公开(公告)号：US10772725B2

公开(公告)日：2020-09-15

申请号：US15865006

申请日：2018-01-08

Applicant: Edwards Lifesciences Corporation

Inventor： Michael C. Murad ,  Emil Karapetian ,  Wesley V. Adzich

IPC: A61F2/24 ,  A61F2/00

Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.

公开(公告)号：US20200060821A1

公开(公告)日：2020-02-27

申请号：US16673487

申请日：2019-11-04

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin ,  Michael C. Murad

IPC: A61F2/24

Abstract: A valve holder for delivering a prosthetic heart valve to an implant site is in various embodiments configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. The valve holder can be configured to deploy or actuate automatically when performing preparatory steps that are already familiar to practitioners, such as attaching a delivery handle to the valve holder, so that the valve holders will not require additional steps or training to use. Therefore, operation of the valve holders is kept simple, and occurrences of mistakes caused by user error can be minimized or reduced. Valve holders according to different embodiments can be designed to accommodate implantation of prosthetic heart valves from either the inflow end or the outflow end of the native valve annulus.

公开(公告)号：US20180289477A1

公开(公告)日：2018-10-11

申请号：US15481283

申请日：2017-04-06

Applicant: Edwards Lifesciences Corporation

Inventor： Brian S. Conklin ,  Michael C. Murad

IPC: A61F2/24

Abstract: A valve holder for delivering a prosthetic heart valve to an implant site is in various embodiments configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. The valve holder can be configured to deploy or actuate automatically when performing preparatory steps that are already familiar to practitioners, such as attaching a delivery handle to the valve holder, so that the valve holders will not require additional steps or training to use. Therefore, operation of the valve holders is kept simple, and occurrences of mistakes caused by user error can be minimized or reduced. Valve holders according to different embodiments can be designed to accommodate implantation of prosthetic heart valves from either the inflow end or the outflow end of the native valve annulus.

公开(公告)号：US09861478B2

公开(公告)日：2018-01-09

申请号：US15076107

申请日：2016-03-21

Applicant: Edwards Lifesciences Corporation

Inventor： Michael C. Murad ,  Emil Karapetian ,  Wesley V. Adzich

IPC: A61F2/24 ,  A61F2/00

CPC classification number: A61F2/2427 ,  A61F2/0095 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2220/0075 ,  A61F2230/0006 ,  A61F2250/001

Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.

公开(公告)号：US20160166248A1

公开(公告)日：2016-06-16

申请号：US14965323

申请日：2015-12-10

Applicant: Edwards Lifesciences Corporation

Inventor： Derek Dee Deville ,  Kevin W. Smith ,  Michael Walter Kirk ,  Carlos Rivera ,  George Nunez ,  Thomas O. Bales, JR. ,  Korey Kline ,  Matthew A. Palmer ,  M. Sean McBrayer ,  Richard Cartledge ,  Max Pierre Mendez ,  Hengchu Cao ,  Anthony Peter Carcia ,  Kevin Dang ,  Carey Hendsbee ,  Brent K. Hoffman ,  Brian R. Jacobs ,  Mohammad Jafari ,  Brian Janish ,  Jeffrey L. Mahoney ,  Raffaele Mazzei ,  Manouchehr A. Miraki ,  Ryan Moehle ,  Jeremiah Morgan ,  Michael C. Murad ,  Travis Zenyo Oba ,  Ralph Schneider ,  Fabian Daniel Schroeder ,  Tyler Douglas Smith ,  Ming H. Wu

IPC: A61B17/04

CPC classification number: A61B17/0485 ,  A61B17/0467 ,  A61B17/0487 ,  A61B2017/00017 ,  A61B2017/00119 ,  A61B2017/00349 ,  A61B2017/00358 ,  A61B2017/00398 ,  A61B2017/00477 ,  A61B2017/00734 ,  A61B2017/00876 ,  A61B2017/00902 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2090/064 ,  A61B2090/0807 ,  A61B2090/309 ,  A61B2090/3937

Abstract: A multiple-fire securing device includes a hollow outer shaft, a reloader, a reloader movement assembly, a rail, and securing structures each defining an inner securing orifice. The reloader longitudinally moves within the outer shaft and has a distal end shaped to temporarily contact one of the securing structures. The rail is disposed within the reloader and has an installing location. The securing structures are disposed on the rail. The reloader movement assembly moves the reloader longitudinally in a distal direction to deliver a first securing structure to the installing location from a first proximal position and moves the reloader proximally away from the installing location without the first securing structure to a position in which the distal end of the reloader temporarily contacts a second one of the securing structures. The second and successive securing structures are moved one at a time to the installing location.

Abstract translation: 多重火焰固定装置包括中空的外轴，重新装载机，重装机运动组件，轨道和固定结构，每个限定内固定孔。 重新装载机在外轴内纵向移动并且具有成形为临时接触其中一个固定结构的远端。 轨道设置在重新装载机内并具有安装位置。 固定结构设置在轨道上。 重新装载机构移动组件沿远侧方向纵向运动重新装载机，以将第一固定结构从第一近端位置传送到安装位置，并将重新装载机向近侧移动远离安装位置而不用第一固定结构移动到远端 的重新加载器临时接触第二个固定结构。 第二和连续的固定结构一次一个地移动到安装位置。

公开(公告)号：US20150313712A1

公开(公告)日：2015-11-05

申请号：US14797110

申请日：2015-07-11

Applicant: Edwards Lifesciences Corporation

Inventor： Alain F. Carpentier ,  Michael C. Murad

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61B2017/00243 ,  A61B2017/0496 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2454 ,  A61F2230/0071

Abstract: A holder for a prosthetic mitral heart valve that attaches to an inflow end of the valve and includes a simple tensioning mechanism that flexes the heart valve commissure posts inward to help prevent suture looping. The tensioning mechanism may include relatively movable rings of the holder or a generally unitary holder with a tensor, or rotatable knob. Connecting sutures thread through internal passages in the holder and travel in the outflow direction along valve commissure posts, emerging at the post tips and mutually crossing over the outflow side of the valve. A handle attaches off-center on the holder to increase visualization of and access to the heart valve through a central window for enhanced access to the commissure posts and leaflets. The holder is constructed of non-metallic materials so as to avoid interfering with imaging devices, and the handle is ergonomically curved and shaped to facilitate manipulation.

Abstract translation: 用于假体二尖瓣心脏瓣膜的保持器，其附接到瓣膜的流入端，并且包括将心脏瓣膜连接柱向内弯曲的简单张紧机构，以帮助防止缝合线循环。 张紧机构可以包括保持器的相对可移动的环或具有张量或可旋转旋钮的大体上一体的保持器。 连接缝合线通过保持器内部的通道，沿着流出方向沿阀门连接柱移动，出现在后端，并在阀的流出侧相互交叉。 手柄靠近座位，通过中央窗口增加对心脏瓣膜的可视化和访问，以增强对连接柱和传单的使用。 保持器由非金属材料构成，以避免干扰成像装置，并且手柄符合人体工程学地弯曲和成形以便于操纵。

公开(公告)号：US20240261089A1

公开(公告)日：2024-08-08

申请号：US18614255

申请日：2024-03-22

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Michael R. Bialas ,  Kristen Hicks ,  Michael C. Murad ,  Gil Senesh ,  Quang Ngoc Vu ,  Gonzalo German Angelico ,  Carla Susana Cerqueira ,  Victoria Mariko Low ,  Andrea Fernandez ,  Karl J. Britzman ,  Shannon Nicole Ash (formerly Hoye) ,  Haley Nicole Whitehead

IPC: A61F2/24 ,  A61B50/30 ,  A61F2/95 ,  A61F2/958 ,  A61M25/10

CPC classification number: A61F2/24 ,  A61B50/30 ,  A61F2/2418 ,  A61F2/2436 ,  A61M25/10 ,  A61F2/2433 ,  A61F2/9517 ,  A61F2002/9583 ,  A61F2220/0025 ,  A61F2220/0075 ,  A61F2230/0002 ,  A61F2250/0098

Abstract: Methods and systems for rotationally aligning a commissure of a prosthetic heart valve with a commissure of a native valve are disclosed. In some examples, a delivery apparatus can include a first shaft configured to rotate around a central longitudinal axis of the delivery apparatus to rotationally align a prosthetic valve mounted on the delivery apparatus with native anatomy, a second shaft extending through the first shaft and having a distal end portion extending distally beyond a distal end portion of the first shaft, an inflatable balloon coupled to the distal end portion of the first shaft, and a distal shoulder mounted on the distal end portion of the second shaft and arranged within a distal end portion of the balloon. The distal shoulder comprises a base portion and a flared portion that extends radially outward from the base portion, and a radiopaque marker is disposed on the flared portion.

公开(公告)号：US12053376B2

公开(公告)日：2024-08-06

申请号：US17473719

申请日：2021-09-13

Applicant: Edwards Lifesciences Corporation

Inventor： Joseph Arthur Passman ,  Linda Thai ,  Michael C. Murad

IPC: A61F2/24 ,  A61F2/95 ,  A61F2/966

CPC classification number: A61F2/2433 ,  A61F2/2436 ,  A61F2/95 ,  A61F2/966 ,  A61F2/9517

Abstract: A catheter device includes a shaft having a steerable distal portion and a plurality of layers including a braided layer. A first pull-wire lumen is disposed at least partially within the braided layer, and a second pull-wire lumen is disposed at least partially within the braided layer. The first pull-wire lumen and the second pull-wire lumen are circumferentially spaced apart from each other in the steerable distal portion of the shaft.

公开(公告)号：US11931251B2

公开(公告)日：2024-03-19

申请号：US18113577

申请日：2023-02-23

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Michael C. Murad

IPC: A61F2/24 ,  A61B50/30 ,  A61M25/10 ,  A61F2/95 ,  A61F2/958

CPC classification number: A61F2/24 ,  A61B50/30 ,  A61F2/2418 ,  A61F2/2436 ,  A61M25/10 ,  A61F2/2433 ,  A61F2/9517 ,  A61F2002/9583 ,  A61F2220/0025 ,  A61F2220/0075 ,  A61F2230/0002 ,  A61F2250/0098

Abstract: Methods and systems for rotationally aligning a commissure of a prosthetic heart valve with a commissure of a native valve are disclosed. In some examples, a delivery apparatus can include a first shaft configured to rotate around a central longitudinal axis of the delivery apparatus, a second shaft extending through the first shaft and having a distal end portion extending distally beyond a distal end portion of the first shaft, an inflatable balloon coupled to the distal end portion of the first shaft, and a third shaft surrounding the first shaft. The first shaft is configured to rotate within the third shaft and translate axially relative to the third shaft, and the third shaft includes a distal tip portion including a plurality of internal helical expansion grooves and a plurality of external helical expansion grooves that are configured to allow the distal tip portion to flex radially outward.

公开(公告)号：US20230363905A1

公开(公告)日：2023-11-16

申请号：US18358855

申请日：2023-07-25

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Ramin Samari ,  Michael C. Murad ,  Michael R. Bialas

IPC: A61F2/24 ,  A61M29/02

CPC classification number: A61F2/2433 ,  A61M29/02 ,  A61M2025/1004

Abstract: The present embodiments relate generally to devices, systems, and methods for dilating implants utilizing dilation devices. An example includes a dilation device for an implant. The dilation device includes an inflatable body having a proximal end and a distal end, and a central body positioned between the proximal end and the distal end and having a length. The central body is configured to press an inner surface of the implant to dilate the implant. The inflatable body includes at least one outer inflatable body fold radius of curvature greater than or equal to one half a thickness of the inflatable body.