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公开(公告)号:US10555810B2
公开(公告)日:2020-02-11
申请号:US15905625
申请日:2018-02-26
Applicant: Edwards Lifesciences Corporation
Inventor: Rafael Pintor , Mark Chau , Travis Zenyo Oba , August R. Yambao , Louis A. Campbell , Tammy Huntley , Qinggang Zeng , Carey L. Cristea , Faisal Kalam
IPC: A61F2/24
Abstract: A quick-connect heart valve prosthesis that can be quickly and easily implanted is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable coupling stent, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the coupling stent attached thereto. The coupling stent may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes a hollow two-piece handle through which a balloon catheter passes. A valve holder is stored with the heart valve and the handle easily attaches thereto to improve valve preparation steps.
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公开(公告)号:US20180338828A1
公开(公告)日:2018-11-29
申请号:US16056252
申请日:2018-08-06
Applicant: Edwards Lifesciences Corporation
Inventor: Rafael Pintor , Michael J. Scott , Thomas H. Chien , Harvey H. Chen , August R. Yambao , Lawrence J. Farhat , Andrew Phung , William C. Brunnett , Carey L. Cristea , Sara M. Walls , Kevin W. Zheng , Faisal Kalam , Qinggang Zeng
IPC: A61F2/24
Abstract: A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable frame, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the frame attached thereto. The frame may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes an integrated handle shaft and balloon catheter. A valve holder is stored with the heart valve and the handle shaft easily attaches thereto to improve valve preparation steps.
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公开(公告)号:US20180271648A1
公开(公告)日:2018-09-27
申请号:US15990599
申请日:2018-05-26
Applicant: Edwards Lifesciences Corporation
Inventor: Mark Chau , Qinggang Zeng
IPC: A61F2/24
CPC classification number: A61F2/243 , A61F2/2418 , A61F2/2427 , A61F2/2433 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/0054 , A61F2230/008 , A61F2250/0063 , A61F2250/0097 , A61F2250/0098
Abstract: An exemplary two-stage prosthetic heart valve system has a radially expandable base stent implanted within a native valve annulus. The base stent desirably has three position markers projecting in the axial direction from the outflow end of the base stent to assist in aligning the stent with respect to the commissures of the native valve. The two-stage heart valve system also has a valve component that is delivered to and mounted within the base stent in a separate or sequential operation after the base stent has been anchored within the annulus. The valve component in certain embodiments comprises a hybrid valve component that includes a conventional, non-expandable surgical valve that is modified to include an expandable coupling stent that can be expanded to engage the inner surface of the base stent, thereby anchoring the valve component to the base stent.
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公开(公告)号:US10039641B2
公开(公告)日:2018-08-07
申请号:US15360483
申请日:2016-11-23
Applicant: Edwards Lifesciences Corporation
Inventor: Rafael Pintor , Michael J. Scott , Thomas H. Chien , Harvey H. Chen , August R. Yambao , Lawrence J. Farhat , Andrew Phung , William C. Brunnett , Carey L. Cristea , Sara M. Walls , Kevin W. Zheng , Faisal Kalam , Qinggang Zeng
IPC: A61F2/24
Abstract: A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable frame, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the frame attached thereto. The frame may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes an integrated handle shaft and balloon catheter. A valve holder is stored with the heart valve and the handle shaft easily attaches thereto to improve valve preparation steps.
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公开(公告)号:US20180042690A1
公开(公告)日:2018-02-15
申请号:US15792441
申请日:2017-10-24
Applicant: Edwards Lifesciences Corporation
Inventor: Qinggang Zeng , Chacphet Limsakoune , Diana E. Ko , Christina M. Aguila
CPC classification number: A61B50/30 , A61B50/33 , A61B2050/002 , A61F2/0095 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2250/0069
Abstract: A packaged bioprosthetic heart valve comprising a bioprosthetic heart valve, an adaptive seal and a package. The bioprosthetic heart valve comprises an at least partially dehydrated biological tissue leaflet structure coupled to a supporting frame. The bioprosthetic heart valve has a periphery, an inflow portion, and an outflow portion. The adaptive seal is coupled to the bioprosthetic heart valve around at least a portion of the periphery. The adaptive seal comprises an expandable material that expands after exposure to an initiating condition. The bioprosthetic heart valve and the adaptive seal is stored and contained within the package, which does not contain a liquid storage solution in contact with the bioprosthetic heart valve and the adaptive seal.
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公开(公告)号:US20170224484A1
公开(公告)日:2017-08-10
申请号:US15360483
申请日:2016-11-23
Applicant: Edwards Lifesciences Corporation
Inventor: Rafael Pintor , Michael J. Scott , Thomas H. Chien , Harvey H. Chen , August R. Yambao , Lawrence J. Farhat , Andrew Phung , William C. Brunnett , Carey L. Cristea , Sara M. Walls , Kevin W. Zheng , Faisal Kalam , Qinggang Zeng
IPC: A61F2/24
CPC classification number: A61F2/2433 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/0067 , A61F2250/0018 , A61F2250/0039 , A61F2250/0048 , A61F2250/006
Abstract: A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable frame, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the frame attached thereto. The frame may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes an integrated handle shaft and balloon catheter. A valve holder is stored with the heart valve and the handle shaft easily attaches thereto to improve valve preparation steps.
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47.
公开(公告)号:US20170000603A1
公开(公告)日:2017-01-05
申请号:US15199743
申请日:2016-06-30
Applicant: Edwards Lifesciences Corporation
Inventor: Brian S. Conklin , Qinggang Zeng
IPC: A61F2/24
Abstract: A hybrid prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be expanded post implant in order to receive and/or support an expandable prosthetic heart valve therein (a valve-in-valve procedure). The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible for delivery and expandable post-implant to facilitate a valve-in-valve procedure.
Abstract translation: 一种混合式假体心脏瓣膜,其构造成替代原生心脏瓣膜并具有支撑框架,所述支撑框架被配置为在植入物之后扩张,以便在其中接收和/或支撑可扩张的假体心脏瓣膜(阀门过程)。 假体心脏瓣膜可以被构造成当最初植入时具有大致刚性和/或抗膨胀的构造,以替代天然瓣膜(或其他假体心脏瓣膜),但是当受到向外的力(例如, 由膨胀气球或其他机械膨胀机提供。 流入支架框架是可扩张的,用于将阀固定在适当位置,并且可具有用于输送和可扩展的植入后可折叠的流出端,以便于阀门过程。
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公开(公告)号:US09504566B2
公开(公告)日:2016-11-29
申请号:US14745287
申请日:2015-06-19
Applicant: Edwards Lifesciences Corporation
Inventor: Jessica Guttenberg , Da-Yu Chang , Derrick Johnson , Brian S. Conklin , Qinggang Zeng , Myron Howanec, Jr. , Grace M. Kim
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/2409 , A61F2250/0085 , A61F2250/0089 , A61F2250/0098
Abstract: A prosthetic heart valve configured to replace a native heart valve and for post-implant expansion and having a valve-type indicator thereon visible from outside the body post-implant. The indicator communicates information about the valve, such as the size or orifice diameter of the valve, and/or that the valve has the capacity for post-implant expansion. The indicator can be an alphanumeric symbol or other symbol or combination of symbols that represent information about the characteristics of the valve such as the valve size. The capacity for post-implant expansion facilitates a valve-in-valve procedure, where the valve-type indicator conveys information to the surgeon about whether the implanted valve is suitable for the procedure and informs the choice of the secondary valve.
Abstract translation: 一种假体心脏瓣膜,其构造成代替天然心脏瓣膜并用于植入后扩张,并且在体外植入物后面具有可从其上观察到的瓣膜型指示器。 指示器传达关于阀的信息,例如阀的尺寸或孔直径,和/或阀具有用于植入物扩张的能力。 指示符可以是代表关于阀的特性的信息的字母数字符号或其它符号或符号的组合,例如阀的尺寸。 植入后扩张的能力有利于瓣膜瓣膜手术,其中瓣膜型指示器向外科医生传达关于植入的瓣膜是否适于手术并且通知二次瓣膜的选择的信息。
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公开(公告)号:US20150366664A1
公开(公告)日:2015-12-24
申请号:US14745287
申请日:2015-06-19
Applicant: Edwards Lifesciences Corporation
Inventor: Jessica Guttenberg , Da-Yu Chang , Derrick Johnson , Brian S. Conklin , Qinggang Zeng , Myron Howanec, JR. , Grace M. Kim
CPC classification number: A61F2/2418 , A61F2/2409 , A61F2250/0085 , A61F2250/0089 , A61F2250/0098
Abstract: A prosthetic heart valve configured to replace a native heart valve and for post-implant expansion and having a valve-type indicator thereon visible from outside the body post-implant. The indicator communicates information about the valve, such as the size or orifice diameter of the valve, and/or that the valve has the capacity for post-implant expansion. The indicator can be an alphanumeric symbol or other symbol or combination of symbols that represent information about the characteristics of the valve such as the valve size. The capacity for post-implant expansion facilitates a valve-in-valve procedure, where the valve-type indicator conveys information to the surgeon about whether the implanted valve is suitable for the procedure and informs the choice of the secondary valve.
Abstract translation: 一种假体心脏瓣膜,其构造成代替天然心脏瓣膜并用于植入后扩张,并且在体外植入物后面具有可从其上观察到的瓣膜型指示器。 指示器传达关于阀的信息,例如阀的尺寸或孔直径,和/或阀具有用于植入物扩张的能力。 指示符可以是代表关于阀的特性的信息的字母数字符号或其他符号或符号的组合,例如阀的尺寸。 植入后扩张的能力有利于瓣膜瓣膜手术,其中瓣膜型指示器向外科医生传达关于植入的瓣膜是否适于手术并且通知二次瓣膜的选择的信息。
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50.
公开(公告)号:US20150216656A1
公开(公告)日:2015-08-06
申请号:US14684267
申请日:2015-04-10
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor: Rafael Pintor , Mark Chau , Travis Oba , August R. Yambao , Louis A. Campbell , Tammy Huntley , Qinggang Zeng , Carey L. Cristea , Faisal Kalam
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/2409 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/0054 , A61F2230/0067 , A61F2230/0069 , A61F2230/0078 , A61F2250/006
Abstract: A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve has a base stent that is deployed at a treatment site, and a valve component configured to quickly connect to the base stent. The base stent may take the form of a self- or balloon-expandable stent that expands outward against the native valve with or without leaflet excision. The valve component has a non-expandable prosthetic valve and a self- or balloon-expandable coupling stent for attachment to the base stent, thereby fixing the position of the valve component relative to the base stent. The prosthetic valve may be a commercially available to valve with a sewing ring and the coupling stent attaches to the sewing ring. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment. A catheter-based system and method for deployment is provided.
Abstract translation: 提供了可以在手术过程中快速且容易地植入的心脏瓣膜假体。 假体瓣膜具有部署在治疗部位的基部支架和构造成快速连接到基部支架的阀部件。 基底支架可以采取自体或球囊扩张的支架的形式,其在具有或不具有小叶切除的情况下相对于天然瓣膜向外扩张。 阀部件具有不可扩张的假体瓣膜和用于附接到基底支架的自支撑或球囊扩张的联接支架,由此固定阀部件相对于基底支架的位置。 人造瓣膜可以是市售的,具有缝合环的阀门,并且联接支架附接到缝合环。 该系统特别适用于在常规开心手术环境中快速部署心脏瓣膜。 提供了基于导管的系统和部署方法。
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