摘要： A medical device and associated method for discriminating cardiac events includes determining whether a cardiac evidence counter is greater than a predetermined detection threshold, advancing from a concerned state to a convinced state in response to the evidence counter being greater than the predetermined detection threshold, determining whether a reduction in the cardiac evidence counter occurs while in the convinced state, determining whether one of a first rate corresponding to the first sensing vector and a second rate corresponding to the second sensing vector is less than a predetermined rate limit, and determining whether to advance from the convinced state to one of a therapy delivery state, the concerned state and the unconcerned state in response to determining whether one of the first rate and the second rate is less than a predetermined rate limit.

摘要翻译： 用于鉴别心脏事件的医疗装置和相关联的方法包括：确定心脏证据计数器是否大于预定检测阈值，响应于证据计数器大于预定检测阈值，从有关状态进入确信状态，确定是否 在令人信服的状态下，发生心脏证据计数器的减少，确定对应于第一感测向量的第一速率和对应于第二感测向量的第二速率中的一个是否小于预定速率限制，并且确定是否前进 响应于确定第一速率和第二速率之一是否小于预定速率限制，从相信状态到治疗传递状态之一，相关状态和不关心状态。

公开(公告)号：US20110270109A1

公开(公告)日：2011-11-03

申请号：US12768917

申请日：2010-04-28

申请人： Xusheng Zhang ,  Robert W. Stadler ,  Saul E. Greenhut ,  Mark L. Brown ,  Troy E. Jackson ,  Teresa A. Whitman

发明人： Xusheng Zhang ,  Robert W. Stadler ,  Saul E. Greenhut ,  Mark L. Brown ,  Troy E. Jackson ,  Teresa A. Whitman

IPC分类号： A61B5/0464 ,  A61B5/02

CPC分类号： A61B5/0452 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/7203 ,  A61N1/3621

摘要： A medical device and associated method obtaining cardiac event intervals corresponding to a tachycardia interval. Evidence of a rhythm breaking point is obtained in response to sensing a cardiac event having a morphology corresponding to a supraventricular beat. A non-treatable rhythm is detected in response to the plurality of cardiac event intervals and the evidence of the rhythm breaking point.

摘要翻译： 获得对应于心动过速间隔的心脏事件间隔的医疗装置和相关方法。 响应于感测具有对应于室上搏动的形态的心脏事件而获得节律断点的证据。 响应于多个心脏事件间隔和节律断点的证据来检测不可治疗的节律。

公开(公告)号：US20110270108A1

公开(公告)日：2011-11-03

申请号：US12768850

申请日：2010-04-28

申请人： Robert W. Stadler ,  Xusheng Zhang ,  Jeffrey M. Gillberg

发明人： Robert W. Stadler ,  Xusheng Zhang ,  Jeffrey M. Gillberg

IPC分类号： A61B5/0464 ,  A61B5/0452

CPC分类号： A61B5/02405 ,  A61B5/0031 ,  A61B5/04011 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/686 ,  A61B5/6869 ,  A61B5/7203 ,  A61N1/3622 ,  A61N1/36507 ,  A61N1/37264

摘要： A medical device and associated method for monitoring a patient's heart rhythm sense cardiac events and detect a sudden change in the heart rhythm in response to the sensed cardiac events. Detecting the sudden change includes determining a variability of intervals between the sensed cardiac events and switching between a low variability mode of operation and a high variability mode of operation in response to the variability of intervals. During the low variability mode, detecting the sudden change includes detecting an increase in the rate of cardiac events. During the high variability mode, detecting the sudden change includes detecting a sudden decrease in the variability of the cardiac event intervals. A concerning cardiac rhythm is detected in response to detecting the sudden change.

摘要翻译： 用于监测患者心律的医疗装置和相关联的方法感测心脏事件并且响应于感测到的心脏事件来检测心律的突然变化。 检测突然变化包括响应于间隔的可变性来确定所感测的心脏事件之间的间隔的可变性和低变异性操作模式与高变异性操作模式之间的切换。 在低变异性模式期间，检测突然变化包括检测心脏事件发生率的增加。 在高可变性模式期间，检测突然变化包括检测心脏事件间隔的变异性的突然降低。 响应于检测到突然变化而检测到关于心律的A。